{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:13:28Z","timestamp":1783757608904,"version":"3.55.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,11]]},"DOI":"10.7759\/cureus.112441","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:33:40Z","timestamp":1783755220000},"source":"Crossref","is-referenced-by-count":0,"title":["Effect of an Integrated Exercise Training Program on Muscle Mass and Functional Capacity in Sarcopenic Patients With Decompensated Liver Cirrhosis"],"prefix":"10.7759","author":[{"given":"Rushikesh  S","family":"Patil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poovishnu T","family":"Devi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran S","family":"Dhaygude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janhavee S","family":"Brahmadande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gin\u00e8s P","year":"2021","unstructured":"Gin\u00e8s P, Krag A, Abraldes JG, Sol\u00e0 E, Fabrellas N, Kamath PS. Liver cirrhosis. Lancet. 2021, 398:1359-76. 10.1016\/S0140-6736(21)01374-X","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.18-2-s60","article-title":"Management of decompensated cirrhosis","volume":"18","author":"Mansour D","year":"2018","unstructured":"Mansour D, McPherson S. Management of decompensated cirrhosis. Clin Med (Lond). 2018, 18:s60-5. 10.7861\/clinmedicine.18-2-s60","journal-title":"Clin Med (Lond)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.06.018","article-title":"Towards a new definition of decompensated cirrhosis","volume":"76","author":"D'Amico G","year":"2022","unstructured":"D'Amico G, Bernardi M, Angeli P. Towards a new definition of decompensated cirrhosis. J Hepatol. 2022, 76:202-7. 10.1016\/j.jhep.2021.06.018","journal-title":"J Hepatol"},{"key":"ref4","article-title":"Robbins Basic Pathology 10th Edition","year":"2018","unstructured":"Robbins Basic Pathology 10th Edition . Kumar V, Abbas AK, Aster JC (ed).  Elsevier, Philadelphia, PA ; 2018."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.024","article-title":"EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis","volume":"69","author":"European Association for the Study of the Liver","year":"2018","unstructured":"European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. J Hepatol. 2018, 69:406-60. 10.1016\/j.jhep.2018.03.024","journal-title":"J Hepatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000323","article-title":"AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease","volume":"77","author":"Rinella ME","year":"2023","unstructured":"Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, et al.. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023, 77:1797-835. 10.1097\/HEP.0000000000000323","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60383-9","article-title":"Liver cirrhosis","volume":"371","author":"Schuppan D","year":"2008","unstructured":"Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008, 371:838-51. 10.1016\/S0140-6736(08)60383-9","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000261","article-title":"Cause and management of muscle wasting in chronic liver disease","volume":"32","author":"Dasarathy S","year":"2016","unstructured":"Dasarathy S. Cause and management of muscle wasting in chronic liver disease. Curr Opin Gastroenterol. 2016, 32:159-65. 10.1097\/MOG.0000000000000261","journal-title":"Curr Opin Gastroenterol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1317049110","article-title":"Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-\u03baB-mediated mechanism","volume":"110","author":"Qiu J","year":"2013","unstructured":"Qiu J, Thapaliya S, Runkana A, et al.. Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-\u03baB-mediated mechanism. Proc Natl Acad Sci U S A. 2013, 110:18162-7. 10.1073\/pnas.1317049110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8866093","article-title":"Prevalence and nonpharmacological interventions for sarcopenia among cirrhotic patients","volume":"2021","author":"Abdelbasset WK","year":"2021","unstructured":"Abdelbasset WK, Nambi G, Elsayed SH, et al.. Prevalence and nonpharmacological interventions for sarcopenia among cirrhotic patients. Dis Markers. 