{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T11:00:45Z","timestamp":1781262045060,"version":"3.54.1"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,12]]},"DOI":"10.7759\/cureus.110725","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:25:02Z","timestamp":1781259902000},"source":"Crossref","is-referenced-by-count":0,"title":["Early-Onset Neutropenia Induced by Rituximab in a Patient With Pemphigus Vulgaris: A Case Report and Literature Review"],"prefix":"10.7759","author":[{"given":"Lamis","family":"El Yamani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouissal","family":"Hormi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nassiba","family":"Zerrouki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Zizi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Rituximab-induced Neutropenia: Clinical and Pathophysiological Studies [Thesis]","author":"Tesfa D","year":"2012","unstructured":"Tesfa D. Rituximab-induced Neutropenia: Clinical and Pathophysiological Studies [Thesis]. Karolinska Institutet, Stockholm; 2012."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13365","article-title":"Early onset neutropenia and thrombocytopenia following rituximab in lupus nephritis","volume":"22","author":"Shah S","year":"2019","unstructured":"Shah S, Kavadichanda CG, Belani P, Ganesh RN, Negi VS. Early onset neutropenia and thrombocytopenia following rituximab in lupus nephritis. Int J Rheum Dis. 2019, 22:946-50. 10.1111\/1756-185X.13365","journal-title":"Int J Rheum Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/616787","article-title":"Early-onset neutropenia induced by rituximab in a patient with lupus nephritis and hemolytic anemia","volume":"2015","author":"Arroyo-\u00c1vila M","year":"2015","unstructured":"Arroyo-\u00c1vila M, Fred-Jim\u00e9nez RM, Vil\u00e1 LM. Early-onset neutropenia induced by rituximab in a patient with lupus nephritis and hemolytic anemia. Case Rep Rheumatol. 2015, 2015:616787. 10.1155\/2015\/616787","journal-title":"Case Rep Rheumatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01418","article-title":"Pemphigus: current and future therapeutic strategies","volume":"10","author":"Didona D","year":"2019","unstructured":"Didona D, Maglie R, Eming R, Hertl M. Pemphigus: current and future therapeutic strategies. Front Immunol. 2019, 10:1418. 10.3389\/fimmu.2019.01418","journal-title":"Front Immunol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18482","article-title":"Rituximab is an effective treatment in patients with pemphigus vulgaris and demonstrates a steroid-sparing effect","volume":"182","author":"Chen DM","year":"2020","unstructured":"Chen DM, Odueyungbo A, Csinady E, et al.. Rituximab is an effective treatment in patients with pemphigus vulgaris and demonstrates a steroid-sparing effect. Br J Dermatol. 2020, 182:1111-9. 10.1111\/bjd.18482","journal-title":"Br J Dermatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04744.x","article-title":"Rituximab in severe pemphigus","volume":"1173","author":"Schmidt E","year":"2009","unstructured":"Schmidt E, Goebeler M, Zillikens D. Rituximab in severe pemphigus. Ann N Y Acad Sci. 2009, 1173:683-91. 10.1111\/j.1749-6632.2009.04744.x","journal-title":"Ann N Y Acad Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.14740\/jh814","article-title":"Early onset neutropenia due to rituximab therapy in mantle cell lymphoma: a case report","volume":"10","author":"Nelson BE","year":"2021","unstructured":"Nelson BE, Tipton S, Venkatesan R. Early onset neutropenia due to rituximab therapy in mantle cell lymphoma: a case report. J Hematol. 2021, 10:136-8. 10.14740\/jh814","journal-title":"J Hematol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa111.032","article-title":"P33: Spontaneous regression of confirmed diffuse large B-cell lymphoma after withdrawal of long-term methotrexate and infliximab therapy for rheumatoid arthritis, with concurrent discovery of rare high-grade urothelial carcinoma","volume":"59","author":"Jones BA","year":"2020","unstructured":"Jones BA, Callaghan AO, Ross EV, Razack A, Yusof H, Wong E. P33: Spontaneous regression of confirmed diffuse large B-cell lymphoma after withdrawal of long-term methotrexate and infliximab therapy for rheumatoid arthritis, with concurrent discovery of rare high-grade urothelial carcinoma. Rheumatology. 2020, 59:keaa111.032. 10.1093\/rheumatology\/keaa111.032","journal-title":"Rheumatology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa111.033","article-title":"P34: Early-onset neutropenia in rituximab treated rheumatoid arthritis patients: a case series","volume":"59","author":"Lin CM","year":"2020","unstructured":"Lin CM, Lorenzi AR, Cooles FAH. P34: Early-onset neutropenia in rituximab treated rheumatoid arthritis patients: a case series. Rheumatology. 2020, 59:keaa111.033. 10.1093\/rheumatology\/keaa111.033","journal-title":"Rheumatology"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.029694","article-title":"Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases","volume":"64","author":"Gottenberg JE","year":"2005","unstructured":"Gottenberg JE, Guillevin L, Lambotte O, et al.. Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases. Ann Rheum Dis. 2005, 64:913-20. 10.1136\/ard.2004.029694","journal-title":"Ann Rheum Dis"},{"key":"ref11","article-title":"Early onset neutropenia after rituximab in lupus nephritis","volume":"25","author":"Enr\u00edquez R","year":"2007","unstructured":"Enr\u00edquez R, Borr\u00e1s-Blasco J, Sirvent AE, Mas\u00eda M, Amor\u00f3s F. Early onset neutropenia after rituximab in lupus nephritis. Clin Exp Rheumatol. 2007, 25:345.","journal-title":"Clin Exp Rheumatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.08.003","article-title":"Favorable outcome of granulocyte colony-stimulating factor use in neuromyelitis optica patients presenting with agranulocytosis in the setting of rituximab","volume":"287","author":"Mealy MA","year":"2015","unstructured":"Mealy MA, Levy M. Favorable outcome of granulocyte colony-stimulating factor use in neuromyelitis optica patients presenting with agranulocytosis in the setting of rituximab. J Neuroimmunol. 2015, 287:29-30. 10.1016\/j.jneuroim.2015.08.003","journal-title":"J Neuroimmunol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13726","article-title":"Early-onset neutropenia after rituximab therapy for bullous pemphigoid","volume":"44","author":"Adler BL","year":"2019","unstructured":"Adler BL, Crew AB, Woodley DT. Early-onset neutropenia after rituximab therapy for bullous pemphigoid. Clin Exp Dermatol. 2019, 44:334-6. 10.1111\/ced.13726","journal-title":"Clin Exp Dermatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/490854-early-onset-neutropenia-induced-by-rituximab-in-a-patient-with-pemphigus-vulgaris-a-case-report-and-literature-review","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:25:04Z","timestamp":1781259904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/490854-early-onset-neutropenia-induced-by-rituximab-in-a-patient-with-pemphigus-vulgaris-a-case-report-and-literature-review"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,12]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.110725","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,12]]}}}