{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:23:38Z","timestamp":1787214218497,"version":"build-2736575974"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,20]]},"DOI":"10.7759\/cureus.114826","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:32:31Z","timestamp":1787211151000},"source":"Crossref","is-referenced-by-count":0,"title":["Histomorphological and Immunohistochemical Profile of Malignant Breast Lesions in a Tertiary Care Center of Central India: A Cross-Sectional Study"],"prefix":"10.7759","author":[{"given":"Himani","family":"Himani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Gangwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray F","year":"2024","unstructured":"Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024, 74:229-63. 10.3322\/caac.21834","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.ijmr_1821_22","article-title":"Cancer incidence estimates for 2022 & projection for 2025: result from National Cancer Registry Programme, India","volume":"156","author":"Sathishkumar K","year":"2022","unstructured":"Sathishkumar K, Chaturvedi M, Das P, Stephen S, Mathur P. Cancer incidence estimates for 2022 &amp; projection for 2025: result from National Cancer Registry Programme, India. Indian J Med Res. 2022, 156:598-607. 10.4103\/ijmr.ijmr_1821_22","journal-title":"Indian J Med Res"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.12661","article-title":"Epidemiology of breast cancer in Indian women","volume":"13","author":"Malvia S","year":"2017","unstructured":"Malvia S, Bagadi SA, Dubey US, Saxena S. Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol. 2017, 13:289-95. 10.1111\/ajco.12661","journal-title":"Asia Pac J Clin Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/his.14091","article-title":"The 2019 World Health Organization classification of tumours of the breast","volume":"77","author":"Tan PH","year":"2020","unstructured":"Tan PH, Ellis I, Allison K, et al.. The 2019 World Health Organization classification of tumours of the breast. Histopathology. 2020, 77:181-5. 10.1111\/his.14091","journal-title":"Histopathology"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1991.tb00229.x","article-title":"Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up","volume":"19","author":"Elston CW","year":"1991","unstructured":"Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology. 1991, 19:403-10. 10.1111\/j.1365-2559.1991.tb00229.x","journal-title":"Histopathology"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0904-SA","article-title":"Estrogen and progesterone receptor testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists Guideline Update","volume":"144","author":"Allison KH","year":"2020","unstructured":"Allison KH, Hammond ME, Dowsett M, et al.. Estrogen and progesterone receptor testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists Guideline Update. Arch Pathol Lab Med. 2020, 144:545-63. 10.5858\/arpa.2019-0904-SA","journal-title":"Arch Pathol Lab Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.77.8738","article-title":"Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists Clinical Practice Guideline Focused Update","volume":"36","author":"Wolff AC","year":"2018","unstructured":"Wolff AC, Hammond ME, Allison KH, et al.. Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology\/College of American Pathologists Clinical Practice Guideline Focused Update. J Clin Oncol. 2018, 36:2105-22. 10.1200\/JCO.2018.77.8738","journal-title":"J Clin Oncol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/35021093","article-title":"Molecular portraits of human breast tumours","volume":"406","author":"Perou CM","year":"2000","unstructured":"Perou CM, S\u00f8rlie T, Eisen MB, et al.. Molecular portraits of human breast tumours. Nature. 2000, 406:747-52. 10.1038\/35021093","journal-title":"Nature"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2607","article-title":"Breast cancer prognostic classification in the molecular era: the role of histological grade","volume":"12","author":"Rakha EA","year":"2010","unstructured":"Rakha EA, Reis-Filho JS, Baehner F, et al.. Breast cancer prognostic classification in the molecular era: the role of histological grade. Breast Cancer Res. 2010, 12:207. 10.1186\/bcr2607","journal-title":"Breast Cancer Res"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3121\/cmr.2009.825","article-title":"Breast cancer subtypes based on ER\/PR and Her2 expression: comparison of clinicopathologic features and survival","volume":"7","author":"Onitilo AA","year":"2009","unstructured":"Onitilo AA, Engel JM, Greenlee RT, Mukesh BN. Breast cancer subtypes based on ER\/PR and Her2 expression: comparison of clinicopathologic features and survival. Clin Med Res. 2009, 7:4-13. 10.3121\/cmr.2009.825","journal-title":"Clin Med Res"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.4103\/njs.NJS_2_18","article-title":"Evaluation of immunohistochemical profile of breast cancer for prognostics and therapeutic use","volume":"24","author":"Chand P","year":"2018","unstructured":"Chand P, Garg A, Singla V, Rani N. Evaluation of immunohistochemical profile of breast cancer for prognostics and therapeutic use. Niger J Surg. 2018, 24:100-6. 10.4103\/njs.NJS_2_18","journal-title":"Niger J Surg"},{"key":"ref12","article-title":"Correlation of hormone receptor expression with histologic parameters in benign and malignant breast tumors","volume":"10","author":"Gupta D","year":"2015","unstructured":"Gupta D, Gupta V, Marwah N, et al.. Correlation of hormone receptor expression with histologic parameters in benign and malignant breast tumors. Iran J Pathol. 2015, 10:23-34.","journal-title":"Iran J Pathol"},{"key":"ref13","article-title":"Comparison of ER, PR and HER-2\/neu (C-erb B 2) reactivity pattern with histologic grade, tumor size and lymph node status in breast cancer","volume":"9","author":"Azizun-Nisa","year":"2008","unstructured":"Azizun-Nisa, Bhurgri Y, Raza F, Kayani N. Comparison of ER, PR and HER-2\/neu (C-erb B 2) reactivity pattern with histologic grade, tumor size and lymph node status in breast cancer. Asian Pac J Cancer Prev. 2008, 9:553-6.","journal-title":"Asian Pac J Cancer Prev"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2011.07.008","article-title":"Characteristics and outcomes according to molecular subtypes of breast cancer as classified by a panel of four biomarkers using immunohistochemistry","volume":"21","author":"Park S","year":"2012","unstructured":"Park S, Koo JS, Kim MS, et al.. Characteristics and outcomes according to molecular subtypes of breast cancer as classified by a panel of four biomarkers using immunohistochemistry. Breast. 2012, 21:50-7. 10.1016\/j.breast.2011.07.008","journal-title":"Breast"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-3045","article-title":"Triple-negative breast cancer: clinical features and patterns of recurrence","volume":"13","author":"Dent R","year":"2007","unstructured":"Dent R, Trudeau M, Pritchard KI, et al.. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res. 2007, 13:4429-34. 10.1158\/1078-0432.CCR-06-3045","journal-title":"Clin Cancer Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/515141-histomorphological-and-immunohistochemical-profile-of-malignant-breast-lesions-in-a-tertiary-care-center-of-central-india-a-cross-sectional-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T07:32:32Z","timestamp":1787211152000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/515141-histomorphological-and-immunohistochemical-profile-of-malignant-breast-lesions-in-a-tertiary-care-center-of-central-india-a-cross-sectional-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.114826","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,20]]}}}