{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:29:06Z","timestamp":1786415346608,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,10]]},"DOI":"10.7759\/cureus.114308","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T01:47:42Z","timestamp":1786412862000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparison Between High-Flow Nasal Cannula (HFNC) Therapy and Noninvasive Ventilation (NIV) in Children With Bronchiolitis-Associated Acute Respiratory Failure: A Systematic Review and Meta-Analysis"],"prefix":"10.7759","author":[{"given":"Zeinh H","family":"Fardan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assraf","family":"Abu Ayish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifal H","family":"AlQahtani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor M","family":"Naser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noura","family":"Alali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliyah","family":"Aldabli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atheer A","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sama","family":"Alghayyadh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manar N","family":"Alahmri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar K","family":"Bakhsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Alaslani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab A","family":"Almarzooq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayar A","family":"Abduljawad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halah","family":"Alasiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayah M","family":"Banaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.70396","article-title":"High-flow oxygen therapy vs. continuous positive airway pressure in hospitalised bronchiolitis: a meta-analysis","volume":"115","author":"Laiho P","year":"2026","unstructured":"Laiho P, Palmu S, Lauhkonen E, Korppi M, Heikkil\u00e4 P. High-flow oxygen therapy vs. continuous positive airway pressure in hospitalised bronchiolitis: a meta-analysis. Acta Paediatr. 2026, 115:527-35. 10.1111\/apa.70396","journal-title":"Acta Paediatr"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2018-315846","article-title":"High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis","volume":"104","author":"Lin J","year":"2019","unstructured":"Lin J, Zhang Y, Xiong L, Liu S, Gong C, Dai J. High-flow nasal cannula therapy for children with bronchiolitis: a systematic review and meta-analysis. Arch Dis Child. 2019, 104:564-76. 10.1136\/archdischild-2018-315846","journal-title":"Arch Dis Child"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD009609.pub3","article-title":"High-flow nasal cannula therapy for infants with bronchiolitis","volume":"3","author":"Armarego M","year":"2024","unstructured":"Armarego M, Forde H, Wills K, Beggs SA. High-flow nasal cannula therapy for infants with bronchiolitis. Cochrane Database Syst Rev. 2024, 3:009609. 10.1002\/14651858.CD009609.pub3","journal-title":"Cochrane Database Syst Rev"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.medin.2020.09.008","article-title":"Continuous positive airway pressure vs. high flow nasal cannula in children with acute severe or moderate bronchiolitis. A systematic review and meta-analysis","volume":"0210-5691","author":"Cata\u00f1o-Jaramillo ML","year":"2020","unstructured":"Cata\u00f1o-Jaramillo ML, Jaramillo-Bustamante JC, Florez ID. Continuous positive airway pressure vs. high flow nasal cannula in children with acute severe or moderate bronchiolitis. A systematic review and meta-analysis. Med Intensiva (Engl Ed). 2020, 0210-5691:30324-7. 10.1016\/j.medin.2020.09.008","journal-title":"Med Intensiva (Engl Ed)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2024.05.004","article-title":"Effectiveness of high flow nasal Cannula (HFNC) therapy compared to standard oxygen therapy (SOT) and continuous positive airway pressure (CPAP) in bronchiolitis","volume":"52","author":"Alexander EC","year":"2024","unstructured":"Alexander EC, Wadia T, Ramnarayan P. Effectiveness of high flow nasal Cannula (HFNC) therapy compared to standard oxygen therapy (SOT) and continuous positive airway pressure (CPAP) in bronchiolitis. Paediatr Respir Rev. 2024, 52:3-8. 10.1016\/j.prrv.2024.05.004","journal-title":"Paediatr Respir Rev"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2020-000844","article-title":"Efficacy and safety of high flow nasal oxygen for children with bronchiolitis: systematic review and meta-analysis","volume":"8","author":"Dafydd C","year":"2021","unstructured":"Dafydd C, Saunders BJ, Kotecha SJ, Edwards MO. Efficacy and safety of high flow nasal oxygen for children with bronchiolitis: systematic review and meta-analysis. BMJ Open Respir Res. 2021, 8:000844. 