{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:05:06Z","timestamp":1785431106901,"version":"3.56.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,30]]},"DOI":"10.7759\/cureus.113676","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:34:23Z","timestamp":1785429263000},"source":"Crossref","is-referenced-by-count":0,"title":["Calcium Channel Subunit Alpha2delta 2 Is Upregulated During Odontoblast-Like Differentiation and Exhibits Higher Basal Expression in Stem Cells From Exfoliated Deciduous Teeth Than in Dental Pulp Stem Cells"],"prefix":"10.7759","author":[{"given":"Fidele","family":"Nabbout","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michella","family":"Ghassibe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Sabbagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41415-023-6384-6","article-title":"The genetic basis of hypodontia in dental development","volume":"235","author":"Duke A","year":"2023","unstructured":"Duke A, Paterson M, P Ashley M, MacNab L. The genetic basis of hypodontia in dental development. Br Dent J. 2023, 235:525-8. 10.1038\/s41415-023-6384-6","journal-title":"Br Dent J"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.108369","article-title":"Familial tooth agenesis in Lebanese patients: clinical characterization and whole-exome identification of rare CACNA2D2 and trio variants","volume":"18","author":"Nabbout F","year":"2026","unstructured":"Nabbout F, El Hajj J, Badran B, Ghassibe M. Familial tooth agenesis in Lebanese patients: clinical characterization and whole-exome identification of rare CACNA2D2 and trio variants. Cureus. 2026, 18:108369. 10.7759\/cureus.108369","journal-title":"Cureus"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.109624","article-title":"Ion channel-Rho GTPase coupling in human odontogenesis: integrative structural and network dissection of TRIO and CACNA2D2 variants from familial tooth agenesis","volume":"18","author":"Nabbout F","year":"2026","unstructured":"Nabbout F, Sabbagh J, El Hajj J, Ghassibe M. Ion channel-Rho GTPase coupling in human odontogenesis: integrative structural and network dissection of TRIO and CACNA2D2 variants from familial tooth agenesis. Cureus. 2026, 18:109624. 10.7759\/cureus.109624","journal-title":"Cureus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27068","article-title":"The emerging role of extracellular Ca(2+) in osteo\/odontogenic differentiation and the involvement of intracellular Ca (2+) signaling: from osteoblastic cells to dental pulp cells and odontoblasts","volume":"234","author":"An S","year":"2019","unstructured":"An S. The emerging role of extracellular Ca(2+) in osteo\/odontogenic differentiation and the involvement of intracellular Ca (2+) signaling: from osteoblastic cells to dental pulp cells and odontoblasts. J Cell Physiol. 2019, 234:2169-93. 10.1002\/jcp.27068","journal-title":"J Cell Physiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009654","article-title":"The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential","volume":"67","author":"Zamponi GW","year":"2015","unstructured":"Zamponi GW, Striessnig J, Koschak A, Dolphin AC. The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential. Pharmacol Rev. 2015, 67:821-70. 10.1124\/pr.114.009654","journal-title":"Pharmacol Rev"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.05.012","article-title":"Calcium-sensing receptor-ERK signaling promotes odontoblastic differentiation of human dental pulp cells","volume":"101","author":"Mizumachi H","year":"2017","unstructured":"Mizumachi H, Yoshida S, Tomokiyo A, et al.. Calcium-sensing receptor-ERK signaling promotes odontoblastic differentiation of human dental pulp cells. Bone. 2017, 101:191-201. 10.1016\/j.bone.2017.05.012","journal-title":"Bone"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-023-01097-w","article-title":"Examining mechanisms for voltage-sensitive calcium channel-mediated secretion events in bone cells","volume":"113","author":"Reyes Fernandez PC","year":"2023","unstructured":"Reyes Fernandez PC, Wright CS, Farach-Carson MC, Thompson WR. Examining mechanisms for voltage-sensitive calcium channel-mediated secretion events in bone cells. Calcif Tissue Int. 2023, 113:126-42. 10.1007\/s00223-023-01097-w","journal-title":"Calcif Tissue Int"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-022-00720-w","article-title":"Ca(v)1.2 regulated odontogenic differentiation of NG2(+) pericytes during pulp injury","volume":"111","author":"Fu Y","year":"2023","unstructured":"Fu Y, Ju Y, Zhao S. Ca(v)1.2 regulated odontogenic differentiation of NG2(+) pericytes during pulp injury. Odontology. 