{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:50:37Z","timestamp":1782373837026,"version":"3.54.5"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,25]]},"DOI":"10.7759\/cureus.111463","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:42:20Z","timestamp":1782373340000},"source":"Crossref","is-referenced-by-count":0,"title":["A Comprehensive Review of the Integration of Biotechnology in Modern Medicine and Pathology: Advances in Diagnostic Techniques, Therapeutic Innovations, and Clinical Outcomes"],"prefix":"10.7759","author":[{"given":"Santosh","family":"Jayant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithi","family":"Doley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Swapna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Prasad","family":"E","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Sambhav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baijnath","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmae013","article-title":"Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review","volume":"30","author":"Rodr\u00edguez-Eguren A","year":"2024","unstructured":"Rodr\u00edguez-Eguren A, Bueno-Fernandez C, G\u00f3mez-\u00c1lvarez M, et al.. Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review. Hum Reprod Update. 2024, 30:584-613. 10.1093\/humupd\/dmae013","journal-title":"Hum Reprod Update"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010181","article-title":"5-Hydroxytryptophan (5-HTP): natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology","volume":"22","author":"Maffei ME","year":"2020","unstructured":"Maffei ME. 5-Hydroxytryptophan (5-HTP): natural occurrence, analysis, biosynthesis, biotechnology, physiology and toxicology. Int J Mol Sci. 2020, 22:181. 10.3390\/ijms22010181","journal-title":"Int J Mol Sci"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05800-5","article-title":"Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1","volume":"14","author":"Xu DH","year":"2023","unstructured":"Xu DH, Du JK, Liu SY, Zhang H, Yang L, Zhu XY, Liu YJ. Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1. Cell Death Dis. 2023, 14:278. 10.1038\/s41419-023-05800-5","journal-title":"Cell Death Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2020.112051","article-title":"Perspectives of photodynamic therapy in biotechnology","volume":"213","author":"Couto GK","year":"2020","unstructured":"Couto GK, Seixas FK, Iglesias BA, Collares T. Perspectives of photodynamic therapy in biotechnology. J Photochem Photobiol B. 2020, 213:112051. 10.1016\/j.jphotobiol.2020.112051","journal-title":"J Photochem Photobiol B"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01746-6","article-title":"Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment","volume":"20","author":"Wu Y","year":"2022","unstructured":"Wu Y, Wan S, Yang S, et al.. Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment. J Nanobiotechnology. 2022, 20:542. 10.1186\/s12951-022-01746-6","journal-title":"J Nanobiotechnology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61239-6","article-title":"Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation","volume":"16","author":"Kubat GB","year":"2025","unstructured":"Kubat GB, Picone P, Tuncay E, et al.. Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation. Nat Commun. 2025, 16:5709. 10.1038\/s41467-025-61239-6","journal-title":"Nat Commun"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2024.101278","article-title":"Modern methods of molecular diagnostics","volume":"98","author":"Kubista M","year":"2024","unstructured":"Kubista M, Andersson D, St\u00e5hlberg A. Modern methods of molecular diagnostics. Mol Aspects Med. 2024, 98:101278. 10.1016\/j.mam.2024.101278","journal-title":"Mol Aspects Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-019-0454-6","article-title":"Enamel remineralization and repair results of biomimetic hydroxyapatite toothpaste on deciduous teeth: an effective option to fluoride toothpaste","volume":"17","author":"Boss\u00f9 M","year":"2019","unstructured":"Boss\u00f9 M, Saccucci M, Salucci A, et al.. Enamel remineralization and repair results of biomimetic hydroxyapatite toothpaste on deciduous teeth: an effective option to fluoride toothpaste. J Nanobiotechnology. 