{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:49:52Z","timestamp":1782391792368,"version":"3.54.5"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,25]]},"DOI":"10.7759\/cureus.111474","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:57:56Z","timestamp":1782388676000},"source":"Crossref","is-referenced-by-count":0,"title":["Early Psychiatric Manifestations of Lafora Disease: A Case Report"],"prefix":"10.7759","author":[{"given":"Anouar","family":"Kaddaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Satte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Bourazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Kadiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2018.07.003","article-title":"A novel EPM2A mutation yields a slow progression form of Lafora disease","volume":"145","author":"Garcia-Gimeno MA","year":"2018","unstructured":"Garcia-Gimeno MA, Rodilla-Ramirez PN, Viana R, Salas-Puig X, Brewer MK, Gentry MS, Sanz P. A novel EPM2A mutation yields a slow progression form of Lafora disease. Epilepsy Res. 2018, 145:169-77. 10.1016\/j.eplepsyres.2018.07.003","journal-title":"Epilepsy Res"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/2470","article-title":"Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy","volume":"20","author":"Minassian BA","year":"1998","unstructured":"Minassian BA, Lee JR, Herbrick JA, et al.. Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat Genet. 1998, 20:171-4. 10.1038\/2470","journal-title":"Nat Genet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13121679","article-title":"Lafora disease: a case report and evolving treatment advancements","volume":"13","author":"Ferrari Aggradi CR","year":"2023","unstructured":"Ferrari Aggradi CR, Rimoldi M, Romagnoli G, et al.. Lafora disease: a case report and evolving treatment advancements. Brain Sci. 2023, 13:1679. 10.3390\/brainsci13121679","journal-title":"Brain Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-3787(07)92642-9","article-title":"Lafora's disease presenting with progressive myoclonus epilepsy (Article in French)","volume":"163","author":"B\u00e9jot Y","year":"2007","unstructured":"B\u00e9jot Y, Lemesle-Martin M, Cont\u00e9gal F, et al.. Lafora's disease presenting with progressive myoclonus epilepsy (Article in French). Rev Neurol (Paris). 2007, 163:975-8. 10.1016\/S0035-3787(07)92642-9","journal-title":"Rev Neurol (Paris)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-01989-w","article-title":"Natural history of Lafora disease: a prognostic systematic review and individual participant data meta-analysis","volume":"16","author":"Pondrelli F","year":"2021","unstructured":"Pondrelli F, Muccioli L, Licchetta L, et al.. Natural history of Lafora disease: a prognostic systematic review and individual participant data meta-analysis. Orphanet J Rare Dis. 2021, 16:362. 10.1186\/s13023-021-01989-w","journal-title":"Orphanet J Rare Dis"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2016.0842","article-title":"Lafora disease","volume":"18","author":"Turnbull J","year":"2016","unstructured":"Turnbull J, Tiberia E, Striano P, Genton P, Carpenter S, Ackerley CA, Minassian BA. Lafora disease. Epileptic Disord. 2016, 18:38-62. 10.1684\/epd.2016.0842","journal-title":"Epileptic Disord"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.annpat.2013.02.002","article-title":"Lafora disease: histopathological study of axillary cutaneous biopsy (Article in French)","volume":"33","author":"Mnif H","year":"2013","unstructured":"Mnif H, Ksentini M, Gheriani M, Charfi S, Kallel R, Makni S, Boudawara TS. Lafora disease: histopathological study of axillary cutaneous biopsy (Article in French). Ann Pathol. 2013, 33:84-6. 10.1016\/j.annpat.2013.02.002","journal-title":"Ann Pathol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02498.x","article-title":"Posterior glucose hypometabolism in Lafora disease: early and late FDG-PET assessment","volume":"51","author":"Jennesson M","year":"2010","unstructured":"Jennesson M, Milh M, Villeneuve N, et al.. Posterior glucose hypometabolism in Lafora disease: early and late FDG-PET assessment. Epilepsia. 2010, 51:708-11. 10.1111\/j.1528-1167.2009.02498.x","journal-title":"Epilepsia"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-022-03537-x","article-title":"Lafora disease: a case report","volume":"16","author":"Zeka N","year":"2022","unstructured":"Zeka N, Zogaj L, Gerguri A, et al.. Lafora disease: a case report. J Med Case Rep. 2022, 16:360. 