{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:28:02Z","timestamp":1786962482406,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,17]]},"DOI":"10.7759\/cureus.114641","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:00:01Z","timestamp":1786960801000},"source":"Crossref","is-referenced-by-count":0,"title":["Cardiometabolic Effects of Ilex paraguariensis (Yerba Mate): A Narrative Review of Evidence and Research Gaps"],"prefix":"10.7759","author":[{"given":"Krystian","family":"Czernikiewicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Frak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urszula","family":"Kowalska-Frak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Lemanska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Karminska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","unstructured":"Cardiovascular diseases (CVDs). (2025). Accessed. June 14, 2026: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)."},{"key":"ref2","unstructured":"Obesity and overweight. (2025). Accessed. August 1, 2026: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight."},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107607","article-title":"Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome","volume":"213","author":"Tolouei SE","year":"2025","unstructured":"Tolouei SE, Marcon R, Vilela FC, et al.. Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome. Pharmacol Res. 2025, 213:107607. 10.1016\/j.phrs.2025.107607","journal-title":"Pharmacol Res"},{"key":"ref4","unstructured":"Diabetes. (2024). Accessed. July 31, 2026: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/diabetes."},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.05.132","article-title":"Effect of yerba mate (Ilex paraguariensis) extract on the metabolism of diabetic rats","volume":"105","author":"Rocha DS","year":"2018","unstructured":"Rocha DS, Casagrande L, Model JF, Dos Santos JT, Hoefel AL, Kucharski LC. Effect of yerba mate (Ilex paraguariensis) extract on the metabolism of diabetic rats. Biomed Pharmacother. 2018, 105:370-6. 10.1016\/j.biopha.2018.05.132","journal-title":"Biomed Pharmacother"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0859-1","article-title":"Anti-obesity effects of yerba mate (Ilex paraguariensis): a randomized, double-blind, placebo-controlled clinical trial","volume":"15","author":"Kim SY","year":"2015","unstructured":"Kim SY, Oh MR, Kim MG, Chae HJ, Chae SW. Anti-obesity effects of yerba mate (Ilex paraguariensis): a randomized, double-blind, placebo-controlled clinical trial. BMC Complement Altern Med. 2015, 15:338. 10.1186\/s12906-015-0859-1","journal-title":"BMC Complement Altern Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/nu15204454","article-title":"Yerba mat\u00e9 (Ilex paraguariensis) supplement exerts beneficial, tissue-specific effects on mitochondrial efficiency and redox status in healthy adult mice","volume":"15","author":"Walton CM","year":"2023","unstructured":"Walton CM, Saito ER, Warren CE, et al.. Yerba mat\u00e9 (Ilex paraguariensis) supplement exerts beneficial, tissue-specific effects on mitochondrial efficiency and redox status in healthy adult mice. Nutrients. 2023, 15:4454. 10.3390\/nu15204454","journal-title":"Nutrients"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.70065","article-title":"Yerba mate (Ilex paraguariensis St. Hill.) tea may have cardiometabolic beneficial effects in healthy and at-risk subjects: a randomized, controlled, blind, crossover trial in nonhabitual consumers","volume":"69","author":"Bravo L","year":"2025","unstructured":"Bravo L, Mart\u00ednez-L\u00f3pez S, Sierra-Cinos JL, Mateos R, Sarri\u00e1 B. Yerba mate (Ilex paraguariensis St. Hill.) tea may have cardiometabolic beneficial effects in healthy and at-risk subjects: a randomized, controlled, blind, crossover trial in nonhabitual consumers. Mol Nutr Food Res. 2025, 69:e70065. 