{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:45:37Z","timestamp":1782841537616,"version":"3.54.5"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,30]]},"DOI":"10.7759\/cureus.111819","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:00:33Z","timestamp":1782838833000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Outcomes After Early Versus Late Initiation of Continuous Renal Replacement Therapy in Adult Patients With Sepsis-Associated Acute Kidney Injury"],"prefix":"10.7759","author":[{"given":"Soumya Sankar","family":"Nath","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharif","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2015.01.003","article-title":"Clinical approach to the patient with AKI and sepsis","volume":"35","author":"Godin M","year":"2015","unstructured":"Godin M, Murray P, Mehta RL. Clinical approach to the patient with AKI and sepsis. Semin Nephrol. 2015, 35:12-22. 10.1016\/j.semnephrol.2015.01.003","journal-title":"Semin Nephrol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.1","article-title":"KDIGO Clinical Practice Guideline for Acute Kidney Injury","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group","year":"2012","unstructured":"Kidney Disease. Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group: KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney International Supplements. 2012, 2:1-138. 10.1038\/kisup.2012.1","journal-title":"Kidney International Supplements"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.05.026","article-title":"Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment","volume":"96","author":"Peerapornratana S","year":"2019","unstructured":"Peerapornratana S, Manrique-Caballero CL, G\u00f3mez H, Kellum JA. Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment. Kidney Int. 2019, 96:1083-99. 10.1016\/j.kint.2019.05.026","journal-title":"Kidney Int"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44408","article-title":"Furosemide stress test and renal resistive index for prediction of severity of acute kidney injury in sepsis","volume":"15","author":"Das PK","year":"2023","unstructured":"Das PK, Maurya SK, Nath SS, Kumar T, Rao N, Shrivastava N. Furosemide stress test and renal resistive index for prediction of severity of acute kidney injury in sepsis. Cureus. 2023, 15:e44408. 10.7759\/cureus.44408","journal-title":"Cureus"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4891","article-title":"Sepsis associated acute kidney injury","volume":"364","author":"Poston JT","year":"2019","unstructured":"Poston JT, Koyner JL. Sepsis associated acute kidney injury. BMJ. 2019, 364:k4891. 10.1136\/bmj.k4891","journal-title":"BMJ"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-040718","article-title":"The timing of continuous renal replacement therapy initiation in sepsis-associated acute kidney injury in the intensive care unit: the CRTSAKI Study (Continuous RRT Timing in Sepsis-associated AKI in ICU): study protocol for a multicentre, randomised controlled trial","volume":"11","author":"Chen WY","year":"2021","unstructured":"Chen WY, Cai LH, Zhang ZH, et al.. The timing of continuous renal replacement therapy initiation in sepsis-associated acute kidney injury in the intensive care unit: the CRTSAKI Study (Continuous RRT Timing in Sepsis-associated AKI in ICU): study protocol for a multicentre, randomised controlled trial. BMJ Open. 2021, 11:e040718. 10.1136\/bmjopen-2020-040718","journal-title":"BMJ Open"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2014.04.003","article-title":"Early reversible acute kidney injury is associated with improved survival in septic shock","volume":"29","author":"Sood MM","year":"2014","unstructured":"Sood MM, Shafer LA, Ho J, et al.. Early reversible acute kidney injury is associated with improved survival in septic shock. J Crit Care. 2014, 29:711-7. 10.1016\/j.jcrc.2014.04.003","journal-title":"J Crit Care"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-24109","article-title":"ISCCM guidelines on acute kidney injury and renal replacement therapy","volume":"26","author":"Mishra RC","year":"2022","unstructured":"Mishra RC, Sodhi K, Prakash KC, et al.. ISCCM guidelines on acute kidney injury and renal replacement therapy. Indian J Crit Care Med. 2022, 26:S13-42. 10.5005\/jp-journals-10071-24109","journal-title":"Indian J Crit Care Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000016800","article-title":"Timing of continuous renal replacement therapy in patients with septic AKI: a systematic review and meta-analysis","volume":"98","author":"Li Y","year":"2019","unstructured":"Li Y, Li H, Zhang D. Timing of continuous renal replacement therapy in patients with septic AKI: a systematic review and meta-analysis. Medicine (Baltimore). 2019, 98:e16800. 10.1097\/MD.0000000000016800","journal-title":"Medicine (Baltimore)"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2000741","article-title":"Timing of initiation of renal-replacement therapy in acute kidney injury","volume":"383","author":"Bagshaw SM","year":"2020","unstructured":"Bagshaw SM, Wald R, Adhikari NK, et al.. Timing of initiation of renal-replacement therapy in acute kidney injury. N Engl J Med. 2020, 383:240-51. 10.1056\/NEJMoa2000741","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61794-8","article-title":"Acute kidney injury","volume":"372","author":"Lameire N","year":"2008","unstructured":"Lameire N, Biesen WV, Vanholder R. Acute kidney injury. Lancet. 2008, 372:1863-5. 10.1016\/S0140-6736(08)61794-8","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2016.04.032","article-title":"Can early initiation of continuous renal replacement therapy improve patient survival with septic acute kidney injury when enrolled in early goal-directed therapy?","volume":"35","author":"Oh HJ","year":"2016","unstructured":"Oh HJ, Kim MH, Ahn JY, et al.. Can early initiation of continuous renal replacement therapy improve patient survival with septic acute kidney injury when enrolled in early goal-directed therapy?. J Crit Care. 2016, 35:51-6. 10.1016\/j.jcrc.2016.04.032","journal-title":"J Crit Care"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1097\/00003246-198510000-00009","article-title":"APACHE II: a severity of disease classification system","volume":"13","author":"Knaus WA","year":"1985","unstructured":"Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985, 13:818-29.","journal-title":"Crit Care Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802639","article-title":"Intensity of renal support in critically ill patients with acute kidney injury","volume":"359","author":"Palevsky PM","year":"2008","unstructured":"Palevsky PM, Zhang JH, O'Connor TZ, et al.. Intensity of renal support in critically ill patients with acute kidney injury. N Engl J Med. 2008, 359:7-20. 