{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:50:59Z","timestamp":1785700259191,"version":"3.56.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"DOI":"10.7759\/cureus.113794","type":"journal-article","created":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:12:20Z","timestamp":1785697940000},"source":"Crossref","is-referenced-by-count":0,"title":["Management of Tibial Adamantinoma: Balancing Oncologic Cure and Reconstructive Longevity"],"prefix":"10.7759","author":[{"given":"Yasser","family":"Amr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aye","family":"Htun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simerjit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Adamantinoma","volume":"73","author":"Kitsoulis P","year":"2007","unstructured":"Kitsoulis P, Charchanti A, Paraskevas G, Marini A, Karatzias G. Adamantinoma. Acta Orthop Belg. 2007, 73:425-31.","journal-title":"Acta Orthop Belg"},{"key":"ref2","article-title":"Adamantinoma of the appendicular skeleton - updated","author":"Moon NF","year":"1986","unstructured":"Moon NF, Mori H. Adamantinoma of the appendicular skeleton - updated. Clin Orthop Relat Res. 1986, 215-37.","journal-title":"Clin Orthop Relat Res"},{"key":"ref3","article-title":"A primary myelogenous squamous cell carcinoma of the ulna [Article in German]","volume":"26","author":"Maier C","year":"1990","unstructured":"Maier C. A primary myelogenous squamous cell carcinoma of the ulna [Article in German]. Bruns' Beitr Klin Chir. 1990, 26:533.","journal-title":"Bruns' Beitr Klin Chir"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20070301-04","article-title":"Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones","volume":"30","author":"Papagelopoulos PJ","year":"2007","unstructured":"Papagelopoulos PJ, Mavrogenis AF, Galanis EC, Savvidou OD, Inwards CY, Sim FH. Clinicopathological features, diagnosis, and treatment of adamantinoma of the long bones. Orthopedics. 2007, 30:211-15; quiz 216-17. 10.3928\/01477447-20070301-04","journal-title":"Orthopedics"},{"key":"ref5","article-title":"On a primary adamantinoma of the tibia [Article in German]","volume":"12","author":"Fischer B","year":"1913","unstructured":"Fischer B. On a primary adamantinoma of the tibia [Article in German]. Virchows Arch (B). 1913, 12:422-41.","journal-title":"Virchows Arch (B)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195705\/06)10:3<540::aid-cncr2820100317>3.0.co;2-c","article-title":"Malignant angioblastoma of bone; a reappraisal of adamantinoma of long bone","volume":"10","author":"Changus GW","year":"1957","unstructured":"Changus GW, Speed JS, Stewart FW. Malignant angioblastoma of bone; a reappraisal of adamantinoma of long bone. Cancer. 1957, 10:540-59. 10.1002\/1097-0142(195705\/06)10:3&lt;540::aid-cncr2820100317&gt;3.0.co;2-c","journal-title":"Cancer"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1978.tb01709.x","article-title":"Ultrastructural findings supporting the angioblastic nature of the so-called adamantinoma of the tibia","volume":"2","author":"Llombart-Bosch A","year":"1978","unstructured":"Llombart-Bosch A, Ortu\u00f1o-Pacheco G. Ultrastructural findings supporting the angioblastic nature of the so-called adamantinoma of the tibia. Histopathology. 1978, 2:189-200. 10.1111\/j.1365-2559.1978.tb01709.x","journal-title":"Histopathology"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/jso.25269","article-title":"Adamantinoma of bone: long-term follow-up of 46 consecutive patients","volume":"118","author":"Houdek MT","year":"2018","unstructured":"Houdek MT, Sherman CE, Inwards CY, Wenger DE, Rose PS, Sim FH. Adamantinoma of bone: long-term follow-up of 46 consecutive patients. J Surg Oncol. 2018, 118:1150-4. 