10.1002\/mnfr.70065","journal-title":"Mol Nutr Food Res"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-023-01117-y","article-title":"Gut microbiota modulation by bioactive compounds from Ilex paraguariensis: an in vivo study","volume":"78","author":"Santos D","year":"2023","unstructured":"Santos D, Vargas BK, Frota EG, et al.. Gut microbiota modulation by bioactive compounds from Ilex paraguariensis: an in vivo study. Plant Foods Hum Nutr. 2023, 78:796-802. 10.1007\/s11130-023-01117-y","journal-title":"Plant Foods Hum Nutr"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2007.00535.x","article-title":"Yerba mate tea (Ilex paraguariensis): a comprehensive review on chemistry, health implications, and technological considerations","volume":"72","author":"Heck CI","year":"2007","unstructured":"Heck CI, de Mejia EG. Yerba mate tea (Ilex paraguariensis): a comprehensive review on chemistry, health implications, and technological considerations. J Food Sci. 2007, 72:R138-51. 10.1111\/j.1750-3841.2007.00535.x","journal-title":"J Food Sci"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111682","article-title":"Health benefits of bioactive compounds from the genus Ilex, a source of traditional caffeinated beverages","volume":"10","author":"Gan RY","year":"2018","unstructured":"Gan RY, Zhang D, Wang M, Corke H. Health benefits of bioactive compounds from the genus Ilex, a source of traditional caffeinated beverages. Nutrients. 2018, 10:1682. 10.3390\/nu10111682","journal-title":"Nutrients"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2023.111881","article-title":"Yerba mate consumption by ovariectomized rats alters white adipose tissue","volume":"564","author":"Andrade VM","year":"2023","unstructured":"Andrade VM, de Moura AF, da Costa Chaves K, et al.. Yerba mate consumption by ovariectomized rats alters white adipose tissue. Mol Cell Endocrinol. 2023, 564:111881. 10.1016\/j.mce.2023.111881","journal-title":"Mol Cell Endocrinol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-3921.pab2019.v54.00856","article-title":"Contents of total phenolics and flavonoids in and antioxidant activity of Ilex paraguariensis leaves","volume":"54","author":"Bisognin DA","year":"2019","unstructured":"Bisognin DA, da Luz LV, Lencina KH, dos Santos CO, Sautter CK. Contents of total phenolics and flavonoids in and antioxidant activity of Ilex paraguariensis leaves. Pesq Agropec Bras. 2019, 54:e00856. 10.1590\/S1678-3921.pab2019.v54.00856","journal-title":"Pesq Agropec Bras"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1641592","article-title":"Yerba Mat\u00e9 and its impact on glycemic control and metabolic health: a systematic review and meta-analysis","volume":"16","author":"Li D","year":"2025","unstructured":"Li D, Yue L, Peng X, et al.. Yerba Mat\u00e9 and its impact on glycemic control and metabolic health: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2025, 16:1641592. 10.3389\/fendo.2025.1641592","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-022-01008-8","article-title":"Phenolic compounds present in yerba mate potentially increase human health: a critical review","volume":"77","author":"de Vasconcellos AC","year":"2022","unstructured":"de Vasconcellos AC, Frazzon J, Zapata Nore\u00f1a CP. Phenolic compounds present in yerba mate potentially increase human health: a critical review. Plant Foods Hum Nutr. 2022, 77:495-503. 10.1007\/s11130-022-01008-8","journal-title":"Plant Foods Hum Nutr"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3390\/nu17040625","article-title":"The incretin effect of yerba mat\u00e9 (Ilex paraguariensis) is partially dependent on gut-mediated metabolism of ferulic acid","volume":"17","author":"Cooper-Leavitt ET","year":"2025","unstructured":"Cooper-Leavitt ET, Shin MJ, Beus CG, et al.. The incretin effect of yerba mat\u00e9 (Ilex paraguariensis) is partially dependent on gut-mediated metabolism of ferulic acid. Nutrients. 2025, 17:625. 10.3390\/nu17040625","journal-title":"Nutrients"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010014","article-title":"A randomized crossover intervention study on the effect a standardized mat\u00e9 extract (Ilex paraguariensis A. St.-Hil.) in men predisposed to cardiovascular risk","volume":"13","author":"Gebara KS","year":"2020","unstructured":"Gebara KS, Gasparotto Junior A, Palozi RA, et al.. A randomized crossover intervention study on the effect a standardized mat\u00e9 extract (Ilex paraguariensis A. St.