{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:24:18Z","timestamp":1783607058695,"version":"3.55.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,9]]},"DOI":"10.7759\/cureus.112338","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:08:56Z","timestamp":1783606136000},"source":"Crossref","is-referenced-by-count":0,"title":["Conservative Management of Invasive Group A Streptococcal Infection With Cervical Necrotizing Fasciitis-Spectrum Disease and Pneumonia in a Healthy Young Adult"],"prefix":"10.7759","author":[{"given":"Phannoch","family":"Neun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Iwai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuichiro","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0103.950301","article-title":"Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment","volume":"1","author":"Stevens DL","year":"1995","unstructured":"Stevens DL. Streptococcal toxic-shock syndrome: spectrum of disease, pathogenesis, and new concepts in treatment. Emerg Infect Dis. 1995, 1:69-78. 10.3201\/eid0103.950301","journal-title":"Emerg Infect Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70267-X","article-title":"The global burden of group A streptococcal diseases","volume":"5","author":"Carapetis JR","year":"2005","unstructured":"Carapetis JR, Steer AC, Mulholland EK, Weber M. The global burden of group A streptococcal diseases. Lancet Infect Dis. 2005, 5:685-94. 10.1016\/S1473-3099(05)70267-X","journal-title":"Lancet Infect Dis"},{"key":"ref3","unstructured":"World Health Organization. increased incidence of scarlet fever and invasive Group A streptococcus infection - multi-country. (2026). Accessed: March 21, 2026: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2022-DON429."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.0910","article-title":"Invasive Group A streptococcal Infections in 10 US states","volume":"333","author":"Gregory CJ","year":"2025","unstructured":"Gregory CJ, Okaro JO, Reingold A, et al.. Invasive Group A streptococcal Infections in 10 US states. JAMA. 2025, 333:1498-507. 10.1001\/jama.2025.0910","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2165\/11634180-000000000-00000","article-title":"Invasive group a streptococcal disease: epidemiology, pathogenesis and management","volume":"72","author":"Steer AC","year":"2012","unstructured":"Steer AC, Lamagni T, Curtis N, Carapetis JR. Invasive group a streptococcal disease: epidemiology, pathogenesis and management. Drugs. 2012, 72:1213-27. 10.2165\/11634180-000000000-00000","journal-title":"Drugs"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.4.467","article-title":"Clinical and epidemiologic features of group a streptococcal pneumonia in Ontario, Canada","volume":"163","author":"Muller MP","year":"2003","unstructured":"Muller MP, Low DE, Green KA, Simor AE, Loeb M, Gregson D, McGeer A. Clinical and epidemiologic features of group a streptococcal pneumonia in Ontario, Canada. Arch Intern Med. 2003, 163:467-72. 10.1001\/archinte.163.4.467","journal-title":"Arch Intern Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2025.108090","article-title":"Risk and determinants of mortality associated with invasive group A streptococcus (iGAS) disease in Scotland: a national surveillance study","volume":"161","author":"Ghaderi E","year":"2025","unstructured":"Ghaderi E, McDonald E, Henderson H, et al.. Risk and determinants of mortality associated with invasive group A streptococcus (iGAS) disease in Scotland: a national surveillance study. Int J Infect Dis. 2025, 161:108090. 10.1016\/j.ijid.2025.108090","journal-title":"Int J Infect Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3201\/eid0908.020745","article-title":"Invasive group A streptococcal disease: risk factors for adults","volume":"9","author":"Factor SH","year":"2003","unstructured":"Factor SH, Levine OS, Schwartz B, Harrison LH, Farley MM, McGeer A, Schuchat A. Invasive group A streptococcal disease: risk factors for adults. Emerg Infect Dis. 2003, 9:970-7. 10.3201\/eid0908.020745","journal-title":"Emerg Infect Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1086\/519936","article-title":"Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden","volume":"45","author":"Darenberg J","year":"2007","unstructured":"Darenberg J, Luca-Harari B, Jasir A, et al.. Molecular and clinical characteristics of invasive group A streptococcal infection in Sweden. Clin Infect Dis. 2007, 45:450-8. 10.1086\/519936","journal-title":"Clin Infect Dis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1600673","article-title":"Necrotizing soft-tissue infections","volume":"377","author":"Stevens DL","year":"2017","unstructured":"Stevens DL, Bryant AE. Necrotizing soft-tissue infections. N Engl J Med. 2017, 377:2253-65. 10.1056\/NEJMra1600673","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.44539","article-title":"Group A streptococcus pneumonia in a previously healthy individual: is it still a thing?","volume":"15","author":"Casillas S","year":"2023","unstructured":"Casillas S, Briski N, Salik A, et al.. Group A streptococcus pneumonia in a previously healthy individual: is it still a thing?. Cureus. 2023, 15:e44539. 10.7759\/cureus.44539","journal-title":"Cureus"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0152640","article-title":"Streptococcus pyogenes pneumonia in adults: clinical presentation and molecular characterization of isolates 2006-2015","volume":"11","author":"Tamayo E","year":"2016","unstructured":"Tamayo E, Montes M, Vicente D, P\u00e9rez-Trallero E. Streptococcus pyogenes pneumonia in adults: clinical presentation and molecular characterization of isolates 2006-2015. PLoS One. 2016, 11:e0152640. 10.1371\/journal.pone.0152640","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1086\/315850","article-title":"Molecular epidemiology of nga and NAD glycohydrolase\/ADP-ribosyltransferase activity among Streptococcus pyogenes causing streptococcal toxic shock syndrome","volume":"182","author":"Stevens DL","year":"2000","unstructured":"Stevens DL, Salmi DB, McIndoo ER, Bryant AE. Molecular epidemiology of nga and NAD glycohydrolase\/ADP-ribosyltransferase activity among Streptococcus pyogenes causing streptococcal toxic shock syndrome. J Infect Dis. 2000, 182:1117-28. 10.1086\/315850","journal-title":"J Infect Dis"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.01.028","article-title":"Diagnosis and management of necrotising fasciitis: a multiparametric approach","volume":"75","author":"Morgan MS","year":"2010","unstructured":"Morgan MS. Diagnosis and management of necrotising fasciitis: a multiparametric approach. J Hosp Infect. 2010, 75:249-57. 10.1016\/j.jhin.2010.01.028","journal-title":"J Hosp Infect"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ1032","article-title":"The impact of obesity and diabetes on the risk of disease and death due to invasive group A Streptococcus infections in adults","volume":"62","author":"Langley G","year":"2016","unstructured":"Langley G, Hao Y, Pondo T, et al.. The impact of obesity and diabetes on the risk of disease and death due to invasive group A Streptococcus infections in adults. Clin Infect Dis. 2016, 62:845-52. 10.1093\/cid\/civ1032","journal-title":"Clin Infect Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/499733-conservative-management-of-invasive-group-a-streptococcal-infection-with-cervical-necrotizing-fasciitis-spectrum-disease-and-pneumonia-in-a-healthy-young-adult","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:08:57Z","timestamp":1783606137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/499733-conservative-management-of-invasive-group-a-streptococcal-infection-with-cervical-necrotizing-fasciitis-spectrum-disease-and-pneumonia-in-a-healthy-young-adult"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.112338","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,9]]}}}