{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:55:13Z","timestamp":1781798113565,"version":"3.54.5"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,18]]},"DOI":"10.7759\/cureus.111094","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:37:43Z","timestamp":1781797063000},"source":"Crossref","is-referenced-by-count":0,"title":["Distribution of Hemoglobin Variants: A Retrospective Study Based on Hemoglobin Electrophoresis Results From a University Hospital in Madagascar"],"prefix":"10.7759","author":[{"given":"Jocia","family":"Fenomanana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faralahy H","family":"Rakotonjafiniarivo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanirisoa","family":"Rasolozakandrainibe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephania","family":"Niry Manantsoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjarasoa Diamondra","family":"Malalanirina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miora Koloina","family":"Ranaivosoa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aim\u00e9e Olivat","family":"Rakoto Alson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-251348","article-title":"The inherited diseases of hemoglobin are an emerging global health burden","volume":"115","author":"Weatherall DJ","year":"2010","unstructured":"Weatherall DJ. The inherited diseases of hemoglobin are an emerging global health burden. Blood. 2010, 115:4331-6. 10.1182\/blood-2010-01-251348","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510865","article-title":"Sickle cell disease","volume":"376","author":"Piel FB","year":"2017","unstructured":"Piel FB, Steinberg MH, Rees DC. Sickle cell disease. N Engl J Med. 2017, 376:1561-73. 10.1056\/NEJMra1510865","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2020.36.329.21478","article-title":"Prevalence of sickle cell trait in blood donors at the regional blood transfusion center in the Haute Matsiatra Region, Madagascar (Article in French)","volume":"36","author":"Fenomanana J","year":"2020","unstructured":"Fenomanana J, Rakotoniaina I, Manantsoa SN, Randriamahenina H, Randriamanantany ZA. Prevalence of sickle cell trait in blood donors at the regional blood transfusion center in the Haute Matsiatra Region, Madagascar (Article in French). Pan Afr Med J. 2020, 36:329. 10.11604\/pamj.2020.36.329.21478","journal-title":"Pan Afr Med J"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-016-0069-1","article-title":"Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections","volume":"16","author":"Maeder MN","year":"2016","unstructured":"Maeder MN, Rabezanahary HM, Zafindraibe NJ, et al.. Sickle-cell disease in febrile children living in a rural village of Madagascar and association with malaria and respiratory infections. BMC Hematol. 2016, 16:30. 10.1186\/s12878-016-0069-1","journal-title":"BMC Hematol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/10245330512331390348","article-title":"Morphology in the diagnosis of red cell disorders","volume":"10 Suppl 1","author":"Bain BJ","year":"2005","unstructured":"Bain BJ. Morphology in the diagnosis of red cell disorders. Hematology. 2005, 10 Suppl 1:178-81. 10.1080\/10245330512331390348","journal-title":"Hematology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1086\/430744","article-title":"Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases","volume":"192","author":"Williams TN","year":"2005","unstructured":"Williams TN, Mwangi TW, Wambua S, Alexander ND, Kortok M, Snow RW, Marsh K. Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases. J Infect Dis. 2005, 192:178-86. 10.1086\/430744","journal-title":"J Infect Dis"},{"key":"ref7","article-title":"Inherited haemoglobin disorders: an increasing global health problem","volume":"79","author":"Weatherall DJ","year":"2001","unstructured":"Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ.  2001, 79:704-12.","journal-title":"Bull World Health Organ"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06006.x","article-title":"Co-inheritance of alpha+-thalassaemia and sickle trait results in specific effects on haematological parameters","volume":"133","author":"Wambua S","year":"2006","unstructured":"Wambua S, Mwacharo J, Uyoga S, Macharia A, Williams TN. Co-inheritance of alpha+-thalassaemia and sickle trait results in specific effects on haematological parameters. Br J Haematol. 2006, 133:206-9. 10.1111\/j.1365-2141.2006.06006.x","journal-title":"Br J Haematol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100516","article-title":"The co-inheritance of alpha-thalassemia and sickle cell anemia is associated with better hematological indices and lower consultations rate in Cameroonian patients and could improve their survival","volume":"9","author":"Rumaney MB","year":"2014","unstructured":"Rumaney MB, Ngo Bitoungui VJ, Vorster AA, Ramesar R, Kengne AP, Ngogang J, Wonkam A. The co-inheritance of alpha-thalassemia and sickle cell anemia is associated with better hematological indices and lower consultations rate in Cameroonian patients and could improve their survival. PLoS One. 2014, 9:e100516. 10.1371\/journal.pone.0100516","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-020-05628-8","article-title":"Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients","volume":"47","author":"Santos B","year":"2020","unstructured":"Santos B, Delgadinho M, Ferreira J, et al.. Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients. Mol Biol Rep. 2020, 47:5397-402. 10.1007\/s11033-020-05628-8","journal-title":"Mol Biol Rep"},{"key":"ref11","doi-asserted-by":"crossref","DOI":"10.1093\/clinchem\/46.8.1284","article-title":"Laboratory investigation of hemoglobinopathies and thalassemias: review and update","volume":"46","author":"Clarke GM","year":"2000","unstructured":"Clarke GM, Higgins TN. Laboratory investigation of hemoglobinopathies and thalassemias: review and update. Clin Chem. 2000, 46:1284-90.","journal-title":"Clin Chem"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.08054.x","article-title":"Significant haemoglobinopathies: guidelines for screening and diagnosis","volume":"149","author":"Ryan K","year":"2010","unstructured":"Ryan K, Bain BJ, Worthington D, et al.. Significant haemoglobinopathies: guidelines for screening and diagnosis. Br J Haematol. 2010, 149:35-49. 10.1111\/j.1365-2141.2009.08054.x","journal-title":"Br J Haematol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/s0268-960x(02)00061-9","article-title":"Screening and genetic diagnosis of haemoglobin disorders","volume":"17","author":"Old JM","year":"2003","unstructured":"Old JM. Screening and genetic diagnosis of haemoglobin disorders. Blood Rev. 2003, 17:43-53. 10.1016\/s0268-960x(02)00061-9","journal-title":"Blood Rev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.034991","article-title":"HPLC retention time as a diagnostic tool for hemoglobin variants and hemoglobinopathies: a study of 60000 samples in a clinical diagnostic laboratory","volume":"50","author":"Joutovsky A","year":"2004","unstructured":"Joutovsky A, Hadzi-Nesic J, Nardi MA. HPLC retention time as a diagnostic tool for hemoglobin variants and hemoglobinopathies: a study of 60000 samples in a clinical diagnostic laboratory. Clin Chem. 2004, 50:1736-47. 10.1373\/clinchem.2004.034991","journal-title":"Clin Chem"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt911","article-title":"Updates of the HbVar database of human hemoglobin variants and thalassemia mutations","volume":"42","author":"Giardine B","year":"2014","unstructured":"Giardine B, Borg J, Viennas E, et al.. Updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res. 2014, 42:D1063-9. 10.1093\/nar\/gkt911","journal-title":"Nucleic Acids Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/490050-distribution-of-hemoglobin-variants-a-retrospective-study-based-on-hemoglobin-electrophoresis-results-from-a-university-hospital-in-madagascar","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:37:44Z","timestamp":1781797064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/490050-distribution-of-hemoglobin-variants-a-retrospective-study-based-on-hemoglobin-electrophoresis-results-from-a-university-hospital-in-madagascar"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.111094","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}