{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T16:00:39Z","timestamp":1781107239336,"version":"3.54.1"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,10]]},"DOI":"10.7759\/cureus.110606","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:27:36Z","timestamp":1781105256000},"source":"Crossref","is-referenced-by-count":0,"title":["Resolving Morphological Ambiguity in Molar Pregnancy: The Diagnostic Role of p57 Immunohistochemistry"],"prefix":"10.7759","author":[{"given":"Ananya","family":"Nath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savitri M","family":"Nerune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayandeep K","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-7494-5","article-title":"Manual of Pathology of the Human Placenta, Second Edition","author":"Baergen RN","year":"2011","unstructured":"Baergen RN. Manual of Pathology of the Human Placenta, Second Edition. Springer, New York, NY; 2011. 10.1007\/978-1-4419-7494-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl MJ","year":"2010","unstructured":"Seckl MJ, Sebire NJ, Berkowitz RS. Gestational trophoblastic disease. Lancet. 2010, 376:717-29. 10.1016\/S0140-6736(10)60280-2","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.073","article-title":"Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole","volume":"203","author":"Lurain JR","year":"2010","unstructured":"Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010, 203:531-9. 10.1016\/j.ajog.2010.06.073","journal-title":"Am J Obstet Gynecol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12615","article-title":"Update on the diagnosis and management of gestational trophoblastic disease","volume":"143 Suppl 2","author":"Ngan HY","year":"2018","unstructured":"Ngan HY, Seckl MJ, Berkowitz RS, et al.. Update on the diagnosis and management of gestational trophoblastic disease. Int J Gynaecol Obstet. 2018, 143 Suppl 2:79-85. 10.1002\/ijgo.12615","journal-title":"Int J Gynaecol Obstet"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109\/15513810903266138","article-title":"Histopathological diagnosis of hydatidiform mole: contemporary features and clinical implications","volume":"29","author":"Sebire NJ","year":"2010","unstructured":"Sebire NJ. Histopathological diagnosis of hydatidiform mole: contemporary features and clinical implications. Fetal Pediatr Pathol. 2010, 29:1-16. 10.3109\/15513810903266138","journal-title":"Fetal Pediatr Pathol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/s0046-8177(96)90402-5","article-title":"Very early complete hydatidiform mole","volume":"27","author":"Keep D","year":"1996","unstructured":"Keep D, Zaragoza MV, Hassold T, Redline RW. Very early complete hydatidiform mole. Hum Pathol. 1996, 27:708-13. 10.1016\/s0046-8177(96)90402-5","journal-title":"Hum Pathol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000157996.23059.c1","article-title":"Interobserver and intraobserver variability in the diagnosis of hydatidiform mole","volume":"29","author":"Fukunaga M","year":"2005","unstructured":"Fukunaga M, Katabuchi H, Nagasaka T, Mikami Y, Minamiguchi S, Lage JM. Interobserver and intraobserver variability in the diagnosis of hydatidiform mole. Am J Surg Pathol. 2005, 29:942-7. 10.1097\/01.pas.0000157996.23059.c1","journal-title":"Am J Surg Pathol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1101\/gad.9.6.650","article-title":"p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene","volume":"9","author":"Matsuoka S","year":"1995","unstructured":"Matsuoka S, Edwards MC, Bai C, et al.. p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene. Genes Dev. 1995, 9:650-62. 10.1101\/gad.9.6.650","journal-title":"Genes Dev"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2002.129421","article-title":"Immunohistochemical characterization of p57(KIP2) expression in early hydatidiform moles","volume":"33","author":"Fukunaga M","year":"2002","unstructured":"Fukunaga M. Immunohistochemical characterization of p57(KIP2) expression in early hydatidiform moles. Hum Pathol. 2002, 33:1188-92. 10.1053\/hupa.2002.129421","journal-title":"Hum Pathol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2004.12.007","article-title":"p57KIP2 immunohistochemistry in early molar pregnancies: emphasis on its complementary role in the differential diagnosis of hydropic abortuses","volume":"36","author":"Merchant SH","year":"2005","unstructured":"Merchant SH, Amin MB, Viswanatha DS, Malhotra RK, Moehlenkamp C, Joste NE. p57KIP2 immunohistochemistry in early molar pregnancies: emphasis on its complementary role in the differential diagnosis of hydropic abortuses. Hum Pathol. 