10.1136\/bmjresp-2020-000844","journal-title":"BMJ Open Respir Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001800","article-title":"Noninvasive high flow versus noninvasive positive pressure in children with severe bronchiolitis: the battle of the PICU continues","volume":"20","author":"Bem RA","year":"2019","unstructured":"Bem RA. Noninvasive high flow versus noninvasive positive pressure in children with severe bronchiolitis: the battle of the PICU continues. Pediatr Crit Care Med. 2019, 20:192-3. 10.1097\/PCC.0000000000001800","journal-title":"Pediatr Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.947667","article-title":"Comparison of high flow nasal cannula and non-invasive positive pressure ventilation in children with bronchiolitis: a meta-analysis of randomized controlled trials","volume":"10","author":"Zhong Z","year":"2022","unstructured":"Zhong Z, Zhao L, Zhao Y, Xia S. Comparison of high flow nasal cannula and non-invasive positive pressure ventilation in children with bronchiolitis: a meta-analysis of randomized controlled trials. Front Pediatr. 2022, 10:947667. 10.3389\/fped.2022.947667","journal-title":"Front Pediatr"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.81826","article-title":"Comparative efficacy of continuous positive airway pressure versus high-flow nasal cannula therapy in children with acute bronchiolitis: a systematic review and meta-analysis","volume":"17","author":"Barot KS","year":"2025","unstructured":"Barot KS, Adusumilli A, Fathema T, et al.. Comparative efficacy of continuous positive airway pressure versus high-flow nasal cannula therapy in children with acute bronchiolitis: a systematic review and meta-analysis. Cureus. 2025, 17:81826. 10.7759\/cureus.81826","journal-title":"Cureus"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.22399\/ijcesen.4422","article-title":"Comparison of high-flow nasal cannula versus continuous positive airway pressure in the management of bronchiolitis: a systematic review of randomized controlled trials","volume":"11","author":"Fadl AA","year":"2025","unstructured":"Fadl AA, Alobaidi RH, Gazzaz RY, Ashgan BA, Slaghour RM. Comparison of high-flow nasal cannula versus continuous positive airway pressure in the management of bronchiolitis: a systematic review of randomized controlled trials. Int J Comput Exp Sci Eng. 2025, 11:9312-21. 10.22399\/ijcesen.4422","journal-title":"Int J Comput Exp Sci Eng"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.26142","article-title":"Systematic review and cost-utility of high flow nasal cannula versus continuous positive airway pressure in children with acute severe or moderate bronchiolitis in Colombia","volume":"57","author":"Buend\u00eda JA","year":"2022","unstructured":"Buend\u00eda JA, Feliciano-Alfonso JE, Florez ID. Systematic review and cost-utility of high flow nasal cannula versus continuous positive airway pressure in children with acute severe or moderate bronchiolitis in Colombia. Pediatr Pulmonol. 2022, 57:3111-8. 10.1002\/ppul.26142","journal-title":"Pediatr Pulmonol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.11613\/bm.2012.031","article-title":"Interrater reliability: the kappa statistic","volume":"22","author":"McHugh ML","year":"2012","unstructured":"McHugh ML. Interrater reliability: the kappa statistic. Biochem Med (Zagreb). 2012, 22:276-82. 10.11613\/bm.2012.031","journal-title":"Biochem Med (Zagreb)"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref15","unstructured":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. (2014). https.\/\/ohri.ca\/en\/who-we-are\/core-facilities-and-platforms\/ottawa-methods-centre\/newcastle-ottawa-scale."},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136\/ebmental-2019-300117","article-title":"How to perform a meta-analysis with R: a practical tutorial","volume":"22","author":"Balduzzi S","year":"2019","unstructured":"Balduzzi S, R\u00fccker G, Schwarzer G. How to perform a meta-analysis with R: a practical tutorial. Evid Based Ment Health. 2019, 22:153-60. 10.1136\/ebmental-2019-300117","journal-title":"Evid Based Ment Health"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range","volume":"14","author":"Wan X","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol. 2014, 14:135. 