10.1002\/jso.25269","journal-title":"J Surg Oncol"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.2106\/00004623-197557020-00003","article-title":"Adamantinoma of long bones. A clinicopathological study of fourteen cases with vascular origin suggested","volume":"57","author":"Huvos AG","year":"1975","unstructured":"Huvos AG, Marcove RC. Adamantinoma of long bones. A clinicopathological study of fourteen cases with vascular origin suggested. J Bone Joint Surg Am. 1975, 57:148-54.","journal-title":"J Bone Joint Surg Am"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890801)64:3<730::aid-cncr2820640327>3.0.co;2-p","article-title":"Adamantinoma of long bones. A clinicopathologic study of 85 cases","volume":"64","author":"Keeney GL","year":"1989","unstructured":"Keeney GL, Unni KK, Beabout JW, Pritchard DJ. Adamantinoma of long bones. A clinicopathologic study of 85 cases. Cancer. 1989, 64:730-7. 10.1002\/1097-0142(19890801)64:3&lt;730::aid-cncr2820640327&gt;3.0.co;2-p","journal-title":"Cancer"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.33.441","article-title":"Adamantinoma of the rib metastasizing to the liver","volume":"33","author":"Beppu H","year":"1994","unstructured":"Beppu H, Yamaguchi H, Yoshimura N, Atarashi K, Tsukimoto K, Nagashima Y. Adamantinoma of the rib metastasizing to the liver. Intern Med. 1994, 33:441-5. 10.2169\/internalmedicine.33.441","journal-title":"Intern Med"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-198603000-00022","article-title":"Primary adamantinoma of rib: thoracic manifestations of a rare bone tumor","volume":"79","author":"Plump D","year":"1986","unstructured":"Plump D, Haponik EF, Katz RS, Tipton-Donovan A. Primary adamantinoma of rib: thoracic manifestations of a rare bone tumor. South Med J. 1986, 79:352-5. 10.1097\/00007611-198603000-00022","journal-title":"South Med J"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000223497.06588.4A","article-title":"Adamantinoma of the spine: case report","volume":"59","author":"Dini LI","year":"2006","unstructured":"Dini LI, Mendon\u00e7a R, Adamy CA, Saraiva GA. Adamantinoma of the spine: case report. Neurosurgery. 2006, 59:E426; discussion E426. 10.1227\/01.NEU.0000223497.06588.4A","journal-title":"Neurosurgery"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1944.00680020073011","article-title":"Adamantinoma of the maxillary sinus","volume":"40","author":"Mosher WF","year":"1944","unstructured":"Mosher WF. Adamantinoma of the maxillary sinus. Arch Otolaryngol. 1944, 40:61-2. 10.1001\/archotol.1944.00680020073011","journal-title":"Arch Otolaryngol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/BF00364050","article-title":"Case report 506: adamantinoma of the soft tissues of leg","volume":"17","author":"Bertoni F","year":"1988","unstructured":"Bertoni F, Zucchi V, Mapelli S, Bacchini P. Case report 506: adamantinoma of the soft tissues of leg. Skeletal Radiol. 1988, 17:522-6. 10.1007\/BF00364050","journal-title":"Skeletal Radiol"},{"key":"ref16","article-title":"Adamantinoma of the soft tissue of the leg","volume":"107","author":"Bambirra EA","year":"1983","unstructured":"Bambirra EA, Nogueira AM, Miranda D. Adamantinoma of the soft tissue of the leg. Arch Pathol Lab Med. 1983, 107:500-1.","journal-title":"Arch Pathol Lab Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/83.1.108","article-title":"Adamantinoma of the pretibial soft tissue. Clinicopathologic features, differential diagnosis, and possible relationship to intraosseous disease","volume":"83","author":"Mills SE","year":"1985","unstructured":"Mills SE, Rosai J. Adamantinoma of the pretibial soft tissue. Clinicopathologic features, differential diagnosis, and possible relationship to intraosseous disease. Am J Clin Pathol. 1985, 83:108-14. 10.1093\/ajcp\/83.1.108","journal-title":"Am J Clin Pathol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.19.01056","article-title":"Surgical outcome and oncological survival of osteofibrous dysplasia-like and classic adamantinomas: an international multicenter study of 318 cases","volume":"102","author":"Schutgens EM","year":"2020","unstructured":"Schutgens EM, Picci P, Baumhoer D, et al.. Surgical outcome and oncological survival of osteofibrous dysplasia-like and classic adamantinomas: an international multicenter study of 318 cases. J Bone Joint Surg Am. 2020, 102:1703-13. 