{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:55:22Z","timestamp":1781891722449,"version":"3.54.5"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,19]]},"DOI":"10.7759\/cureus.111159","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:23:02Z","timestamp":1781889782000},"source":"Crossref","is-referenced-by-count":0,"title":["Validation of Endometriosis Fertility Index for the Prediction of Non-Assisted Reproductive Technology (ART) Pregnancy in Women With Endometriosis-Associated Infertility: A Prospective Cohort Study"],"prefix":"10.7759","author":[{"given":"Divya","family":"Mishra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantanu","family":"Shubham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neena","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei135","article-title":"ESHRE guideline for the diagnosis and treatment of endometriosis","volume":"20","author":"Kennedy S","year":"2005","unstructured":"Kennedy S, Bergqvist A, Chapron C, et al.. ESHRE guideline for the diagnosis and treatment of endometriosis. Hum Reprod. 2005, 20:2698-704. 10.1093\/humrep\/dei135","journal-title":"Hum Reprod"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.04.019","article-title":"Is there a critical endometrioma size associated with reduced ovarian responsiveness in assisted reproduction techniques?","volume":"29","author":"Coccia ME","year":"2014","unstructured":"Coccia ME, Rizzello F, Barone S, et al.. Is there a critical endometrioma size associated with reduced ovarian responsiveness in assisted reproduction techniques?. Reprod Biomed Online. 2014, 29:259-66. 10.1016\/j.rbmo.2014.04.019","journal-title":"Reprod Biomed Online"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-11-112","article-title":"Endometriosis fertility index score maybe more accurate for predicting the outcomes of in vitro fertilisation than r-AFS classification in women with endometriosis","volume":"11","author":"Wang W","year":"2013","unstructured":"Wang W, Li R, Fang T, et al.. Endometriosis fertility index score maybe more accurate for predicting the outcomes of in vitro fertilisation than r-AFS classification in women with endometriosis. Reprod Biol Endocrinol. 2013, 11:112. 10.1186\/1477-7827-11-112","journal-title":"Reprod Biol Endocrinol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det457","article-title":"ESHRE guideline: management of women with endometriosis","volume":"29","author":"Dunselman GA","year":"2014","unstructured":"Dunselman GA, Vermeulen N, Becker C, et al.. ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014, 29:400-12. 10.1093\/humrep\/det457","journal-title":"Hum Reprod"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000163071","article-title":"Advances in treatment options of endometriosis","volume":"67","author":"Ozkan S","year":"2009","unstructured":"Ozkan S, Arici A. Advances in treatment options of endometriosis. Gynecol Obstet Invest. 2009, 67:81-91. 10.1159\/000163071","journal-title":"Gynecol Obstet Invest"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/17.2.426","article-title":"Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial","volume":"17","author":"Bedaiwy MA","year":"2002","unstructured":"Bedaiwy MA, Falcone T, Sharma RK, Goldberg JM, Attaran M, Nelson DR, Agarwal A. Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial. Hum Reprod. 2002, 17:426-31. 10.1093\/humrep\/17.2.426","journal-title":"Hum Reprod"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000067717","article-title":"Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosis","volume":"54","author":"Pizzo A","year":"2002","unstructured":"Pizzo A, Salmeri FM, Ardita FV, Sofo V, Tripepi M, Marsico S. Behaviour of cytokine levels in serum and peritoneal fluid of women with endometriosis. Gynecol Obstet Invest. 2002, 54:82-7. 10.1159\/000067717","journal-title":"Gynecol Obstet Invest"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.05.031","article-title":"Endometriosis and infertility: a committee opinion","volume":"98","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2012","unstructured":"Practice Committee of the American Society for Reproductive Medicine. Endometriosis and infertility: a committee opinion. Fertil Steril. 2012, 98:591-8. 10.1016\/j.fertnstert.2012.05.031","journal-title":"Fertil Steril"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2011.593664","article-title":"Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis","volume":"28","author":"Malhotra N","year":"2012","unstructured":"Malhotra N, Karmakar D, Tripathi V, Luthra K, Kumar S. Correlation of angiogenic cytokines-leptin and IL-8 in stage, type and presentation of endometriosis. Gynecol Endocrinol. 2012, 28:224-7. 10.3109\/09513590.2011.593664","journal-title":"Gynecol Endocrinol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.11.022","article-title":"Deep infiltrating endometriosis is a determinant factor of cumulative pregnancy rate after intracytoplasmic sperm injection\/in vitro fertilization cycles in patients with endometriomas","volume":"97","author":"Ballester M","year":"2012","unstructured":"Ballester M, Oppenheimer A, Mathieu d'Argent E, Touboul C, Antoine JM, Nisolle M, Dara\u00ef E. Deep infiltrating endometriosis is a determinant factor of cumulative pregnancy rate after intracytoplasmic sperm injection\/in vitro fertilization cycles in patients with endometriomas. Fertil Steril. 2012, 97:367-72. 