{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:49:56Z","timestamp":1782229796884,"version":"3.54.5"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,23]]},"DOI":"10.7759\/cureus.111364","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:31:19Z","timestamp":1782228679000},"source":"Crossref","is-referenced-by-count":0,"title":["Wiskott-Aldrich Syndrome With Severe Thrombocytopenia and Hemorrhagic Manifestations: A Case Report"],"prefix":"10.7759","author":[{"given":"Chaymae","family":"Cherrabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassnae","family":"Tkak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bellaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayad","family":"Ghanam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Rkain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.70962\/jhi.20250002","article-title":"The 2024 update of IUIS phenotypic classification of human inborn errors of immunity","volume":"1","author":"Bousfiha AA","year":"2025","unstructured":"Bousfiha AA, Jeddane L, Moundir A, et al.. The 2024 update of IUIS phenotypic classification of human inborn errors of immunity. J Hum Immun. 2025, 1:e20250002. 10.70962\/jhi.20250002","journal-title":"J Hum Immun"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2008.10.007","article-title":"Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment","volume":"15","author":"Ochs HD","year":"2009","unstructured":"Ochs HD, Filipovich AH, Veys P, Cowan MJ, Kapoor N. Wiskott-Aldrich syndrome: diagnosis, clinical and laboratory manifestations, and treatment. Biol Blood Marrow Transplant. 2009, 15:84-90. 10.1016\/j.bbmt.2008.10.007","journal-title":"Biol Blood Marrow Transplant"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2147\/TACG.S58444","article-title":"Wiskott-Aldrich syndrome: diagnosis, current management, and emerging treatments","volume":"7","author":"Buchbinder D","year":"2014","unstructured":"Buchbinder D, Nugent DJ, Fillipovich AH. Wiskott-Aldrich syndrome: diagnosis, current management, and emerging treatments. Appl Clin Genet. 2014, 7:55-66. 10.2147\/TACG.S58444","journal-title":"Appl Clin Genet"},{"key":"ref4","article-title":"Familial, congenital Werlhof's disease? [Article in German]","volume":"68","author":"Wiskott A","year":"1937","unstructured":"Wiskott A. Familial, congenital Werlhof's disease? [Article in German]. Monatsschr Kinderheilkd. 1937, 68:212-6.","journal-title":"Monatsschr Kinderheilkd"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.13.2.133","article-title":"Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea","volume":"13","author":"Aldrich RA","year":"1954","unstructured":"Aldrich RA, Steinberg AG, Campbell DC. Pedigree demonstrating a sex-linked recessive condition characterized by draining ears, eczematoid dermatitis and bloody diarrhea. Pediatrics. 1954, 13:133-9. 10.1542\/peds.13.2.133","journal-title":"Pediatrics"},{"key":"ref6","unstructured":"Wiskott-Aldrich syndrome. (2024). https.\/\/emedicine.medscape.com\/article\/137015-overview."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25196","article-title":"X-linked thrombocytopenia in three males with normal sized platelets due to novel WAS gene mutations","volume":"61","author":"Mantadakis E","year":"2014","unstructured":"Mantadakis E, Sawalle-Belohradsky J, Tzanoudaki M, Kanariou M, Chatzimichael A, Albert MH. X-linked thrombocytopenia in three males with normal sized platelets due to novel WAS gene mutations. Pediatr Blood Cancer. 2014, 61:2305-6. 10.1002\/pbc.25196","journal-title":"Pediatr Blood Cancer"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1177\/26330040211009905","article-title":"Wiskott-Aldrich syndrome with normal platelet volume in a low-income setting: a case report","volume":"2","author":"Mawalla WF","year":"2021","unstructured":"Mawalla WF, Iddy H, Kindole CA, Nasser A, Schuh A. Wiskott-Aldrich syndrome with normal platelet volume in a low-income setting: a case report. Ther Adv Rare Dis. 2021, 2:26330040211009905. 10.1177\/26330040211009905","journal-title":"Ther Adv Rare Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-448118","article-title":"Characteristics and outcome of early-onset, severe forms of Wiskott-Aldrich syndrome","volume":"121","author":"Mahlaoui N","year":"2013","unstructured":"Mahlaoui N, Pellier I, Mignot C, et al.. Characteristics and outcome of early-onset, severe forms of Wiskott-Aldrich syndrome. Blood. 2013, 121:1510-6. 10.1182\/blood-2012-08-448118","journal-title":"Blood"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(05)82002-5","article-title":"A multiinstitutional survey of the Wiskott-Aldrich syndrome","volume":"125","author":"Sullivan KE","year":"1994","unstructured":"Sullivan KE, Mullen CA, Blaese RM, et al.. A multiinstitutional survey of the Wiskott-Aldrich syndrome. J Pediatr. 1994, 125:876-85. 10.1016\/s0022-3476(05)82002-5","journal-title":"J Pediatr"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1177\/19253621251333176","article-title":"Disease, accident, and trauma: a case report on sudden death in Wiskott-Aldrich's syndrome","volume":"15","author":"Manral I","year":"2025","unstructured":"Manral I, Sagoo GK, T A, Manral R, Radhakrishna KV, Makhani CS, Khan RN. Disease, accident, and trauma: a case report on sudden death in Wiskott-Aldrich's syndrome. Acad Forensic Pathol. 2025, 15:148-54. 10.1177\/19253621251333176","journal-title":"Acad Forensic Pathol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.5.436","article-title":"Intravenous immunoglobulin, splenectomy, and antibiotic prophylaxis in Wiskott-Aldrich syndrome","volume":"75","author":"Litzman J","year":"1996","unstructured":"Litzman J, Jones A, Hann I, Chapel H, Strobel S, Morgan G. Intravenous immunoglobulin, splenectomy, and antibiotic prophylaxis in Wiskott-Aldrich syndrome. Arch Dis Child. 1996, 75:436-9. 10.1136\/adc.75.5.436","journal-title":"Arch Dis Child"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-076679","article-title":"Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation","volume":"111","author":"Ozsahin H","year":"2008","unstructured":"Ozsahin H, Cavazzana-Calvo M, Notarangelo LD, et al.. Long-term outcome following hematopoietic stem-cell transplantation in Wiskott-Aldrich syndrome: collaborative study of the European Society for Immunodeficiencies and European Group for Blood and Marrow Transplantation. Blood. 2008, 111:439-45. 10.1182\/blood-2007-03-076679","journal-title":"Blood"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/503845-wiskott-aldrich-syndrome-with-severe-thrombocytopenia-and-hemorrhagic-manifestations-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T15:31:25Z","timestamp":1782228685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/503845-wiskott-aldrich-syndrome-with-severe-thrombocytopenia-and-hemorrhagic-manifestations-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.111364","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,23]]}}}