2019, 17:17. 10.1186\/s12951-019-0454-6","journal-title":"J Nanobiotechnology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2023.06.010","article-title":"Prokaryotic Argonautes for in vivo biotechnology and molecular diagnostics","volume":"42","author":"Graver BA","year":"2024","unstructured":"Graver BA, Chakravarty N, Solomon KV. Prokaryotic Argonautes for in vivo biotechnology and molecular diagnostics. Trends Biotechnol. 2024, 42:61-73. 10.1016\/j.tibtech.2023.06.010","journal-title":"Trends Biotechnol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c12131","article-title":"Multifunctional nanomedicine for targeted atherosclerosis therapy: activating plaque clearance cascade and suppressing inflammation","volume":"19","author":"Tang C","year":"2025","unstructured":"Tang C, Wang H, Guo L, et al.. Multifunctional nanomedicine for targeted atherosclerosis therapy: activating plaque clearance cascade and suppressing inflammation. ACS Nano. 2025, 19:3339-61. 10.1021\/acsnano.4c12131","journal-title":"ACS Nano"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2018.10.001","article-title":"Galectin-carbohydrate interactions in biomedicine and biotechnology","volume":"37","author":"Laaf D","year":"2019","unstructured":"Laaf D, Bojarov\u00e1 P, Elling L, K\u0159en V. Galectin-carbohydrate interactions in biomedicine and biotechnology. Trends Biotechnol. 2019, 37:402-15. 10.1016\/j.tibtech.2018.10.001","journal-title":"Trends Biotechnol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2024.106529","article-title":"Recent advances in the investigation of fusion RNAs and their role in molecular pathology of cancer","volume":"168","author":"Xu SM","year":"2024","unstructured":"Xu SM, Cheng Y, Fisher H, Janitz M. Recent advances in the investigation of fusion RNAs and their role in molecular pathology of cancer. Int J Biochem Cell Biol. 2024, 168:106529. 10.1016\/j.biocel.2024.106529","journal-title":"Int J Biochem Cell Biol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27228093","article-title":"Biotechnology and in vitro culture as an alternative system for secondary metabolite production","volume":"27","author":"Mohaddab M","year":"2022","unstructured":"Mohaddab M, El Goumi Y, Gallo M, Montesano D, Zengin G, Bouyahya A, Fakiri M. Biotechnology and in vitro culture as an alternative system for secondary metabolite production. Molecules. 2022, 27:8093. 10.3390\/molecules27228093","journal-title":"Molecules"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-01447-4","article-title":"In vivo optical imaging-guided targeted sampling for precise diagnosis and molecular pathology","volume":"11","author":"Sahu A","year":"2021","unstructured":"Sahu A, Oh Y, Peterson G, et al.. In vivo optical imaging-guided targeted sampling for precise diagnosis and molecular pathology. Sci Rep. 2021, 11:23124. 10.1038\/s41598-021-01447-4","journal-title":"Sci Rep"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7150\/thno.110389","article-title":"An AIM2 inflammasome biomimetic mineralization inhibitor for vascular dementia therapy","volume":"15","author":"Zhang Y","year":"2025","unstructured":"Zhang Y, Jiang L, Wu R, et al.. An AIM2 inflammasome biomimetic mineralization inhibitor for vascular dementia therapy. Theranostics. 2025, 15:6347-68. 10.7150\/thno.110389","journal-title":"Theranostics"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115194","article-title":"Emerging strategies for nanomedicine in autoimmunity","volume":"207","author":"Thatte AS","year":"2024","unstructured":"Thatte AS, Billingsley MM, Weissman D, Melamed JR, Mitchell MJ. Emerging strategies for nanomedicine in autoimmunity. Adv Drug Deliv Rev. 2024, 207:115194. 10.1016\/j.addr.2024.115194","journal-title":"Adv Drug Deliv Rev"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c13470","article-title":"Enhanced antiglioma effect by a vitamin D3-inserted lipid hybrid neutrophil membrane biomimetic multimodal nanoplatform","volume":"18","author":"He W","year":"2024","unstructured":"He W, Lv W, Liu L, et al.. Enhanced antiglioma effect by a vitamin D3-inserted lipid hybrid neutrophil membrane biomimetic multimodal nanoplatform. ACS Nano. 2024, 18:35559-74. 