{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T13:26:07Z","timestamp":1786800367828,"version":"build-2736575974"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,15]]},"DOI":"10.7759\/cureus.114562","type":"journal-article","created":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:31:11Z","timestamp":1786797071000},"source":"Crossref","is-referenced-by-count":0,"title":["Newly Detected Atrial Flutter After Enclomiphene Dose Escalation in a Patient With Prior Mitral Valve Repair and Chronic Immune Thrombocytopenia: A Case Report"],"prefix":"10.7759","author":[{"given":"Muhammad N","family":"Tariq","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed T","family":"Abdel Halim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2016.1204294","article-title":"Enclomiphene citrate for the treatment of secondary male hypogonadism","volume":"17","author":"Rodriguez KM","year":"2016","unstructured":"Rodriguez KM, Pastuszak AW, Lipshultz LI. Enclomiphene citrate for the treatment of secondary male hypogonadism. Expert Opin Pharmacother. 2016, 17:1561-7. 10.1080\/14656566.2016.1204294","journal-title":"Expert Opin Pharmacother"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad526","article-title":"Associations of serum testosterone and sex hormone-binding globulin with incident arrhythmias in men from UK Biobank","volume":"109","author":"Xu B","year":"2024","unstructured":"Xu B, Mo W, Tan X, et al.. Associations of serum testosterone and sex hormone-binding globulin with incident arrhythmias in men from UK Biobank. J Clin Endocrinol Metab. 2024, 109:e745-56. 10.1210\/clinem\/dgad526","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.12.002","article-title":"Postoperative atrial tachycardias after mitral valve surgery: mechanisms and outcomes of catheter ablation","volume":"14","author":"Enriquez A","year":"2017","unstructured":"Enriquez A, Santangeli P, Zado ES, et al.. Postoperative atrial tachycardias after mitral valve surgery: mechanisms and outcomes of catheter ablation. Heart Rhythm. 2017, 14:520-6. 10.1016\/j.hrthm.2016.12.002","journal-title":"Heart Rhythm"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.07.083","article-title":"Atrial incision affects the incidence of atrial tachycardia after mitral valve surgery","volume":"81","author":"Lukac P","year":"2006","unstructured":"Lukac P, Hjortdal VE, Pedersen AK, Mortensen PT, Jensen HK, Hansen PS. Atrial incision affects the incidence of atrial tachycardia after mitral valve surgery. Ann Thorac Surg. 2006, 81:509-13. 10.1016\/j.athoracsur.2005.07.083","journal-title":"Ann Thorac Surg"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0735-1097(02)01905-8","article-title":"Lesional tachycardias related to mitral valve surgery","volume":"39","author":"Markowitz SM","year":"2002","unstructured":"Markowitz SM, Brodman RF, Stein KM, et al.. Lesional tachycardias related to mitral valve surgery. J Am Coll Cardiol. 2002, 39:1973-83. 10.1016\/s0735-1097(02)01905-8","journal-title":"J Am Coll Cardiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.05.028","article-title":"EHRA\/HRS\/APHRS\/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication","volume":"14","author":"Goette A","year":"2017","unstructured":"Goette A, Kalman JM, Aguinaga L, et al.. EHRA\/HRS\/APHRS\/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. Heart Rhythm. 2017, 14:e3-e40. 10.1016\/j.hrthm.2016.05.028","journal-title":"Heart Rhythm"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.2","article-title":"Inflammation and the pathogenesis of atrial fibrillation","volume":"12","author":"Hu YF","year":"2015","unstructured":"Hu YF, Chen YJ, Lin YJ, Chen SA. Inflammation and the pathogenesis of atrial fibrillation. Nat Rev Cardiol. 2015, 12:230-43. 10.1038\/nrcardio.2015.2","journal-title":"Nat Rev Cardiol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2003.021121","article-title":"Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life","volume":"90","author":"Malkin CJ","year":"2004","unstructured":"Malkin CJ, Pugh PJ, Morris PD, Kerry KE, Jones RD, Jones TH, Channer KS. Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life. Heart. 2004, 90:871-6. 10.1136\/hrt.2003.021121","journal-title":"Heart"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.04.063","article-title":"Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene-without QT interval prolongation","volume":"318","author":"Yuill KH","year":"2004","unstructured":"Yuill KH, Borg JJ, Ridley JM, et al.. Potent inhibition of human cardiac potassium (HERG) channels by the anti-estrogen agent clomiphene-without QT interval prolongation. Biochem Biophys Res Commun. 