-Hil.) in men predisposed to cardiovascular risk. Nutrients. 2020, 13:14. 10.3390\/nu13010014","journal-title":"Nutrients"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/nu7020730","article-title":"The positive effects of yerba mat\u00e9 (Ilex paraguariensis) in obesity","volume":"7","author":"Gambero A","year":"2015","unstructured":"Gambero A, Ribeiro ML. The positive effects of yerba mat\u00e9 (Ilex paraguariensis) in obesity. Nutrients. 2015, 7:730-50. 10.3390\/nu7020730","journal-title":"Nutrients"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3390\/nu9121310","article-title":"Functional foods and lifestyle approaches for diabetes prevention and management","volume":"9","author":"Alkhatib A","year":"2017","unstructured":"Alkhatib A, Tsang C, Tiss A, et al.. Functional foods and lifestyle approaches for diabetes prevention and management. Nutrients. 2017, 9:1310. 10.3390\/nu9121310","journal-title":"Nutrients"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-024-01254-y","article-title":"The acute ingestion of yerba mate (Ilex paraguariensis) infusion does not modify endothelial function, hemodynamics, or heart rate variability: a randomized crossover clinical trial","volume":"80","author":"Filipini RE","year":"2024","unstructured":"Filipini RE, Jos\u00e9 MF, Speretta GF. The acute ingestion of yerba mate (Ilex paraguariensis) infusion does not modify endothelial function, hemodynamics, or heart rate variability: a randomized crossover clinical trial. Plant Foods Hum Nutr. 2024, 80:17. 10.1007\/s11130-024-01254-y","journal-title":"Plant Foods Hum Nutr"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz350","article-title":"Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans","volume":"40","author":"Thijssen DH","year":"2019","unstructured":"Thijssen DH, Bruno RM, van Mil AC, et al.. Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. Eur Heart J. 2019, 40:2534-47. 10.1093\/eurheartj\/ehz350","journal-title":"Eur Heart J"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2014.12.016","article-title":"Yerba mate (Ilex paraguariensis) improves microcirculation of volunteers with high blood viscosity: a randomized, double-blind, placebo-controlled trial","volume":"62","author":"Yu S","year":"2015","unstructured":"Yu S, Yue Sw, Liu Z, Zhang T, Xiang N, Fu H. Yerba mate (Ilex paraguariensis) improves microcirculation of volunteers with high blood viscosity: a randomized, double-blind, placebo-controlled trial. Exp Gerontol. 2015, 62:14-22. 10.1016\/j.exger.2014.12.016","journal-title":"Exp Gerontol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.18.5.768","article-title":"Plasma viscosity and the risk of coronary heart disease: results from the MONICA-Augsburg Cohort Study, 1984 to 1992","volume":"18","author":"Koenig W","year":"1998","unstructured":"Koenig W, Sund M, Filipiak B, D\u00f6ring A, L\u00f6wel H, Ernst E. Plasma viscosity and the risk of coronary heart disease: results from the MONICA-Augsburg Cohort Study, 1984 to 1992. Arterioscler Thromb Vasc Biol. 1998, 18:768-72. 10.1161\/01.atv.18.5.768","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30752-2","article-title":"Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"396","author":"GBD 2019 Risk Factors Collaborators","year":"2020","unstructured":"GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020, 396:1223-49. 10.1016\/S0140-6736(20)30752-2","journal-title":"Lancet"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000146672.10582.17","article-title":"Chemokines in the pathogenesis of vascular disease","volume":"95","author":"Charo IF","year":"2004","unstructured":"Charo IF, Taubman MB. Chemokines in the pathogenesis of vascular disease. Circ Res. 2004, 95:858-66. 10.1161\/01.RES.0000146672.10582.17","journal-title":"Circ Res"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby P","year":"2002","unstructured":"Libby P. Inflammation in atherosclerosis. Nature. 2002, 420:868-74. 