10.1021\/acsnano.4c13470","journal-title":"ACS Nano"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120297","article-title":"Nanomedicine progress in thrombolytic therapy","volume":"258","author":"Zenych A","year":"2020","unstructured":"Zenych A, Fournier L, Chauvierre C. Nanomedicine progress in thrombolytic therapy. Biomaterials. 2020, 258:120297. 10.1016\/j.biomaterials.2020.120297","journal-title":"Biomaterials"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbt.2023.09.006","article-title":"Provenance of specimen and data - a prerequisite for AI development in computational pathology","volume":"78","author":"Plass M","year":"2023","unstructured":"Plass M, Wittner R, Holub P, et al.. Provenance of specimen and data - a prerequisite for AI development in computational pathology. N Biotechnol. 2023, 78:22-8. 10.1016\/j.nbt.2023.09.006","journal-title":"N Biotechnol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2021.06.011","article-title":"Molecular pathology of rare progeroid diseases","volume":"27","author":"Rieckher M","year":"2021","unstructured":"Rieckher M, Garinis GA, Schumacher B. Molecular pathology of rare progeroid diseases. Trends Mol Med. 2021, 27:907-22. 10.1016\/j.molmed.2021.06.011","journal-title":"Trends Mol Med"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092437","article-title":"Chenodeoxycholic acid pharmacology in biotechnology and transplantable pharmaceutical applications for tissue delivery: an acute preclinical study","volume":"10","author":"Mooranian A","year":"2021","unstructured":"Mooranian A, Ionescu CM, Wagle SR, et al.. Chenodeoxycholic acid pharmacology in biotechnology and transplantable pharmaceutical applications for tissue delivery: an acute preclinical study. Cells. 2021, 10:10.3390\/cells10092437","journal-title":"Cells"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ucl.2020.07.006","article-title":"Biotech and breakthroughs in immuno-oncology","volume":"47","author":"Bockman JM","year":"2020","unstructured":"Bockman JM. Biotech and breakthroughs in immuno-oncology. Urol Clin North Am. 2020, 47:511-21. 10.1016\/j.ucl.2020.07.006","journal-title":"Urol Clin North Am"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-2651-1_23","article-title":"CRISPR manipulations in stem cell lines","volume":"2560","author":"Chang YJ","year":"2023","unstructured":"Chang YJ, Cui X, Levi SR, Jenny LA, Tsang SH. CRISPR manipulations in stem cell lines. Methods Mol Biol. 2023, 2560:249-56. 10.1007\/978-1-0716-2651-1_23","journal-title":"Methods Mol Biol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c00218","article-title":"Inflammation and acinar cell dual-targeting nanomedicines for synergistic treatment of acute pancreatitis via Ca2+ homeostasis regulation and pancreas autodigestion inhibition","volume":"18","author":"Wang Y","year":"2024","unstructured":"Wang Y, Wang X, Zhang X, et al.. Inflammation and acinar cell dual-targeting nanomedicines for synergistic treatment of acute pancreatitis via Ca2+ homeostasis regulation and pancreas autodigestion inhibition. ACS Nano. 2024, 18:11778-803. 10.1021\/acsnano.4c00218","journal-title":"ACS Nano"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.10.038","article-title":"Discovery and significance of protein-protein interactions in health and disease","volume":"187","author":"Greenblatt JF","year":"2024","unstructured":"Greenblatt JF, Alberts BM, Krogan NJ. Discovery and significance of protein-protein interactions in health and disease. Cell. 2024, 187:6501-17. 10.1016\/j.cell.2024.10.038","journal-title":"Cell"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfab021","article-title":"Chemistry and biology of ferritin","volume":"13","author":"Plays M","year":"2021","unstructured":"Plays M, M\u00fcller S, Rodriguez R. Chemistry and biology of ferritin. Metallomics. 2021, 13:mfab021. 10.1093\/mtomcs\/mfab021","journal-title":"Metallomics"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-019-01633-4","article-title":"Nanobody: outstanding features for diagnostic and therapeutic applications","volume":"411","author":"Salvador JP","year":"2019","unstructured":"Salvador JP, Vilaplana L, Marco MP. Nanobody: outstanding features for diagnostic and therapeutic applications. Anal Bioanal Chem. 2019, 411:1703-13. 