{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T17:01:08Z","timestamp":1781456468785,"version":"3.54.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,13]]},"DOI":"10.7759\/cureus.110806","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:43:19Z","timestamp":1781455399000},"source":"Crossref","is-referenced-by-count":0,"title":["Cross-Disorder Pruning-Plasticity-Aging Architecture in Substance Use Disorders and Anxiety: Transcriptome-Wide Association Insights and Mechanistic Synthesis"],"prefix":"10.7759","author":[{"given":"Ngo","family":"Cheung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.15288\/jsad.2016.77.676","article-title":"Meta-analyses of genome-wide association data hold new promise for addiction genetics","volume":"77","author":"Agrawal A","year":"2016","unstructured":"Agrawal A, Edenberg HJ, Gelernter J. Meta-analyses of genome-wide association data hold new promise for addiction genetics. J Stud Alcohol Drugs. 2016, 77:676-80. 10.15288\/jsad.2016.77.676","journal-title":"J Stud Alcohol Drugs"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.86","article-title":"Genetics and alcoholism","volume":"10","author":"Edenberg HJ","year":"2013","unstructured":"Edenberg HJ, Foroud T. Genetics and alcoholism. Nat Rev Gastroenterol Hepatol. 2013, 10:487-94. 10.1038\/nrgastro.2013.86","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-0677-9","article-title":"Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium","volume":"25","author":"Polimanti R","year":"2020","unstructured":"Polimanti R, Walters RK, Johnson EC, et al.. Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium. Mol Psychiatry. 2020, 25:1673-87. 10.1038\/s41380-020-0677-9","journal-title":"Mol Psychiatry"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02174-0","article-title":"Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse","volume":"28","author":"Thijssen AB","year":"2023","unstructured":"Thijssen AB, Dick DM, Posthuma D, Savage JE. Investigating genetically stratified subgroups to better understand the etiology of alcohol misuse. Mol Psychiatry. 2023, 28:4225-33. 10.1038\/s41380-023-02174-0","journal-title":"Mol Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-023-01563-z","article-title":"Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications","volume":"55","author":"Levey DF","year":"2023","unstructured":"Levey DF, Galimberti M, Deak JD, et al.. Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications. Nat Genet. 2023, 55:2094-103. 10.1038\/s41588-023-01563-z","journal-title":"Nat Genet"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-025-02485-8","article-title":"Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling","volume":"58","author":"Strom NI","year":"2026","unstructured":"Strom NI, Verhulst B, Bacanu SA, et al.. Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. Nat Genet. 2026, 58:275-88. 10.1038\/s41588-025-02485-8","journal-title":"Nat Genet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3367","article-title":"A gene-based association method for mapping traits using reference transcriptome data","volume":"47","author":"Gamazon ER","year":"2015","unstructured":"Gamazon ER, Wheeler HE, Shah KP, et al.. A gene-based association method for mapping traits using reference transcriptome data. Nat Genet. 2015, 47:1091-8. 10.1038\/ng.3367","journal-title":"Nat Genet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3506","article-title":"Integrative approaches for large-scale transcriptome-wide association studies","volume":"48","author":"Gusev A","year":"2016","unstructured":"Gusev A, Ko A, Shi H, et al.. Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet. 2016, 48:245-52. 10.1038\/ng.3506","journal-title":"Nat Genet"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03621-1","article-title":"Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics","volume":"9","author":"Barbeira AN","year":"2018","unstructured":"Barbeira AN, Dickinson SP, Bonazzola R, et al.. Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics. Nat Commun. 2018, 9:1825. 10.1038\/s41467-018-03621-1","journal-title":"Nat Commun"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","year":"2020","unstructured":"The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science. 2020, 369.1318-30. 10.1126\/science.aaz1776","journal-title":"Science"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0385-z","article-title":"Opportunities and challenges for transcriptome-wide association studies","volume":"51","author":"Wainberg M","year":"2019","unstructured":"Wainberg M, Sinnott-Armstrong N, Mancuso N, et al.. Opportunities and challenges for transcriptome-wide association studies. Nat Genet. 2019, 51:592-9. 