2023, 111:57-67. 10.1007\/s10266-022-00720-w","journal-title":"Odontology"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.09.022","article-title":"The role of Rho-GEF Trio in regulating tooth root development through the p38 MAPK pathway","volume":"372","author":"Chen H","year":"2018","unstructured":"Chen H, Guo S, Xia Y, et al.. The role of Rho-GEF Trio in regulating tooth root development through the p38 MAPK pathway. Exp Cell Res. 2018, 372:158-67. 10.1016\/j.yexcr.2018.09.022","journal-title":"Exp Cell Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.job.2022.01.004","article-title":"LPA(6)-RhoA signals regulate junctional complexes for polarity and morphology establishment of maturation stage ameloblasts","volume":"64","author":"Inaba A","year":"2022","unstructured":"Inaba A, Harada H, Ikezaki S, et al.. LPA(6)-RhoA signals regulate junctional complexes for polarity and morphology establishment of maturation stage ameloblasts. J Oral Biosci. 2022, 64:85-92. 10.1016\/j.job.2022.01.004","journal-title":"J Oral Biosci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5982","article-title":"Rho\/Rho-associated protein kinase signaling pathway-mediated downregulation of runt-related transcription factor 2 expression promotes the differentiation of dental pulp stem cells into odontoblasts","volume":"15","author":"Huang X","year":"2018","unstructured":"Huang X, Chen X, Chen H, Xu D, Lin C, Peng B. Rho\/Rho-associated protein kinase signaling pathway-mediated downregulation of runt-related transcription factor 2 expression promotes the differentiation of dental pulp stem cells into odontoblasts. Exp Ther Med. 2018, 15:4457-64. 10.3892\/etm.2018.5982","journal-title":"Exp Ther Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2009.07.024","article-title":"Stem cell proliferation pathways comparison between human exfoliated deciduous teeth and dental pulp stem cells by gene expression profile from promising dental pulp","volume":"35","author":"Nakamura S","year":"2009","unstructured":"Nakamura S, Yamada Y, Katagiri W, Sugito T, Ito K, Ueda M. Stem cell proliferation pathways comparison between human exfoliated deciduous teeth and dental pulp stem cells by gene expression profile from promising dental pulp. J Endod. 2009, 35:1536-42. 10.1016\/j.joen.2009.07.024","journal-title":"J Endod"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0937635100","article-title":"SHED: stem cells from human exfoliated deciduous teeth","volume":"100","author":"Miura M","year":"2003","unstructured":"Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S. SHED: stem cells from human exfoliated deciduous teeth. Proc Natl Acad Sci U S A. 2003, 100:5807-12. 10.1073\/pnas.0937635100","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s10528-026-11411-4","article-title":"Comparative analysis of stemness and differentiation gene expression in mesenchymal stem cells from permanent and deciduous teeth: an in vitro study to evaluate implications for regenerative dentistry","author":"Noorbakhsh SA","year":"2026","unstructured":"Noorbakhsh SA, Pourmohammadi-Nejad F, Pirsadeghi A, Yousefi-Ahmadipour A. Comparative analysis of stemness and differentiation gene expression in mesenchymal stem cells from permanent and deciduous teeth: an in vitro study to evaluate implications for regenerative dentistry. Biochem Genet. 2026, 10.1007\/s10528-026-11411-4","journal-title":"Biochem Genet"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaf176","article-title":"Real-time reverse transcription quantitative PCR (RT-qPCR) methodological standards and reporting practices","volume":"72","author":"Bustin SA","year":"2026","unstructured":"Bustin SA, Wittwer CT. Real-time reverse transcription quantitative PCR (RT-qPCR) methodological standards and reporting practices. Clin Chem. 2026, 72:641-51. 10.1093\/clinchem\/hvaf176","journal-title":"Clin Chem"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.8725","article-title":"Comparative characterization of SHED and DPSCs during extended cultivation in\u00a0vitro","volume":"17","author":"Wang H","year":"2018","unstructured":"Wang H, Zhong Q, Yang T, et al.. Comparative characterization of SHED and DPSCs during extended cultivation in\u00a0vitro. Mol Med Rep. 2018, 17:6551-9. 10.3892\/mmr.2018.8725","journal-title":"Mol Med Rep"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2017.1347705","article-title":"Dental stem cells: recent progresses in tissue engineering and regenerative medicine","volume":"49","author":"Botelho J","year":"2017","unstructured":"Botelho J, Cavacas MA, Machado V, Mendes JJ. Dental stem cells: recent progresses in tissue engineering and regenerative medicine. Ann Med. 2017, 49:644-51. 