2021, 2021:8866093. 10.1155\/2021\/8866093","journal-title":"Dis Markers"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.025","article-title":"Sarcopenia and frailty in decompensated cirrhosis","volume":"75 Suppl 1","author":"Tandon P","year":"2021","unstructured":"Tandon P, Montano-Loza AJ, Lai JC, Dasarathy S, Merli M. Sarcopenia and frailty in decompensated cirrhosis. J Hepatol. 2021, 75 Suppl 1:S147-62. 10.1016\/j.jhep.2021.01.025","journal-title":"J Hepatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2023.00207","article-title":"Approaching the sarcopenic patient with nonalcoholic steatohepatitis-related cirrhosis","volume":"12","author":"Gallo P","year":"2024","unstructured":"Gallo P, Flagiello V, Falcomat\u00e0 A, et al.. Approaching the sarcopenic patient with nonalcoholic steatohepatitis-related cirrhosis. J Clin Transl Hepatol. 2024, 12:278-86. 10.14218\/JCTH.2023.00207","journal-title":"J Clin Transl Hepatol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2019.04.023","article-title":"Low muscle mass and low muscle strength associate with nonalcoholic fatty liver disease","volume":"39","author":"Gan D","year":"2020","unstructured":"Gan D, Wang L, Jia M, et al.. Low muscle mass and low muscle strength associate with nonalcoholic fatty liver disease. Clin Nutr. 2020, 39:1124-30. 10.1016\/j.clnu.2019.04.023","journal-title":"Clin Nutr"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24087517","article-title":"Osteosarcopenia in NAFLD\/MAFLD: an underappreciated clinical problem in chronic liver disease","volume":"24","author":"Musio A","year":"2023","unstructured":"Musio A, Perazza F, Leoni L, et al.. Osteosarcopenia in NAFLD\/MAFLD: an underappreciated clinical problem in chronic liver disease. Int J Mol Sci. 2023, 24:7517. 10.3390\/ijms24087517","journal-title":"Int J Mol Sci"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v30.i7.636","article-title":"Muscle strength and non-alcoholic fatty liver disease\/metabolic-associated fatty liver disease","volume":"30","author":"Hao XY","year":"2024","unstructured":"Hao XY, Zhang K, Huang XY, Yang F, Sun SY. Muscle strength and non-alcoholic fatty liver disease\/metabolic-associated fatty liver disease. World J Gastroenterol. 2024, 30:636-43. 10.3748\/wjg.v30.i7.636","journal-title":"World J Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph192215009","article-title":"Effects of 12-week progressive sandbag exercise training on glycemic control and muscle strength in patients with type 2 diabetes mellitus combined with possible sarcopenia","volume":"19","author":"Chien YH","year":"2022","unstructured":"Chien YH, Tsai CJ, Wang DC, Chuang PH, Lin HT. Effects of 12-week progressive sandbag exercise training on glycemic control and muscle strength in patients with type 2 diabetes mellitus combined with possible sarcopenia. Int J Environ Res Public Health. 2022, 19:15009. 10.3390\/ijerph192215009","journal-title":"Int J Environ Res Public Health"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-021-02642-8","article-title":"Effects of different exercise training modes on muscle strength and physical performance in older people with sarcopenia: a systematic review and meta-analysis","volume":"21","author":"Lu L","year":"2021","unstructured":"Lu L, Mao L, Feng Y, Ainsworth BE, Liu Y, Chen N. Effects of different exercise training modes on muscle strength and physical performance in older people with sarcopenia: a systematic review and meta-analysis. BMC Geriatr. 2021, 21:708. 10.1186\/s12877-021-02642-8","journal-title":"BMC Geriatr"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13225","article-title":"Exercise for sarcopenia in older people: a systematic review and network meta-analysis","volume":"14","author":"Shen Y","year":"2023","unstructured":"Shen Y, Shi Q, Nong K, et al.. Exercise for sarcopenia in older people: a systematic review and network meta-analysis. J Cachexia Sarcopenia Muscle. 2023, 14:1199-211. 