{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T18:43:47Z","timestamp":1785869027844,"version":"3.56.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"DOI":"10.7759\/cureus.113954","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:45:47Z","timestamp":1785865547000},"source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Psychotropic Agents on Sick Sinus Syndrome: A Case Report"],"prefix":"10.7759","author":[{"given":"Lynn","family":"Fadel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansar","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhakar","family":"Pemminati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"Sinus node dysfunction","volume":"104","author":"Hawks MK","year":"2021","unstructured":"Hawks MK, Paul ML, Malu OO. Sinus node dysfunction. Am Fam Physician. 2021, 104:179-85.","journal-title":"Am Fam Physician"},{"key":"ref2","article-title":"Diagnosis and management of common types of supraventricular tachycardia","volume":"92","author":"Helton MR","year":"2015","unstructured":"Helton MR. Diagnosis and management of common types of supraventricular tachycardia. Am Fam Physician. 2015, 92:793-800.","journal-title":"Am Fam Physician"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0076","article-title":"Diagnosis and management of paroxysmal supraventricular tachycardia","volume":"331","author":"Peng G","year":"2024","unstructured":"Peng G, Zei PC. Diagnosis and management of paroxysmal supraventricular tachycardia. JAMA. 2024, 331:601-10. 10.1001\/jama.2024.0076","journal-title":"JAMA"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2305655","article-title":"Management of insomnia","volume":"391","author":"Morin CM","year":"2024","unstructured":"Morin CM, Buysse DJ. Management of insomnia. N Engl J Med. 2024, 391:247-58. 10.1056\/NEJMcp2305655","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1490585","article-title":"Pharmacological and psychological approaches to insomnia treatment in cardiac patients: a narrative literature review","volume":"16","author":"Stapel B","year":"2025","unstructured":"Stapel B, Alvarenga ME, Kahl KG. Pharmacological and psychological approaches to insomnia treatment in cardiac patients: a narrative literature review. Front Psychiatry. 2025, 16:1490585. 10.3389\/fpsyt.2025.1490585","journal-title":"Front Psychiatry"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.043","article-title":"2018 ACC\/AHA\/HRS Guideline on the\u00a0Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society","volume":"74","author":"Kusumoto FM","year":"2019","unstructured":"Kusumoto FM, Schoenfeld MH, Barrett C, et al.. 2018 ACC\/AHA\/HRS Guideline on the\u00a0Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society. J Am Coll Cardiol. 2019, 74:932-87. 10.1016\/j.jacc.2018.10.043","journal-title":"J Am Coll Cardiol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/2045125313510194","article-title":"Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports","volume":"4","author":"Hasnain M","year":"2014","unstructured":"Hasnain M, Vieweg WV, Howland RH, et al.. Quetiapine, QTc interval prolongation, and torsade de pointes: a review of case reports. Ther Adv Psychopharmacol. 2014, 4:130-8. 10.1177\/2045125313510194","journal-title":"Ther Adv Psychopharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000311","article-title":"2015 ACC\/AHA\/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"133","author":"Page RL","year":"2016","unstructured":"Page RL, Joglar JA, Caldwell MA, et al.. 2015 ACC\/AHA\/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation. 2016, 133:e506-74. 10.1161\/CIR.0000000000000311","journal-title":"Circulation"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.309","article-title":"Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug","volume":"5","author":"Schlit AF","year":"2017","unstructured":"Schlit AF, Delaunois A, Colomar A, et al.. Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug. Pharmacol Res Perspect. 2017, 5:e00309. 10.1002\/prp2.309","journal-title":"Pharmacol Res Perspect"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.7382-21","article-title":"Hydroxyzine-induced torsade de pointes in a patient with complete atrioventricular block","volume":"60","author":"Koshino K","year":"2021","unstructured":"Koshino K, Endo A, Watanabe N, Okazaki K, Tanabe K. Hydroxyzine-induced torsade de pointes in a patient with complete atrioventricular block. Intern Med. 2021, 60:3257-60. 