{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:41:54Z","timestamp":1786297314509,"version":"build-2736575974"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,9]]},"DOI":"10.7759\/cureus.114216","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:13:50Z","timestamp":1786295630000},"source":"Crossref","is-referenced-by-count":0,"title":["A Case Report of Acquired Hepatocerebral Degeneration Mimicking Parkinson\u2019s Disease in Presumed Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)-Related Cirrhosis"],"prefix":"10.7759","author":[{"given":"Fahmida","family":"Tithi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arundhathy","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazia Binte","family":"Salam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Pedro","family":"Simon-Turriate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870100604","article-title":"Chronic acquired hepatocerebral degeneration: case reports and new insights","volume":"10","author":"Jog MS","year":"1995","unstructured":"Jog MS, Lang AE. Chronic acquired hepatocerebral degeneration: case reports and new insights. Mov Disord. 1995, 10:714-22. 10.1002\/mds.870100604","journal-title":"Mov Disord"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02109357","article-title":"Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy","volume":"10","author":"Butterworth RF","year":"1995","unstructured":"Butterworth RF, Spahr L, Fontaine S, Layrargues GP. Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy. Metab Brain Dis. 1995, 10:259-67. 10.1007\/BF02109357","journal-title":"Metab Brain Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360611","article-title":"Manganese intoxication and chronic liver failure","volume":"36","author":"Hauser RA","year":"1994","unstructured":"Hauser RA, Zesiewicz TA, Rosemurgy AS, Martinez C, Olanow CW. Manganese intoxication and chronic liver failure. Ann Neurol. 1994, 36:871-5. 10.1002\/ana.410360611","journal-title":"Ann Neurol"},{"key":"ref4","article-title":"La cirrhose h\u00e9patique avec alt\u00e9rations dans les centres nerveux \u00e9voluant chez des sujets d'\u00e2ge moyen [Hepatic cirrhosis with alterations in the nervous centres developing in middle-aged subjects]","volume":"27","author":"Van Woerkom W","year":"1914","unstructured":"Van Woerkom W. La cirrhose h\u00e9patique avec alt\u00e9rations dans les centres nerveux \u00e9voluant chez des sujets d'\u00e2ge moyen [Hepatic cirrhosis with alterations in the nervous centres developing in middle-aged subjects]. Nouv Iconogr Salp\u00eatri\u00e8re. 1914, 27:41-5.","journal-title":"Nouv Iconogr Salp\u00eatri\u00e8re"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196509000-00001","article-title":"The acquired (non-Wilsonian) type of chronic hepatocerebral degeneration","volume":"44","author":"Victor M","year":"1965","unstructured":"Victor M, Adams RD, Cole M. The acquired (non-Wilsonian) type of chronic hepatocerebral degeneration. Medicine (Baltimore). 1965, 44:345-96. 10.1097\/00005792-196509000-00001","journal-title":"Medicine (Baltimore)"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03076.x","article-title":"Acquired hepatocerebral degeneration: clinical characteristics and MRI findings","volume":"17","author":"Fern\u00e1ndez-Rodriguez R","year":"2010","unstructured":"Fern\u00e1ndez-Rodriguez R, Contreras A, De Villoria JG, Grandas F. Acquired hepatocerebral degeneration: clinical characteristics and MRI findings. Eur J Neurol. 2010, 17:1463-70. 10.1111\/j.1468-1331.2010.03076.x","journal-title":"Eur J Neurol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800600817","article-title":"Transection of the oesophagus for bleeding oesophageal varices","volume":"60","author":"Pugh RN","year":"1973","unstructured":"Pugh RN, Lyon MM, Dawson JL, et al.. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg. 1973, 60:646-9. 10.1002\/bjs.1800600817","journal-title":"Br J Surg"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801209","article-title":"Hyponatremia and mortality among patients on the liver-transplant waiting list","volume":"359","author":"Kim WR","year":"2008","unstructured":"Kim WR, Biggins SW, Kremers WK, et al.. Hyponatremia and mortality among patients on the liver-transplant waiting list. NEJM. 2008, 359:1018-26. 10.1056\/NEJMoa0801209","journal-title":"NEJM"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27210","article-title":"Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver","volume":"60","author":"Wong P","year":"2014","unstructured":"Wong P, Weissenborn K, Mullen K, et al.. Hepatic encephalopathy in chronic liver disease: 2014 Practice Guideline by the American Association for the Study Of Liver Diseases and the European Association for the Study of the Liver. AASLD Practice Guideline. 