{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:18:34Z","timestamp":1790983114358,"version":"4.1.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"DOI":"10.7759\/cureus.114424","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:24:05Z","timestamp":1786548245000},"source":"Crossref","is-referenced-by-count":1,"title":["Generalized Maculopapular Eruption Induced by Minocycline: A Case Report"],"prefix":"10.7759","author":[{"given":"Shruti","family":"Brahmbhatt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpit M","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-018-0609-x","article-title":"Resistance trends and treatment options in gram-negative ventilator-associated pneumonia","volume":"20","author":"Rhodes NJ","year":"2018","unstructured":"Rhodes NJ, Cruce CE, O'Donnell JN, Wunderink RG, Hauser AR. Resistance trends and treatment options in gram-negative ventilator-associated pneumonia. Curr Infect Dis Rep. 2018, 20:3. 10.1007\/s11908-018-0609-x","journal-title":"Curr Infect Dis Rep"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.01.022","article-title":"Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: back to the future","volume":"22","author":"Asadi A","year":"2020","unstructured":"Asadi A, Abdi M, Kouhsari E, et al.. Minocycline, focus on mechanisms of resistance, antibacterial activity, and clinical effectiveness: back to the future. J Glob Antimicrob Resist. 2020, 22:161-74. 10.1016\/j.jgar.2020.01.022","journal-title":"J Glob Antimicrob Resist"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000012467","article-title":"Adverse events of high-dose tigecycline in the treatment of ventilator-associated pneumonia due to multidrug-resistant pathogens","volume":"97","author":"Chen Z","year":"2018","unstructured":"Chen Z, Shi X. Adverse events of high-dose tigecycline in the treatment of ventilator-associated pneumonia due to multidrug-resistant pathogens. Medicine (Baltimore). 2018, 97:e12467. 10.1097\/MD.0000000000012467","journal-title":"Medicine (Baltimore)"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10070757","article-title":"A review of systemic minocycline side effects and topical minocycline as a safer alternative for treating acne and rosacea","volume":"10","author":"Martins AM","year":"2021","unstructured":"Martins AM, Marto JM, Johnson JL, Graber EM. A review of systemic minocycline side effects and topical minocycline as a safer alternative for treating acne and rosacea. Antibiotics (Basel). 2021, 10:757. 10.3390\/antibiotics10070757","journal-title":"Antibiotics (Basel)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo CA","year":"1981","unstructured":"Naranjo CA, Busto U, Sellers EM, et al.. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981, 30:239-45. 10.1038\/clpt.1981.154","journal-title":"Clin Pharmacol Ther"},{"key":"ref6","unstructured":"The use of the WHO-UMC system for standardised case causality assessment. (2013). https.\/\/www.who.int\/docs\/default-source\/medicines\/pharmacovigilance\/whocausality-assessment.pdf."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00262","article-title":"Molecular epidemiology and risk factors of ventilator-associated pneumonia infection caused by carbapenem-resistant Enterobacteriaceae","volume":"10","author":"Gao B","year":"2019","unstructured":"Gao B, Li X, Yang F, Chen W, Zhao Y, Bai G, Zhang Z. Molecular epidemiology and risk factors of ventilator-associated pneumonia infection caused by carbapenem-resistant Enterobacteriaceae. Front Pharmacol. 2019, 10:262. 10.3389\/fphar.2019.00262","journal-title":"Front Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.87a.19117","article-title":"Hospital-acquired and ventilator-associated pneumonia: diagnosis, management, and prevention","volume":"87","author":"Modi AR","year":"2020","unstructured":"Modi AR, Kovacs CS. Hospital-acquired and ventilator-associated pneumonia: diagnosis, management, and prevention. Cleve Clin J Med. 2020, 87:633-9. 10.3949\/ccjm.87a.19117","journal-title":"Cleve Clin J Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb03920.x","article-title":"Penetration of minocycline into lung tissues","volume":"32","author":"Naline E","year":"1991","unstructured":"Naline E, Sanceaume M, Toty L, Bakdach H, Pays M, Advenier C. Penetration of minocycline into lung tissues. Br J Clin Pharmacol. 1991, 32:402-4. 10.1111\/j.1365-2125.1991.tb03920.x","journal-title":"Br J Clin Pharmacol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01671-18","article-title":"Pharmacodynamics of minocycline against Acinetobacter baumannii in a rat pneumonia model","volume":"63","author":"Tarazi Z","year":"2019","unstructured":"Tarazi Z, Sabet M, Dudley MN, Griffith DC. Pharmacodynamics of minocycline against Acinetobacter baumannii in a rat pneumonia model. Antimicrob Agents Chemother. 2019, 63:e01671-18. 10.1128\/AAC.01671-18","journal-title":"Antimicrob Agents Chemother"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12139","article-title":"Minocycline: far beyond an antibiotic","volume":"169","author":"Garrido-Mesa N","year":"2013","unstructured":"Garrido-Mesa N, Zarzuelo A, G\u00e1lvez J. Minocycline: far beyond an antibiotic. Br J Pharmacol. 2013, 169:337-52. 10.1111\/bph.12139","journal-title":"Br J Pharmacol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1355774","article-title":"Case report: minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review","volume":"15","author":"Zhao Z","year":"2024","unstructured":"Zhao Z, Lu M, Ying Y. Case report: minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review. Front Pharmacol. 2024, 15:1355774. 10.3389\/fphar.2024.1355774","journal-title":"Front Pharmacol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.95786","article-title":"Minocycline-induced angioedema with chronic recurrent urticaria even after drug withdrawal: a case report","volume":"17","author":"Ajit Kumar K","year":"2025","unstructured":"Ajit Kumar K, Dubey S. Minocycline-induced angioedema with chronic recurrent urticaria even after drug withdrawal: a case report. Cureus. 2025, 17:e95786. 10.7759\/cureus.95786","journal-title":"Cureus"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.101371","article-title":"Nimesulide-associated generalized bullous fixed drug eruption: a rare pharmacovigilance case report","volume":"18","author":"Marshal M","year":"2026","unstructured":"Marshal M, Aggarwal S, Joseph G, Bhatti N, Badyal DK. Nimesulide-associated generalized bullous fixed drug eruption: a rare pharmacovigilance case report. Cureus. 2026, 18:e101371. 10.7759\/cureus.101371","journal-title":"Cureus"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v90i3-S.8159","article-title":"Mild cutaneous reactions to drugs","volume":"90","author":"Crisafulli G","year":"2019","unstructured":"Crisafulli G, Franceschini F, Caimmi S, et al.. Mild cutaneous reactions to drugs. Acta Biomed. 2019, 90:36-43. 10.23750\/abm.v90i3-S.8159","journal-title":"Acta Biomed"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2021.05.006","article-title":"Dermatological complications of critical care","volume":"21","author":"Bromley M","year":"2021","unstructured":"Bromley M, Marsh S, Layton A. Dermatological complications of critical care. BJA Educ. 2021, 21:408-13. 10.1016\/j.bjae.2021.05.006","journal-title":"BJA Educ"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/499967-generalized-maculopapular-eruption-induced-by-minocycline-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:24:07Z","timestamp":1786548247000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/499967-generalized-maculopapular-eruption-induced-by-minocycline-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":16,"URL":"https:\/\/doi.org\/10.7759\/cureus.114424","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}