10.1038\/nature01323","journal-title":"Nature"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-018-0426-y","article-title":"Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial","volume":"18","author":"Balsan G","year":"2019","unstructured":"Balsan G, Pellanda LC, Sausen G, Galarraga T, Zaffari D, Pontin B, Portal VL. Effect of yerba mate and green tea on paraoxonase and leptin levels in patients affected by overweight or obesity and dyslipidemia: a randomized clinical trial. Nutr J. 2019, 18:5. 10.1186\/s12937-018-0426-y","journal-title":"Nutr J"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-27661-0_9","article-title":"Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development","author":"Aviram M","year":"2005","unstructured":"Aviram M, Kaplan M, Rosenblat M, Fuhrman B. Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development. Handb Exp Pharmacol. 2005, 263-300. 10.1007\/3-540-27661-0_9","journal-title":"Handb Exp Pharmacol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7377","article-title":"Beneficial effects of Ilex paraguariensis in the prevention of obesity-associated metabolic disorders in mice","volume":"36","author":"Valen\u00e7a HD","year":"2022","unstructured":"Valen\u00e7a HD, E Silva CP, de Brito Gitirana L, Valen\u00e7a SS, Lanzetti M. Beneficial effects of Ilex paraguariensis in the prevention of obesity-associated metabolic disorders in mice. Phytother Res. 2022, 36:1032-42. 10.1002\/ptr.7377","journal-title":"Phytother Res"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.03.008","article-title":"Beneficial effects of yerba mate tea (Ilex paraguariensis) on hyperlipidemia in high-fat-fed hamsters","volume":"48","author":"Gao H","year":"2013","unstructured":"Gao H, Long Y, Jiang X, et al.. Beneficial effects of yerba mate tea (Ilex paraguariensis) on hyperlipidemia in high-fat-fed hamsters. Exp Gerontol. 2013, 48:572-8. 10.1016\/j.exger.2013.03.008","journal-title":"Exp Gerontol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2011.06.036","article-title":"Protective and ameliorative effects of mat\u00e9 (Ilex paraguariensis) on metabolic syndrome in TSOD mice","volume":"19","author":"Hussein GM","year":"2011","unstructured":"Hussein GM, Matsuda H, Nakamura S, Akiyama T, Tamura K, Yoshikawa M. Protective and ameliorative effects of mat\u00e9 (Ilex paraguariensis) on metabolic syndrome in TSOD mice. Phytomedicine. 2011, 19:88-97. 10.1016\/j.phymed.2011.06.036","journal-title":"Phytomedicine"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1021\/jf901660g","article-title":"Consumption of yerba mate ( Ilex paraguariensis ) improves serum lipid parameters in healthy dyslipidemic subjects and provides an additional LDL-cholesterol reduction in individuals on statin therapy","volume":"57","author":"de Morais EC","year":"2009","unstructured":"de Morais EC, Stefanuto A, Klein GA, et al.. Consumption of yerba mate ( Ilex paraguariensis ) improves serum lipid parameters in healthy dyslipidemic subjects and provides an additional LDL-cholesterol reduction in individuals on statin therapy. J Agric Food Chem. 2009, 57:8316-24. 10.1021\/jf901660g","journal-title":"J Agric Food Chem"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2013.02.008","article-title":"Lipid-lowering effects of standardized extracts of Ilex paraguariensis in high-fat-diet rats","volume":"86","author":"Balzan S","year":"2013","unstructured":"Balzan S, Hernandes A, Reichert CL, Donaduzzi C, Pires VA, Gasparotto A Jr, Cardozo EL Jr. Lipid-lowering effects of standardized extracts of Ilex paraguariensis in high-fat-diet rats. Fitoterapia. 2013, 86:115-22. 10.1016\/j.fitote.2013.02.008","journal-title":"Fitoterapia"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2009.189","article-title":"Mat\u00e9 tea inhibits in vitro pancreatic lipase activity and has hypolipidemic effect on high-fat diet-induced obese mice","volume":"18","author":"Martins F","year":"2010","unstructured":"Martins F, Noso TM, Porto VB, et al.. Mat\u00e9 tea inhibits in vitro pancreatic lipase activity and has hypolipidemic effect on high-fat diet-induced obese mice. Obesity (Silver Spring). 2010, 18:42-7. 