10.1007\/s00216-019-01633-4","journal-title":"Anal Bioanal Chem"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.1c00267","article-title":"Ferritin: a multifunctional nanoplatform for biological detection, imaging diagnosis, and drug delivery","volume":"54","author":"Song N","year":"2021","unstructured":"Song N, Zhang J, Zhai J, Hong J, Yuan C, Liang M. Ferritin: a multifunctional nanoplatform for biological detection, imaging diagnosis, and drug delivery. Acc Chem Res. 2021, 54:3313-25. 10.1021\/acs.accounts.1c00267","journal-title":"Acc Chem Res"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-022620-081059","article-title":"Microbes as biosensors","volume":"74","author":"Inda ME","year":"2020","unstructured":"Inda ME, Lu TK. Microbes as biosensors. Annu Rev Microbiol. 2020, 74:337-59. 10.1146\/annurev-micro-022620-081059","journal-title":"Annu Rev Microbiol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ihj.2017.02.007","article-title":"Nanomedicine in coronary artery disease","volume":"69","author":"Ambesh P","year":"2017","unstructured":"Ambesh P, Campia U, Obiagwu C, Bansal R, Shetty V, Hollander G, Shani J. Nanomedicine in coronary artery disease. Indian Heart J. 2017, 69:244-51. 10.1016\/j.ihj.2017.02.007","journal-title":"Indian Heart J"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms262211188","article-title":"Leveraging dental biotechnology for population oral health: innovations in prevention, diagnosis, and treatment","volume":"26","author":"Sonmez OF","year":"2025","unstructured":"Sonmez OF, Makara TS, Bedi R. Leveraging dental biotechnology for population oral health: innovations in prevention, diagnosis, and treatment. Int J Mol Sci. 2025, 26:11188. 10.3390\/ijms262211188","journal-title":"Int J Mol Sci"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.49801","article-title":"Application of nanotechnology in cancer diagnosis and therapy - a mini-review","volume":"17","author":"Jin C","year":"2020","unstructured":"Jin C, Wang K, Oppong-Gyebi A, Hu J. Application of nanotechnology in cancer diagnosis and therapy - a mini-review. Int J Med Sci. 2020, 17:2964-73. 10.7150\/ijms.49801","journal-title":"Int J Med Sci"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1039\/d2tb01633h","article-title":"Application of nanotechnology in thrombus therapy","volume":"11","author":"Liao K","year":"2023","unstructured":"Liao K, Wu Q, Li Y, Wu C, Zhou Y, Zeng Q. Application of nanotechnology in thrombus therapy. J Mater Chem B. 2023, 11:5043-50. 10.1039\/d2tb01633h","journal-title":"J Mater Chem B"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2017.1417863","article-title":"Advancement in nanotechnology-based approaches for the treatment and diagnosis of hypercholesterolemia","volume":"46","author":"Gupta N","year":"2018","unstructured":"Gupta N, Sharma N, Mathur SK, Chandra R, Nimesh S. Advancement in nanotechnology-based approaches for the treatment and diagnosis of hypercholesterolemia. Artif Cells Nanomed Biotechnol. 2018, 46:188-97. 10.1080\/21691401.2017.1417863","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118859","article-title":"Advancement of nanoscience in development of conjugated drugs for enhanced disease prevention","volume":"268","author":"Taneja P","year":"2021","unstructured":"Taneja P, Sharma S, Sinha VB, Yadav AK. Advancement of nanoscience in development of conjugated drugs for enhanced disease prevention. Life Sci. 2021, 268:118859. 10.1016\/j.lfs.2020.118859","journal-title":"Life Sci"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s12033-023-00760-9","article-title":"Microfluidics-based nanobiosensors for healthcare monitoring","volume":"66","author":"Kumari M","year":"2024","unstructured":"Kumari M, Gupta V, Kumar N, Arun RK. Microfluidics-based nanobiosensors for healthcare monitoring. Mol Biotechnol. 2024, 66:378-401. 10.1007\/s12033-023-00760-9","journal-title":"Mol Biotechnol"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.4c00009","article-title":"Ultrasound-based micro-\/nanosystems for biomedical applications","volume":"124","author":"Huang H","year":"2024","unstructured":"Huang H, Zheng Y, Chang M, et al.. Ultrasound-based micro-\/nanosystems for biomedical applications. Chem Rev. 2024, 124:8307-472. 