{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T11:01:52Z","timestamp":1785495712068,"version":"3.56.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"DOI":"10.7759\/cureus.113713","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:52:42Z","timestamp":1785495162000},"source":"Crossref","is-referenced-by-count":0,"title":["Monocyte-to-Platelet Ratio Shows Modestly Improved Discrimination Over Model for End-Stage Liver Disease (MELD) 3.0 in Predicting 1-Year Mortality in Patients With Chronic Liver Failure and Hepatic Encephalopathy"],"prefix":"10.7759","author":[{"given":"Jing-tao","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-shan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-qin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2147\/HMER.S450638","article-title":"The free triiodothyronine, gamma-glutamyl transpeptidase and spontaneous bacterial peritonitis index: a novel model for predicting 1-year mortality in patients with HBV-related hepatic encephalopathy","volume":"16","author":"Lin L","year":"2024","unstructured":"Lin L, Huang ZY, Liu K, Tong XC, Zhang ZX, Xue Y. The free triiodothyronine, gamma-glutamyl transpeptidase and spontaneous bacterial peritonitis index: a novel model for predicting 1-year mortality in patients with HBV-related hepatic encephalopathy. Hepat Med. 2024, 16:1-9. 10.2147\/HMER.S450638","journal-title":"Hepat Med"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2024.101751","article-title":"The burden of hepatic encephalopathy and the use of albumin as a potential treatment","volume":"30","author":"Bajaj JS","year":"2025","unstructured":"Bajaj JS, Pompili E, Caraceni P. The burden of hepatic encephalopathy and the use of albumin as a potential treatment. Ann Hepatol. 2025, 30:101751. 10.1016\/j.aohep.2024.101751","journal-title":"Ann Hepatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-025-01415-9","article-title":"Hepatic encephalopathy: current thoughts on pathophysiology and management","volume":"25","author":"Sen BK","year":"2025","unstructured":"Sen BK, Pan K, Chakravarty A. Hepatic encephalopathy: current thoughts on pathophysiology and management. Curr Neurol Neurosci Rep. 2025, 25:28. 10.1007\/s11910-025-01415-9","journal-title":"Curr Neurol Neurosci Rep"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00366-6","article-title":"Hepatic encephalopathy","volume":"8","author":"H\u00e4ussinger D","year":"2022","unstructured":"H\u00e4ussinger D, Dhiman RK, Felipo V, et al.. Hepatic encephalopathy. Nat Rev Dis Primers. 2022, 8:43. 10.1038\/s41572-022-00366-6","journal-title":"Nat Rev Dis Primers"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.5009\/gnl240584","article-title":"Predicting mortality and cirrhosis-related complications with MELD3.0: a multicenter cohort analysis","volume":"19","author":"Lim J","year":"2025","unstructured":"Lim J, Kim JH, Lee A, et al.. Predicting mortality and cirrhosis-related complications with MELD3.0: a multicenter cohort analysis. Gut Liver. 2025, 19:427-37. 10.5009\/gnl240584","journal-title":"Gut Liver"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-024-00970-9","article-title":"Ammonia-induced stress response in liver disease progression and hepatic encephalopathy","volume":"21","author":"Gallego-Dur\u00e1n R","year":"2024","unstructured":"Gallego-Dur\u00e1n R, Hadjihambi A, Ampuero J, Rose CF, Jalan R, Romero-G\u00f3mez M. Ammonia-induced stress response in liver disease progression and hepatic encephalopathy. Nat Rev Gastroenterol Hepatol. 2024, 21:774-91. 10.1038\/s41575-024-00970-9","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-022-01146-6","article-title":"Management of hepatic encephalopathy associated with advanced liver disease","volume":"42","author":"Garc\u00eda-Mart\u00ednez R","year":"2022","unstructured":"Garc\u00eda-Mart\u00ednez R, Diaz-Ruiz R, Poncela M. Management of hepatic encephalopathy associated with advanced liver disease. Clin Drug Investig. 2022, 42:5-13. 