10.1016\/j.fertnstert.2011.11.022","journal-title":"Fertil Steril"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00794","article-title":"Epithelial mutations in endometriosis: link to ovarian cancer","volume":"160","author":"Bulun SE","year":"2019","unstructured":"Bulun SE, Wan Y, Matei D. Epithelial mutations in endometriosis: link to ovarian cancer. Endocrinology. 2019, 160:626-38. 10.1210\/en.2018-00794","journal-title":"Endocrinology"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.04.020","article-title":"Smoking habits of 411 women with histologically proven endometriosis and 567 unaffected women","volume":"94","author":"Chapron C","year":"2010","unstructured":"Chapron C, Souza C, de Ziegler D, et al.. Smoking habits of 411 women with histologically proven endometriosis and 567 unaffected women. Fertil Steril. 2010, 94:2353-5. 10.1016\/j.fertnstert.2010.04.020","journal-title":"Fertil Steril"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.035","article-title":"Endometriosis fertility index: the new, validated endometriosis staging system","volume":"94","author":"Adamson GD","year":"2010","unstructured":"Adamson GD, Pasta DJ. Endometriosis fertility index: the new, validated endometriosis staging system. Fertil Steril. 2010, 94:1609-15. 10.1016\/j.fertnstert.2009.09.035","journal-title":"Fertil Steril"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2015.56.4.1079","article-title":"The prognostic value of individual adhesion scores from the revised American Fertility Society classification system for recurrent endometriosis","volume":"56","author":"Yun BH","year":"2015","unstructured":"Yun BH, Jeon YE, Chon SJ, et al.. The prognostic value of individual adhesion scores from the revised American Fertility Society classification system for recurrent endometriosis. Yonsei Med J. 2015, 56:1079-86. 10.3349\/ymj.2015.56.4.1079","journal-title":"Yonsei Med J"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)46690-2","article-title":"Endometriosis: studies of a method for the design of a surgical staging system","volume":"38","author":"Adamson GD","year":"1982","unstructured":"Adamson GD, Frison L, Lamb EJ. Endometriosis: studies of a method for the design of a surgical staging system. Fertil Steril. 1982, 38:659-66. 10.1016\/S0015-0282(16)46690-2","journal-title":"Fertil Steril"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.61186\/ijrr.22.4.998","article-title":"Logistic regression analysis of imaging characteristics of transvaginal ultrasonography for predicting severe endometriosis by r-ASRM classification via laparoscopy","volume":"22","author":"Su Q","year":"2024","unstructured":"Su Q, Luo H, Guo J, et al.. Logistic regression analysis of imaging characteristics of transvaginal ultrasonography for predicting severe endometriosis by r-ASRM classification via laparoscopy. Int J Radiat Res. 2024, 22:991-8. 10.61186\/ijrr.22.4.998","journal-title":"Int J Radiat Res"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.211892","article-title":"Endometriosis Fertility Index for predicting pregnancy after endometriosis surgery","volume":"130","author":"Li X","year":"2017","unstructured":"Li X, Zeng C, Zhou YF, Yang HX, Shang J, Zhu SN, Xue Q. Endometriosis Fertility Index for predicting pregnancy after endometriosis surgery. Chin Med J (Engl). 2017, 130:1932-7. 10.4103\/0366-6999.211892","journal-title":"Chin Med J (Engl)"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.03.028","article-title":"External validation of the Endometriosis Fertility Index in a French population","volume":"104","author":"Boujenah J","year":"2015","unstructured":"Boujenah J, Bonneau C, Hugues JN, Sifer C, Poncelet C. External validation of the Endometriosis Fertility Index in a French population. Fertil Steril. 2015, 104:119-23.e1. 10.1016\/j.fertnstert.2015.03.028","journal-title":"Fertil Steril"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000366443","article-title":"External validation of the endometriosis fertility index (EFI) for predicting spontaneous pregnancy after surgery: further considerations on its validity","volume":"79","author":"Garavaglia E","year":"2015","unstructured":"Garavaglia E, Pagliardini L, Tandoi I, Sigismondi C, Vigan\u00f2 P, Ferrari S, Candiani M. External validation of the endometriosis fertility index (EFI) for predicting spontaneous pregnancy after surgery: further considerations on its validity. Gynecol Obstet Invest. 2015, 79:113-8. 10.1159\/000366443","journal-title":"Gynecol Obstet Invest"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159\/000358390","article-title":"Reproductive performance after surgery for endometriosis: predictive value of the revised American Fertility Society classification and the endometriosis fertility index","volume":"77","author":"Zeng C","year":"2014","unstructured":"Zeng C, Xu JN, Zhou Y, Zhou YF, Zhu SN, Xue Q. Reproductive performance after surgery for endometriosis: predictive value of the revised American Fertility Society classification and the endometriosis fertility index. Gynecol Obstet Invest. 2014, 77:180-5. 10.1159\/000358390","journal-title":"Gynecol Obstet Invest"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det017","article-title":"External validation of the endometriosis fertility index (EFI) staging system for predicting non-ART pregnancy after endometriosis surgery","volume":"28","author":"Tomassetti C","year":"2013","unstructured":"Tomassetti C, Geysenbergh B, Meuleman C, Timmerman D, Fieuws S, D'Hooghe T. External validation of the endometriosis fertility index (EFI) staging system for predicting non-ART pregnancy after endometriosis surgery. Hum Reprod. 