10.2169\/internalmedicine.7382-21","journal-title":"Intern Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.dmd.2025.100070","article-title":"The strong clinical interaction between bupropion and CYP2D6 is primarily mediated through bupropion metabolites and their stereoisomers: a paradigm for evaluating metabolites in drug-drug interaction risk","volume":"53","author":"Tanaudommongkon I","year":"2025","unstructured":"Tanaudommongkon I, Rashidian A, Gufford BT, Lu JB, Desta Z. The strong clinical interaction between bupropion and CYP2D6 is primarily mediated through bupropion metabolites and their stereoisomers: a paradigm for evaluating metabolites in drug-drug interaction risk. Drug Metab Dispos. 2025, 53:100070. 10.1016\/j.dmd.2025.100070","journal-title":"Drug Metab Dispos"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1637471","article-title":"Arrhythmic events pertinent with antidepressants: a Bayesian disproportional analysis mining the FDA Adverse Event Reporting System database","volume":"16","author":"Cao S","year":"2025","unstructured":"Cao S, Huang Z, Yang W, Yang S, Chen X, Xie X. Arrhythmic events pertinent with antidepressants: a Bayesian disproportional analysis mining the FDA Adverse Event Reporting System database. Front Psychiatry. 2025, 16:1637471. 10.3389\/fpsyt.2025.1637471","journal-title":"Front Psychiatry"},{"key":"ref13","unstructured":"DailyMed. Label. Mirtazapine tablet, film coated. (2023). Accessed: June 12, 2026: https:\/\/dailymed.nlm.nih.gov\/dailymed\/drugInfo.cfm?setid=8b2a08f7-4803-42fa-a2b5-5ea51f8ef7e4#LINK_f005e9e1-a2fc-4d56...."},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.03.458","article-title":"Psychopharmacology and cardiovascular\u00a0disease","volume":"71","author":"Pi\u00f1a IL","year":"2018","unstructured":"Pi\u00f1a IL, Di Palo KE, Ventura HO. Psychopharmacology and cardiovascular\u00a0disease. J Am Coll Cardiol. 2018, 71:2346-59. 10.1016\/j.jacc.2018.03.458","journal-title":"J Am Coll Cardiol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2165\/00139709-200524030-00013","article-title":"Tricyclic antidepressant poisoning: cardiovascular toxicity","volume":"24","author":"Thanacoody HK","year":"2005","unstructured":"Thanacoody HK, Thomas SH. Tricyclic antidepressant poisoning: cardiovascular toxicity. Toxicol Rev. 2005, 24:205-14. 10.2165\/00139709-200524030-00013","journal-title":"Toxicol Rev"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2014.09.002","article-title":"Citalopram, QTc prolongation, and torsades de pointes","volume":"56","author":"Tampi RR","year":"2015","unstructured":"Tampi RR, Balderas M, Carter KV, Tampi DJ, Moca M, Knudsen A, May J. Citalopram, QTc prolongation, and torsades de pointes. Psychosomatics. 2015, 56:36-43. 10.1016\/j.psym.2014.09.002","journal-title":"Psychosomatics"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.121.007955","article-title":"Drug interactions affecting antiarrhythmic drug use","volume":"15","author":"Mar PL","year":"2022","unstructured":"Mar PL, Horbal P, Chung MK, et al.. Drug interactions affecting antiarrhythmic drug use. Circ Arrhythm Electrophysiol. 2022, 15:e007955. 10.1161\/CIRCEP.121.007955","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.47102\/annals-acadmedsg.V30N6p625","article-title":"Cardiac effects of psychotropic drugs","volume":"30","author":"Chong SA","year":"2001","unstructured":"Chong SA, Mythily, Mahendran R. Cardiac effects of psychotropic drugs. Ann Acad Med Singap. 2001, 30:625-31.","journal-title":"Ann Acad Med Singap"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0003319718780145","article-title":"Cardiovascular safety of psychiatric agents: a cautionary tale","volume":"70","author":"Manolis TA","year":"2019","unstructured":"Manolis TA, Manolis AA, Manolis AS. Cardiovascular safety of psychiatric agents: a cautionary tale. Angiology. 2019, 70:103-29. 10.1177\/0003319718780145","journal-title":"Angiology"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/507549-the-effect-of-psychotropic-agents-on-sick-sinus-syndrome-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:45:49Z","timestamp":1785865549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/507549-the-effect-of-psychotropic-agents-on-sick-sinus-syndrome-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.113954","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,4]]}}}