{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:58:44Z","timestamp":1786546724911,"version":"build-2736575974"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"DOI":"10.7759\/cureus.114415","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:01:45Z","timestamp":1786543305000},"source":"Crossref","is-referenced-by-count":0,"title":["Dimethylarginine Dimethylaminohydrolase 1 (DDAH1)-Arginine Metabolic Axis Is Independently Associated With Alzheimer\u2019s Disease Risk in the UK Biobank"],"prefix":"10.7759","author":[{"given":"Steven","family":"Lehrer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rheinstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50205-0","article-title":"Targeted metabolomic analysis of nitric oxide\/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes","volume":"9","author":"Fleszar MG","year":"2019","unstructured":"Fleszar MG, Wi\u015bniewski J, Zboch M, Diakowska D, Gamian A, Krzystek-Korpacka M. Targeted metabolomic analysis of nitric oxide\/L-arginine pathway metabolites in dementia: association with pathology, severity, and structural brain changes. Sci Rep. 2019, 9:13764. 10.1038\/s41598-019-50205-0","journal-title":"Sci Rep"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2026.05.285","article-title":"Dysregulation of arginase and arginine pathways in neurodegenerative diseases: metabolic and cellular dysfunction and therapeutic implications","volume":"252","author":"Nalepa M","year":"2026","unstructured":"Nalepa M, Skweres A, W\u0119grzynowicz M. Dysregulation of arginase and arginine pathways in neurodegenerative diseases: metabolic and cellular dysfunction and therapeutic implications. Free Radic Biol Med. 2026, 252:559-79. 10.1016\/j.freeradbiomed.2026.05.285","journal-title":"Free Radic Biol Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155291","article-title":"Arginase as a potential biomarker of disease progression: a molecular imaging perspective","volume":"21","author":"Clemente GS","year":"2020","unstructured":"Clemente GS, van Waarde A, Antunes IF, D\u00f6mling A, Elsinga PH. Arginase as a potential biomarker of disease progression: a molecular imaging perspective. Int J Mol Sci. 2020, 21:5291. 10.3390\/ijms21155291","journal-title":"Int J Mol Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0149-z","article-title":"Altered plasma arginine metabolome precedes behavioural and brain arginine metabolomic profile changes in the APPswe\/PS1\u0394E9 mouse model of Alzheimer's disease","volume":"8","author":"Bergin DH","year":"2018","unstructured":"Bergin DH, Jing Y, Mockett BG, Zhang H, Abraham WC, Liu P. Altered plasma arginine metabolome precedes behavioural and brain arginine metabolomic profile changes in the APPswe\/PS1\u0394E9 mouse model of Alzheimer's disease. Transl Psychiatry. 2018, 8:108. 10.1038\/s41398-018-0149-z","journal-title":"Transl Psychiatry"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3390\/nu17040665","article-title":"L-arginine and nitric oxide in vascular regulation-experimental findings in the context of blood donation","volume":"17","author":"Kurhaluk N","year":"2025","unstructured":"Kurhaluk N, Tkaczenko H. L-arginine and nitric oxide in vascular regulation-experimental findings in the context of blood donation. Nutrients. 2025, 17:665. 10.3390\/nu17040665","journal-title":"Nutrients"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1177\/1535370221997052","article-title":"Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells","volume":"246","author":"Liy PM","year":"2021","unstructured":"Liy PM, Puzi NN, Jose S, Vidyadaran S. Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells. Exp Biol Med (Maywood). 2021, 246:2399-406. 10.1177\/1535370221997052","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2025.1511397","article-title":"Arginine metabolism and neurocognitive impairment in offspring of bipolar parents: a high-risk case-control study","volume":"16","author":"Ar\u0131c\u0131 Sa\u011fl\u0131yan G","year":"2025","unstructured":"Ar\u0131c\u0131 Sa\u011fl\u0131yan G, \u00c7etin FH, Aky\u00fcrek F, et al.. Arginine metabolism and neurocognitive impairment in offspring of bipolar parents: a high-risk case-control study. Front Psychiatry. 2025, 16:1511397. 10.3389\/fpsyt.2025.1511397","journal-title":"Front Psychiatry"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.12334","article-title":"Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology","volume":"127","author":"Austin SA","year":"2013","unstructured":"Austin SA, Santhanam AV, Hinton DJ, Choi DS, Katusic ZS. Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology. J Neurochem. 2013, 127:691-700. 10.1111\/jnc.12334","journal-title":"J Neurochem"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(98)00119-1","article-title":"Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease","volume":"25","author":"Smith MA","year":"1998","unstructured":"Smith MA, Va\u0161\u00e1k M, Knipp M, Castellani RJ, Perry G. Dimethylargininase, a nitric oxide regulatory protein, in Alzheimer disease. Free Radic Biol Med. 1998, 25:898-902. 10.1016\/S0891-5849(98)00119-1","journal-title":"Free Radic Biol Med"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1567-5688(03)00032-1","article-title":"The DDAH\/ADMA\/NOS pathway","volume":"4","author":"Tran CT","year":"2003","unstructured":"Tran CT, Leiper JM, Vallance P. The DDAH\/ADMA\/NOS pathway. Atheroscler Suppl. 2003, 4:33-40. 10.1016\/S1567-5688(03)00032-1","journal-title":"Atheroscler Suppl"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-023-00523-w","article-title":"TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer's disease","volume":"3","author":"Shulman M","year":"2023","unstructured":"Shulman M, Kong J, O'Gorman J, et al.. TANGO: a placebo-controlled randomized phase 2 study of efficacy and safety of the anti-tau monoclonal antibody gosuranemab in early Alzheimer's disease. Nat Aging. 2023, 3:1591-601. 10.1038\/s43587-023-00523-w","journal-title":"Nat Aging"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2025.106082","article-title":"Oral administration of arginine suppresses A\u03b2 pathology in animal models of Alzheimer's disease","volume":"191","author":"Fujii K","year":"2025","unstructured":"Fujii K, Takeuchi T, Fujino Y, et al.. Oral administration of arginine suppresses A\u03b2 pathology in animal models of Alzheimer's disease. Neurochem Int. 2025, 191:106082. 10.1016\/j.neuint.2025.106082","journal-title":"Neurochem Int"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06563-x","article-title":"Large-scale plasma proteomics comparisons through genetics and disease associations","volume":"622","author":"Eldjarn GH","year":"2023","unstructured":"Eldjarn GH, Ferkingstad E, Lund SH, et al.. Large-scale plasma proteomics comparisons through genetics and disease associations. Nature. 2023, 622:348-58. 10.1038\/s41586-023-06563-x","journal-title":"Nature"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12876","article-title":"Principal and independent genomic components of brain structure and function","volume":"23","author":"Oblong LM","year":"2024","unstructured":"Oblong LM, Soheili-Nezhad S, Trevisan N, Shi Y, Beckmann CF, Sprooten E. Principal and independent genomic components of brain structure and function. Genes Brain Behav. 2024, 23:e12876. 10.1111\/gbb.12876","journal-title":"Genes Brain Behav"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06772-w","article-title":"DDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson's disease","volume":"15","author":"Zhao Y","year":"2024","unstructured":"Zhao Y, Shen W, Zhang M, et al.. DDAH-1 maintains endoplasmic reticulum-mitochondria contacts and protects dopaminergic neurons in Parkinson's disease. Cell Death Dis. 2024, 15:399. 10.1038\/s41419-024-06772-w","journal-title":"Cell Death Dis"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-022-00545-z","article-title":"Early-life educational attainment, APOE \u03b54 alleles, and incident dementia risk in late life","volume":"44","author":"Ma H","year":"2022","unstructured":"Ma H, Zhou T, Li X, Maraganore D, Heianza Y, Qi L. Early-life educational attainment, APOE \u03b54 alleles, and incident dementia risk in late life. Geroscience. 2022, 44:1479-88. 10.1007\/s11357-022-00545-z","journal-title":"Geroscience"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/523469-dimethylarginine-dimethylaminohydrolase-1-ddah1-arginine-metabolic-axis-is-independently-associated-with-alzheimers-disease-risk-in-the-uk-biobank","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:01:46Z","timestamp":1786543306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/523469-dimethylarginine-dimethylaminohydrolase-1-ddah1-arginine-metabolic-axis-is-independently-associated-with-alzheimers-disease-risk-in-the-uk-biobank"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.114415","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}