{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:26:30Z","timestamp":1787214390186,"version":"build-2736575974"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,20]]},"DOI":"10.7759\/cureus.114831","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:19:12Z","timestamp":1787213952000},"source":"Crossref","is-referenced-by-count":0,"title":["Emergence of Two Rare Malignancies, Langerhans Cell Sarcoma and Myeloid Sarcoma, After Targeted Therapy for Chronic Lymphocytic Leukaemia: A Case Report"],"prefix":"10.7759","author":[{"given":"A.","family":"Niblock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Mannion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerrie","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27546","article-title":"Chronic lymphocytic leukemia: update on the epidemiology, pathogenesis, diagnosis, and therapy","volume":"100","author":"Hallek M","year":"2025","unstructured":"Hallek M. Chronic lymphocytic leukemia: update on the epidemiology, pathogenesis, diagnosis, and therapy. Am J Hematol. 2025, 100:450-80. 10.1002\/ajh.27546","journal-title":"Am J Hematol"},{"key":"ref2","article-title":"Chronic lymphocytic leukemia\/small lymphocytic lymphoma, version 4.2020, NCCN Clinical Practice Guidelines in Oncology","volume":"18","author":"Wierda WG","year":"2020","unstructured":"Wierda WG, Byrd JC, Abramson JS, et al.. Chronic lymphocytic leukemia\/small lymphocytic lymphoma, version 4.2020, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 2020, 18:185-217.","journal-title":"J Natl Compr Canc Netw"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.02.011","article-title":"Langerhans cell sarcoma: a systematic review","volume":"41","author":"Howard JE","year":"2015","unstructured":"Howard JE, Dwivedi RC, Masterson L, Jani P. Langerhans cell sarcoma: a systematic review. Cancer Treat Rev. 2015, 41:320-31. 10.1016\/j.ctrv.2015.02.011","journal-title":"Cancer Treat Rev"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.989366","article-title":"Incidence, clinical characteristics, and prognostic nomograms for patients with myeloid sarcoma: a SEER-based study","volume":"12","author":"Xing Z","year":"2022","unstructured":"Xing Z, Zhu X, Li Z, Wang H, Qian M, Zhai X. Incidence, clinical characteristics, and prognostic nomograms for patients with myeloid sarcoma: a SEER-based study. Front Oncol. 2022, 12:989366. 10.3389\/fonc.2022.989366","journal-title":"Front Oncol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810701)48:1<198::aid-cncr2820480131>3.0.co;2-v","article-title":"A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis","volume":"48","author":"Binet JL","year":"1981","unstructured":"Binet JL, Auquier A, Dighiero G, et al.. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis. Cancer. 1981, 48:198-206. 10.1002\/1097-0142(19810701)48:1&lt;198::aid-cncr2820480131&gt;3.0.co;2-v","journal-title":"Cancer"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02115-1","article-title":"Restoration of the immune function as a complementary strategy to treat chronic lymphocytic leukemia effectively","volume":"40","author":"Moreno C","year":"2021","unstructured":"Moreno C, Mu\u00f1oz C, Terol MJ, Hern\u00e1ndez-Rivas J\u00c1, Villanueva M. Restoration of the immune function as a complementary strategy to treat chronic lymphocytic leukemia effectively. J Exp Clin Cancer Res. 2021, 40:321. 10.1186\/s13046-021-02115-1","journal-title":"J Exp Clin Cancer Res"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2022.12.001","article-title":"Assessing the frequency of CD163+ tumor-associated macrophages and CD3+ T lymphocytes between MGUS and plasma cell myeloma","volume":"119-120","author":"Niblock A","year":"2023","unstructured":"Niblock A, Rajendran S, Laverty C, Logue P, Alexander HD. Assessing the frequency of CD163+ tumor-associated macrophages and CD3+ T lymphocytes between MGUS and plasma cell myeloma. Exp Hematol. 2023, 119-120:3-7. 10.1016\/j.exphem.2022.12.001","journal-title":"Exp Hematol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i34.10715","article-title":"Chronic lymphocytic leukemia\/small lymphocytic lymphoma complicated with skin Langerhans cell sarcoma: a case report","volume":"9","author":"Li SY","year":"2021","unstructured":"Li SY, Wang Y, Wang LH. Chronic lymphocytic leukemia\/small lymphocytic lymphoma complicated with skin Langerhans cell sarcoma: a case report. World J Clin Cases. 2021, 9:10715-22. 10.12998\/wjcc.v9.i34.10715","journal-title":"World J Clin Cases"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.102","article-title":"Clonally related histiocytic\/dendritic cell sarcoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a study of seven cases","volume":"24","author":"Shao H","year":"2011","unstructured":"Shao H, Xi L, Raffeld M, et al.. Clonally related histiocytic\/dendritic cell sarcoma and chronic lymphocytic leukemia\/small lymphocytic lymphoma: a study of seven cases. Mod Pathol. 2011, 24:1421-32. 10.1038\/modpathol.2011.102","journal-title":"Mod Pathol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqad022","article-title":"B-cell lineage neoplasms transdifferentiating into histiocytic\/dendritic cell neoplasms: diversity, differentiation lineage, genomic alterations, and therapy: report from the 2021 SH\/EAHP workshop","volume":"159","author":"Xiao W","year":"2023","unstructured":"Xiao W, Amador C, Cook JR, et al.. B-cell lineage neoplasms transdifferentiating into histiocytic\/dendritic cell neoplasms: diversity, differentiation lineage, genomic alterations, and therapy: report from the 2021 SH\/EAHP workshop. Am J Clin Pathol. 2023, 159:522-37. 10.1093\/ajcp\/aqad022","journal-title":"Am J Clin Pathol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1750-9378-9-15","article-title":"High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues","volume":"9","author":"Murakami I","year":"2014","unstructured":"Murakami I, Matsushita M, Iwasaki T, et al.. High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues. Infect Agent Cancer. 2014, 9:15. 10.1186\/1750-9378-9-15","journal-title":"Infect Agent Cancer"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2011.01361.x","article-title":"State of the art in myeloid sarcoma","volume":"33","author":"Klco JM","year":"2011","unstructured":"Klco JM, Welch JS, Nguyen TT, et al.. State of the art in myeloid sarcoma. Int J Lab Hematol. 2011, 33:555-65. 10.1111\/j.1751-553X.2011.01361.x","journal-title":"Int J Lab Hematol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/509485-emergence-of-two-rare-malignancies-langerhans-cell-sarcoma-and-myeloid-sarcoma-after-targeted-therapy-for-chronic-lymphocytic-leukaemia-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:19:13Z","timestamp":1787213953000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/509485-emergence-of-two-rare-malignancies-langerhans-cell-sarcoma-and-myeloid-sarcoma-after-targeted-therapy-for-chronic-lymphocytic-leukaemia-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,20]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.114831","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,20]]}}}