10.1007\/s40261-022-01146-6","journal-title":"Clin Drug Investig"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11030611","article-title":"Ammonia and the muscle: an emerging point of view on hepatic encephalopathy","volume":"11","author":"Di Cola S","year":"2022","unstructured":"Di Cola S, Nardelli S, Ridola L, Gioia S, Riggio O, Merli M. Ammonia and the muscle: an emerging point of view on hepatic encephalopathy. J Clin Med. 2022, 11:10.3390\/jcm11030611","journal-title":"J Clin Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02814-w","article-title":"Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes","volume":"20","author":"Claeys W","year":"2023","unstructured":"Claeys W, Van Hoecke L, Lernout H, et al.. Experimental hepatic encephalopathy causes early but sustained glial transcriptional changes. J Neuroinflammation. 2023, 20:130. 10.1186\/s12974-023-02814-w","journal-title":"J Neuroinflammation"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1528733","article-title":"Inflammatory lipid biomarkers and transplant-free mortality risk in hepatitis B-related cirrhosis and hepatic encephalopathy","volume":"12","author":"Shi K","year":"2025","unstructured":"Shi K, Wang X, Yi Z, Li Y, Feng Y, Wang X. Inflammatory lipid biomarkers and transplant-free mortality risk in hepatitis B-related cirrhosis and hepatic encephalopathy. Front Med (Lausanne). 2025, 12:1528733. 10.3389\/fmed.2025.1528733","journal-title":"Front Med (Lausanne)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.70110","article-title":"Development and validation of a new model including inflammation indexes for the long-term prognosis of hepatitis B-related acute-on-chronic liver failure","volume":"96","author":"Zhang Y","year":"2024","unstructured":"Zhang Y, Luo Q, Lin X, et al.. Development and validation of a new model including inflammation indexes for the long-term prognosis of hepatitis B-related acute-on-chronic liver failure. J Med Virol. 2024, 96:e70110. 10.1002\/jmv.70110","journal-title":"J Med Virol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03995-9","article-title":"CD45(+) erythroid progenitor cells as potential biomarkers for disease progression in hepatitis B virus-related acute-on-chronic liver failure","volume":"25","author":"Zhang N","year":"2025","unstructured":"Zhang N, Wu HS, Pang XQ, Yu CY, Li X, Gao ZL. CD45(+) erythroid progenitor cells as potential biomarkers for disease progression in hepatitis B virus-related acute-on-chronic liver failure. BMC Gastroenterol. 2025, 25:405. 10.1186\/s12876-025-03995-9","journal-title":"BMC Gastroenterol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-025-03955-x","article-title":"Neutrophil-lymphocyte ratio is associated with worse outcomes in patients with cirrhosis: insights from the PRO-LIVER Registry","volume":"20","author":"D'Amico T","year":"2025","unstructured":"D'Amico T, Miglionico M, Cangemi R, et al.. Neutrophil-lymphocyte ratio is associated with worse outcomes in patients with cirrhosis: insights from the PRO-LIVER Registry. Intern Emerg Med. 2025, 20:1371-80. 10.1007\/s11739-025-03955-x","journal-title":"Intern Emerg Med"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13206208","article-title":"Hospital mortality in acute decompensation of alcoholic liver cirrhosis: can novel survival markers outperform traditional ones?","volume":"13","author":"Dejanovi\u0107 B","year":"2024","unstructured":"Dejanovi\u0107 B, Barak O, \u010colovi\u0107 P, Janji\u0107 N, Savi\u0107 \u017d, Gvozdanovi\u0107 N, Ru\u017ei\u0107 M. Hospital mortality in acute decompensation of alcoholic liver cirrhosis: can novel survival markers outperform traditional ones?. J Clin Med. 2024, 13:10.3390\/jcm13206208","journal-title":"J Clin Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1007-3418.2019.01.006","article-title":"[Guideline for diagnosis and treatment of liver failure]","volume":"27","author":"Liver Failure and Artificial Liver Group","year":"2019","unstructured":"Liver Failure and Artificial Liver Group, Chinese Society of Infectious Diseases, Chinese Medical Association; Severe Liver Disease and Artificial Liver Group, Chinese Society of Hepatology, Chinese Medical Association. [Guideline for diagnosis and treatment of liver failure]. Zhonghua Gan Zang Bing Za Zhi. 2019, 27:18-26. 10.3760\/cma.j.issn.1007-3418.2019.01.006","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i36.5403","article-title":"Chinese guidelines on management of hepatic encephalopathy in cirrhosis","volume":"25","author":"Xu XY","year":"2019","unstructured":"Xu XY, Ding HG, Li WG, et al.. Chinese guidelines on management of hepatic encephalopathy in cirrhosis. World J Gastroenterol. 