10.2106\/JBJS.19.01056","journal-title":"J Bone Joint Surg Am"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10330-012-0981-1","article-title":"Adamantinoma of the pelvic bone, a difficult diagnosis with fatal outcome","volume":"11","author":"Binesh F","year":"2012","unstructured":"Binesh F, Abrisham J, Sobhan M, et al.. Adamantinoma of the pelvic bone, a difficult diagnosis with fatal outcome. Chin Ger J Clin Oncol. 2012, 11:425-8. 10.1007\/s10330-012-0981-1","journal-title":"Chin Ger J Clin Oncol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s43465-020-00196-2","article-title":"Adamantinoma of pelvis: a rare tumor at an uncommon site, with diagnostic implications","volume":"55","author":"Virk JS","year":"2021","unstructured":"Virk JS, Pruthi M, Rekhi B, Pasricha S. Adamantinoma of pelvis: a rare tumor at an uncommon site, with diagnostic implications. Indian J Orthop. 2021, 55:261-6. 10.1007\/s43465-020-00196-2","journal-title":"Indian J Orthop"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.862243","article-title":"Rapidly progressive classic adamantinoma of the spine: case report and literature review","volume":"12","author":"Lou Y","year":"2022","unstructured":"Lou Y, Li Y, Xu L, et al.. Rapidly progressive classic adamantinoma of the spine: case report and literature review. Front Oncol. 2022, 12:862243. 10.3389\/fonc.2022.862243","journal-title":"Front Oncol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5493750","article-title":"Long-term follow-up of adamantinoma of the tibia complicated by metastases and a second unrelated primary cancer: a case report and literature review","volume":"2018","author":"Southam BR","year":"2018","unstructured":"Southam BR, Crawford AH, Billmire DA, Geller J, Von Allmen D, Schumaier AP, Szabo S. Long-term follow-up of adamantinoma of the tibia complicated by metastases and a second unrelated primary cancer: a case report and literature review. Case Rep Orthop. 2018, 2018:5493750. 10.1155\/2018\/5493750","journal-title":"Case Rep Orthop"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199312000-00003","article-title":"Adamantinoma of the long bones: keratin subclass immunoreactivity pattern with reference to its histogenesis","volume":"17","author":"Hazelbag HM","year":"1993","unstructured":"Hazelbag HM, Fleuren GJ, vd Broek LJ, Taminiau AH, Hogendoorn PC. Adamantinoma of the long bones: keratin subclass immunoreactivity pattern with reference to its histogenesis. Am J Surg Pathol. 1993, 17:1225-33. 10.1097\/00000478-199312000-00003","journal-title":"Am J Surg Pathol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-018-0115-6","article-title":"Genetic and molecular reappraisal of spindle cell adamantinoma of bone reveals a small subset of misclassified intraosseous synovial sarcoma","volume":"32","author":"Horvai A","year":"2019","unstructured":"Horvai A, Dashti NK, Rubin BP, et al.. Genetic and molecular reappraisal of spindle cell adamantinoma of bone reveals a small subset of misclassified intraosseous synovial sarcoma. Mod Pathol. 2019, 32:231-41. 10.1038\/s41379-018-0115-6","journal-title":"Mod Pathol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.14670\/HH-18-950","article-title":"Osteofibrous dysplasia (OFD) and adamantinoma: a comprehensive review and updates","volume":"41","author":"Jayan R","year":"2026","unstructured":"Jayan R, Rekhi B. Osteofibrous dysplasia (OFD) and adamantinoma: a comprehensive review and updates. Histol Histopathol. 2026, 41:11-23. 10.14670\/HH-18-950","journal-title":"Histol Histopathol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-241615","article-title":"Adamantinoma: metastatic disease masquerading as a gynaecological malignancy","volume":"14","author":"Smyth S","year":"2021","unstructured":"Smyth S, Addley S, Alazzam M, Soleymani Majd H. Adamantinoma: metastatic disease masquerading as a gynaecological malignancy. BMJ Case Rep. 2021, 14:e241615. 10.1136\/bcr-2021-241615","journal-title":"BMJ Case Rep"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000145","article-title":"Tibial adamantinoma: late metastasis to the brain","volume":"74","author":"Schowinsky JT","year":"2015","unstructured":"Schowinsky JT, Ormond DR, Kleinschmidt-DeMasters BK. Tibial adamantinoma: late metastasis to the brain. J Neuropathol Exp Neurol. 