{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:54:45Z","timestamp":1781772885644,"version":"3.54.5"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,18]]},"DOI":"10.7759\/cureus.111070","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:23:39Z","timestamp":1781771019000},"source":"Crossref","is-referenced-by-count":0,"title":["Dependence on Cardiac Contractility Modulation Therapy: Loss of Continuous and Effective Modulation as a Cause of Heart Failure Exacerbation"],"prefix":"10.7759","author":[{"given":"Krzysztof","family":"Kaczmarek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Wojtaszczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawel","family":"Ptaszynski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerzy K","family":"Wranicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Cygankiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.59497","article-title":"Racial and socioeconomic determinants of cardiovascular health: a comprehensive review","volume":"16","author":"Borkowski P","year":"2024","unstructured":"Borkowski P, Borkowska N, Mangeshkar S, Adal BH, Singh N. Racial and socioeconomic determinants of cardiovascular health: a comprehensive review. Cureus. 2024, 16:e59497. 10.7759\/cureus.59497","journal-title":"Cureus"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh TA","year":"2021","unstructured":"McDonagh TA, Metra M, Adamo M, et al.. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021, 42:3599-726. 10.1093\/eurheartj\/ehab368","journal-title":"Eur Heart J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9769724","article-title":"Outcomes of cardiac contractility modulation: a systematic review and meta-analysis of randomized clinical trials","volume":"2019","author":"Mando R","year":"2019","unstructured":"Mando R, Goel A, Habash F, Saad M, Ayoub K, Vallurupalli S, Maskoun W. Outcomes of cardiac contractility modulation: a systematic review and meta-analysis of randomized clinical trials. Cardiovasc Ther. 2019, 2019:9769724. 10.1155\/2019\/9769724","journal-title":"Cardiovasc Ther"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00399-025-01118-1","article-title":"Cardiac contractility modulation: an update","volume":"36","author":"Kuschyk J","year":"2025","unstructured":"Kuschyk J, Butler J, Fendler T, Varma N. Cardiac contractility modulation: an update. Herzschrittmacherther Elektrophysiol. 2025, 36:329-35. 10.1007\/s00399-025-01118-1","journal-title":"Herzschrittmacherther Elektrophysiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1752-8062.2009.00097.x","article-title":"Ca(2+)-binding proteins in dogs with heart failure: effects of cardiac contractility modulation electrical signals","volume":"2","author":"Gupta RC","year":"2009","unstructured":"Gupta RC, Mishra S, Rastogi S, et al.. Ca(2+)-binding proteins in dogs with heart failure: effects of cardiac contractility modulation electrical signals. Clin Transl Sci. 2009, 2:211-5. 10.1111\/j.1752-8062.2009.00097.x","journal-title":"Clin Transl Sci"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.01.036","article-title":"Cardiac contractility modulation electrical signals improve myocardial gene expression in patients with heart failure","volume":"51","author":"Butter C","year":"2008","unstructured":"Butter C, Rastogi S, Minden HH, Meyh\u00f6fer J, Burkhoff D, Sabbah HN. Cardiac contractility modulation electrical signals improve myocardial gene expression in patients with heart failure. J Am Coll Cardiol. 2008, 51:1784-9. 10.1016\/j.jacc.2008.01.036","journal-title":"J Am Coll Cardiol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000445624","article-title":"Cardiac contractility modulation attenuate myocardial fibrosis by inhibiting TGF-\u03b21\/Smad3 signaling pathway in a rabbit model of chronic heart failure","volume":"39","author":"Zhang F","year":"2016","unstructured":"Zhang F, Dang Y, Li Y, Hao Q, Li R, Qi X. Cardiac contractility modulation attenuate myocardial fibrosis by inhibiting TGF-\u03b21\/Smad3 signaling pathway in a rabbit model of chronic heart failure. Cell Physiol Biochem. 2016, 39:294-302. 10.1159\/000445624","journal-title":"Cell Physiol Biochem"},{"key":"ref8","unstructured":"Premarket Approval (PMA). (2026). Accessed. April 23, 2026: https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfpma\/pma.cfm."