{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:00:23Z","timestamp":1785200423295,"version":"3.55.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,27]]},"DOI":"10.7759\/cureus.113471","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:10:36Z","timestamp":1785197436000},"source":"Crossref","is-referenced-by-count":0,"title":["Persistent Oropharyngeal Hemangioma Causing Progressive Upper Airway Compromise: Diagnostic and Therapeutic Challenges"],"prefix":"10.7759","author":[{"given":"Maria Claudia","family":"Rodr\u00edguez Duplat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel Enrique","family":"Manjarres Guevara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita Maria","family":"Martinez Manjarres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Lara Carvajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Gomez Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/JOVA.0000000000000113","article-title":"Updated classification of vascular anomalies. A living document from the International Society for the Study of Vascular Anomalies Classification Group","volume":"6","author":"Goldenberg DC","year":"2025","unstructured":"Goldenberg DC, Vikkula M, Penington A, Blei F, Kool LS, Wassef M, Frieden IJ. Updated classification of vascular anomalies. A living document from the International Society for the Study of Vascular Anomalies Classification Group. J Vasc Anom (Phila). 2025, 6:10.1097\/JOVA.0000000000000113","journal-title":"J Vasc Anom (Phila)"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01661.x","article-title":"Diagnosis and management of hemangiomas and vascular malformations of the head and neck","volume":"16","author":"Buckmiller LM","year":"2010","unstructured":"Buckmiller LM, Richter GT, Suen JY. Diagnosis and management of hemangiomas and vascular malformations of the head and neck. Oral Dis. 2010, 16:405-18. 10.1111\/j.1601-0825.2010.01661.x","journal-title":"Oral Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.150284","article-title":"Hypoxia-induced mediators of stem\/progenitor cell trafficking are increased in children with hemangioma","volume":"27","author":"Kleinman ME","year":"2007","unstructured":"Kleinman ME, Greives MR, Churgin SS, et al.. Hypoxia-induced mediators of stem\/progenitor cell trafficking are increased in children with hemangioma. Arterioscler Thromb Vasc Biol. 2007, 27:2664-70. 10.1161\/ATVBAHA.107.150284","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2010.01521.x","article-title":"Hypothesis: the metastatic niche theory can elucidate infantile hemangioma development","volume":"37 Suppl 1","author":"Mihm MC Jr","year":"2010","unstructured":"Mihm MC Jr, Nelson JS. Hypothesis: the metastatic niche theory can elucidate infantile hemangioma development. J Cutan Pathol. 2010, 37 Suppl 1:83-7. 10.1111\/j.1600-0560.2010.01521.x","journal-title":"J Cutan Pathol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/JOVA.0000000000000112","article-title":"Characteristics and outcomes of infantile hemangioma with non, poor, and partial response to standard-dose systemic beta-blocker therapy","volume":"6","author":"Afarideh M","year":"2025","unstructured":"Afarideh M, Rodriguez Baisi KE, Aghazadeh Mohandesi N, et al.. Characteristics and outcomes of infantile hemangioma with non, poor, and partial response to standard-dose systemic beta-blocker therapy. J Vasc Anom. 2025, 6:112. 10.1097\/JOVA.0000000000000112","journal-title":"J Vasc Anom"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-306197","article-title":"Incidence and treatment of infantile haemangioma in preterm infants","volume":"100","author":"Goelz R","year":"2015","unstructured":"Goelz R, Poets CF. Incidence and treatment of infantile haemangioma in preterm infants. Arch Dis Child Fetal Neonatal Ed. 2015, 100:F85-91. 10.1136\/archdischild-2014-306197","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3475","article-title":"Clinical practice guideline for the management of infantile hemangiomas","volume":"143","author":"Krowchuk DP","year":"2019","unstructured":"Krowchuk DP, Frieden IJ, Mancini AJ, et al.. Clinical practice guideline for the management of infantile hemangiomas. Pediatrics. 2019, 143:10.1542\/peds.2018-3475","journal-title":"Pediatrics"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00645-0","article-title":"Infantile haemangioma","volume":"390","author":"L\u00e9aut\u00e9-Labr\u00e8ze C","year":"2017","unstructured":"L\u00e9aut\u00e9-Labr\u00e8ze C, Harper JI, Hoeger PH. Infantile haemangioma. Lancet. 2017, 390:85-94. 10.1016\/S0140-6736(16)00645-0","journal-title":"Lancet"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-025-02030-7","article-title":"Complicated infantile hemangiomas in the palate: case report of a newborn patient and review of the literature","volume":"51","author":"Pensabene M","year":"2025","unstructured":"Pensabene M, Cambiaso C, Patti M, et al.. Complicated infantile hemangiomas in the palate: case report of a newborn patient and review of the literature. Ital J Pediatr. 