10.1186\/1471-2288-14-135","journal-title":"BMC Med Res Methodol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1164","article-title":"Methods to estimate the between-study variance and its uncertainty in meta-analysis","volume":"7","author":"Veroniki AA","year":"2016","unstructured":"Veroniki AA, Jackson D, Viechtbauer W, et al.. Methods to estimate the between-study variance and its uncertainty in meta-analysis. Res Synth Methods. 2016, 7:55-79. 10.1002\/jrsm.1164","journal-title":"Res Synth Methods"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010247","article-title":"Plea for routinely presenting prediction intervals in meta-analysis","volume":"6","author":"IntHout J","year":"2016","unstructured":"IntHout J, Ioannidis JP, Rovers MM, Goeman JJ. Plea for routinely presenting prediction intervals in meta-analysis. BMJ Open. 2016, 6:010247. 10.1136\/bmjopen-2015-010247","journal-title":"BMJ Open"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger M","year":"1997","unstructured":"Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997, 315:629-34. 10.1136\/bmj.315.7109.629","journal-title":"BMJ"},{"key":"ref21","article-title":"Operating characteristics of a rank correlation test for publication bias","volume":"50","author":"Begg CB","year":"1994","unstructured":"Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994, 50:1088-101.","journal-title":"Biometrics"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.317.7168.1309","article-title":"Confidence intervals for the number needed to treat","volume":"317","author":"Altman DG","year":"1998","unstructured":"Altman DG. Confidence intervals for the number needed to treat. BMJ. 1998, 317:1309-12. 10.1136\/bmj.317.7168.1309","journal-title":"BMJ"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt GH","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Sch\u00fcnemann HJ. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008, 336:924-6. 10.1136\/bmj.39489.470347.AD","journal-title":"BMJ"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/children4040028","article-title":"Comparison of CPAP and HFNC in management of bronchiolitis in infants and young children","volume":"4","author":"Pedersen MB","year":"2017","unstructured":"Pedersen MB, Vahlkvist S. Comparison of CPAP and HFNC in management of bronchiolitis in infants and young children. Children (Basel). 2017, 4:28. 10.3390\/children4040028","journal-title":"Children (Basel)"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000003521","article-title":"High-flow nasal cannula versus nasal prong bubble continuous positive airway pressure in children with moderate to severe acute bronchiolitis: a randomized controlled trial","volume":"25","author":"Maya M","year":"2024","unstructured":"Maya M, Rameshkumar R, Selvan T, Delhikumar CG. High-flow nasal cannula versus nasal prong bubble continuous positive airway pressure in children with moderate to severe acute bronchiolitis: a randomized controlled trial. Pediatr Crit Care Med. 2024, 25:748-57. 10.1097\/PCC.0000000000003521","journal-title":"Pediatr Crit Care Med"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-014-2275-9","article-title":"Comparison of a high-flow humidified nasal cannula to nasal continuous positive airway pressure in children with acute bronchiolitis: experience in a pediatric intensive care unit","volume":"173","author":"Metge P","year":"2014","unstructured":"Metge P, Grimaldi C, Hassid S, Thomachot L, Loundou A, Martin C, Michel F. Comparison of a high-flow humidified nasal cannula to nasal continuous positive airway pressure in children with acute bronchiolitis: experience in a pediatric intensive care unit. Eur J Pediatr. 2014, 173:953-8. 10.1007\/s00431-014-2275-9","journal-title":"Eur J Pediatr"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001798","article-title":"Outcomes of children with bronchiolitis treated with high-flow nasal cannula or noninvasive positive pressure ventilation","volume":"20","author":"Clayton JA","year":"2019","unstructured":"Clayton JA, McKee B, Slain KN, Rotta AT, Shein SL. Outcomes of children with bronchiolitis treated with high-flow nasal cannula or noninvasive positive pressure ventilation. Pediatr Crit Care Med. 2019, 20:128-35. 10.1097\/PCC.0000000000001798","journal-title":"Pediatr Crit Care Med"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.4103\/ijccm.IJCCM_274_17","article-title":"Comparative study between noninvasive continuous positive airway pressure and hot humidified high-flow nasal cannulae as a mode of respiratory support in infants with acute bronchiolitis in pediatric intensive care unit of a tertiary care hospital","volume":"22","author":"Sarkar M","year":"2018","unstructured":"Sarkar M, Sinha R, Roychowdhoury S, Mukhopadhyay S, Ghosh P, Dutta K, Ghosh S. Comparative study between noninvasive continuous positive airway pressure and hot humidified high-flow nasal cannulae as a mode of respiratory support in infants with acute bronchiolitis in pediatric intensive care unit of a tertiary care hospital. Indian J Crit Care Med. 2018, 22:85-90. 