10.1080\/07853890.2017.1347705","journal-title":"Ann Med"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.654559","article-title":"Dental-derived mesenchymal stem cells: state of the art","volume":"9","author":"Li B","year":"2021","unstructured":"Li B, Ouchi T, Cao Y, Zhao Z, Men Y. Dental-derived mesenchymal stem cells: state of the art. Front Cell Dev Biol. 2021, 9:654559. 10.3389\/fcell.2021.654559","journal-title":"Front Cell Dev Biol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2021.02.005","article-title":"Tooth repair and regeneration: potential of dental stem cells","volume":"27","author":"Zhang W","year":"2021","unstructured":"Zhang W, Yelick PC. Tooth repair and regeneration: potential of dental stem cells. Trends Mol Med. 2021, 27:501-11. 10.1016\/j.molmed.2021.02.005","journal-title":"Trends Mol Med"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-022-04443-8","article-title":"Cytokine co-stimulation effect on odontogenic differentiation of stem cells","volume":"26","author":"Shamszadeh S","year":"2022","unstructured":"Shamszadeh S, Asgary S, Torabzadeh H, Hosseinzadeh S, Nosrat A. Cytokine co-stimulation effect on odontogenic differentiation of stem cells. Clin Oral Investig. 2022, 26:4789-96. 10.1007\/s00784-022-04443-8","journal-title":"Clin Oral Investig"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1174579","article-title":"The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes","volume":"11","author":"Pan H","year":"2023","unstructured":"Pan H, Yang Y, Xu H, et al.. The odontoblastic differentiation of dental mesenchymal stem cells: molecular regulation mechanism and related genetic syndromes. Front Cell Dev Biol. 2023, 11:1174579. 10.3389\/fcell.2023.1174579","journal-title":"Front Cell Dev Biol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1272764","article-title":"Effects of different signaling pathways on odontogenic differentiation of dental pulp stem cells: a review","volume":"14","author":"Zhou L","year":"2023","unstructured":"Zhou L, Zhao S, Xing X. Effects of different signaling pathways on odontogenic differentiation of dental pulp stem cells: a review. Front Physiol. 2023, 14:1272764. 10.3389\/fphys.2023.1272764","journal-title":"Front Physiol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.11817\/j.issn.1672-7347.2020.190102","article-title":"Comparison of odontoblast differentiation capacity between stem cells from human exfoliated deciduous teeth and dental pulp stem cells","volume":"45","author":"Li C","year":"2020","unstructured":"Li C, Zheng L, Zhang Y, Luo D, Tang Y, Ding X, Hu Y. Comparison of odontoblast differentiation capacity between stem cells from human exfoliated deciduous teeth and dental pulp stem cells. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2020, 45:678-83. 10.11817\/j.issn.1672-7347.2020.190102","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.61336\/jccp\/25-07-87","article-title":"Dental stem cells in regenerative dentistry: a narrative review of therapeutic strategies and biomaterials","volume":"11","author":"Khushi KY","year":"2025","unstructured":"Khushi KY, Urvi UV, Betigeri AV, et al.. Dental stem cells in regenerative dentistry: a narrative review of therapeutic strategies and biomaterials. J Contemp Clin Pract. 2025, 11:623-30. 10.61336\/jccp\/25-07-87","journal-title":"J Contemp Clin Pract"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-01963-x","article-title":"Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo","volume":"28","author":"Bonnet M","year":"2023","unstructured":"Bonnet M, Roche F, Fagotto-Kaufmann C, et al.. Pathogenic TRIO variants associated with neurodevelopmental disorders perturb the molecular regulation of TRIO and axon pathfinding in vivo. Mol Psychiatry. 2023, 28:1527-44. 10.1038\/s41380-023-01963-x","journal-title":"Mol Psychiatry"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/512499-calcium-channel-subunit-alpha2delta-2-is-upregulated-during-odontoblast-like-differentiation-and-exhibits-higher-basal-expression-in-stem-cells-from-exfoliated-deciduous-teeth-than-in-dental-pulp-stem-cells","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:34:24Z","timestamp":1785429264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/512499-calcium-channel-subunit-alpha2delta-2-is-upregulated-during-odontoblast-like-differentiation-and-exhibits-higher-basal-expression-in-stem-cells-from-exfoliated-deciduous-teeth-than-in-dental-pulp-stem-cells"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.113676","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,30]]}}}