2025, 51:171. 10.1186\/s13052-025-02030-7","journal-title":"Ital J Pediatr"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-019-00327-2","article-title":"Risk factors for infantile hemangioma: a meta-analysis","volume":"16","author":"Ding Y","year":"2020","unstructured":"Ding Y, Zhang JZ, Yu SR, Xiang F, Kang XJ. Risk factors for infantile hemangioma: a meta-analysis. World J Pediatr. 2020, 16:377-84. 10.1007\/s12519-019-00327-2","journal-title":"World J Pediatr"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237X.68593","article-title":"Capillary hemangioma or pyogenic granuloma: a diagnostic dilemma","volume":"1","author":"Rachappa MM","year":"2010","unstructured":"Rachappa MM, Triveni MN. Capillary hemangioma or pyogenic granuloma: a diagnostic dilemma. Contemp Clin Dent. 2010, 1:119-22. 10.4103\/0976-237X.68593","journal-title":"Contemp Clin Dent"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1675194","article-title":"Decoding infantile hemangioma: cellular dynamics, molecular signals, and microenvironmental influences","volume":"15","author":"Zhu Z","year":"2025","unstructured":"Zhu Z, Jiang X, Wang F, Zhao L, Song Q. Decoding infantile hemangioma: cellular dynamics, molecular signals, and microenvironmental influences. Front Oncol. 2025, 15:1675194. 10.3389\/fonc.2025.1675194","journal-title":"Front Oncol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-025-00762-1","article-title":"Early plasma changes of HIF-1 alpha, matrix metalloproteinases-2 and -\u20099, and tissue inhibitor of matrix metalloproteinase-1 in patients with infantile hemangiomas treated with propranolol","volume":"77","author":"Kowalska M","year":"2025","unstructured":"Kowalska M, Koper-Lenkiewicz OM, Kami\u0144ska J, D\u0119bek W, Hermanowicz A, Matuszczak E. Early plasma changes of HIF-1 alpha, matrix metalloproteinases-2 and -\u20099, and tissue inhibitor of matrix metalloproteinase-1 in patients with infantile hemangiomas treated with propranolol. Pharmacol Rep. 2025, 77:1364-73. 10.1007\/s43440-025-00762-1","journal-title":"Pharmacol Rep"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.012","article-title":"Multifocal vascular tumors and fetal hydrops","volume":"164","author":"Funk T","year":"2014","unstructured":"Funk T, Prok L, Brown LD, Bruckner AL. Multifocal vascular tumors and fetal hydrops. J Pediatr. 2014, 164:1214-8. 10.1016\/j.jpeds.2013.12.012","journal-title":"J Pediatr"},{"key":"ref15","article-title":"Differential diagnosis difficulties related to infantile hemangioma - case report and literature review","author":"\u0162arc\u0103 E","year":"2019","unstructured":"\u0162arc\u0103 E, Cojocaru E, Ro\u015fu ST, Butnariu LI, Pl\u0103m\u0103deal\u0103 P, Mois\u0103 \u015eM. Differential diagnosis difficulties related to infantile hemangioma - case report and literature review. Rom J Morphol Embryol. 2019, 1375-9.","journal-title":"Rom J Morphol Embryol"},{"key":"ref16","article-title":"Cavernous haemangioma of the left nasal cavity","volume":"28","author":"Archontaki M","year":"2008","unstructured":"Archontaki M, Stamou AK, Hajiioannou JK, Kalomenopoulou M, Korkolis DP, Kyrmizakis DE. Cavernous haemangioma of the left nasal cavity. Acta Otorhinolaryngol Ital. 2008, 28:309-11.","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198203000-00002","article-title":"Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics","volume":"69","author":"Mulliken JB","year":"1982","unstructured":"Mulliken JB, Glowacki J. Hemangiomas and vascular malformations in infants and children: a classification based on endothelial characteristics. Plast Reconstr Surg. 1982, 69:412-22. 10.1097\/00006534-198203000-00002","journal-title":"Plast Reconstr Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2023.4484","article-title":"Propranolol for the treatment of infantile hemangiomas: a nine-year monocentric experience from a tertiary hospital","volume":"33","author":"Volont\u00e9 M","year":"2023","unstructured":"Volont\u00e9 M, Codazzi AC, Davidovich S, et al.. Propranolol for the treatment of infantile hemangiomas: a nine-year monocentric experience from a tertiary hospital. Eur J Dermatol. 2023, 33:265-9. 10.1684\/ejd.2023.4484","journal-title":"Eur J Dermatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/515040-persistent-oropharyngeal-hemangioma-causing-progressive-upper-airway-compromise-diagnostic-and-therapeutic-challenges","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:10:37Z","timestamp":1785197437000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/515040-persistent-oropharyngeal-hemangioma-causing-progressive-upper-airway-compromise-diagnostic-and-therapeutic-challenges"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":18,"URL":"https:\/\/doi.org\/10.7759\/cureus.113471","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}