10.4103\/ijccm.IJCCM_274_17","journal-title":"Indian J Crit Care Med"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24553","article-title":"A comparison between high-flow nasal cannula and noninvasive ventilation in the management of infants and young children with acute bronchiolitis in the PICU","volume":"55","author":"Habra B","year":"2020","unstructured":"Habra B, Janahi IA, Dauleh H, Chandra P, Veten A. A comparison between high-flow nasal cannula and noninvasive ventilation in the management of infants and young children with acute bronchiolitis in the PICU. Pediatr Pulmonol. 2020, 55:455-61. 10.1002\/ppul.24553","journal-title":"Pediatr Pulmonol"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4617-8","article-title":"High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study)","volume":"43","author":"Mil\u00e9si C","year":"2017","unstructured":"Mil\u00e9si C, Essouri S, Pouyau R, et al.. High flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study). Intensive Care Med. 2017, 43:209-16. 10.1007\/s00134-016-4617-8","journal-title":"Intensive Care Med"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2021.40.133.30350","article-title":"High flow nasal cannula therapy versus continuous positive airway pressure and nasal positive pressure ventilation in infants with severe bronchiolitis: a randomized controlled trial","volume":"40","author":"Borgi A","year":"2021","unstructured":"Borgi A, Louati A, Ghali N, et al.. High flow nasal cannula therapy versus continuous positive airway pressure and nasal positive pressure ventilation in infants with severe bronchiolitis: a randomized controlled trial. Pan Afr Med J. 2021, 40:133. 10.11604\/pamj.2021.40.133.30350","journal-title":"Pan Afr Med J"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-019-03533-2","article-title":"High flow nasal cannula and continuous positive airway pressure therapy in treatment of viral bronchiolitis: a randomized clinical trial","volume":"179","author":"Vahlkvist S","year":"2020","unstructured":"Vahlkvist S, J\u00fcrgensen L, la Cour A, Markoew S, Petersen TH, Kofoed PE. High flow nasal cannula and continuous positive airway pressure therapy in treatment of viral bronchiolitis: a randomized clinical trial. Eur J Pediatr. 2020, 179:513-8. 10.1007\/s00431-019-03533-2","journal-title":"Eur J Pediatr"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-024-05058-6","article-title":"Comparison between high-flow nasal cannula (HFNC) therapy and noninvasive ventilation (NIV) in children with acute respiratory failure by bronchiolitis: a randomized controlled trial","volume":"24","author":"Santos AC","year":"2024","unstructured":"Santos AC, Caiado CM, Lopes AG, et al.. Comparison between high-flow nasal cannula (HFNC) therapy and noninvasive ventilation (NIV) in children with acute respiratory failure by bronchiolitis: a randomized controlled trial. BMC Pediatr. 2024, 24:595. 10.1186\/s12887-024-05058-6","journal-title":"BMC Pediatr"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1007\/s44253-023-00013-2","article-title":"Physiological effects of standard oxygen therapy, high-flow nasal cannula, and helmet CPAP in acute bronchiolitis: a randomized cross-over study","volume":"1","author":"Chidini G","year":"2023","unstructured":"Chidini G, Mauri T, Conti G, et al.. Physiological effects of standard oxygen therapy, high-flow nasal cannula, and helmet CPAP in acute bronchiolitis: a randomized cross-over study. Intensive Care Med Paediatr Neonatal. 2023, 1:13. 10.1007\/s44253-023-00013-2","journal-title":"Intensive Care Med Paediatr Neonatal"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/517642-comparison-between-high-flow-nasal-cannula-hfnc-therapy-and-noninvasive-ventilation-niv-in-children-with-bronchiolitis-associated-acute-respiratory-failure-a-systematic-review-and-meta-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T01:47:43Z","timestamp":1786412863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/517642-comparison-between-high-flow-nasal-cannula-hfnc-therapy-and-noninvasive-ventilation-niv-in-children-with-bronchiolitis-associated-acute-respiratory-failure-a-systematic-review-and-meta-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":34,"URL":"https:\/\/doi.org\/10.7759\/cureus.114308","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,10]]}}}