2013, 28:1280-8. 10.1093\/humrep\/det017","journal-title":"Hum Reprod"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0251372","article-title":"Infertility management according to the Endometriosis Fertility Index in patients operated for endometriosis: what is the optimal time frame?","volume":"16","author":"Bailleul A","year":"2021","unstructured":"Bailleul A, Niro J, Du Cheyron J, Panel P, Fauconnier A. Infertility management according to the Endometriosis Fertility Index in patients operated for endometriosis: what is the optimal time frame?. PLoS One. 2021, 16:e0251372. 10.1371\/journal.pone.0251372","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1080\/03630242.2021.1986458","article-title":"Endometriosis fertility index predicts pregnancy in women operated on for moderate and severe symptomatic endometriosis","volume":"62","author":"Rodrigues DM","year":"2022","unstructured":"Rodrigues DM, de \u00c1vila I, Amorim LV, Carneiro MM, Ferreira MC. Endometriosis fertility index predicts pregnancy in women operated on for moderate and severe symptomatic endometriosis. Women Health. 2022, 62:3-11. 10.1080\/03630242.2021.1986458","journal-title":"Women Health"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13051488","article-title":"An ultrasound-based preoperative evaluation of the Endometriosis Fertility Index: a further step towards personalized treatment","volume":"13","author":"Marchetti M","year":"2024","unstructured":"Marchetti M, Noventa M, Panizzolo E, et al.. An ultrasound-based preoperative evaluation of the Endometriosis Fertility Index: a further step towards personalized treatment. J Clin Med. 2024, 13:1488. 10.3390\/jcm13051488","journal-title":"J Clin Med"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S512359","article-title":"The improved-EFI score: a multi-omics-based novel efficacy predictive tool for predicting the natural fertility of endometriosis patients","volume":"18","author":"He Q","year":"2025","unstructured":"He Q, Zhang C, Hu Y, Deng J, Zhang S. The improved-EFI score: a multi-omics-based novel efficacy predictive tool for predicting the natural fertility of endometriosis patients. Int J Gen Med. 2025, 18:881-95. 10.2147\/IJGM.S512359","journal-title":"Int J Gen Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16180","article-title":"Why and when you should use the endometriosis fertility index (EFI)","volume":"127","author":"Tomassetti C","year":"2020","unstructured":"Tomassetti C. Why and when you should use the endometriosis fertility index (EFI). BJOG. 2020, 127:810. 10.1111\/1471-0528.16180","journal-title":"BJOG"},{"key":"ref27","article-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"World Health Organization","year":"2010","unstructured":"World Health Organization. WHO Laboratory Manual for the Examination and Processing of Human Semen. World Health Organization, Geneva, Switzerland; 2010."},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11216","article-title":"Reproducibility of assessment of severity of pelvic endometriosis using transvaginal ultrasound","volume":"41","author":"Holland TK","year":"2013","unstructured":"Holland TK, Hoo WL, Mavrelos D, Saridogan E, Cutner A, Jurkovic D. Reproducibility of assessment of severity of pelvic endometriosis using transvaginal ultrasound. Ultrasound Obstet Gynecol. 2013, 41:210-5. 10.1002\/uog.11216","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del230","article-title":"Reproductive performance, pain recurrence and disease relapse after conservative surgical treatment for endometriosis: the predictive value of the current classification system","volume":"21","author":"Vercellini P","year":"2006","unstructured":"Vercellini P, Fedele L, Aimi G, De Giorgi O, Consonni D, Crosignani PG. Reproductive performance, pain recurrence and disease relapse after conservative surgical treatment for endometriosis: the predictive value of the current classification system. Hum Reprod. 2006, 21:2679-85. 10.1093\/humrep\/del230","journal-title":"Hum Reprod"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dex291","article-title":"Endometriosis fertility index predicts live births following surgical resection of moderate and severe endometriosis","volume":"32","author":"Maheux-Lacroix S","year":"2017","unstructured":"Maheux-Lacroix S, Nesbitt-Hawes E, Deans R, Won H, Budden A, Adamson D, Abbott JA. Endometriosis fertility index predicts live births following surgical resection of moderate and severe endometriosis. Hum Reprod. 2017, 32:2243-9. 10.1093\/humrep\/dex291","journal-title":"Hum Reprod"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/500341-validation-of-endometriosis-fertility-index-for-the-prediction-of-non-assisted-reproductive-technology-art-pregnancy-in-women-with-endometriosis-associated-infertility-a-prospective-cohort-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T17:23:03Z","timestamp":1781889783000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/500341-validation-of-endometriosis-fertility-index-for-the-prediction-of-non-assisted-reproductive-technology-art-pregnancy-in-women-with-endometriosis-associated-infertility-a-prospective-cohort-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":30,"URL":"https:\/\/doi.org\/10.7759\/cureus.111159","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,19]]}}}