{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:32:16Z","timestamp":1786559536188,"version":"build-2736575974"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"DOI":"10.7759\/cureus.114433","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:11:28Z","timestamp":1786558288000},"source":"Crossref","is-referenced-by-count":0,"title":["Enriched Versus Standard NICU Environments and Preterm Brain Development: A Systematic Review of Structural, Diffusion, and Functional Neuroimaging Studies"],"prefix":"10.7759","author":[{"given":"Saritha","family":"Tammali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saritha","family":"Kamsetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Urakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kotha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70294-1","article-title":"Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances","volume":"8","author":"Volpe JJ","year":"2009","unstructured":"Volpe JJ. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol. 2009, 8:110-24. 10.1016\/S1474-4422(08)70294-1","journal-title":"Lancet Neurol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2006.07.006","article-title":"Diffusion tensor imaging of brain development","volume":"11","author":"H\u00fcppi PS","year":"2006","unstructured":"H\u00fcppi PS, Dubois J. Diffusion tensor imaging of brain development. Semin Fetal Neonatal Med. 2006, 11:489-97. 10.1016\/j.siny.2006.07.006","journal-title":"Semin Fetal Neonatal Med"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1718-6","article-title":"White matter injury in the preterm infant: pathology and mechanisms","volume":"134","author":"Back SA","year":"2017","unstructured":"Back SA. White matter injury in the preterm infant: pathology and mechanisms. Acta Neuropathol. 2017, 134:331-49. 10.1007\/s00401-017-1718-6","journal-title":"Acta Neuropathol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM, et al.. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021, 372:n71. 10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.4.846","article-title":"Early experience alters brain function and structure","volume":"113","author":"Als H","year":"2004","unstructured":"Als H, Duffy FH, McAnulty GB, et al.. Early experience alters brain function and structure. Pediatrics. 2004, 113:846-57. 10.1542\/peds.113.4.846","journal-title":"Pediatrics"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2011.201","article-title":"NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction","volume":"32","author":"Als H","year":"2012","unstructured":"Als H, Duffy FH, McAnulty G, et al.. NIDCAP improves brain function and structure in preterm infants with severe intrauterine growth restriction. J Perinatol. 2012, 32:797-803. 10.1038\/jp.2011.201","journal-title":"J Perinatol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/2249-4847.105982","article-title":"School age effects of the newborn individualized developmental care and assessment program for medically low-risk preterm infants: preliminary findings","volume":"1","author":"McAnulty G","year":"2012","unstructured":"McAnulty G, Duffy FH, Kosta S, et al.. School age effects of the newborn individualized developmental care and assessment program for medically low-risk preterm infants: preliminary findings. J Clin Neonatol. 2012, 1:184-94. 10.4103\/2249-4847.105982","journal-title":"J Clin Neonatol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-25","article-title":"School-age effects of the newborn individualized developmental care and assessment program for preterm infants with intrauterine growth restriction: preliminary findings","volume":"13","author":"McAnulty G","year":"2013","unstructured":"McAnulty G, Duffy FH, Kosta S, et al.. School-age effects of the newborn individualized developmental care and assessment program for preterm infants with intrauterine growth restriction: preliminary findings. BMC Pediatr. 2013, 13:25. 10.1186\/1471-2431-13-25","journal-title":"BMC Pediatr"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181cb8e2f","article-title":"Early sensitivity training for parents of preterm infants: impact on the developing brain","volume":"67","author":"Milgrom J","year":"2010","unstructured":"Milgrom J, Newnham C, Anderson PJ, et al.. Early sensitivity training for parents of preterm infants: impact on the developing brain. Pediatr Res. 2010, 67:330-5. 