{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:41:05Z","timestamp":1786293665766,"version":"build-2736575974"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,9]]},"DOI":"10.7759\/cureus.114209","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T15:42:42Z","timestamp":1786290162000},"source":"Crossref","is-referenced-by-count":0,"title":["Enterococcus faecalis Endocarditis as a Diagnostic Clue to Occult Rectal Cancer: A Two-Case Series"],"prefix":"10.7759","author":[{"given":"Hiba","family":"Rizkou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joumana","family":"Elmasrioui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihane","family":"Rizkou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadija","family":"Krati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"El Hattaoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2174\/1874285801711010001","article-title":"Virulence factors associated with Enterococcus faecalis infective endocarditis: a mini review","volume":"11","author":"Madsen KT","year":"2017","unstructured":"Madsen KT, Skov MN, Gill S, Kemp M. Virulence factors associated with Enterococcus faecalis infective endocarditis: a mini review. Open Microbiol J. 2017, 11:1-11. 10.2174\/1874285801711010001","journal-title":"Open Microbiol J"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 ESC Guidelines for the management of endocarditis","volume":"44","author":"Delgado V","year":"2023","unstructured":"Delgado V, Ajmone Marsan N, de Waha S, et al.. 2023 ESC Guidelines for the management of endocarditis. Eur Heart J. 2023, 44:3948-4042. 10.1093\/eurheartj\/ehad193","journal-title":"Eur Heart J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12166","article-title":"Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis-Prospective Cohort Study","volume":"19","author":"Chirouze C","year":"2013","unstructured":"Chirouze C, Athan E, Alla F, et al.. Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis-Prospective Cohort Study. Clin Microbiol Infect. 2013, 19:1140-7. 10.1111\/1469-0691.12166","journal-title":"Clin Microbiol Infect"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.047","article-title":"A contemporary picture of enterococcal endocarditis","volume":"75","author":"Peric\u00e0s JM","year":"2020","unstructured":"Peric\u00e0s JM, Llopis J, Mu\u00f1oz P, et al.. A contemporary picture of enterococcal endocarditis. J Am Coll Cardiol. 2020, 75:482-94. 10.1016\/j.jacc.2019.11.047","journal-title":"J Am Coll Cardiol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2016.10.013","article-title":"Relationship between Enterococcus faecalis infective endocarditis and colorectal neoplasm: preliminary results from a cohort of 154 patients","volume":"70","author":"Peric\u00e0s JM","year":"2017","unstructured":"Peric\u00e0s JM, Corredoira J, Moreno A, et al.. Relationship between Enterococcus faecalis infective endocarditis and colorectal neoplasm: preliminary results from a cohort of 154 patients. Rev Esp Cardiol (Engl Ed). 2017, 70:451-8. 10.1016\/j.rec.2016.10.013","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2019.07.007","article-title":"Prevalence of colorectal disease in Enterococcus faecalis infective endocarditis: results of an observational multicenter study","volume":"73","author":"Escol\u00e0-Verg\u00e9 L","year":"2020","unstructured":"Escol\u00e0-Verg\u00e9 L, Peghin M, Givone F, et al.. Prevalence of colorectal disease in Enterococcus faecalis infective endocarditis: results of an observational multicenter study. Rev Esp Cardiol (Engl Ed). 2020, 73:711-7. 10.1016\/j.rec.2019.07.007","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.06.056","article-title":"Prevalence of colorectal neoplasms among patients with Enterococcus faecalis endocarditis in the GAMES cohort (2008-2017)","volume":"96","author":"Peric\u00e0s JM","year":"2021","unstructured":"Peric\u00e0s JM, Ambrosioni J, Mu\u00f1oz P, et al.. Prevalence of colorectal neoplasms among patients with Enterococcus faecalis endocarditis in the GAMES cohort (2008-2017). Mayo Clin Proc. 2021, 96:132-46. 10.1016\/j.mayocp.2020.06.056","journal-title":"Mayo Clin Proc"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2025.106644","article-title":"Prevalence of colorectal cancer in patients with Enterococcus faecalis blood stream infection: a nationwide study","volume":"91","author":"\u00d8stergaard L","year":"2025","unstructured":"\u00d8stergaard L, Dahl A, Chamat-Hedemand S, et al.. Prevalence of colorectal cancer in patients with Enterococcus faecalis blood stream infection: a nationwide study. J Infect. 2025, 91:106644. 10.1016\/j.jinf.2025.106644","journal-title":"J Infect"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.55096","article-title":"Enterococcus faecalis infective endocarditis associated with colorectal cancer","volume":"16","author":"Alziyadi A","year":"2024","unstructured":"Alziyadi A, Al Adwani M, Abdulaziz H, Aloufi R, Althagafi A, Alsulaimani A, Alotaibi A. Enterococcus faecalis infective endocarditis associated with colorectal cancer. Cureus. 2024, 16:e55096. 10.7759\/cureus.55096","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.14740\/gr996w","article-title":"Enterococcus faecalis infective endocarditis and colorectal carcinoma: case of new association gaining ground","volume":"11","author":"Khan Z","year":"2018","unstructured":"Khan Z, Siddiqui N, Saif MW. Enterococcus faecalis infective endocarditis and colorectal carcinoma: case of new association gaining ground. Gastroenterology Res. 2018, 11:238-40. 10.14740\/gr996w","journal-title":"Gastroenterology Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/23.3.529","article-title":"Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA","volume":"23","author":"Huycke MM","year":"2002","unstructured":"Huycke MM, Abrams V, Moore DR. Enterococcus faecalis produces extracellular superoxide and hydrogen peroxide that damages colonic epithelial cell DNA. Carcinogenesis. 2002, 23:529-36. 10.1093\/carcin\/23.3.529","journal-title":"Carcinogenesis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1551","article-title":"Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect","volume":"68","author":"Wang X","year":"2008","unstructured":"Wang X, Allen TD, May RJ, Lightfoot S, Houchen CW, Huycke MM. Enterococcus faecalis induces aneuploidy and tetraploidy in colonic epithelial cells through a bystander effect. Cancer Res. 2008, 68:9909-17. 10.1158\/0008-5472.CAN-08-1551","journal-title":"Cancer Res"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir609","article-title":"Clinical Importance of Streptococcus gallolyticus infection among colorectal cancer patients: systematic review and meta-analysis","volume":"53","author":"Boleij A","year":"2011","unstructured":"Boleij A, van Gelder MM, Swinkels DW, Tjalsma H. Clinical Importance of Streptococcus gallolyticus infection among colorectal cancer patients: systematic review and meta-analysis. Clin Infect Dis. 2011, 53:870-8. 10.1093\/cid\/cir609","journal-title":"Clin Infect Dis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/520888-enterococcus-faecalis-endocarditis-as-a-diagnostic-clue-to-occult-rectal-cancer-a-two-case-series","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T15:42:43Z","timestamp":1786290163000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/520888-enterococcus-faecalis-endocarditis-as-a-diagnostic-clue-to-occult-rectal-cancer-a-two-case-series"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,9]]},"references-count":13,"URL":"https:\/\/doi.org\/10.7759\/cureus.114209","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,9]]}}}