10.1038\/s41588-019-0385-z","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1010921","article-title":"On the interpretation of transcriptome-wide association studies","volume":"19","author":"de Leeuw C","year":"2023","unstructured":"de Leeuw C, Werme J, Savage JE, Peyrot WJ, Posthuma D. On the interpretation of transcriptome-wide association studies. PLoS Genet. 2023, 19:e1010921. 10.1371\/journal.pgen.1010921","journal-title":"PLoS Genet"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn C","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013, 153:1194-217. 10.1016\/j.cell.2013.05.039","journal-title":"Cell"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn C","year":"2023","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023, 186:243-78. 10.1016\/j.cell.2022.11.001","journal-title":"Cell"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD+ metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias AJ","year":"2021","unstructured":"Covarrubias AJ, Perrone R, Grozio A, Verdin E. NAD+ metabolism and its roles in cellular processes during ageing. Nat Rev Mol Cell Biol. 2021, 22:119-41. 10.1038\/s41580-020-00313-x","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.117","article-title":"Physiological and pathophysiological roles of NAMPT and NAD metabolism","volume":"11","author":"Garten A","year":"2015","unstructured":"Garten A, Schuster S, Penke M, Gorski T, de Giorgis T, Kiess W. Physiological and pathophysiological roles of NAMPT and NAD metabolism. Nat Rev Endocrinol. 2015, 11:535-46. 10.1038\/nrendo.2015.117","journal-title":"Nat Rev Endocrinol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NAD+ intermediates: the biology and therapeutic potential of NMN and NR","volume":"27","author":"Yoshino J","year":"2018","unstructured":"Yoshino J, Baur JA, Imai SI. NAD+ intermediates: the biology and therapeutic potential of NMN and NR. Cell Metab. 2018, 27:513-28. 10.1016\/j.cmet.2017.11.002","journal-title":"Cell Metab"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer R","year":"2008","unstructured":"Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci. 2008, 9:46-56. 10.1038\/nrn2297","journal-title":"Nat Rev Neurosci"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi C","year":"2018","unstructured":"Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018, 14:576-90. 10.1038\/s41574-018-0059-4","journal-title":"Nat Rev Endocrinol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"Kalivas PW","year":"2009","unstructured":"Kalivas PW. The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci. 2009, 10:561-72. 10.1038\/nrn2515","journal-title":"Nat Rev Neurosci"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1124\/pr.116.012484","article-title":"The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis","volume":"68","author":"Scofield MD","year":"2016","unstructured":"Scofield MD, Heinsbroek JA, Gipson CD, et al.. The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis. Pharmacol Rev. 2016, 68:816-71. 10.1124\/pr.116.012484","journal-title":"Pharmacol Rev"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.01.017","article-title":"Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling","volume":"69","author":"L\u00fcscher C","year":"2011","unstructured":"L\u00fcscher C, Malenka RC. Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron. 2011, 69:650-63. 10.1016\/j.neuron.2011.01.017","journal-title":"Neuron"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-122414-033457","article-title":"Drug addiction: updating actions to habits to compulsions ten years on","volume":"67","author":"Everitt BJ","year":"2016","unstructured":"Everitt BJ, Robbins TW. Drug addiction: updating actions to habits to compulsions ten years on. Annu Rev Psychol. 2016, 67:23-50. 10.1146\/annurev-psych-122414-033457","journal-title":"Annu Rev Psychol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.08.062","article-title":"The dynorphin\/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors","volume":"1314","author":"Bruchas MR","year":"2010","unstructured":"Bruchas MR, Land BB, Chavkin C. The dynorphin\/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res. 2010, 1314:44-55. 10.1016\/j.brainres.2009.08.062","journal-title":"Brain Res"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: a neurocircuitry analysis","volume":"3","author":"Koob GF","year":"2016","unstructured":"Koob GF, Volkow ND. Neurobiology of addiction: a neurocircuitry analysis. Lancet Psychiatry. 2016, 3:760-73. 10.1016\/S2215-0366(16)00104-8","journal-title":"Lancet Psychiatry"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.32306040.v1","article-title":"Latent-class TWAS reveals opposing glutamatergic-plasticity architectures and neuroimmune-pruning signals in alcohol misuse subtypes","author":"Cheung N","year":"2026","unstructured":"Cheung N. Latent-class TWAS reveals opposing glutamatergic-plasticity architectures and neuroimmune-pruning signals in alcohol misuse subtypes. figshare. 