10.1021\/acs.chemrev.4c00009","journal-title":"Chem Rev"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.066","article-title":"Biotechnology challenges to in\u00a0vitro maturation of hepatic stem cells","volume":"154","author":"Chen C","year":"2018","unstructured":"Chen C, Soto-Gutierrez A, Baptista PM, Spee B. Biotechnology challenges to in\u00a0vitro maturation of hepatic stem cells. Gastroenterology. 2018, 154:1258-72. 10.1053\/j.gastro.2018.01.066","journal-title":"Gastroenterology"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2019.11.005","article-title":"Leukemia inhibitory factor: recent advances and implications in biotechnology","volume":"52","author":"Pinho V","year":"2020","unstructured":"Pinho V, Fernandes M, da Costa A, Machado R, Gomes AC. Leukemia inhibitory factor: recent advances and implications in biotechnology. Cytokine Growth Factor Rev. 2020, 52:25-33. 10.1016\/j.cytogfr.2019.11.005","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-023-00580-2","article-title":"Methods and applications for single-cell and spatial multi-omics","volume":"24","author":"Vandereyken K","year":"2023","unstructured":"Vandereyken K, Sifrim A, Thienpont B, Voet T. Methods and applications for single-cell and spatial multi-omics. Nat Rev Genet. 2023, 24:494-515. 10.1038\/s41576-023-00580-2","journal-title":"Nat Rev Genet"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0150-2","article-title":"RNA sequencing: the teenage years","volume":"20","author":"Stark R","year":"2019","unstructured":"Stark R, Grzelak M, Hadfield J. RNA sequencing: the teenage years. Nat Rev Genet. 2019, 20:631-56. 10.1038\/s41576-019-0150-2","journal-title":"Nat Rev Genet"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-024-01106-8","article-title":"Artificial intelligence in digital pathology: a systematic review and meta-analysis of diagnostic test accuracy","volume":"7","author":"McGenity C","year":"2024","unstructured":"McGenity C, Clarke EL, Jennings C, et al.. Artificial intelligence in digital pathology: a systematic review and meta-analysis of diagnostic test accuracy. NPJ Digit Med. 2024, 7:114. 10.1038\/s41746-024-01106-8","journal-title":"NPJ Digit Med"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-02021-w","article-title":"Liquid biopsy in cancer current: status, challenges and future prospects","volume":"9","author":"Ma L","year":"2024","unstructured":"Ma L, Guo H, Zhao Y, et al.. Liquid biopsy in cancer current: status, challenges and future prospects. Signal Transduct Target Ther. 2024, 9:336. 10.1038\/s41392-024-02021-w","journal-title":"Signal Transduct Target Ther"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.001","article-title":"Targeting strategies for tissue-specific drug delivery","volume":"181","author":"Zhao Z","year":"2020","unstructured":"Zhao Z, Ukidve A, Kim J, Mitragotri S. Targeting strategies for tissue-specific drug delivery. Cell. 2020, 181:151-67. 10.1016\/j.cell.2020.02.001","journal-title":"Cell"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1101\/gr.190595.115","article-title":"Defining cell types and states with single-cell genomics","volume":"25","author":"Trapnell C","year":"2015","unstructured":"Trapnell C. Defining cell types and states with single-cell genomics. Genome Res. 2015, 25:1491-8. 10.1101\/gr.190595.115","journal-title":"Genome Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/485948-a-comprehensive-review-of-the-integration-of-biotechnology-in-modern-medicine-and-pathology-advances-in-diagnostic-techniques-therapeutic-innovations-and-clinical-outcomes","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T07:42:21Z","timestamp":1782373341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/485948-a-comprehensive-review-of-the-integration-of-biotechnology-in-modern-medicine-and-pathology-advances-in-diagnostic-techniques-therapeutic-innovations-and-clinical-outcomes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":45,"URL":"https:\/\/doi.org\/10.7759\/cureus.111463","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}