{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:58:49Z","timestamp":1781643529259,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,16]]},"DOI":"10.7759\/cureus.110988","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:45:52Z","timestamp":1781642752000},"source":"Crossref","is-referenced-by-count":0,"title":["Graft-Versus-Host Disease After Liver Transplantation: Diagnostic and Therapeutic Challenges"],"prefix":"10.7759","author":[{"given":"Jerry","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kareem","family":"Latif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Kejriwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Schill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001406","article-title":"Graft versus host disease after liver transplantation in adults: a case series, review of literature, and an approach to management","volume":"100","author":"Murali AR","year":"2016","unstructured":"Murali AR, Chandra S, Stewart Z, Blazar BR, Farooq U, Ince MN, Dunkelberg J. Graft versus host disease after liver transplantation in adults: a case series, review of literature, and an approach to management. Transplantation. 2016, 100:2661-70. 10.1097\/TP.0000000000001406","journal-title":"Transplantation"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000260","article-title":"Graft-versus-host disease following liver transplantation: a systematic review of literature","volume":"7","author":"Kneifel F","year":"2023","unstructured":"Kneifel F, Vogel T, Bormann E, et al.. Graft-versus-host disease following liver transplantation: a systematic review of literature. Hepatol Commun. 2023, 7:e0260. 10.1097\/HC9.0000000000000260","journal-title":"Hepatol Commun"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i30.9255","article-title":"Diagnosis and treatment of acute graft-versus-host disease after liver transplantation: report of six cases","volume":"9","author":"Tian M","year":"2021","unstructured":"Tian M, Lyu Y, Wang B, et al.. Diagnosis and treatment of acute graft-versus-host disease after liver transplantation: report of six cases. World J Clin Cases. 2021, 9:9255-68. 10.12998\/wjcc.v9.i30.9255","journal-title":"World J Clin Cases"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.liver.2021.100021","article-title":"Post-liver transplantation GVHD: time to consider histocompatibility testing","volume":"3","author":"Ghandorah SS","year":"2021","unstructured":"Ghandorah SS, Alwosaibai K. Post-liver transplantation GVHD: time to consider histocompatibility testing. J Liver Transpl. 2021, 3:100021. 10.1016\/j.liver.2021.100021","journal-title":"J Liver Transpl"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000000499","article-title":"Graft-vs-host disease after liver transplantation: a diagnostic and management challenge","volume":"7","author":"Chin JY","year":"2020","unstructured":"Chin JY, Gong J, Gane E. Graft-vs-host disease after liver transplantation: a diagnostic and management challenge. ACG Case Rep J. 2020, 7:e00499. 10.14309\/crj.0000000000000499","journal-title":"ACG Case Rep J"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003607","article-title":"Incidence and risk factors for fatal graft-versus-host disease after liver transplantation","volume":"105","author":"Kitajima T","year":"2021","unstructured":"Kitajima T, Henry M, Ivanics T, et al.. Incidence and risk factors for fatal graft-versus-host disease after liver transplantation. Transplantation. 2021, 105:2571-8. 10.1097\/TP.0000000000003607","journal-title":"Transplantation"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000002904","article-title":"Achievement of durable and complete remission of graft-versus-host disease after liver transplantation with ruxolitinib: a case report","volume":"103","author":"Endo Y","year":"2019","unstructured":"Endo Y, Oshima G, Hibi T, et al.. Achievement of durable and complete remission of graft-versus-host disease after liver transplantation with ruxolitinib: a case report. Transplantation. 2019, 103:e375-7. 10.1097\/TP.0000000000002904","journal-title":"Transplantation"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015954","article-title":"How I diagnose and treat acute graft-versus-host disease after solid organ transplantation","volume":"141","author":"Cooper JP","year":"2023","unstructured":"Cooper JP, Abkowitz JL. How I diagnose and treat acute graft-versus-host disease after solid organ transplantation. Blood. 2023, 141:1136-46. 10.1182\/blood.2022015954","journal-title":"Blood"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12627","article-title":"Graft-versus-host disease after orthotopic liver transplantation: multivariate analysis of risk factors","volume":"29","author":"Elfeki MA","year":"2015","unstructured":"Elfeki MA, Pungpapong S, Genco PV, Nakhleh RE, Nguyen JH, Harnois DM. Graft-versus-host disease after orthotopic liver transplantation: multivariate analysis of risk factors. Clin Transplant. 2015, 29:1063-6. 