{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T08:05:17Z","timestamp":1784534717057,"version":"3.55.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,20]]},"DOI":"10.7759\/cureus.112987","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:30:42Z","timestamp":1784532642000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison of the Safety and Efficacy of Oral L-arginine for the Treatment of Cognitive Impairment in Older Adults: A Prospective, Randomized, Placebo-Controlled Pilot Study"],"prefix":"10.7759","author":[{"given":"Sonia","family":"Teotia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay K","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vani","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12190","article-title":"Mild cognitive impairment: a concept in evolution","volume":"275","author":"Petersen RC","year":"2014","unstructured":"Petersen RC, Caracciolo B, Brayne C, Gauthier S, Jelic V, Fratiglioni L. Mild cognitive impairment: a concept in evolution. J Intern Med. 2014, 275:214-28. 10.1111\/joim.12190","journal-title":"J Intern Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.01.002","article-title":"Mild cognitive impairment: disparity of incidence and prevalence estimates","volume":"8","author":"Ward A","year":"2012","unstructured":"Ward A, Arrighi HM, Michels S, Cedarbaum JM. Mild cognitive impairment: disparity of incidence and prevalence estimates. Alzheimers Dement. 2012, 8:14-21. 10.1016\/j.jalz.2011.01.002","journal-title":"Alzheimers Dement"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/geroni\/igx004.2133","article-title":"Gerontological Society of America\u2019s cognitive impairment detection and earlier diagnosis initiative","volume":"1","author":"Fortinsky RH","year":"2017","unstructured":"Fortinsky RH, Simmons J. Gerontological Society of America\u2019s cognitive impairment detection and earlier diagnosis initiative. Innov Aging. 2017, 1:609. 10.1093\/geroni\/igx004.2133","journal-title":"Innov Aging"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.226621","article-title":"Arginine metabolism revisited","volume":"146","author":"Morris SM Jr","year":"2016","unstructured":"Morris SM Jr. Arginine metabolism revisited. J Nutr. 2016, 146:2579S-86S. 10.3945\/jn.115.226621","journal-title":"J Nutr"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/336385a0","article-title":"Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain","volume":"336","author":"Garthwaite J","year":"1988","unstructured":"Garthwaite J, Charles SL, Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature. 1988, 336:385-8. 10.1038\/336385a0","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21588","article-title":"Involvement of l-arginine-nitric oxide pathway in the antidepressant and memory promoting effects of morin in mice","volume":"80","author":"Ben-Azu B","year":"2019","unstructured":"Ben-Azu B, Aderibigbe AO, Ajayi AM, Umukoro S, Iwalewa EO. Involvement of l-arginine-nitric oxide pathway in the antidepressant and memory promoting effects of morin in mice. Drug Dev Res. 2019, 80:1071-9. 10.1002\/ddr.21588","journal-title":"Drug Dev Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2017.1336173","article-title":"Protective effect against brain tissues oxidative damage as a possible mechanism for beneficial effects of L-arginine on lipopolysaccharide induced memory impairment in rats","volume":"41","author":"Hosseini M","year":"2018","unstructured":"Hosseini M, Anaeigoudari A, Beheshti F, Soukhtanloo M, Nosratabadi R. Protective effect against brain tissues oxidative damage as a possible mechanism for beneficial effects of L-arginine on lipopolysaccharide induced memory impairment in rats. Drug Chem Toxicol. 2018, 41:175-81. 10.1080\/01480545.2017.1336173","journal-title":"Drug Chem Toxicol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2018.01.035","article-title":"Cognitive performance of 20 healthy humans supplemented with L-homoarginine for 4\u202fweeks","volume":"50","author":"Sch\u00f6nhoff M","year":"2018","unstructured":"Sch\u00f6nhoff M, Weineck G, Hoppe J, et al.. Cognitive performance of 20 healthy humans supplemented with L-homoarginine for 4\u202fweeks. J Clin Neurosci. 2018, 50:237-41. 10.1016\/j.jocn.2018.01.035","journal-title":"J Clin Neurosci"},{"key":"ref9","unstructured":"Addenbrooke\u2019s Cognitive Examination - ACE-III. Hindi literate. Accessed: July 16, 2026: https:\/\/www.sydney.edu.au\/content\/dam\/corporate\/documents\/brain-and-mind-centre\/ace-diagnostic-tests\/ace-iii---standa...."