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PLoS One. 2011, 6:e21351. 10.1371\/journal.pone.0021351","journal-title":"PLoS One"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1792","article-title":"Photoperiod regulates vitamin A and Wnt\/\u03b2-catenin signaling in F344 rats","volume":"153","author":"Helfer G","year":"2012","unstructured":"Helfer G, Ross AW, Russell L, et al.. Photoperiod regulates vitamin A and Wnt\/\u03b2-catenin signaling in F344 rats. Endocrinology. 2012, 153:815-24. 10.1210\/en.2011-1792","journal-title":"Endocrinology"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1002\/neu.20237","article-title":"Retinoic acid signaling and function in the adult hippocampus","volume":"66","author":"McCaffery P","year":"2006","unstructured":"McCaffery P, Zhang J, Crandall JE. Retinoic acid signaling and function in the adult hippocampus. J Neurobiol. 2006, 66:780-91. 10.1002\/neu.20237","journal-title":"J Neurobiol"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2212","article-title":"Retinoic acid in the development, regeneration and maintenance of the nervous system","volume":"8","author":"Maden M","year":"2007","unstructured":"Maden M. Retinoic acid in the development, regeneration and maintenance of the nervous system. Nat Rev Neurosci. 2007, 8:755-65. 10.1038\/nrn2212","journal-title":"Nat Rev Neurosci"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3079","article-title":"Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche","volume":"15","author":"Lee DA","year":"2012","unstructured":"Lee DA, Bedont JL, Pak T, et al.. Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nat Neurosci. 2012, 15:700-2. 10.1038\/nn.3079","journal-title":"Nat Neurosci"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2479-09.2010","article-title":"De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance","volume":"30","author":"Pierce AA","year":"2010","unstructured":"Pierce AA, Xu AW. De novo neurogenesis in adult hypothalamus as a compensatory mechanism to regulate energy balance. J Neurosci. 2010, 30:723-30. 10.1523\/JNEUROSCI.2479-09.2010","journal-title":"J Neurosci"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.186","article-title":"Thyroid transcription factors in development, differentiation and disease","volume":"11","author":"Fern\u00e1ndez LP","year":"2015","unstructured":"Fern\u00e1ndez LP, L\u00f3pez-M\u00e1rquez A, Santisteban P. Thyroid transcription factors in development, differentiation and disease. Nat Rev Endocrinol. 2015, 11:29-42. 10.1038\/nrendo.2014.186","journal-title":"Nat Rev Endocrinol"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2000.0933","article-title":"TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion","volume":"17","author":"Lee BJ","year":"2001","unstructured":"Lee BJ, Cho GJ, Norgren RB Jr, et al.. TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion. Mol Cell Neurosci. 2001, 17:107-26. 10.1006\/mcne.2000.0933","journal-title":"Mol Cell Neurosci"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M206443200","article-title":"Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor","volume":"277","author":"Kim MS","year":"2002","unstructured":"Kim MS, Hur MK, Son YJ, et al.. Regulation of pituitary adenylate cyclase-activating polypeptide gene transcription by TTF-1, a homeodomain-containing transcription factor. J Biol Chem. 2002, 277:36863-71. 10.1074\/jbc.M206443200","journal-title":"J Biol Chem"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2006.09.002","article-title":"CLOCK gene T3111C polymorphism is associated with Japanese schizophrenics: a preliminary study","volume":"17","author":"Takao T","year":"2007","unstructured":"Takao T, Tachikawa H, Kawanishi Y, Mizukami K, Asada T. CLOCK gene T3111C polymorphism is associated with Japanese schizophrenics: a preliminary study. Eur Neuropsychopharmacol. 2007, 17:273-6. 10.1016\/j.euroneuro.2006.09.002","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.01.031","article-title":"Prenatal water deprivation alters brain angiotensin system and dipsogenic changes in the offspring","volume":"1382","author":"Zhang H","year":"2011","unstructured":"Zhang H, Fan Y, Xia F, et al.. Prenatal water deprivation alters brain angiotensin system and dipsogenic changes in the offspring. Brain Res. 2011, 1382:128-36. 10.1016\/j.brainres.2011.01.031","journal-title":"Brain Res"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2012.02302.x","article-title":"Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression","volume":"24","author":"Matagne V","year":"2012","unstructured":"Matagne V, Kim JG, Ryu BJ, et al.. Thyroid transcription factor 1, a homeodomain containing transcription factor, contributes to regulating periodic oscillations in GnRH gene expression. J Neuroendocrinol. 2012, 24:916-29. 10.1111\/j.1365-2826.2012.02302.x","journal-title":"J Neuroendocrinol"},{"key":"ref63","article-title":"Circadian rhythms and clock genes in psychotic disorders","volume":"47","author":"Lamont EW","year":"2010","unstructured":"Lamont EW, Coutu DL, Cermakian N, Boivin DB. Circadian rhythms and clock genes in psychotic disorders. Isr J Psychiatry Relat Sci. 2010, 47:27-35.","journal-title":"Isr J Psychiatry Relat Sci"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1080\/07853890310005164","article-title":"Glia-to-neuron signaling and the neuroendocrine control of female puberty","volume":"35","author":"Ojeda SR","year":"2003","unstructured":"Ojeda SR, Prevot V, Heger S, Lomniczi A, Dziedzic B, Mungenast A. Glia-to-neuron signaling and the neuroendocrine control of female puberty. Ann Med. 2003, 35:244-55. 10.1080\/07853890310005164","journal-title":"Ann Med"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-3-31","article-title":"Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia","volume":"3","author":"Benzel I","year":"2007","unstructured":"Benzel I, Bansal A, Browning BL, et al.. Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to schizophrenia. Behav Brain Funct. 2007, 3:31. 10.1186\/1744-9081-3-31","journal-title":"Behav Brain Funct"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2013.06.030","article-title":"ErbB4 is an upstream regulator of TTF-1 fetal mouse lung type II cell development in vitro","volume":"1833","author":"Zscheppang K","year":"2013","unstructured":"Zscheppang K, Giese U, Hoenzke S, Wiegel D, Dammann CE. ErbB4 is an upstream regulator of TTF-1 fetal mouse lung type II cell development in vitro. 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