2015, 74:95-7. 10.1097\/NEN.0000000000000145","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1177\/230949901402200330","article-title":"Multiple recurrences and late metastasis of adamantinoma in the tibia: a case report","volume":"22","author":"Giannoulis DK","year":"2014","unstructured":"Giannoulis DK, Gantsos A, Giotis D, et al.. Multiple recurrences and late metastasis of adamantinoma in the tibia: a case report. J Orthop Surg (Hong Kong). 2014, 22:420-2. 10.1177\/230949901402200330","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200008000-00009","article-title":"Current trends in the management of adamantinoma of long bones. An international study","volume":"82","author":"Qureshi AA","year":"2000","unstructured":"Qureshi AA, Shott S, Mallin BA, Gitelis S. Current trends in the management of adamantinoma of long bones. An international study. J Bone Joint Surg Am. 2000, 82:1122-31. 10.2106\/00004623-200008000-00009","journal-title":"J Bone Joint Surg Am"},{"key":"ref30","article-title":"A case of liver and pulmonary metastases from adamantinoma, a bone tumor","volume":"42","author":"Kurata T","year":"2015","unstructured":"Kurata T, Tajima H, Obatake Y, et al.. A case of liver and pulmonary metastases from adamantinoma, a bone tumor. Cancer and ChemoTherapy. 2015, 42:1677-9.","journal-title":"Cancer and ChemoTherapy"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1053-x","article-title":"Free vascularized fibular graft reconstruction of large skeletal defects after tumor resection","volume":"468","author":"Eward WC","year":"2010","unstructured":"Eward WC, Kontogeorgakos V, Levin LS, Brigman BE. Free vascularized fibular graft reconstruction of large skeletal defects after tumor resection. Clin Orthop Relat Res. 2010, 468:590-8. 10.1007\/s11999-009-1053-x","journal-title":"Clin Orthop Relat Res"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjac165","article-title":"Adamantinoma of tibia: excision and reconstruction with free vascularized fibula flap: a case report and review of literature","volume":"2022","author":"Sahu SA","year":"2022","unstructured":"Sahu SA, Mishra JK, Kar BK, Manju R, De M. Adamantinoma of tibia: excision and reconstruction with free vascularized fibula flap: a case report and review of literature. J Surg Case Rep. 2022, 2022:rjac165. 10.1093\/jscr\/rjac165","journal-title":"J Surg Case Rep"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3656913","article-title":"Tibia adamantinoma resection and reconstruction with a custom-made total tibia endoprosthesis: a case report with 8-year follow-up","volume":"2018","author":"Kask G","year":"2018","unstructured":"Kask G, Pakarinen TK, Parkkinen J, Kuokkanen H, Nieminen J, Laitinen MK. Tibia adamantinoma resection and reconstruction with a custom-made total tibia endoprosthesis: a case report with 8-year follow-up. Case Rep Orthop. 2018, 2018:3656913. 10.1155\/2018\/3656913","journal-title":"Case Rep Orthop"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5563931","article-title":"Fibula-assisted segment Transport (FAST) for defect reconstruction after resection of tibial adamantinoma: report of two treatments","volume":"2021","author":"Rachbauer A","year":"2021","unstructured":"Rachbauer A, Laufer A, Gosheger G, et al.. Fibula-assisted segment Transport (FAST) for defect reconstruction after resection of tibial adamantinoma: report of two treatments. Case Rep Orthop. 2021, 2021:5563931. 10.1155\/2021\/5563931","journal-title":"Case Rep Orthop"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1177\/0300060518774992","article-title":"Bone transport for reconstruction of large bone defects after tibial tumor resection: a report of five cases","volume":"46","author":"Yang Z","year":"2018","unstructured":"Yang Z, Tao H, Ye Z, Jin L, Lin N, Yang D. Bone transport for reconstruction of large bone defects after tibial tumor resection: a report of five cases. J Int Med Res. 2018, 46:3219-25. 