{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:05:31Z","timestamp":1789398331020,"version":"build-2803163510"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,19]]},"DOI":"10.7759\/cureus.111170","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:57:16Z","timestamp":1781909836000},"source":"Crossref","is-referenced-by-count":1,"title":["Necrobiotic Xanthogranuloma Associated With IgG Kappa Smoldering Myeloma Presenting as Vision-Threatening Orbital Disease: Clinical Response to Plasma Cell-Directed Therapy"],"prefix":"10.7759","author":[{"given":"Hira I","family":"Cheema","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Zangari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Schinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frits","family":"Van Rhee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharmilan","family":"Thanendrarajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2008.583","article-title":"Necrobiotic xanthogranuloma: a review of 17 cases with emphasis on clinical and pathologic correlation","volume":"145","author":"Wood AJ","year":"2009","unstructured":"Wood AJ, Wagner MV, Abbott JJ, Gibson LE. Necrobiotic xanthogranuloma: a review of 17 cases with emphasis on clinical and pathologic correlation. Arch Dermatol. 2009, 145:279-84. 10.1001\/archdermatol.2008.583","journal-title":"Arch Dermatol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.4221","article-title":"A multicenter cross-sectional study and systematic review of necrobiotic xanthogranuloma with proposed diagnostic criteria","volume":"156","author":"Nelson CA","year":"2020","unstructured":"Nelson CA, Zhong CS, Hashemi DA, et al.. A multicenter cross-sectional study and systematic review of necrobiotic xanthogranuloma with proposed diagnostic criteria. JAMA Dermatol. 2020, 156:270-9. 10.1001\/jamadermatol.2019.4221","journal-title":"JAMA Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)00469-9","article-title":"Necrobiotic xanthogranuloma: long-term outcome of ocular and systemic involvement","volume":"129","author":"Ugurlu S","year":"2000","unstructured":"Ugurlu S, Bartley GB, Gibson LE. Necrobiotic xanthogranuloma: long-term outcome of ocular and systemic involvement. Am J Ophthalmol. 2000, 129:651-7. 10.1016\/S0002-9394(99)00469-9","journal-title":"Am J Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3301-1","article-title":"Necrobiotic xanthogranuloma: a 30-year single-center experience","volume":"97","author":"Hilal T","year":"2018","unstructured":"Hilal T, DiCaudo DJ, Connolly SM, Reeder CB. Necrobiotic xanthogranuloma: a 30-year single-center experience. Ann Hematol. 2018, 97:1471-9. 10.1007\/s00277-018-3301-1","journal-title":"Ann Hematol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2020000122","article-title":"Monoclonal gammopathies of clinical significance","volume":"2020","author":"Dispenzieri A","year":"2020","unstructured":"Dispenzieri A. Monoclonal gammopathies of clinical significance. Hematology Am Soc Hematol Educ Program. 2020, 2020:380-8. 10.1182\/hematology.2020000122","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-356907","article-title":"Pathogenesis and treatment of xanthomatosis associated with monoclonal gammopathy","volume":"118","author":"Szalat R","year":"2011","unstructured":"Szalat R, Arnulf B, Karlin L, et al.. Pathogenesis and treatment of xanthomatosis associated with monoclonal gammopathy. Blood. 2011, 118:3777-84. 10.1182\/blood-2011-05-356907","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12195","article-title":"Physiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy","volume":"276","author":"Szalat R","year":"2014","unstructured":"Szalat R, Pirault J, Fermand JP, et al.. Physiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy. J Intern Med. 2014, 276:269-84. 10.1111\/joim.12195","journal-title":"J Intern Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13786","article-title":"Treatment of necrobiotic xanthogranuloma - a systematic review","volume":"31","author":"Miguel D","year":"2017","unstructured":"Miguel D, Lukacs J, Illing T, Elsner P. Treatment of necrobiotic xanthogranuloma - a systematic review. J Eur Acad Dermatol Venereol. 2017, 31:221-35. 10.1111\/jdv.13786","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2011.03.020","article-title":"Complete response to thalidomide and dexamethasone in a patient with necrobiotic xanthogranuloma associated with monoclonal gammopathy: a case report and review of the literature","volume":"11","author":"Efebera Y","year":"2011","unstructured":"Efebera Y, Blanchard E, Allam C, Han A, Lee S, Munshi N. Complete response to thalidomide and dexamethasone in a patient with necrobiotic xanthogranuloma associated with monoclonal gammopathy: a case report and review of the literature. Clin Lymphoma Myeloma Leuk. 2011, 11:298-302. 10.1016\/j.clml.2011.03.020","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-016-2604-3","article-title":"Necrobiotic xanthogranuloma associated with monoclonal gammopathy: successful treatment with lenalidomide and dexamethasone","volume":"95","author":"Dholaria BR","year":"2016","unstructured":"Dholaria BR, Cappel M, Roy V. Necrobiotic xanthogranuloma associated with monoclonal gammopathy: successful treatment with lenalidomide and dexamethasone. Ann Hematol. 2016, 95:671-2. 10.1007\/s00277-016-2604-3","journal-title":"Ann Hematol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000485913","article-title":"Periorbital necrobiotic xanthogranuloma successfully treated with intravenous immunoglobulin","volume":"9","author":"Olson RM","year":"2018","unstructured":"Olson RM, Harrison AR, Maltry A, Mokhtarzadeh A. Periorbital necrobiotic xanthogranuloma successfully treated with intravenous immunoglobulin. Case Rep Ophthalmol. 2018, 9:70-5. 10.1159\/000485913","journal-title":"Case Rep Ophthalmol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2626","article-title":"Periocular necrobiotic xanthogranuloma successfully treated with intravenous immunoglobulin","volume":"97","author":"Luk\u00e1cs J","year":"2017","unstructured":"Luk\u00e1cs J, Goetze S, Elsner P. Periocular necrobiotic xanthogranuloma successfully treated with intravenous immunoglobulin. Acta Derm Venereol. 2017, 97:754-5. 10.2340\/00015555-2626","journal-title":"Acta Derm Venereol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/502681-necrobiotic-xanthogranuloma-associated-with-igg-kappa-smoldering-myeloma-presenting-as-vision-threatening-orbital-disease-clinical-response-to-plasma-cell-directed-therapy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T22:57:17Z","timestamp":1781909837000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/502681-necrobiotic-xanthogranuloma-associated-with-igg-kappa-smoldering-myeloma-presenting-as-vision-threatening-orbital-disease-clinical-response-to-plasma-cell-directed-therapy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.111170","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,19]]}}}