2019, 25:5403-22. 10.3748\/wjg.v25.i36.5403","journal-title":"World J Gastroenterol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03964.x","article-title":"Hepatic encephalopathy","volume":"96","author":"Blei AT","year":"2001","unstructured":"Blei AT, C\u00f3rdoba J. Hepatic encephalopathy. Am J Gastroenterol. 2001, 96:1968-76. 10.1111\/j.1572-0241.2001.03964.x","journal-title":"Am J Gastroenterol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0103","article-title":"Acute-on-chronic liver failure: terminology, mechanisms and management","volume":"29","author":"Br VK","year":"2023","unstructured":"Br VK, Sarin SK. Acute-on-chronic liver failure: terminology, mechanisms and management. Clin Mol Hepatol. 2023, 29:670-89. 10.3350\/cmh.2022.0103","journal-title":"Clin Mol Hepatol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.08.050","article-title":"MELD 3.0: the model for end-stage liver disease updated for the modern era","volume":"161","author":"Kim WR","year":"2021","unstructured":"Kim WR, Mannalithara A, Heimbach JK, et al.. MELD 3.0: the model for end-stage liver disease updated for the modern era. Gastroenterology. 2021, 161:1887-1895.e4. 10.1053\/j.gastro.2021.08.050","journal-title":"Gastroenterology"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000013324","article-title":"Evaluation of prognostic values of inflammation-based makers in patients with HBV-related acute-on-chronic liver failure","volume":"97","author":"Cai J","year":"2018","unstructured":"Cai J, Wang K, Han T, Jiang H. Evaluation of prognostic values of inflammation-based makers in patients with HBV-related acute-on-chronic liver failure. Medicine (Baltimore). 2018, 97:e13324. 10.1097\/MD.0000000000013324","journal-title":"Medicine (Baltimore)"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/6646156","article-title":"Platelet-to-monocyte ratio as a novel promising agent for the prognosis of hepatitis b virus-associated decompensated cirrhosis","volume":"2023","author":"Zhou J","year":"2023","unstructured":"Zhou J, Li X, Wang M, Gu C, Liu J. Platelet-to-monocyte ratio as a novel promising agent for the prognosis of hepatitis b virus-associated decompensated cirrhosis. Can J Gastroenterol Hepatol. 2023, 2023:6646156. 10.1155\/2023\/6646156","journal-title":"Can J Gastroenterol Hepatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17051727","article-title":"Lymphocyte-to-monocyte ratio as the best simple predictor of bacterial infection in patients with liver cirrhosis","volume":"17","author":"Piotrowski D","year":"2020","unstructured":"Piotrowski D, S\u0105czewska-Piotrowska A, Jaroszewicz J, Boro\u0144-Kaczmarska A. Lymphocyte-to-monocyte ratio as the best simple predictor of bacterial infection in patients with liver cirrhosis. Int J Environ Res Public Health. 2020, 17:10.3390\/ijerph17051727","journal-title":"Int J Environ Res Public Health"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-11267-w","article-title":"Influence of chronic hepatitis C infection on the monocyte-to-platelet ratio: data analysis from the National Health and Nutrition Examination Survey (2009-2016)","volume":"21","author":"Nikiforuk AM","year":"2021","unstructured":"Nikiforuk AM, Karim ME, Patrick DM, Jassem AN. Influence of chronic hepatitis C infection on the monocyte-to-platelet ratio: data analysis from the National Health and Nutrition Examination Survey (2009-2016). BMC Public Health. 2021, 21:1388. 10.1186\/s12889-021-11267-w","journal-title":"BMC Public Health"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/455514-monocyte-to-platelet-ratio-shows-modestly-improved-discrimination-over-model-for-end-stage-liver-disease-meld-30-in-predicting-1-year-mortality-in-patients-with-chronic-liver-failure-and-hepatic-encephalopathy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T10:52:44Z","timestamp":1785495164000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/455514-monocyte-to-platelet-ratio-shows-modestly-improved-discrimination-over-model-for-end-stage-liver-disease-meld-30-in-predicting-1-year-mortality-in-patients-with-chronic-liver-failure-and-hepatic-encephalopathy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":23,"URL":"https:\/\/doi.org\/10.7759\/cureus.113713","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}