10.1056\/NEJMoa0802639","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.647371","article-title":"Timing of initiation of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis","volume":"34","author":"Wang X","year":"2012","unstructured":"Wang X, Jie Yuan W. Timing of initiation of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis. Ren Fail. 2012, 34:396-402. 10.3109\/0886022X.2011.647371","journal-title":"Ren Fail"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2011.589945","article-title":"Does early initiation of continuous renal replacement therapy affect outcome: experience in a tertiary care center","volume":"33","author":"Vats HS","year":"2011","unstructured":"Vats HS, Dart RA, Okon TR, Liang H, Paganini EP. Does early initiation of continuous renal replacement therapy affect outcome: experience in a tertiary care center. Ren Fail. 2011, 33:698-706. 10.3109\/0886022X.2011.589945","journal-title":"Ren Fail"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200210000-00005","article-title":"Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial","volume":"30","author":"Bouman CS","year":"2002","unstructured":"Bouman CS, Oudemans-Van Straaten HM, Tijssen JG, Zandstra DF, Kesecioglu J. Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: a prospective, randomized trial. Crit Care Med. 2002, 30:2205-11. 10.1097\/00003246-200210000-00005","journal-title":"Crit Care Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-4758.2009.00407.x","article-title":"Effect of timing of dialysis on mortality in critically ill, septic patients with acute renal failure","volume":"14","author":"Carl DE","year":"2010","unstructured":"Carl DE, Grossman C, Behnke M, Sessler CN, Gehr TW. Effect of timing of dialysis on mortality in critically ill, septic patients with acute renal failure. Hemodial Int. 2010, 14:11-7. 10.1111\/j.1542-4758.2009.00407.x","journal-title":"Hemodial Int"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2007.12.017","article-title":"Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury","volume":"24","author":"Bagshaw SM","year":"2009","unstructured":"Bagshaw SM, Uchino S, Bellomo R, et al.. Timing of renal replacement therapy and clinical outcomes in critically ill patients with severe acute kidney injury. J Crit Care. 2009, 24:129-40. 10.1016\/j.jcrc.2007.12.017","journal-title":"J Crit Care"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.5828","article-title":"Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial","volume":"315","author":"Zarbock A","year":"2016","unstructured":"Zarbock A, Kellum JA, Schmidt C, et al.. Effect of early vs delayed initiation of renal replacement therapy on mortality in critically ill patients with acute kidney injury: the ELAIN randomized clinical trial. JAMA. 2016, 315:2190-9. 10.1001\/jama.2016.5828","journal-title":"JAMA"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn121430-20200304-00206","article-title":"Relationship between the timing of initiation of continuous renal replacement therapy and the prognosis of patients with sepsis-associated acute kidney injury (Article in Chinese)","volume":"32","author":"Wu X","year":"2020","unstructured":"Wu X, Ye J, Sun M, Wang Z, Chen Q, Zhu J. Relationship between the timing of initiation of continuous renal replacement therapy and the prognosis of patients with sepsis-associated acute kidney injury (Article in Chinese). Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2020, 32:1352-5. 10.3760\/cma.j.cn121430-20200304-00206","journal-title":"Zhonghua Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jointm.2022.03.004","article-title":"Timely renal replacement therapy linked to better outcome in patients with sepsis-associated acute kidney injury","volume":"2","author":"Fan Y","year":"2022","unstructured":"Fan Y, Chen L, Jiang S, Huang Y, Leng Y, Gao C. Timely renal replacement therapy linked to better outcome in patients with sepsis-associated acute kidney injury. J Intensive Med. 2022, 2:173-82. 10.1016\/j.jointm.2022.03.004","journal-title":"J Intensive Med"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.18618","article-title":"Effect of regional citrate anticoagulation vs systemic heparin anticoagulation during continuous kidney replacement therapy on dialysis filter life span and mortality among critically ill patients with acute kidney injury: a randomized clinical trial","volume":"324","author":"Zarbock A","year":"2020","unstructured":"Zarbock A, K\u00fcllmar M, Kindgen-Milles D, et al.. Effect of regional citrate anticoagulation vs systemic heparin anticoagulation during continuous kidney replacement therapy on dialysis filter life span and mortality among critically ill patients with acute kidney injury: a randomized clinical trial. JAMA. 2020, 324:1629-39. 10.1001\/jama.2020.18618","journal-title":"JAMA"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-24797","article-title":"Protocolized regional citrate anticoagulation during continuous renal replacement therapy: a single center experience","volume":"28","author":"Pachisia AV","year":"2024","unstructured":"Pachisia AV, Kumar GP, Harne R, et al.. Protocolized regional citrate anticoagulation during continuous renal replacement therapy: a single center experience. Indian J Crit Care Med. 2024, 28:859-65. 10.5005\/jp-journals-10071-24797","journal-title":"Indian J Crit Care Med"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/508455-evaluation-of-outcomes-after-early-versus-late-initiation-of-continuous-renal-replacement-therapy-in-adult-patients-with-sepsis-associated-acute-kidney-injury","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:00:35Z","timestamp":1782838835000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/508455-evaluation-of-outcomes-after-early-versus-late-initiation-of-continuous-renal-replacement-therapy-in-adult-patients-with-sepsis-associated-acute-kidney-injury"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":24,"URL":"https:\/\/doi.org\/10.7759\/cureus.111819","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,30]]}}}