10.1038\/oby.2009.189","journal-title":"Obesity (Silver Spring)"},{"key":"ref35","doi-asserted-by":"crossref","DOI":"10.1590\/fst.39817","article-title":"Ilex paraguariensis extract prevents body weight gain in rats fed a high-fat diet","volume":"39","author":"Uecker JN","year":"2019","unstructured":"Uecker JN, Schneider JP, Cerqueira JH, et al.. Ilex paraguariensis extract prevents body weight gain in rats fed a high-fat diet. Food Sci Technol. 2019, 39:620-6.","journal-title":"Food Sci Technol"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.007","article-title":"Mate tea reduces high fat diet-induced liver and metabolic disorders in mice","volume":"109","author":"Barroso MV","year":"2019","unstructured":"Barroso MV, Gra\u00e7a-Reis A, Cattani-Cavalieri I, Gitirana LB, Valenca SS, Lanzetti M. Mate tea reduces high fat diet-induced liver and metabolic disorders in mice. Biomed Pharmacother. 2019, 109:1547-55. 10.1016\/j.biopha.2018.11.007","journal-title":"Biomed Pharmacother"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1590\/s2175-97902019000217615","article-title":"The anti-obesity potential of Ilex paraguariensis: results from a meta-analysis","volume":"55","author":"Lu\u00eds \u00c2FS","year":"2019","unstructured":"Lu\u00eds \u00c2FS, Domingues FC, Amaral LM. The anti-obesity potential of Ilex paraguariensis: results from a meta-analysis. Braz J Pharm Sci. 2019, 55:17615-10. 10.1590\/s2175-97902019000217615","journal-title":"Braz J Pharm Sci"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.3390\/nu12010202","article-title":"Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women","volume":"12","author":"Ko SH","year":"2020","unstructured":"Ko SH, Kim HS. Menopause-associated lipid metabolic disorders and foods beneficial for postmenopausal women. Nutrients. 2020, 12:202. 10.3390\/nu12010202","journal-title":"Nutrients"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.32.4.764","article-title":"Early cardiac changes after menopause","volume":"32","author":"Schillaci G","year":"1998","unstructured":"Schillaci G, Verdecchia P, Borgioni C, Ciucci A, Porcellati C. Early cardiac changes after menopause. Hypertension. 1998, 32:764-9. 10.1161\/01.hyp.32.4.764","journal-title":"Hypertension"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205058","article-title":"The beige adipocyte as a therapy for metabolic diseases","volume":"20","author":"Lizcano F","year":"2019","unstructured":"Lizcano F. The beige adipocyte as a therapy for metabolic diseases. Int J Mol Sci. 2019, 20:5058. 10.3390\/ijms20205058","journal-title":"Int J Mol Sci"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcme.2020.07.002","article-title":"Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery","volume":"11","author":"Rocha DS","year":"2021","unstructured":"Rocha DS, Argenta Model JF, Von Dentz M, et al.. Adipose tissue of female Wistar rats respond to Ilex paraguariensis treatment after ovariectomy surgery. J Tradit Complement Med. 2021, 11:238-48. 10.1016\/j.jtcme.2020.07.002","journal-title":"J Tradit Complement Med"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuac109","article-title":"Physiological effects of yerba mat\u00e9 (Ilex paraguariensis): a systematic review","volume":"81","author":"Jos\u00e9 MF","year":"2023","unstructured":"Jos\u00e9 MF, Machado RP, Araujo PA, Speretta GF. Physiological effects of yerba mat\u00e9 (Ilex paraguariensis): a systematic review. Nutr Rev. 2023, 81:1163-79. 10.1093\/nutrit\/nuac109","journal-title":"Nutr Rev"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/523475-cardiometabolic-effects-of-ilex-paraguariensis-yerba-mate-a-narrative-review-of-evidence-and-research-gaps","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T10:00:05Z","timestamp":1786960805000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/523475-cardiometabolic-effects-of-ilex-paraguariensis-yerba-mate-a-narrative-review-of-evidence-and-research-gaps"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,17]]},"references-count":42,"URL":"https:\/\/doi.org\/10.7759\/cureus.114641","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,17]]}}}