{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:53:20Z","timestamp":1781841200335,"version":"3.54.5"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,18]]},"DOI":"10.7759\/cureus.111116","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:30:17Z","timestamp":1781839817000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of Cardiac Autonomic Dysfunction and Cognitive Impairment With Disease Severity in Parkinson\u2019s Disease: A Cross-Sectional Study"],"prefix":"10.7759","author":[{"given":"Usha","family":"Dhanaradja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajasegaran","family":"Rajalakshmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeswari","family":"Aghoram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravati","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharbari","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moushumi P","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harichandrakumar","family":"KT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.226451","article-title":"Parkinson's disease: a review","volume":"66","author":"Radhakrishnan DM","year":"2018","unstructured":"Radhakrishnan DM, Goyal V. Parkinson's disease: a review. Neurol India. 2018, 66:S26-35. 10.4103\/0028-3886.226451","journal-title":"Neurol India"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21198","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): process, format, and clinimetric testing plan","volume":"22","author":"Goetz CG","year":"2007","unstructured":"Goetz CG, Fahn S, Martinez-Martin P, et al.. Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): process, format, and clinimetric testing plan. Mov Disord. 2007, 22:41-7. 10.1002\/mds.21198","journal-title":"Mov Disord"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.10.025","article-title":"Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis","volume":"46","author":"Jain S","year":"2012","unstructured":"Jain S, Goldstein DS. Cardiovascular dysautonomia in Parkinson disease: from pathophysiology to pathogenesis. Neurobiol Dis. 2012, 46:572-80. 10.1016\/j.nbd.2011.10.025","journal-title":"Neurobiol Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/bs.irn.2017.05.002","article-title":"Cognition in Parkinson's disease","volume":"133","author":"O'Callaghan C","year":"2017","unstructured":"O'Callaghan C, Lewis SJ. Cognition in Parkinson's disease. Int Rev Neurobiol. 2017, 133:557-83. 10.1016\/bs.irn.2017.05.002","journal-title":"Int Rev Neurobiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.33425\/2641-4333.1032","article-title":"Biochemical markers in Parkinson's disease","volume":"3","author":"\u010ceprnja M","year":"2020","unstructured":"\u010ceprnja M, Vuleti\u0107 V. Biochemical markers in Parkinson's disease. Neurol Res Surg. 2020, 3:1-10. 10.33425\/2641-4333.1032","journal-title":"Neurol Res Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/ijoy.ijoy_176_24","article-title":"Effect of 12-week practice of Anulom Vilom pranayama as adjunctive therapy on the cardiac autonomic balance, cognition, psychological status, and quality of life in individuals with mild-to-moderate Parkinson's disease: a randomized controlled trial","volume":"18","author":"Dhanaradja U","year":"2025","unstructured":"Dhanaradja U, Rajasegaran R, Aghoram R, Pal P, Basu S, Mukherjee MP, Harichandrakumar KT. Effect of 12-week practice of Anulom Vilom pranayama as adjunctive therapy on the cardiac autonomic balance, cognition, psychological status, and quality of life in individuals with mild-to-moderate Parkinson's disease: a randomized controlled trial. Int J Yoga. 2025, 18:189-98. 10.4103\/ijoy.ijoy_176_24","journal-title":"Int J Yoga"},{"key":"ref7","article-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen J","year":"1988","unstructured":"Cohen J. Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates, Hillsdale, NJ; 1988."},{"key":"ref8","article-title":"International Standards for Anthropometric Assessment","year":"2011","unstructured":"International Standards for Anthropometric Assessment. International Society for the Advancement of Kinanthropometry, Lower Hutt, New Zealand; 2011."},{"key":"ref9","article-title":"Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology","volume":"93","year":"1996","unstructured":"Heart rate variability. standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996, 93:1043-65.","journal-title":"Circulation"},{"key":"ref10","article-title":"Cognitive event-related potentials. The International Federation of Clinical Neurophysiology","volume":"52","author":"Heinze HJ","year":"1999","unstructured":"Heinze HJ, M\u00fcnte TF, Kutas M, Butler SR, N\u00e4\u00e4t\u00e4nen R, Nuwer MR, Goodin DS. Cognitive event-related potentials. The International Federation of Clinical Neurophysiology. Electroencephalogr Clin Neurophysiol Suppl. 