{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:55:22Z","timestamp":1781708122161,"version":"3.54.5"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,17]]},"DOI":"10.7759\/cureus.111033","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:14:56Z","timestamp":1781705696000},"source":"Crossref","is-referenced-by-count":0,"title":["The Paradox of Support: Mechanical Ventilation-Induced Hypoxemia Through a Patent Foramen Ovale"],"prefix":"10.7759","author":[{"given":"Mohamad   A","family":"Soudan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Awais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osama","family":"Hallak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J","family":"Filby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"The incidence of congenital heart disease","volume":"39","author":"Hoffman JIE","year":"2002","unstructured":"Hoffman JIE, Kaplan S. The incidence of congenital heart disease. J Am Coll Cardiol. 2002, 39:1890-900.","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.105.6.e47","article-title":"Mechanisms of platypnea-orthodeoxia: what causes water to flow uphill?","volume":"105","author":"Cheng TO","year":"2002","unstructured":"Cheng TO. Mechanisms of platypnea-orthodeoxia: what causes water to flow uphill?. Circulation. 2002, 105:e47. 10.1161\/circ.105.6.e47","journal-title":"Circulation"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1522-726x(199905)47:1<64::aid-ccd15>3.0.co;2-6","article-title":"Platypnea-orthodeoxia syndrome: etiology, differential diagnosis, and management","volume":"47","author":"Cheng TO","year":"1999","unstructured":"Cheng TO. Platypnea-orthodeoxia syndrome: etiology, differential diagnosis, and management. Catheter Cardiovasc Interv. 1999, 47:64-6. 10.1002\/(sici)1522-726x(199905)47:1&lt;64::aid-ccd15&gt;3.0.co;2-6","journal-title":"Catheter Cardiovasc Interv"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0334","article-title":"Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure","volume":"143","author":"Shaikh ZF","year":"2013","unstructured":"Shaikh ZF, Jaye J, Ward N, et al.. Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure. Chest. 2013, 143:56-63. 10.1378\/chest.12-0334","journal-title":"Chest"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fstro.2022.916154","article-title":"Obstructive sleep apnea (OSA) and patent foramen ovale (PFO), the \"perfect storm\" for a cryptogenic stroke? Case series of four patients","volume":"1","author":"Schwarz A","year":"2022","unstructured":"Schwarz A, Lee A, Gadallah NE, Wong J, Gupta D. Obstructive sleep apnea (OSA) and patent foramen ovale (PFO), the \"perfect storm\" for a cryptogenic stroke? Case series of four patients. Front Stroke. 2022, 1:916154. 10.3389\/fstro.2022.916154","journal-title":"Front Stroke"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2005.08.015","article-title":"Prevalence and clinical significance of a patent foramen ovale in patients with chronic obstructive pulmonary disease","volume":"100","author":"Hacievliyagil SS","year":"2006","unstructured":"Hacievliyagil SS, Gunen H, Kosar FM, Sahin I, Kilic T. Prevalence and clinical significance of a patent foramen ovale in patients with chronic obstructive pulmonary disease. Respir Med. 2006, 100:903-10. 10.1016\/j.rmed.2005.08.015","journal-title":"Respir Med"},{"key":"ref7","article-title":"Hemodynamic and respiratory factors that influence the opening of patent foramen ovale in mechanically ventilated patients","volume":"20","author":"Vavlitou A","year":"2016","unstructured":"Vavlitou A, Minas G, Zannetos S, Kyprianou T, Tsagourias M, Matamis D. Hemodynamic and respiratory factors that influence the opening of patent foramen ovale in mechanically ventilated patients. Hippokratia. 2016, 20:209-13.","journal-title":"Hippokratia"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.97.19.1946","article-title":"Patent foramen ovale is an important predictor of adverse outcome in patients with major pulmonary embolism","volume":"97","author":"Konstantinides S","year":"1998","unstructured":"Konstantinides S, Geibel A, Kasper W, Olschewski M, Bl\u00fcmel L, Just H. Patent foramen ovale is an important predictor of adverse outcome in patients with major pulmonary embolism. Circulation. 1998, 97:1946-51. 10.1161\/01.cir.97.19.1946","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.iccl.2017.05.003","article-title":"Patent foramen ovale closure for hypoxemia","volume":"6","author":"Tobis JM","year":"2017","unstructured":"Tobis JM, Narasimha D, Abudayyeh I. Patent foramen ovale closure for hypoxemia. Interv Cardiol Clin. 2017, 6:547-54. 10.1016\/j.iccl.2017.05.003","journal-title":"Interv Cardiol Clin"},{"key":"ref10","article-title":"Patent foramen ovale causing refractory hypoxemia after off-pump coronary artery bypass: a case report","volume":"6","author":"Tabry I","year":"2003","unstructured":"Tabry I, Villanueva L, Walker E. Patent foramen ovale causing refractory hypoxemia after off-pump coronary artery bypass: a case report. Heart Surg Forum. 2003, 6:74-6.","journal-title":"Heart Surg Forum"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/474090-the-paradox-of-support-mechanical-ventilation-induced-hypoxemia-through-a-patent-foramen-ovale","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:14:57Z","timestamp":1781705697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/474090-the-paradox-of-support-mechanical-ventilation-induced-hypoxemia-through-a-patent-foramen-ovale"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":10,"URL":"https:\/\/doi.org\/10.7759\/cureus.111033","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,17]]}}}