2014, 60:715-35. 10.1002\/hep.27210","journal-title":"AASLD Practice Guideline"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2014.02.004","article-title":"Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure","volume":"5","author":"Butterworth RF","year":"2015","unstructured":"Butterworth RF. Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure. J Clin Exp Hepatol. 2015, 5:S96-S103. 10.1016\/j.jceh.2014.02.004","journal-title":"J Clin Exp Hepatol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2007.131045","article-title":"Parkinson\u2019s disease: clinical features and diagnosis","volume":"79","author":"Jankovic J","year":"2008","unstructured":"Jankovic J. Parkinson\u2019s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008, 79:368-76. 10.1136\/jnnp.2007.131045","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/JOMM.JOMM_6_23","article-title":"Spectrum of movement disorders in liver disease: a case series","volume":"1","author":"Kumar SR","year":"2023","unstructured":"Kumar SR, Himanshu K, Jatin J, et al.. Spectrum of movement disorders in liver disease: a case series. J Mod Med. 2023, 1:34-8. 10.4103\/JOMM.JOMM_6_23","journal-title":"J Mod Med"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22261","article-title":"Diagnosis and treatment of Wilson disease: an update","volume":"47","author":"Roberts EA","year":"2008","unstructured":"Roberts EA, Schilsky ML. Diagnosis and treatment of Wilson disease: an update. Hepatology. 2008, 47:2089-111. 10.1002\/hep.22261","journal-title":"Hepatology"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-018-1018-z","article-title":"Hepatic encephalopathy: definition, clinical grading and diagnostic principles","volume":"79","author":"Weissenborn K","year":"2019","unstructured":"Weissenborn K. Hepatic encephalopathy: definition, clinical grading and diagnostic principles. Drugs. 2019, 79:5-9. 10.1007\/s40265-018-1018-z","journal-title":"Drugs"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi ZM","year":"2016","unstructured":"Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016, 64:73-84. 10.1002\/hep.28431","journal-title":"Hepatology"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.60.4.521","article-title":"Chronic parkinsonism associated with cirrhosis: a distinct subset of acquired hepatocerebral degeneration","volume":"60","author":"Burkhard PR","year":"2003","unstructured":"Burkhard PR, Delavelle J, Du Pasquier R, Spahr L. Chronic parkinsonism associated with cirrhosis: a distinct subset of acquired hepatocerebral degeneration. Arch Neurol. 2003, 60:521-8. 10.1001\/archneur.60.4.521","journal-title":"Arch Neurol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0016-5085(99)70457-9","article-title":"Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction","volume":"117","author":"Rose C","year":"1999","unstructured":"Rose C, Butterworth RF, Zayed J, et al.. Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction. Gastroenterology. 1999, 117:604-40. 10.1016\/s0016-5085(99)70457-9","journal-title":"Gastroenterology"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510240523","article-title":"Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms","volume":"24","author":"Spahr L","year":"1996","unstructured":"Spahr L, Butterworth RF, Fontaine S, et al.. Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms. Hepatology. 1996, 24:1116-20. 10.1002\/hep.510240523","journal-title":"Hepatology"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.1016\/0016-5085(90)90036-Z","article-title":"Improvement in chronic hepatocerebral degeneration following liver transplantation","volume":"98","author":"Powell EE","year":"1990","unstructured":"Powell EE, Pender MP, Chalk JB, et al.. Improvement in chronic hepatocerebral degeneration following liver transplantation. Gastroenterology. 1990, 98:1079-82.","journal-title":"Gastroenterology"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/496296-a-case-report-of-acquired-hepatocerebral-degeneration-mimicking-parkinsons-disease-in-presumed-metabolic-dysfunction-associated-steatotic-liver-disease-masld-related-cirrhosis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:13:51Z","timestamp":1786295631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/496296-a-case-report-of-acquired-hepatocerebral-degeneration-mimicking-parkinsons-disease-in-presumed-metabolic-dysfunction-associated-steatotic-liver-disease-masld-related-cirrhosis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,9]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.114216","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,9]]}}}