10.1177\/0300060518774992","journal-title":"J Int Med Res"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5982313","article-title":"A case of metastatic adamantinoma that responded well to sunitinib","volume":"2016","author":"Liman AD","year":"2016","unstructured":"Liman AD, Liman AK, Shields J, Englert B, Shah R. A case of metastatic adamantinoma that responded well to sunitinib. Case Rep Oncol Med. 2016, 2016:5982313. 10.1155\/2016\/5982313","journal-title":"Case Rep Oncol Med"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1007\/BF00439285","article-title":"A perplexing malignant bone tumor. Highly malignant so-called adamantinoma or non-typical Ewing's sarcoma","volume":"365","author":"van Haelst UJ","year":"1975","unstructured":"van Haelst UJ, de Haas van Dorsser AH. A perplexing malignant bone tumor. Highly malignant so-called adamantinoma or non-typical Ewing's sarcoma. Virchows Arch A Pathol Anat Histol. 1975, 365:63-74. 10.1007\/BF00439285","journal-title":"Virchows Arch A Pathol Anat Histol"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2013.770921","article-title":"A case of metastatic adamantinoma responding to treatment with pazopanib","volume":"52","author":"Cohen Y","year":"2013","unstructured":"Cohen Y, Cohen JE, Zick A, et al.. A case of metastatic adamantinoma responding to treatment with pazopanib. Acta Oncol. 2013, 52:1229-30. 10.3109\/0284186X.2013.770921","journal-title":"Acta Oncol"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199410000-00008","article-title":"Adamantinoma of the long bones. A clinicopathological study of thirty-two patients with emphasis on histological subtype, precursor lesion, and biological behavior","volume":"76","author":"Hazelbag HM","year":"1994","unstructured":"Hazelbag HM, Taminiau AH, Fleuren GJ, Hogendoorn PC. Adamantinoma of the long bones. A clinicopathological study of thirty-two patients with emphasis on histological subtype, precursor lesion, and biological behavior. J Bone Joint Surg Am. 1994, 76:1482-99. 10.2106\/00004623-199410000-00008","journal-title":"J Bone Joint Surg Am"},{"key":"ref40","doi-asserted-by":"crossref","DOI":"10.1097\/00000421-199404000-00013","article-title":"Metastatic adamantinoma of bone to lung. A case report of the natural history and the use of chemotherapy and radiation therapy","volume":"17","author":"Lokich J","year":"1994","unstructured":"Lokich J. Metastatic adamantinoma of bone to lung. A case report of the natural history and the use of chemotherapy and radiation therapy. Am J Clin Oncol. 1994, 17:157-9.","journal-title":"Am J Clin Oncol"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3109\/02841860902913579","article-title":"Metastatic adamantinoma responds to treatment with receptor tyrosine kinase inhibitor","volume":"49","author":"Dudek AZ","year":"2010","unstructured":"Dudek AZ, Murthaiah PK, Franklin M, Truskinovsky AM. Metastatic adamantinoma responds to treatment with receptor tyrosine kinase inhibitor. Acta Oncol. 2010, 49:101-4. 10.3109\/02841860902913579","journal-title":"Acta Oncol"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2809647","article-title":"Epidemiological study of adamantinoma from US Surveillance, Epidemiology, and End Results Program: III retrospective analysis","volume":"2020","author":"Aytekin MN","year":"2020","unstructured":"Aytekin MN, \u00d6zt\u00fcrk R, Amer K. Epidemiological study of adamantinoma from US Surveillance, Epidemiology, and End Results Program: III retrospective analysis. J Oncol. 2020, 2020:2809647. 10.1155\/2020\/2809647","journal-title":"J Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/516741-management-of-tibial-adamantinoma-balancing-oncologic-cure-and-reconstructive-longevity","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T19:12:22Z","timestamp":1785697942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/516741-management-of-tibial-adamantinoma-balancing-oncologic-cure-and-reconstructive-longevity"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,1]]},"references-count":42,"URL":"https:\/\/doi.org\/10.7759\/cureus.113794","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,1]]}}}