10.1186\/s13256-022-03537-x","journal-title":"J Med Case Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0503285102","article-title":"Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin","volume":"102","author":"Gentry MS","year":"2005","unstructured":"Gentry MS, Worby CA, Dixon JE. Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin. Proc Natl Acad Sci U S A. 2005, 102:8501-6. 10.1073\/pnas.0503285102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0370-4475(78)80126-9","article-title":"Lafora disease (Article in French)","volume":"8","author":"Tassinari CA","year":"1978","unstructured":"Tassinari CA, Bureau-Paillas M, Dalla Bernardina B, et al.. Lafora disease (Article in French). Rev Electroencephalogr Neurophysiol Clin. 1978, 8:107-22. 10.1016\/S0370-4475(78)80126-9","journal-title":"Rev Electroencephalogr Neurophysiol Clin"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s42466-019-0040-2","article-title":"Genotypes and phenotypes of patients with Lafora disease living in Germany","volume":"1","author":"Brenner D","year":"2019","unstructured":"Brenner D, Baumgartner T, von Spiczak S, et al.. Genotypes and phenotypes of patients with Lafora disease living in Germany. Neurol Res Pract. 2019, 1:10.1186\/s42466-019-0040-2","journal-title":"Neurol Res Pract"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.encep.2016.06.004","article-title":"Pediatric obsessive compulsive disorder: an unusual form of Lafora disease (Article in French)","volume":"43","author":"Nasri A","year":"2017","unstructured":"Nasri A, Mansour M, Kacem A, et al.. Pediatric obsessive compulsive disorder: an unusual form of Lafora disease (Article in French). Encephale. 2017, 43:90-4. 10.1016\/j.encep.2016.06.004","journal-title":"Encephale"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210681","article-title":"Epilepsy in early onset Alzheimer's disease","volume":"85","author":"Haoudy S","year":"2022","unstructured":"Haoudy S, Jonveaux T, Puisieux S, et al.. Epilepsy in early onset Alzheimer's disease. J Alzheimers Dis. 2022, 85:615-26. 10.3233\/JAD-210681","journal-title":"J Alzheimers Dis"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-023-02851-x","article-title":"Psychiatric burden in a cohort of adults with Niemann Pick type C disease: from psychotic symptoms to frontal lobe behavioral disorders","volume":"18","author":"Morin A","year":"2023","unstructured":"Morin A, Carle G, Ponchel A, Fern\u00e1ndez-Eulate G, Nadjar Y. Psychiatric burden in a cohort of adults with Niemann Pick type C disease: from psychotic symptoms to frontal lobe behavioral disorders. Orphanet J Rare Dis. 2023, 18:298. 10.1186\/s13023-023-02851-x","journal-title":"Orphanet J Rare Dis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(75)90270-1","article-title":"Lafora disease: report of a case in a Senegalese patient (Article in French)","volume":"25","author":"Girard PL","year":"1975","unstructured":"Girard PL, Escourolle R, Dumas M, Papy JJ, Iwata M. Lafora disease: report of a case in a Senegalese patient (Article in French). J Neurol Sci. 1975, 25:507-27. 10.1016\/0022-510X(75)90270-1","journal-title":"J Neurol Sci"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.969297","article-title":"Electro-clinical features and management of the late stage of Lafora disease","volume":"13","author":"d'Orsi G","year":"2022","unstructured":"d'Orsi G, Di Claudio MT, Palumbo O, Carella M. Electro-clinical features and management of the late stage of Lafora disease. Front Neurol. 2022, 13:969297. 10.3389\/fneur.2022.969297","journal-title":"Front Neurol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.729381","article-title":"The psychiatric misdiagnosis of behavioral variant frontotemporal dementia in a Colombian sample","volume":"12","author":"Zapata-Restrepo L","year":"2021","unstructured":"Zapata-Restrepo L, Rivas J, Miranda C, Miller BL, Ibanez A, Allen IE, Possin K. The psychiatric misdiagnosis of behavioral variant frontotemporal dementia in a Colombian sample. Front Neurol. 2021, 12:729381. 10.3389\/fneur.2021.729381","journal-title":"Front Neurol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/503134-early-psychiatric-manifestations-of-lafora-disease-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:57:56Z","timestamp":1782388676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/503134-early-psychiatric-manifestations-of-lafora-disease-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.111474","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,25]]}}}