10.1002\/jcsm.13225","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19138212","article-title":"Efficacy of exercise on muscle function and physical performance in older adults with sarcopenia: an updated systematic review and meta-analysis","volume":"19","author":"Wang H","year":"2022","unstructured":"Wang H, Huang WY, Zhao Y. Efficacy of exercise on muscle function and physical performance in older adults with sarcopenia: an updated systematic review and meta-analysis. Int J Environ Res Public Health. 2022, 19:8212. 10.3390\/ijerph19138212","journal-title":"Int J Environ Res Public Health"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i4.526","article-title":"Cardiopulmonary complications in chronic liver disease","volume":"12","author":"Moller S","year":"2006","unstructured":"Moller S, Henriksen JH. Cardiopulmonary complications in chronic liver disease. World J Gastroenterol. 2006, 12:526-38. 10.3748\/wjg.v12.i4.526","journal-title":"World J Gastroenterol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0707185","article-title":"Hepatopulmonary syndrome-a liver-induced lung vascular disorder","volume":"358","author":"Rodr\u00edguez-Roisin R","year":"2008","unstructured":"Rodr\u00edguez-Roisin R, Krowka MJ. Hepatopulmonary syndrome-a liver-induced lung vascular disorder. N Engl J Med. 2008, 358:2378-87. 10.1056\/NEJMra0707185","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v17.i11.110331","article-title":"Intra-rater reliability of the 6-min walk test in people with liver cirrhosis","volume":"17","author":"Corr\u00eaa FC","year":"2025","unstructured":"Corr\u00eaa FC, Nader IS, Riolino MR, Silva E. Intra-rater reliability of the 6-min walk test in people with liver cirrhosis. World J Hepatol. 2025, 17:110331. 10.4254\/wjh.v17.i11.110331","journal-title":"World J Hepatol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2004.06.004","article-title":"Bioelectrical impedance analysis-part I: review of principles and methods","volume":"23","author":"Kyle UG","year":"2004","unstructured":"Kyle UG, Bosaeus I, De Lorenzo AD, et al.. Bioelectrical impedance analysis-part I: review of principles and methods. Clin Nutr. 2004, 23:1226-43. 10.1016\/j.clnu.2004.06.004","journal-title":"Clin Nutr"},{"key":"ref24","article-title":"Use Of The Child Pugh Score In Liver Disease","author":"Tsoris A","year":"2026","unstructured":"Tsoris A, Marlar CA. Use Of The Child Pugh Score In Liver Disease. StatPearls [Internet], StatPearls Publishing, Treasure Island, FL; 2026."},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado CM","year":"2008","unstructured":"Prado CM, Lieffers JR, McCargar LJ, Reiman T, Sawyer MB, Martin L, Baracos VE. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet Oncol. 2008, 9:629-35. 10.1016\/S1470-2045(08)70153-0","journal-title":"Lancet Oncol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-79948-3_1964","article-title":"Six-Minute Walk Test","author":"Dunning K","year":"2011","unstructured":"Dunning K. Six-Minute Walk Test. Encyclopedia of Clinical Neuropsychology. Kreutzer JS, DeLuca J, Caplan B (ed): Springer, New York City, NY; 2011. 2303-4. 10.1007\/978-0-387-79948-3_1964"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.148","article-title":"Bioelectrical impedance analysis","volume":"67 Suppl 1","author":"Ward LC","year":"2013","unstructured":"Ward LC, M\u00fcller MJ. Bioelectrical impedance analysis. Eur J Clin Nutr. 2013, 67 Suppl 1:S1. 10.1038\/ejcn.2012.148","journal-title":"Eur J Clin Nutr"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13334","article-title":"Impact of sarcopenia on the survival of patients undergoing liver transplantation for decompensated liver cirrhosis","volume":"14","author":"Zhou D","year":"2023","unstructured":"Zhou D, Zhang D, Zeng C, Zhang L, Gao X, Wang X. Impact of sarcopenia on the survival of patients undergoing liver transplantation for decompensated liver cirrhosis. J Cachexia Sarcopenia Muscle. 2023, 14:2602-12. 10.1002\/jcsm.13334","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2015.05.003","article-title":"Quality of life and physical components linked to sarcopenia: The SarcoPhAge study","volume":"69","author":"Beaudart C","year":"2015","unstructured":"Beaudart C, Reginster JY, Petermans J, et al.. Quality of life and physical components linked to sarcopenia: The SarcoPhAge study. Exp Gerontol. 2015, 69:103-10. 