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Front Med (Lausanne). 2024, 11:1289259. 10.3389\/fmed.2024.1289259","journal-title":"Front Med (Lausanne)"},{"key":"ref151","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106105","article-title":"Sex differences between women and men with COPD: A new analysis of the 3CIA study","volume":"171","author":"Perez TA","year":"2020","unstructured":"Perez TA, Castillo EG, Ancochea J, et al.. Sex differences between women and men with COPD: A new analysis of the 3CIA study. Respir Med. 2020, 171:106105. 10.1016\/j.rmed.2020.106105","journal-title":"Respir Med"},{"key":"ref152","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2400424","article-title":"Prevalence and prognostic significance of COPD in adults younger than 50 years of age","volume":"4","author":"Diaz AA","year":"2025","unstructured":"Diaz AA, Balte PP, Han M, et al.. Prevalence and prognostic significance of COPD in adults younger than 50 years of age. 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