{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:25:01Z","timestamp":1787210701115,"version":"build-2736575974"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,20]]},"DOI":"10.7759\/cureus.114824","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:02:32Z","timestamp":1787209352000},"source":"Crossref","is-referenced-by-count":0,"title":["Metastatic Malignant Mesothelioma of the Tunica Vaginalis Testis Treated With Sequential Immunotherapy, Chemotherapy, and Radiotherapy With Prolonged Disease Stabilisation: A Case Report"],"prefix":"10.7759","author":[{"given":"Navin","family":"Mathiyalagan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Pascoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitum","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Adeel","family":"Sarwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa N","family":"Abuzahra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Azad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Mohindru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0142(19981215)83:12<2437::aid-cncr6>3.0.co;2-g","article-title":"Malignant mesothelioma of the tunica vaginalis testis: review of the literature and assessment of prognostic parameters","volume":"83","author":"Plas E","year":"1998","unstructured":"Plas E, Riedl CR, Pfl\u00fcger H. Malignant mesothelioma of the tunica vaginalis testis: review of the literature and assessment of prognostic parameters. Cancer. 1998, 83:2437-46. 10.1002\/(sici)1097-0142(19981215)83:12&lt;2437::aid-cncr6&gt;3.0.co;2-g","journal-title":"Cancer"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199507000-00010","article-title":"Malignant mesothelioma of the tunica vaginalis: a clinicopathologic analysis of 11 cases with review of the literature","volume":"19","author":"Jones MA","year":"1995","unstructured":"Jones MA, Young RH, Scully RE. Malignant mesothelioma of the tunica vaginalis: a clinicopathologic analysis of 11 cases with review of the literature. Am J Surg Pathol. 1995, 19:815-25. 10.1097\/00000478-199507000-00010","journal-title":"Am J Surg Pathol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16233956","article-title":"Mesothelioma of the tunica vaginalis testis: diagnostic and therapeutic management. A comprehensive review, 1982-2024","volume":"16","author":"Stella S","year":"2024","unstructured":"Stella S, Ceresoli GL, Dallari B, et al.. Mesothelioma of the tunica vaginalis testis: diagnostic and therapeutic management. A comprehensive review, 1982-2024. Cancers (Basel). 2024, 16:3956. 10.3390\/cancers16233956","journal-title":"Cancers (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04348-y","article-title":"Testicular mesothelioma disguised as hydrocele: a case report","volume":"18","author":"Nazar T","year":"2024","unstructured":"Nazar T, Gopalakrishnabhaktan A, Tashrifwala FA, Sathish A, Dave T. Testicular mesothelioma disguised as hydrocele: a case report. J Med Case Rep. 2024, 18:114. 10.1186\/s13256-024-04348-y","journal-title":"J Med Case Rep"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1997.5460776.x","article-title":"Pathology of malignant mesothelioma","volume":"30","author":"Attanoos RL","year":"1997","unstructured":"Attanoos RL, Gibbs AR. Pathology of malignant mesothelioma. Histopathology. 1997, 30:403-18. 10.1046\/j.1365-2559.1997.5460776.x","journal-title":"Histopathology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.11.136","article-title":"Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma","volume":"21","author":"Vogelzang NJ","year":"2003","unstructured":"Vogelzang NJ, Rusthoven JJ, Symanowski J, et al.. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol. 2003, 21:2636-44. 10.1200\/JCO.2003.11.136","journal-title":"J Clin Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32714-8","article-title":"First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial","volume":"397","author":"Baas P","year":"2021","unstructured":"Baas P, Scherpereel A, Nowak AK, et al.. First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial. Lancet. 2021, 397:375-86. 10.1016\/S0140-6736(20)32714-8","journal-title":"Lancet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.01.074","article-title":"First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743","volume":"33","author":"Peters S","year":"2022","unstructured":"Peters S, Scherpereel A, Cornelissen R, et al.. First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743. Ann Oncol. 2022, 33:488-99. 10.1016\/j.annonc.2022.01.074","journal-title":"Ann Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7610","article-title":"A rare presentation of malignant mesothelioma of the tunica vaginalis managed with immunotherapy and review of the literature","volume":"11","author":"Mishra K","year":"2023","unstructured":"Mishra K, Siddiquee S, Mislang AR. A rare presentation of malignant mesothelioma of the tunica vaginalis managed with immunotherapy and review of the literature. Clin Case Rep. 2023, 11:e7610. 10.1002\/ccr3.7610","journal-title":"Clin Case Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.03.030","article-title":"The use of radiation therapy for the treatment of malignant pleural mesothelioma: expert opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation","volume":"14","author":"Gomez DR","year":"2019","unstructured":"Gomez DR, Rimner A, Simone CB 2nd, et al.. The use of radiation therapy for the treatment of malignant pleural mesothelioma: expert opinion from the National Cancer Institute Thoracic Malignancy Steering Committee, International Association for the Study of Lung Cancer, and Mesothelioma Applied Research Foundation. J Thorac Oncol. 2019, 14:1172-83. 10.1016\/j.jtho.2019.03.030","journal-title":"J Thorac Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2020.11.022","article-title":"Salvage radiotherapy for oligo-progressive malignant pleural mesothelioma","volume":"152","author":"Ghirardelli P","year":"2021","unstructured":"Ghirardelli P, Franceschini D, D'Aveni A, et al.. Salvage radiotherapy for oligo-progressive malignant pleural mesothelioma. Lung Cancer. 2021, 152:1-6. 10.1016\/j.lungcan.2020.11.022","journal-title":"Lung Cancer"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/523255-metastatic-malignant-mesothelioma-of-the-tunica-vaginalis-testis-treated-with-sequential-immunotherapy-chemotherapy-and-radiotherapy-with-prolonged-disease-stabilisation-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:02:33Z","timestamp":1787209353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/523255-metastatic-malignant-mesothelioma-of-the-tunica-vaginalis-testis-treated-with-sequential-immunotherapy-chemotherapy-and-radiotherapy-with-prolonged-disease-stabilisation-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":11,"URL":"https:\/\/doi.org\/10.7759\/cureus.114824","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,20]]}}}