10.1016\/j.exger.2015.05.003","journal-title":"Exp Gerontol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1177\/1559827614552986","article-title":"Immune and inflammatory signaling pathways in exercise and obesity","volume":"10","author":"Kr\u00fcger K","year":"2016","unstructured":"Kr\u00fcger K, Mooren FC, Eder K, Ringseis R. Immune and inflammatory signaling pathways in exercise and obesity. Am J Lifestyle Med. 2016, 10:268-79. 10.1177\/1559827614552986","journal-title":"Am J Lifestyle Med"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01028.2007","article-title":"Exercise and cardiovascular risk reduction: time to update the rationale for exercise?","volume":"105","author":"Green DJ","year":"2008","unstructured":"Green DJ, O'Driscoll G, Joyner MJ, Cable NT. Exercise and cardiovascular risk reduction: time to update the rationale for exercise?. J Appl Physiol (1985). 2008, 105:766-8. 10.1152\/japplphysiol.01028.2007","journal-title":"J Appl Physiol (1985)"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.04.016","article-title":"Eight weeks of exercise training increases aerobic capacity and muscle mass and reduces fatigue in patients with cirrhosis","volume":"12","author":"Zenith L","year":"2014","unstructured":"Zenith L, Meena N, Ramadi A, et al.. Eight weeks of exercise training increases aerobic capacity and muscle mass and reduces fatigue in patients with cirrhosis. Clin Gastroenterol Hepatol. 2014, 12:1920-6.e2. 10.1016\/j.cgh.2014.04.016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28132","article-title":"Physical activity and liver diseases","volume":"63","author":"Berzigotti A","year":"2016","unstructured":"Berzigotti A, Saran U, Dufour JF. Physical activity and liver diseases. Hepatology. 2016, 63:1026-40. 10.1002\/hep.28132","journal-title":"Hepatology"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i29.3996","article-title":"Six Minute Walk Test to assess functional capacity in chronic liver disease patients","volume":"13","author":"Alameri HF","year":"2007","unstructured":"Alameri HF, Sanai FM, Al Dukhayil M, Azzam NA, Al-Swat KA, Hersi AS, Abdo AA. Six Minute Walk Test to assess functional capacity in chronic liver disease patients. World J Gastroenterol. 2007, 13:3996-4001. 10.3748\/wjg.v13.i29.3996","journal-title":"World J Gastroenterol"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9710086","article-title":"Reference equations for the six-minute walk in healthy adults","volume":"158","author":"Enright PL","year":"1998","unstructured":"Enright PL, Sherrill DL. Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med. 1998, 158:1384-7. 10.1164\/ajrccm.158.5.9710086","journal-title":"Am J Respir Crit Care Med"},{"key":"ref36","article-title":"The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure","volume":"132","author":"Guyatt GH","year":"1985","unstructured":"Guyatt GH, Sullivan MJ, Thompson PJ, Fallen EL, Pugsley SO, Taylor DW, Berman LB. The 6-minute walk: a new measure of exercise capacity in patients with chronic heart failure. Can Med Assoc J. 1985, 132:919-23.","journal-title":"Can Med Assoc J"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00061.2017","article-title":"Sarcopenia: aging-related loss of muscle mass and function","volume":"99","author":"Larsson L","year":"2019","unstructured":"Larsson L, Degens H, Li M, et al.. Sarcopenia: aging-related loss of muscle mass and function. Physiol Rev. 2019, 99:427-511. 10.1152\/physrev.00061.2017","journal-title":"Physiol Rev"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/503979-effect-of-an-integrated-exercise-training-program-on-muscle-mass-and-functional-capacity-in-sarcopenic-patients-with-decompensated-liver-cirrhosis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T07:33:41Z","timestamp":1783755221000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/503979-effect-of-an-integrated-exercise-training-program-on-muscle-mass-and-functional-capacity-in-sarcopenic-patients-with-decompensated-liver-cirrhosis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,11]]},"references-count":37,"URL":"https:\/\/doi.org\/10.7759\/cureus.112441","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,11]]}}}