2026, 10.6084\/m9.figshare.32306040.v1","journal-title":"figshare"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.32288634.v1","article-title":"Opposing ageing-related transcriptomic profiles distinguish opioid exposure liability from dependence liability","author":"Cheung N","year":"2026","unstructured":"Cheung N. Opposing ageing-related transcriptomic profiles distinguish opioid exposure liability from dependence liability. figshare. 2026, 10.6084\/m9.figshare.32288634.v1","journal-title":"figshare"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.32302038.v1","article-title":"Transcriptomic ageing pathways in alcohol misuse and anxiety: senescence-like striatal stress programs and anxiety-linked inflammatory-apoptotic signatures","author":"Cheung N","year":"2026","unstructured":"Cheung N. Transcriptomic ageing pathways in alcohol misuse and anxiety: senescence-like striatal stress programs and anxiety-linked inflammatory-apoptotic signatures. figshare. 2026, 10.6084\/m9.figshare.32302038.v1","journal-title":"figshare"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.32310600.v1","article-title":"Transcriptomic stage-specific architecture of opioid exposure versus dependence progression: TWAS insights, mechanisms, and translational implications","author":"Cheung N","year":"2026","unstructured":"Cheung N. Transcriptomic stage-specific architecture of opioid exposure versus dependence progression: TWAS insights, mechanisms, and translational implications. figshare. 2026, 10.6084\/m9.figshare.32310600.v1","journal-title":"figshare"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.32306829.v1","article-title":"TWAS of cannabis use disorder and anxiety GWAS signals against ageing gene sets: mechanistic divergence and translational implications","author":"Cheung N","year":"2026","unstructured":"Cheung N. TWAS of cannabis use disorder and anxiety GWAS signals against ageing gene sets: mechanistic divergence and translational implications. figshare. 2026, 10.6084\/m9.figshare.32306829.v1","journal-title":"figshare"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.258","article-title":"Dynorphin, dysphoria, and dependence: the stress of addiction","volume":"41","author":"Chavkin C","year":"2016","unstructured":"Chavkin C, Koob GF. Dynorphin, dysphoria, and dependence: the stress of addiction. Neuropsychopharmacology. 2016, 41:373-4. 10.1038\/npp.2015.258","journal-title":"Neuropsychopharmacology"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4458-07.2008","article-title":"The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system","volume":"28","author":"Land BB","year":"2008","unstructured":"Land BB, Bruchas MR, Lemos JC, Xu M, Melief EJ, Chavkin C. The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci. 2008, 28:407-14. 10.1523\/JNEUROSCI.4458-07.2008","journal-title":"J Neurosci"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.1.299","article-title":"Cellular and synaptic adaptations mediating opioid dependence","volume":"81","author":"Williams JT","year":"2001","unstructured":"Williams JT, Christie MJ, Manzoni O. Cellular and synaptic adaptations mediating opioid dependence. Physiol Rev. 2001, 81:299-343. 10.1152\/physrev.2001.81.1.299","journal-title":"Physiol Rev"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/nm1490","article-title":"GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence","volume":"12","author":"Tegeder I","year":"2006","unstructured":"Tegeder I, Costigan M, Griffin RS, et al.. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med. 2006, 12:1269-77. 10.1038\/nm1490","journal-title":"Nat Med"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.024","article-title":"Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids","volume":"141","author":"Sancak Y","year":"2010","unstructured":"Sancak Y, Bar-Peled L, Zoncu R, Markhard AL, Nada S, Sabatini DM. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell. 2010, 141:290-303. 10.1016\/j.cell.2010.02.024","journal-title":"Cell"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.07.032","article-title":"Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1","volume":"150","author":"Bar-Peled L","year":"2012","unstructured":"Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini DM. Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1. Cell. 2012, 150:1196-208. 10.1016\/j.cell.2012.07.032","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R114.563148","article-title":"The pyruvate dehydrogenase complexes: structure-based function and regulation","volume":"289","author":"Patel MS","year":"2014","unstructured":"Patel MS, Nemeria NS, Furey W, Jordan F. The pyruvate dehydrogenase complexes: structure-based function and regulation. J Biol Chem. 2014, 289:16615-23. 