2004, 318:556-61. 10.1016\/j.bbrc.2004.04.063","journal-title":"Biochem Biophys Res Commun"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.2165\/11633140-000000000-00000","article-title":"Drug-induced atrial fibrillation","volume":"72","author":"Kaakeh Y","year":"2012","unstructured":"Kaakeh Y, Overholser BR, Lopshire JC, Tisdale JE. Drug-induced atrial fibrillation. Drugs. 2012, 72:1617-30. 10.2165\/11633140-000000000-00000","journal-title":"Drugs"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154","article-title":"A method for estimating the probability of adverse drug reactions","volume":"30","author":"Naranjo CA","year":"1981","unstructured":"Naranjo CA, Busto U, Sellers EM, et al.. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981, 30:239-45. 10.1038\/clpt.1981.154","journal-title":"Clin Pharmacol Ther"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001193","article-title":"ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines","volume":"149","author":"Joglar JA","year":"2024","unstructured":"Joglar JA, Chung MK, Armbruster AL, et al.. ACC\/AHA\/ACCP\/HRS guideline for the diagnosis and management of atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2024, 149:e1-e156. 10.1161\/CIR.0000000000001193","journal-title":"Circulation"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000310","article-title":"2015 ACC\/AHA\/hrs guideline for the management of adult patients with supraventricular tachycardia: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines and the Heart Rhythm Society","volume":"133","author":"Page RL","year":"2016","unstructured":"Page RL, Joglar JA, Caldwell MA, et al.. 2015 ACC\/AHA\/hrs guideline for the management of adult patients with supraventricular tachycardia: executive summary: a report of the American College of Cardiology\/American Heart Association Task Force on clinical practice guidelines and the Heart Rhythm Society. Circulation. 2016, 133:e471-505. 10.1161\/CIR.0000000000000310","journal-title":"Circulation"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2024.01.012","article-title":"Anticoagulation in cancer patients with atrial fibrillation and grade 3-4 thrombocytopenia","volume":"235","author":"Drozdinsky G","year":"2024","unstructured":"Drozdinsky G, Arad N, Spectre G, et al.. Anticoagulation in cancer patients with atrial fibrillation and grade 3-4 thrombocytopenia. Thromb Res. 2024, 235:92-7. 10.1016\/j.thromres.2024.01.012","journal-title":"Thromb Res"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjms.2025.05.008","article-title":"Trends and outcomes of atrial fibrillation patients with thrombocytopenia: insights from the national inpatient sample","volume":"370","author":"Younes AM","year":"2025","unstructured":"Younes AM, Mahmoud AK, Kamel I, Maraey A, Khalil M. Trends and outcomes of atrial fibrillation patients with thrombocytopenia: insights from the national inpatient sample. Am J Med Sci. 2025, 370:353-7. 10.1016\/j.amjms.2025.05.008","journal-title":"Am J Med Sci"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011235","article-title":"Influence of thrombocytopenia on bleeding and vascular events in atrial fibrillation","volume":"7","author":"Iyengar V","year":"2023","unstructured":"Iyengar V, Patell R, Ren S, et al.. Influence of thrombocytopenia on bleeding and vascular events in atrial fibrillation. Blood Adv. 2023, 7:7516-24. 10.1182\/bloodadvances.2023011235","journal-title":"Blood Adv"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-025-03188-x","article-title":"Anticoagulant therapy in patients with cancer and thrombocytopenia","volume":"58","author":"Szmit S","year":"2025","unstructured":"Szmit S, K\u0119pski J, Lech-Mara\u0144da E, Kowalski DM, Krzakowski M, Zaborowska-Szmit M. Anticoagulant therapy in patients with cancer and thrombocytopenia. J Thromb Thrombolysis. 2025, 58:1006-20. 10.1007\/s11239-025-03188-x","journal-title":"J Thromb Thrombolysis"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/522662-newly-detected-atrial-flutter-after-enclomiphene-dose-escalation-in-a-patient-with-prior-mitral-valve-repair-and-chronic-immune-thrombocytopenia-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T12:31:12Z","timestamp":1786797072000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/522662-newly-detected-atrial-flutter-after-enclomiphene-dose-escalation-in-a-patient-with-prior-mitral-valve-repair-and-chronic-immune-thrombocytopenia-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,15]]},"references-count":17,"URL":"https:\/\/doi.org\/10.7759\/cureus.114562","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,15]]}}}