{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T01:11:12Z","timestamp":1783905072595,"version":"3.55.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,12]]},"DOI":"10.7759\/cureus.112527","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:39:12Z","timestamp":1783903152000},"source":"Crossref","is-referenced-by-count":0,"title":["Perianal Crohn Disease in a Patient With Congenital Afibrinogenemia: A Multidisciplinary Therapeutic Management Challenge"],"prefix":"10.7759","author":[{"given":"Ayoub","family":"Bouziane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ouiam","family":"Elmqaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajar","family":"Koulali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelkrim","family":"Zazour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahi","family":"Ismaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghizlane","family":"Kharrasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13941","article-title":"Management of rare inherited bleeding disorders: proposals of the French Reference Centre on Haemophilia and Rare Coagulation Disorders","volume":"110","author":"Trossaert M","year":"2023","unstructured":"Trossaert M, Chamouard V, Biron-Andreani C, et al.. Management of rare inherited bleeding disorders: proposals of the French Reference Centre on Haemophilia and Rare Coagulation Disorders. Eur J Haematol. 2023, 110:584-601. 10.1111\/ejh.13941","journal-title":"Eur J Haematol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830460416","article-title":"Congenital afibrinogenemia","volume":"46","author":"Al-Mondhiry H","year":"1994","unstructured":"Al-Mondhiry H, Ehmann WC. Congenital afibrinogenemia. Am J Hematol. 1994, 46:343-7. 10.1002\/ajh.2830460416","journal-title":"Am J Hematol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.04.010","article-title":"Crohn disease: epidemiology, diagnosis, and management","volume":"92","author":"Feuerstein JD","year":"2017","unstructured":"Feuerstein JD, Cheifetz AS. Crohn disease: epidemiology, diagnosis, and management. Mayo Clin Proc. 2017, 92:1088-103. 10.1016\/j.mayocp.2017.04.010","journal-title":"Mayo Clin Proc"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000271","article-title":"Impact of drug therapy and surgery on quality of life in Crohn's disease: a systematic review","volume":"21","author":"Wright EK","year":"2015","unstructured":"Wright EK, Kamm MA. Impact of drug therapy and surgery on quality of life in Crohn's disease: a systematic review. Inflamm Bowel Dis. 2015, 21:1187-94. 10.1097\/MIB.0000000000000271","journal-title":"Inflamm Bowel Dis"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.12.019","article-title":"Predictors of Crohn's disease","volume":"130","author":"Beaugerie L","year":"2006","unstructured":"Beaugerie L, Seksik P, Nion-Larmurier I, Gendre JP, Cosnes J. Predictors of Crohn's disease. Gastroenterology. 2006, 130:650-6. 10.1053\/j.gastro.2005.12.019","journal-title":"Gastroenterology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112140","article-title":"Congenital afibrinogenemia and hypofibrinogenemia: laboratory and genetic testing in rare bleeding disorders with life-threatening clinical manifestations and challenging management","volume":"11","author":"Simurda T","year":"2021","unstructured":"Simurda T, Asselta R, Zolkova J, et al.. Congenital afibrinogenemia and hypofibrinogenemia: laboratory and genetic testing in rare bleeding disorders with life-threatening clinical manifestations and challenging management. Diagnostics (Basel). 2021, 11:2140. 10.3390\/diagnostics11112140","journal-title":"Diagnostics (Basel)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/life16010182","article-title":"Perianal Crohn's disease in inflammatory bowel disease: diagnosis, assessment and treatment","volume":"16","author":"Faggiani I","year":"2026","unstructured":"Faggiani I, Villaseca IL, D'Amico F, et al.. Perianal Crohn's disease in inflammatory bowel disease: diagnosis, assessment and treatment. Life (Basel). 2026, 16:182. 10.3390\/life16010182","journal-title":"Life (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae091","article-title":"ECCO guidelines on therapeutics in Crohn's disease: medical treatment","volume":"18","author":"Gordon H","year":"2024","unstructured":"Gordon H, Minozzi S, Kopylov U, et al.. ECCO guidelines on therapeutics in Crohn's disease: medical treatment. J Crohns Colitis. 2024, 18:1531-55. 10.1093\/ecco-jcc\/jjae091","journal-title":"J Crohns Colitis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/jha2.70246","article-title":"Concurrent presentation of von Willebrand disease and inflammatory bowel disease\u2014a case report and literature review","volume":"7","author":"Pratap S","year":"2026","unstructured":"Pratap S, Foord A. Concurrent presentation of von Willebrand disease and inflammatory bowel disease\u2014a case report and literature review. eJHaem. 2026, 7:e70246. 10.1002\/jha2.70246","journal-title":"eJHaem"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13209","article-title":"Acquired von Willebrand syndrome in inflammatory bowel disease","volume":"23","author":"Di Sabatino A","year":"2017","unstructured":"Di Sabatino A, Ambaglio C, Aronico N, Ghidelli N, Lenti MV, Gamba G, Corazza GR. Acquired von Willebrand syndrome in inflammatory bowel disease. Haemophilia. 2017, 23:e231-3. 10.1111\/hae.13209","journal-title":"Haemophilia"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000002065","article-title":"Crohn's disease complicated by undiagnosed hemophilia A: a case of recurrent massive lower gastrointestinal bleeding","volume":"13","author":"Soares C","year":"2026","unstructured":"Soares C, Rodrigues M, Martins D, et al.. Crohn's disease complicated by undiagnosed hemophilia A: a case of recurrent massive lower gastrointestinal bleeding. ACG Case Rep J. 2026, 13:e02065. 10.14309\/crj.0000000000002065","journal-title":"ACG Case Rep J"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/505342-perianal-crohn-disease-in-a-patient-with-congenital-afibrinogenemia-a-multidisciplinary-therapeutic-management-challenge","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:39:13Z","timestamp":1783903153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/505342-perianal-crohn-disease-in-a-patient-with-congenital-afibrinogenemia-a-multidisciplinary-therapeutic-management-challenge"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,12]]},"references-count":11,"URL":"https:\/\/doi.org\/10.7759\/cureus.112527","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,12]]}}}