10.1074\/jbc.R114.563148","journal-title":"J Biol Chem"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1038\/nature06736","article-title":"SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin","volume":"452","author":"Michishita E","year":"2008","unstructured":"Michishita E, McCord RA, Berber E, et al.. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature. 2008, 452:492-6. 10.1038\/nature06736","journal-title":"Nature"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.07.001","article-title":"Functional relevance of neurotransmitter receptor heteromers in the central nervous system","volume":"30","author":"Ferr\u00e9 S","year":"2007","unstructured":"Ferr\u00e9 S, Ciruela F, Woods AS, Lluis C, Franco R. Functional relevance of neurotransmitter receptor heteromers in the central nervous system. Trends Neurosci. 2007, 30:440-6. 10.1016\/j.tins.2007.07.001","journal-title":"Trends Neurosci"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.05.028","article-title":"Allosteric mechanisms within the adenosine A2A-dopamine D2 receptor heterotetramer","volume":"104","author":"Ferr\u00e9 S","year":"2016","unstructured":"Ferr\u00e9 S, Bonaventura J, Tomasi D, et al.. Allosteric mechanisms within the adenosine A2A-dopamine D2 receptor heterotetramer. Neuropharmacology. 2016, 104:154-60. 10.1016\/j.neuropharm.2015.05.028","journal-title":"Neuropharmacology"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s10059-013-0192-9","article-title":"Adenosine signaling in striatal circuits and alcohol use disorders","volume":"36","author":"Nam HW","year":"2013","unstructured":"Nam HW, Bruner RC, Choi DS. Adenosine signaling in striatal circuits and alcohol use disorders. Mol Cells. 2013, 36:195-202. 10.1007\/s10059-013-0192-9","journal-title":"Mol Cells"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.7","article-title":"TREM2 variants: new keys to decipher Alzheimer disease pathogenesis","volume":"17","author":"Colonna M","year":"2016","unstructured":"Colonna M, Wang Y. TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nat Rev Neurosci. 2016, 17:201-7. 10.1038\/nrn.2016.7","journal-title":"Nat Rev Neurosci"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.08.008","article-title":"The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases","volume":"47","author":"Krasemann S","year":"2017","unstructured":"Krasemann S, Madore C, Cialic R, et al.. The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases. Immunity. 2017, 47:566-81.e9. 10.1016\/j.immuni.2017.08.008","journal-title":"Immunity"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens B","year":"2007","unstructured":"Stevens B, Allen NJ, Vazquez LE, et al.. The classical complement cascade mediates CNS synapse elimination. Cell. 2007, 131:1164-78. 10.1016\/j.cell.2007.10.036","journal-title":"Cell"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer DP","year":"2012","unstructured":"Schafer DP, Lehrman EK, Kautzman AG, et al.. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron. 2012, 74:691-705. 10.1016\/j.neuron.2012.03.026","journal-title":"Neuron"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong S","year":"2016","unstructured":"Hong S, Beja-Glasser VF, Nfonoyim BM, et al.. Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science. 2016, 352:712-6. 10.1126\/science.aad8373","journal-title":"Science"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.859","article-title":"The CLN3 gene and protein: what we know","volume":"7","author":"Mirza M","year":"2019","unstructured":"Mirza M, Vainshtein A, DiRonza A, et al.. The CLN3 gene and protein: what we know. Mol Genet Genomic Med. 2019, 7:e859. 10.1002\/mgg3.859","journal-title":"Mol Genet Genomic Med"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183653","article-title":"Aging, cellular senescence, and cancer","volume":"75","author":"Campisi J","year":"2013","unstructured":"Campisi J. Aging, cellular senescence, and cancer. Annu Rev Physiol. 2013, 75:685-705. 10.1146\/annurev-physiol-030212-183653","journal-title":"Annu Rev Physiol"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs BG","year":"2015","unstructured":"Childs BG, Durik M, Baker DJ, van Deursen JM. Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med. 2015, 21:1424-35. 10.1038\/nm.4000","journal-title":"Nat Med"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32552-1","article-title":"A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues","volume":"13","author":"Saul D","year":"2022","unstructured":"Saul D, Kosinsky RL, Atkinson EJ, et al.. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun. 2022, 13:4827. 