10.1203\/PDR.0b013e3181cb8e2f","journal-title":"Pediatr Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.08.047","article-title":"Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments","volume":"164","author":"Pineda RG","year":"2014","unstructured":"Pineda RG, Neil J, Dierker D, et al.. Alterations in brain structure and neurodevelopmental outcome in preterm infants hospitalized in different neonatal intensive care unit environments. J Pediatr. 2014, 164:52-60.e2. 10.1016\/j.jpeds.2013.08.047","journal-title":"J Pediatr"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-4252","article-title":"Single-family room care and neurobehavioral and medical outcomes in preterm infants","volume":"134","author":"Lester BM","year":"2014","unstructured":"Lester BM, Hawes K, Abar B, et al.. Single-family room care and neurobehavioral and medical outcomes in preterm infants. Pediatrics. 2014, 134:754-60. 10.1542\/peds.2013-4252","journal-title":"Pediatrics"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1817536116","article-title":"Music in premature infants enhances high-level cognitive brain networks","volume":"116","author":"Lordier L","year":"2019","unstructured":"Lordier L, Meskaldji DE, Grouiller F, et al.. Music in premature infants enhances high-level cognitive brain networks. Proc Natl Acad Sci U S A. 2019, 116:12103-8. 10.1073\/pnas.1817536116","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116391","article-title":"Music enhances structural maturation of emotional processing neural pathways in very preterm infants","volume":"207","author":"Sa de Almeida J","year":"2020","unstructured":"Sa de Almeida J, Lordier L, Zollinger B, et al.. Music enhances structural maturation of emotional processing neural pathways in very preterm infants. Neuroimage. 2020, 207:116391. 10.1016\/j.neuroimage.2019.116391","journal-title":"Neuroimage"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2023.101254","article-title":"Music impacts brain cortical microstructural maturation in very preterm infants: a longitudinal diffusion MR imaging study","volume":"61","author":"Sa de Almeida J","year":"2023","unstructured":"Sa de Almeida J, Baud O, Fau S, et al.. Music impacts brain cortical microstructural maturation in very preterm infants: a longitudinal diffusion MR imaging study. Dev Cogn Neurosci. 2023, 61:101254. 10.1016\/j.dcn.2023.101254","journal-title":"Dev Cogn Neurosci"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22545","article-title":"Neonatal intensive care unit stress is associated with brain development in preterm infants","volume":"70","author":"Smith GC","year":"2011","unstructured":"Smith GC, Gutovich J, Smyser C, et al.. Neonatal intensive care unit stress is associated with brain development in preterm infants. Ann Neurol. 2011, 70:541-9. 10.1002\/ana.22545","journal-title":"Ann Neurol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22267","article-title":"Procedural pain and brain development in premature newborns","volume":"71","author":"Brummelte S","year":"2012","unstructured":"Brummelte S, Grunau RE, Chau V, et al.. Procedural pain and brain development in premature newborns. Ann Neurol. 2012, 71:385-96. 10.1002\/ana.22267","journal-title":"Ann Neurol"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2012.07.006","article-title":"The influence of preterm birth on the developing thalamocortical connectome","volume":"49","author":"Ball G","year":"2013","unstructured":"Ball G, Boardman JP, Aljabar P, et al.. The influence of preterm birth on the developing thalamocortical connectome. Cortex. 2013, 49:1711-21. 10.1016\/j.cortex.2012.07.006","journal-title":"Cortex"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00899","article-title":"Early pain exposure influences functional brain connectivity in very preterm neonates","volume":"13","author":"Tortora D","year":"2019","unstructured":"Tortora D, Severino M, Di Biase C, et al.. Early pain exposure influences functional brain connectivity in very preterm neonates. Front Neurosci. 2019, 13:899. 10.3389\/fnins.2019.00899","journal-title":"Front Neurosci"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2013.11.010","article-title":"Regional white matter microstructure in very preterm infants: predictors and 7 year outcomes","volume":"52","author":"Thompson DK","year":"2014","unstructured":"Thompson DK, Lee KJ, Egan GF, Warfield SK, Doyle LW, Anderson PJ, Inder TE. Regional white matter microstructure in very preterm infants: predictors and 7 year outcomes. Cortex. 