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The gut microbiome in early-onset colorectal cancer: distinct signatures, targeted prevention and therapeutic strategies. J Pers Med. 2025, 15:552. 10.3390\/jpm15110552","journal-title":"J Pers Med"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13235933","article-title":"The role of diet and lifestyle in early-onset colorectal cancer: a systematic review","volume":"13","author":"Puzzono M","year":"2021","unstructured":"Puzzono M, Mannucci A, Grann\u00f2 S, Zuppardo RA, Galli A, Danese S, Cavestro GM. The role of diet and lifestyle in early-onset colorectal cancer: a systematic review. Cancers (Basel). 2021, 13:5933. 10.3390\/cancers13235933","journal-title":"Cancers (Basel)"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.01.037","article-title":"Risk factors for early-onset colorectal cancer: a systematic review and meta-analysis","volume":"20","author":"O'Sullivan DE","year":"2022","unstructured":"O'Sullivan DE, Sutherland RL, Town S, et al.. Risk factors for early-onset colorectal cancer: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2022, 20:1229-40.e5. 10.1016\/j.cgh.2021.01.037","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.2174\/1389450121999201117115717","article-title":"Colorectal cancer epidemiology: recent trends and impact on outcomes","volume":"22","author":"Baidoun F","year":"2021","unstructured":"Baidoun F, Elshiwy K, Elkeraie Y, et al.. Colorectal cancer epidemiology: recent trends and impact on outcomes. Curr Drug Targets. 2021, 22:998-1009. 10.2174\/1389450121999201117115717","journal-title":"Curr Drug Targets"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2013.09.006","article-title":"The increasing incidence of young-onset colorectal cancer: a call to action","volume":"89","author":"Ahnen DJ","year":"2014","unstructured":"Ahnen DJ, Wade SW, Jones WF, et al.. The increasing incidence of young-onset colorectal cancer: a call to action. Mayo Clin Proc. 2014, 89:216-24. 10.1016\/j.mayocp.2013.09.006","journal-title":"Mayo Clin Proc"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-020-00445-1","article-title":"Rising incidence of early-onset colorectal cancer - a call to action","volume":"18","author":"Akimoto N","year":"2021","unstructured":"Akimoto N, Ugai T, Zhong R, et al.. Rising incidence of early-onset colorectal cancer - a call to action. 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