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001063","article-title":"2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich PA","year":"2022","unstructured":"Heidenreich PA, Bozkurt B, Aguilar D, et al.. 2022 AHA\/ACC\/HFSA Guideline for the Management of Heart Failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2022, 145:e895-e1032. 10.1161\/CIR.0000000000001063","journal-title":"Circulation"},{"key":"ref10","article-title":"Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels","year":"1994","unstructured":"Nomenclature and Criteria for Diagnosis of Diseases of the Heart and Great Vessels. New York Heart Association, Boston, MA, USA; 1994."},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrcr.2017.02.004","article-title":"Cardiac contractility modulation therapy: aare there superresponders?","volume":"3","author":"Al-Ghamdi B","year":"2017","unstructured":"Al-Ghamdi B, Shafquat A, Mallawi Y. Cardiac contractility modulation therapy: aare there superresponders?. HeartRhythm Case Rep. 2017, 3:229-32. 10.1016\/j.hrcr.2017.02.004","journal-title":"HeartRhythm Case Rep"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/jce.70053","article-title":"Cardiac contractility modulation in symptomatic heart failure with reduced ejection fraction: a systematic review and single-arm meta-analysis","volume":"36","author":"Suruagy-Motta RF","year":"2025","unstructured":"Suruagy-Motta RF, Fukunaga CK, da Silva EV, et al.. Cardiac contractility modulation in symptomatic heart failure with reduced ejection fraction: a systematic review and single-arm meta-analysis. J Cardiovasc Electrophysiol. 2025, 36:2544-55. 10.1111\/jce.70053","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1374","article-title":"Cardiac contractility modulation improves long-term survival and hospitalizations in heart failure with reduced ejection fraction","volume":"21","author":"Anker SD","year":"2019","unstructured":"Anker SD, Borggrefe M, Neuser H, et al.. Cardiac contractility modulation improves long-term survival and hospitalizations in heart failure with reduced ejection fraction. Eur J Heart Fail. 2019, 21:1103-13. 10.1002\/ejhf.1374","journal-title":"Eur J Heart Fail"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.04.010","article-title":"A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation","volume":"6","author":"Abraham WT","year":"2018","unstructured":"Abraham WT, Kuck KH, Goldsmith RL, et al.. A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation. JACC Heart Fail. 2018, 6:874-83. 10.1016\/j.jchf.2018.04.010","journal-title":"JACC Heart Fail"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2011.04.014","article-title":"Risk factors for lead complications in cardiac pacing: a population-based cohort study of 28,860 Danish patients","volume":"8","author":"Kirkfeldt RE","year":"2011","unstructured":"Kirkfeldt RE, Johansen JB, Nohr EA, Moller M, Arnsbo P, Nielsen JC. Risk factors for lead complications in cardiac pacing: a population-based cohort study of 28,860 Danish patients. Heart Rhythm. 2011, 8:1622-8. 10.1016\/j.hrthm.2011.04.014","journal-title":"Heart Rhythm"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaccas.2025.103756","article-title":"First human implant with cardiac contractility modulation in a patient with an extravascular implantable cardioverter-defibrillator","volume":"30","author":"Kindler J","year":"2025","unstructured":"Kindler J, Silva J, Sackett M, Mareddy C. First human implant with cardiac contractility modulation in a patient with an extravascular implantable cardioverter-defibrillator. JACC Case Rep. 2025, 30:103756. 10.1016\/j.jaccas.2025.103756","journal-title":"JACC Case Rep"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/489932-dependence-on-cardiac-contractility-modulation-therapy-loss-of-continuous-and-effective-modulation-as-a-cause-of-heart-failure-exacerbation","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T08:23:46Z","timestamp":1781771026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/489932-dependence-on-cardiac-contractility-modulation-therapy-loss-of-continuous-and-effective-modulation-as-a-cause-of-heart-failure-exacerbation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.111070","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}