10.1111\/ctr.12627","journal-title":"Clin Transplant"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/petr.14205","article-title":"Graft-versus-host disease after pediatric liver transplantation: a diagnostic challenge","volume":"26","author":"Attas RA","year":"2022","unstructured":"Attas RA, Bader RM, Mashhour M, et al.. Graft-versus-host disease after pediatric liver transplantation: a diagnostic challenge. Pediatr Transplant. 2022, 26:e14205. 10.1111\/petr.14205","journal-title":"Pediatr Transplant"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000190431.94252.3f","article-title":"Use of short tandem repeats for DNA fingerprinting to rapidly diagnose graft-versus-host disease in solid organ transplant patients","volume":"81","author":"Schrager JJ","year":"2006","unstructured":"Schrager JJ, Vnencak-Jones CL, Graber SE, et al.. Use of short tandem repeats for DNA fingerprinting to rapidly diagnose graft-versus-host disease in solid organ transplant patients. Transplantation. 2006, 81:21-5. 10.1097\/01.tp.0000190431.94252.3f","journal-title":"Transplantation"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917635","article-title":"Ruxolitinib for glucocorticoid-refractory acute graft-versus-host disease","volume":"382","author":"Zeiser R","year":"2020","unstructured":"Zeiser R, von Bubnoff N, Butler J, et al.. Ruxolitinib for glucocorticoid-refractory acute graft-versus-host disease. N Engl J Med. 2020, 382:1800-10. 10.1056\/NEJMoa1917635","journal-title":"N Engl J Med"},{"key":"ref13","unstructured":"NCCN Clinical Practice Guidelines in Oncology. Hematopoietic Cell Transplantation (Version 2.2026). (2026). Accessed: June 14, 2026: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?category=3&amp;id=1501.."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002\/lt.20982","article-title":"Acute graft-versus-host disease after liver transplantation: role of withdrawal of immunosuppression in therapeutic management","volume":"13","author":"Chinnakotla S","year":"2007","unstructured":"Chinnakotla S, Smith DM, Domiati-Saad R, et al.. Acute graft-versus-host disease after liver transplantation: role of withdrawal of immunosuppression in therapeutic management. Liver Transpl. 2007, 13:157-61. 10.1002\/lt.20982","journal-title":"Liver Transpl"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13239","article-title":"Graft versus host disease after multivisceral transplantation: a UK center experience and update on management","volume":"32","author":"Sharkey LM","year":"2018","unstructured":"Sharkey LM, Peacock S, Russell NK, Middleton SJ, Butler AJ. Graft versus host disease after multivisceral transplantation: a UK center experience and update on management. Clin Transplant. 2018, 32:e13239. 10.1111\/ctr.13239","journal-title":"Clin Transplant"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-25-00809","article-title":"Ruxolitinib versus best available therapy in patients with steroid-refractory acute graft-versus-host disease: final analysis from the randomized phase III REACH2 trial","volume":"43","author":"Mohty M","year":"2025","unstructured":"Mohty M, Soci\u00e9 G, Szer J, et al.. Ruxolitinib versus best available therapy in patients with steroid-refractory acute graft-versus-host disease: final analysis from the randomized phase III REACH2 trial. J Clin Oncol. 2025, 43:3639-45. 10.1200\/JCO-25-00809","journal-title":"J Clin Oncol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15579","article-title":"The use of ruxolitinib for acute graft-versus-host disease developing after solid organ transplantation","volume":"20","author":"Jacobs MT","year":"2020","unstructured":"Jacobs MT, Olson M, Ferreira BP, et al.. The use of ruxolitinib for acute graft-versus-host disease developing after solid organ transplantation. Am J Transplant. 2020, 20:589-92. 10.1111\/ajt.15579","journal-title":"Am J Transplant"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000005226","article-title":"Treatment of late-onset acute graft-versus-host disease following double lung transplantation using a JAK2 inhibitor","volume":"109","author":"Alyamany R","year":"2025","unstructured":"Alyamany R, Alnughmush A, Albaiz F, Aversa M, Law A. Treatment of late-onset acute graft-versus-host disease following double lung transplantation using a JAK2 inhibitor. Transplantation. 2025, 109:e248-52. 10.1097\/TP.0000000000005226","journal-title":"Transplantation"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/465474-graft-versus-host-disease-after-liver-transplantation-diagnostic-and-therapeutic-challenges","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:45:55Z","timestamp":1781642755000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/465474-graft-versus-host-disease-after-liver-transplantation-diagnostic-and-therapeutic-challenges"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,16]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.110988","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,16]]}}}