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000351671","article-title":"Validation of the Addenbrooke's Cognitive Examination III in frontotemporal dementia and Alzheimer's disease","volume":"36","author":"Hsieh S","year":"2013","unstructured":"Hsieh S, Schubert S, Hoon C, Mioshi E, Hodges JR. Validation of the Addenbrooke's Cognitive Examination III in frontotemporal dementia and Alzheimer's disease. Dement Geriatr Cogn Disord. 2013, 36:242-50. 10.1159\/000351671","journal-title":"Dement Geriatr Cogn Disord"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.03.023","article-title":"Modulation of learning and memory by natural polyamines","volume":"112","author":"Guerra GP","year":"2016","unstructured":"Guerra GP, Rubin MA, Mello CF. Modulation of learning and memory by natural polyamines. Pharmacol Res. 2016, 112:99-118. 10.1016\/j.phrs.2016.03.023","journal-title":"Pharmacol Res"},{"key":"ref12","article-title":"Neurotransmitters & neuromodulators","author":"Barrett KE","year":"2016","unstructured":"Barrett KE, Barman SM, Boitano S, Brooks HL. Neurotransmitters &amp; neuromodulators. Ganong's Review of Medical Physiology. Barrett KE (ed): McGraw-Hill Education, New York, USA; 2016."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515\/tnsci-2018-0009","article-title":"Intracerebroventricular administration of L-arginine improves spatial memory acquisition in triple transgenic mice via reduction of oxidative stress and apoptosis","volume":"9","author":"Fonar G","year":"2018","unstructured":"Fonar G, Polis B, Meirson T, Maltsev A, Elliott E, Samson AO. Intracerebroventricular administration of L-arginine improves spatial memory acquisition in triple transgenic mice via reduction of oxidative stress and apoptosis. Transl Neurosci. 2018, 9:43-53. 10.1515\/tnsci-2018-0009","journal-title":"Transl Neurosci"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176030","article-title":"Protective effects of L-arginine on Alzheimer's disease: modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model","volume":"958","author":"Geravand S","year":"2023","unstructured":"Geravand S, Karami M, Sahraei H, Rahimi F. Protective effects of L-arginine on Alzheimer's disease: modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model. Eur J Pharmacol. 2023, 958:176030. 10.1016\/j.ejphar.2023.176030","journal-title":"Eur J Pharmacol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.344672","article-title":"Protective effect of L-arginine in an animal model of Alzheimer's disease induced by intra-hippocampal injection of AlCl3","volume":"70","author":"Karami M","year":"2022","unstructured":"Karami M, Geravand S, Rahimpour M. Protective effect of L-arginine in an animal model of Alzheimer's disease induced by intra-hippocampal injection of AlCl3. Neurol India. 2022, 70:548-53. 10.4103\/0028-3886.344672","journal-title":"Neurol India"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-017-1548-2","article-title":"Decreased diabetes risk over 9\u00a0year after 18-month oral L-arginine treatment in middle-aged subjects with impaired glucose tolerance and metabolic syndrome (extension evaluation of L-arginine study)","volume":"57","author":"Monti LD","year":"2018","unstructured":"Monti LD, Galluccio E, Villa V, Fontana B, Spadoni S, Piatti PM. Decreased diabetes risk over 9\u00a0year after 18-month oral L-arginine treatment in middle-aged subjects with impaired glucose tolerance and metabolic syndrome (extension evaluation of L-arginine study). Eur J Nutr. 2018, 57:2805-17. 10.1007\/s00394-017-1548-2","journal-title":"Eur J Nutr"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-023-03354-6","article-title":"Safety assessment of L-Arg oral intake in healthy subjects: a systematic review of randomized control trials","volume":"55","author":"Kuramochi Y","year":"2023","unstructured":"Kuramochi Y, Murata M, Sumino A, Sone H, Hayamizu K. Safety assessment of L-Arg oral intake in healthy subjects: a systematic review of randomized control trials. Amino Acids. 2023, 55:1949-64. 10.1007\/s00726-023-03354-6","journal-title":"Amino Acids"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/491204-comparison-of-the-safety-and-efficacy-of-oral-l-arginine-for-the-treatment-of-cognitive-impairment-in-older-adults-a-prospective-randomized-placebo-controlled-pilot-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T07:30:44Z","timestamp":1784532644000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/491204-comparison-of-the-safety-and-efficacy-of-oral-l-arginine-for-the-treatment-of-cognitive-impairment-in-older-adults-a-prospective-randomized-placebo-controlled-pilot-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,20]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.112987","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,20]]}}}