10.1038\/s41467-022-32552-1","journal-title":"Nat Commun"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.022","article-title":"The SARM1 toll\/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration","volume":"93","author":"Essuman K","year":"2017","unstructured":"Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J. The SARM1 toll\/interleukin-1 receptor domain possesses intrinsic NAD(+) cleavage activity that promotes pathological axonal degeneration. Neuron. 2017, 93:1334-43.e5. 10.1016\/j.neuron.2017.02.022","journal-title":"Neuron"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0269-3","article-title":"Programmed axon degeneration: from mouse to mechanism to medicine","volume":"21","author":"Coleman MP","year":"2020","unstructured":"Coleman MP, H\u00f6ke A. Programmed axon degeneration: from mouse to mechanism to medicine. Nat Rev Neurosci. 2020, 21:183-96. 10.1038\/s41583-020-0269-3","journal-title":"Nat Rev Neurosci"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.958900","article-title":"Multifaceted roles of SARM1 in axon degeneration and signaling","volume":"16","author":"Waller TJ","year":"2022","unstructured":"Waller TJ, Collins CA. Multifaceted roles of SARM1 in axon degeneration and signaling. Front Cell Neurosci. 2022, 16:958900. 10.3389\/fncel.2022.958900","journal-title":"Front Cell Neurosci"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25495","article-title":"ATP-sensitive potassium channelopathies: focus on insulin secretion","volume":"115","author":"Ashcroft FM","year":"2005","unstructured":"Ashcroft FM. ATP-sensitive potassium channelopathies: focus on insulin secretion. J Clin Invest. 2005, 115:2047-58. 10.1172\/JCI25495","journal-title":"J Clin Invest"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3311","article-title":"AMPK: a nutrient and energy sensor that maintains energy homeostasis","volume":"13","author":"Hardie DG","year":"2012","unstructured":"Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. 2012, 13:251-62. 10.1038\/nrm3311","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.017","article-title":"mTOR signaling in growth control and disease","volume":"149","author":"Laplante M","year":"2012","unstructured":"Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012, 149:274-93. 10.1016\/j.cell.2012.03.017","journal-title":"Cell"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1702448","article-title":"The potential role of GLP-1 receptor agonists in substance use disorders - a systematic review","volume":"16","author":"V\u00f6lker KM","year":"2025","unstructured":"V\u00f6lker KM, Prechtl BL, Bormann NL, Choi DS. The potential role of GLP-1 receptor agonists in substance use disorders - a systematic review. Front Pharmacol. 2025, 16:1702448. 10.3389\/fphar.2025.1702448","journal-title":"Front Pharmacol"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock FJ","year":"2020","unstructured":"Bock FJ, Tait SW. Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol. 2020, 21:85-100. 10.1038\/s41580-019-0173-8","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2017","article-title":"Neuronal cell death","volume":"98","author":"Fricker M","year":"2018","unstructured":"Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC. Neuronal cell death. Physiol Rev. 2018, 98:813-80. 10.1152\/physrev.00011.2017","journal-title":"Physiol Rev"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0591-6","article-title":"Developing neuroscience-based treatments for alcohol addiction: a matter of choice?","volume":"9","author":"Heilig M","year":"2019","unstructured":"Heilig M, Augier E, Pfarr S, Sommer WH. Developing neuroscience-based treatments for alcohol addiction: a matter of choice?. Transl Psychiatry. 2019, 9:255. 10.1038\/s41398-019-0591-6","journal-title":"Transl Psychiatry"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1038\/nature16549","article-title":"Schizophrenia risk from complex variation of complement component 4","volume":"530","author":"Sekar A","year":"2016","unstructured":"Sekar A, Bialas AR, de Rivera H, et al.. Schizophrenia risk from complex variation of complement component 4. Nature. 2016, 530:177-83. 10.1038\/nature16549","journal-title":"Nature"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/499951-cross-disorder-pruning-plasticity-aging-architecture-in-substance-use-disorders-and-anxiety-transcriptome-wide-association-insights-and-mechanistic-synthesis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T16:43:21Z","timestamp":1781455401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/499951-cross-disorder-pruning-plasticity-aging-architecture-in-substance-use-disorders-and-anxiety-transcriptome-wide-association-insights-and-mechanistic-synthesis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,13]]},"references-count":61,"URL":"https:\/\/doi.org\/10.7759\/cureus.110806","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,13]]}}}