1999, 52:91-5.","journal-title":"Electroencephalogr Clin Neurophysiol Suppl"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00524","article-title":"Genetic architecture of Parkinson's disease in the Indian population: harnessing genetic diversity to address critical gaps in Parkinson's disease research","volume":"11","author":"Rajan R","year":"2020","unstructured":"Rajan R, Divya KP, Kandadai RM, et al.. Genetic architecture of Parkinson's disease in the Indian population: harnessing genetic diversity to address critical gaps in Parkinson's disease research. Front Neurol. 2020, 11:524. 10.3389\/fneur.2020.00524","journal-title":"Front Neurol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.70.3.305","article-title":"Ambulatory ECG and analysis of heart rate variability in Parkinson's disease","volume":"70","author":"Haapaniemi TH","year":"2001","unstructured":"Haapaniemi TH, Pursiainen V, Korpelainen JT, Huikuri HV, Sotaniemi KA, Myllyl\u00e4 VV. Ambulatory ECG and analysis of heart rate variability in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2001, 70:305-10. 10.1136\/jnnp.70.3.305","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.626640","article-title":"Autonomic function in patients with Parkinson's disease: from rest to exercise","volume":"12","author":"Sabino-Carvalho JL","year":"2021","unstructured":"Sabino-Carvalho JL, Fisher JP, Vianna LC. Autonomic function in patients with Parkinson's disease: from rest to exercise. Front Physiol. 2021, 12:626640. 10.3389\/fphys.2021.626640","journal-title":"Front Physiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2014\/9470.4550","article-title":"Influence of deep breathing on heart rate variability in Parkinson's disease: co-relation with severity of disease and non-motor symptom scale score","volume":"8","author":"Bidikar MP","year":"2014","unstructured":"Bidikar MP, Jagtap GJ, Chakor RT. Influence of deep breathing on heart rate variability in Parkinson's disease: co-relation with severity of disease and non-motor symptom scale score. J Clin Diagn Res. 2014, 8:BC01-3. 10.7860\/JCDR\/2014\/9470.4550","journal-title":"J Clin Diagn Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2016.70.453-456","article-title":"P300 wave changes in patients with Parkinson's disease","volume":"70","author":"Tokic K","year":"2016","unstructured":"Tokic K, Titlic M, Beganovic-Petrovic A, Suljic E, Romac R, Silic S. P300 wave changes in patients with Parkinson's disease. Med Arch. 2016, 70:453-6. 10.5455\/medarh.2016.70.453-456","journal-title":"Med Arch"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.45933","article-title":"Auditory evoked P300 potential in patients with Parkinson's disease","volume":"15","author":"Rajendran D","year":"2023","unstructured":"Rajendran D, Bandhu R, Gautam S, K Dhamija R, Mondal S. Auditory evoked P300 potential in patients with Parkinson's disease. Cureus. 2023, 15:e45933. 10.7759\/cureus.45933","journal-title":"Cureus"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2076942","article-title":"Cognition deficits in Parkinson's disease: mechanisms and treatment","volume":"2020","author":"Fang C","year":"2020","unstructured":"Fang C, Lv L, Mao S, Dong H, Liu B. Cognition deficits in Parkinson's disease: mechanisms and treatment. Parkinsons Dis. 2020, 2020:2076942. 10.1155\/2020\/2076942","journal-title":"Parkinsons Dis"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51227","article-title":"Role of homocysteine in the development and progression of Parkinson's disease","volume":"7","author":"Fan X","year":"2020","unstructured":"Fan X, Zhang L, Li H, Chen G, Qi G, Ma X, Jin Y. Role of homocysteine in the development and progression of Parkinson's disease. Ann Clin Transl Neurol. 2020, 7:2332-8. 10.1002\/acn3.51227","journal-title":"Ann Clin Transl Neurol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1080\/10590500902885684","article-title":"8-hydroxy-2' -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis","volume":"27","author":"Valavanidis A","year":"2009","unstructured":"Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2' -deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009, 27:120-39. 10.1080\/10590500902885684","journal-title":"J Environ Sci Health C Environ Carcinog Ecotoxicol Rev"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/493737-association-of-cardiac-autonomic-dysfunction-and-cognitive-impairment-with-disease-severity-in-parkinsons-disease-a-cross-sectional-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:30:18Z","timestamp":1781839818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/493737-association-of-cardiac-autonomic-dysfunction-and-cognitive-impairment-with-disease-severity-in-parkinsons-disease-a-cross-sectional-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,18]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.111116","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,18]]}}}