2014, 52:60-74. 10.1016\/j.cortex.2013.11.010","journal-title":"Cortex"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne JA","year":"2019","unstructured":"Sterne JA, Savovi\u0107 J, Page MJ, et al.. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019, 366:l4898. 10.1136\/bmj.l4898","journal-title":"BMJ"},{"key":"ref21","article-title":"Chapter 8: Assessing Risk of Bias in a Randomized Trial","author":"Higgins JP","year":"2024","unstructured":"Higgins JP, Savovi\u0107 J, Page MJ, Elbers RG, Sterne JA. Chapter 8: Assessing Risk of Bias in a Randomized Trial. Higgins JP, Thomas J, Chandler J (ed): 2024."},{"key":"ref22","article-title":"The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses","author":"Wells GA","year":"2014","unstructured":"Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Ottawa Hospital Research Institute, Ottawa; 2014."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-015-0439-z","article-title":"PPREMO: a prospective cohort study of preterm infant brain structure and function to predict neurodevelopmental outcome","volume":"15","author":"George JM","year":"2015","unstructured":"George JM, Boyd RN, Colditz PB, et al.. PPREMO: a prospective cohort study of preterm infant brain structure and function to predict neurodevelopmental outcome. BMC Pediatr. 2015, 15:123. 10.1186\/s12887-015-0439-z","journal-title":"BMC Pediatr"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-015-3307-y","article-title":"Data quality in diffusion tensor imaging studies of the preterm brain: a systematic review","volume":"45","author":"Pieterman K","year":"2015","unstructured":"Pieterman K, Plaisier A, Govaert P, Leemans A, Lequin MH, Dudink J. Data quality in diffusion tensor imaging studies of the preterm brain: a systematic review. Pediatr Radiol. 2015, 45:1372-81. 10.1007\/s00247-015-3307-y","journal-title":"Pediatr Radiol"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12486","article-title":"Cerebral white matter maturation patterns in preterm infants: an MRI T2 relaxation anisotropy and diffusion tensor imaging study","volume":"28","author":"Knight MJ","year":"2018","unstructured":"Knight MJ, Smith-Collins A, Newell S, Denbow M, Kauppinen RA. Cerebral white matter maturation patterns in preterm infants: an MRI T2 relaxation anisotropy and diffusion tensor imaging study. J Neuroimaging. 2018, 28:86-94. 10.1111\/jon.12486","journal-title":"J Neuroimaging"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.157","article-title":"Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18-22 mo of age: an MRI and DTI study","volume":"78","author":"Rose J","year":"2015","unstructured":"Rose J, Cahill-Rowley K, Vassar R, et al.. Neonatal brain microstructure correlates of neurodevelopment and gait in preterm children 18-22 mo of age: an MRI and DTI study. Pediatr Res. 2015, 78:700-8. 10.1038\/pr.2015.157","journal-title":"Pediatr Res"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/children9030356","article-title":"Advanced brain imaging in preterm infants: a narrative review of microstructural and connectomic disruption","volume":"9","author":"Vo Van P","year":"2022","unstructured":"Vo Van P, Alison M, Morel B, Beck J, Bednarek N, Hertz-Pannier L, Loron G. Advanced brain imaging in preterm infants: a narrative review of microstructural and connectomic disruption. Children (Basel). 2022, 9:356. 10.3390\/children9030356","journal-title":"Children (Basel)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/519162-enriched-versus-standard-nicu-environments-and-preterm-brain-development-a-systematic-review-of-structural-diffusion-and-functional-neuroimaging-studies","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T18:11:29Z","timestamp":1786558289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/519162-enriched-versus-standard-nicu-environments-and-preterm-brain-development-a-systematic-review-of-structural-diffusion-and-functional-neuroimaging-studies"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":27,"URL":"https:\/\/doi.org\/10.7759\/cureus.114433","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}