2005, 36:180-6. 10.1016\/j.humpath.2004.12.007","journal-title":"Hum Pathol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0B013E3181B1904D","article-title":"Diagnosis and subclassification of hydatidiform moles utilizing p57 immunohistochemistry and molecular genotyping: validation and prospective analysis in routine and consultation practice settings with development of an algorithmic approach","volume":"33","author":"McConnell TG","year":"2009","unstructured":"McConnell TG, Murphy KM, Hafez MJ, Vang R, Ronnett BM. Diagnosis and subclassification of hydatidiform moles utilizing p57 immunohistochemistry and molecular genotyping: validation and prospective analysis in routine and consultation practice settings with development of an algorithmic approach. Am J Surg Pathol. 2009, 33:805-17. 10.1097\/PAS.0B013E3181B1904D","journal-title":"Am J Surg Pathol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/JLP.JLP_130_19","article-title":"Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles","volume":"11","author":"Mondal SK","year":"2019","unstructured":"Mondal SK, Mandal S, Bhattacharya S, Panda UK, Ray A, Ali SM. Expression of p57 immunomarker in the classification and differential diagnosis of partial and complete hydatidiform moles. J Lab Physicians. 2019, 11:270-4. 10.4103\/JLP.JLP_130_19","journal-title":"J Lab Physicians"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_982_15","article-title":"Utility of p57 immunohistochemistry in differentiating between complete mole, partial mole & non-molar or hydropic abortus","volume":"145","author":"Samadder A","year":"2017","unstructured":"Samadder A, Kar R. Utility of p57 immunohistochemistry in differentiating between complete mole, partial mole &amp; non-molar or hydropic abortus. Indian J Med Res. 2017, 145:133-7. 10.4103\/ijmr.IJMR_982_15","journal-title":"Indian J Med Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1982.tb00714.x","article-title":"Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole","volume":"46","author":"Jacobs PA","year":"1982","unstructured":"Jacobs PA, Szulman AE, Funkhouser J, Matsuura JS, Wilson CC. Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole. Ann Hum Genet. 1982, 46:223-31. 10.1111\/j.1469-1809.1982.tb00714.x","journal-title":"Ann Hum Genet"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200110000-00001","article-title":"Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2","volume":"25","author":"Castrillon DH","year":"2001","unstructured":"Castrillon DH, Sun D, Weremowicz S, Fisher RA, Crum CP, Genest DR. Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2. Am J Surg Pathol. 2001, 25:1225-30. 10.1097\/00000478-200110000-00001","journal-title":"Am J Surg Pathol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2006.04.030","article-title":"Multiplex short tandem repeat DNA analysis confirms the accuracy of p57(KIP2) immunostaining in the diagnosis of complete hydatidiform mole","volume":"37","author":"Popiolek DA","year":"2006","unstructured":"Popiolek DA, Yee H, Mittal K, Chiriboga L, Prinz MK, Caragine TA, Budimlija ZM. Multiplex short tandem repeat DNA analysis confirms the accuracy of p57(KIP2) immunostaining in the diagnosis of complete hydatidiform mole. Hum Pathol. 2006, 37:1426-34. 10.1016\/j.humpath.2006.04.030","journal-title":"Hum Pathol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2003.01667.x","article-title":"p57kip2 is useful in the classification and differential diagnosis of complete and partial hydatidiform moles","volume":"43","author":"Jun SY","year":"2003","unstructured":"Jun SY, Ro JY, Kim KR. p57kip2 is useful in the classification and differential diagnosis of complete and partial hydatidiform moles. Histopathology. 2003, 43:17-25. 10.1046\/j.1365-2559.2003.01667.x","journal-title":"Histopathology"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/497069-resolving-morphological-ambiguity-in-molar-pregnancy-the-diagnostic-role-of-p57-immunohistochemistry","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:27:37Z","timestamp":1781105257000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/497069-resolving-morphological-ambiguity-in-molar-pregnancy-the-diagnostic-role-of-p57-immunohistochemistry"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,10]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.110606","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,10]]}}}