{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:21:00Z","timestamp":1787656860659,"version":"build-2736575974"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"DOI":"10.7759\/cureus.115139","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:41:18Z","timestamp":1787654478000},"source":"Crossref","is-referenced-by-count":0,"title":["Improving Compliance With the Sepsis Six Care Bundle in the Surgical Emergency Department: A Closed-Loop Clinical Audit"],"prefix":"10.7759","author":[{"given":"Basit","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qirat H","family":"Aizdee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umair Ahmad","family":"Munir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Atif Kanjoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizan E","family":"Mustafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer M","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, et al.. The Third International Consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016, 315:801-10. 10.1001\/jama.2016.0287","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd KE","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, et al.. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020, 395:200-11. 10.1016\/S0140-6736(19)32989-7","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijregi.2023.12.002","article-title":"Review of sepsis in Pakistan: how far have we come?","volume":"10","author":"Raza HA","year":"2024","unstructured":"Raza HA, Hashmi AP, Khakwani MM, Ali MH, Jamil B. Review of sepsis in Pakistan: how far have we come?. IJID Reg. 2024, 10:108-13. 10.1016\/j.ijregi.2023.12.002","journal-title":"IJID Reg"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2020.047","article-title":"Sepsis and septic shock in low- and middle-income countries","volume":"21","author":"Stephen AH","year":"2020","unstructured":"Stephen AH, Montoya RL, Aluisio AR. Sepsis and septic shock in low- and middle-income countries. Surg Infect (Larchmt). 2020, 21:571-8. 10.1089\/sur.2020.047","journal-title":"Surg Infect (Larchmt)"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2010.095067","article-title":"The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study","volume":"28","author":"Daniels R","year":"2011","unstructured":"Daniels R, Nutbeam T, McNamara G, Galvin C. The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study. Emerg Med J. 2011, 28:507-12. 10.1136\/emj.2010.095067","journal-title":"Emerg Med J"},{"key":"ref6","unstructured":"UK Sepsis Trust. Healthcare professionals. Accessed. August 5, 2025: https:\/\/sepsistrust.org\/healthcare-professionals\/."},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/nicc.12358","article-title":"Improving outcome of sepsis on the ward: introducing the 'Sepsis Six' bundle","volume":"24","author":"Burke J","year":"2019","unstructured":"Burke J, Wood S, Hermon A, Szakmany T. Improving outcome of sepsis on the ward: introducing the 'Sepsis Six' bundle. Nurs Crit Care. 2019, 24:33-9. 10.1111\/nicc.12358","journal-title":"Nurs Crit Care"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-23204","article-title":"A snapshot of compliance with the sepsis six care bundle in two acute hospitals in the West Midlands, UK","volume":"23","author":"Frankling C","year":"2019","unstructured":"Frankling C, Patel J, Sharif B, Melody T, Yeung J, Gao F, Szakmany T. A snapshot of compliance with the sepsis six care bundle in two acute hospitals in the West Midlands, UK. Indian J Crit Care Med. 2019, 23:310-5. 10.5005\/jp-journals-10071-23204","journal-title":"Indian J Crit Care Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-95648-6","article-title":"Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards","volume":"11","author":"Kopczynska M","year":"2021","unstructured":"Kopczynska M, Unwin H, Pugh RJ, et al.. Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards. Sci Rep. 2021, 11:16222. 10.1038\/s41598-021-95648-6","journal-title":"Sci Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10432","article-title":"Multicentre observational study of adherence to Sepsis Six guidelines in emergency general surgery","volume":"104","author":"UK National Surgical Research Collaborative","year":"2017","unstructured":"UK National Surgical Research Collaborative. Multicentre observational study of adherence to Sepsis Six guidelines in emergency general surgery. Br J Surg. 2017, 104:e165-71. 10.1002\/bjs.10432","journal-title":"Br J Surg"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.20344\/amp.6998","article-title":"Impact of compliance with a sepsis resuscitation bundle in a Portuguese emergency department","volume":"29","author":"Carvas JM","year":"2016","unstructured":"Carvas JM, Canelas C, Montanha G, Silva C, Esteves F. Impact of compliance with a sepsis resuscitation bundle in a Portuguese emergency department. Acta Med Port. 2016, 29:88-94. 10.20344\/amp.6998","journal-title":"Acta Med Port"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4266\/acc.000625","article-title":"Impact of the National Early Warning Score-based sepsis response system on hospital-onset sepsis in a tertiary hospital in South Korea","volume":"40","author":"Hyun DG","year":"2025","unstructured":"Hyun DG, Lee S, Choi S, Son J, Park SH, Hong SB, Lim CM. Impact of the National Early Warning Score-based sepsis response system on hospital-onset sepsis in a tertiary hospital in South Korea. Acute Crit Care. 2025, 40:186-96. 10.4266\/acc.000625","journal-title":"Acute Crit Care"},{"key":"ref13","article-title":"Compliance with the sepsis resuscitation care bundles in the emergency department of a developing world tertiary care hospital - a clinical audit","volume":"27","author":"Baig MA","year":"2018","unstructured":"Baig MA, Sheikh S, Hussain E, Waheed S, Mian A. Compliance with the sepsis resuscitation care bundles in the emergency department of a developing world tertiary care hospital - a clinical audit. Infect Dis J Pak. 2018, 27:30-3.","journal-title":"Infect Dis J Pak"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.55629\/pakjpathol.v37i2.1012","article-title":"Implementation and compliance with the Sepsis Six bundle in the emergency department: a quality improvement project in a resource-limited tertiary care setting","volume":"37","author":"Shafquat Y","year":"2026","unstructured":"Shafquat Y, Ujjan ID, Shankar R, Kumar S, Rai L, Soothar K. Implementation and compliance with the Sepsis Six bundle in the emergency department: a quality improvement project in a resource-limited tertiary care setting. Pak J Pathol. 2026, 37:95-101. 10.55629\/pakjpathol.v37i2.1012","journal-title":"Pak J Pathol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136\/pmj.78.922.508","article-title":"Principles for best practice in clinical audit","volume":"78","author":"Hart A","year":"2002","unstructured":"Hart A. Principles for best practice in clinical audit. Postgrad Med J. 2002, 78:508. 10.1136\/pmj.78.922.508","journal-title":"Postgrad Med J"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans L","year":"2021","unstructured":"Evans L, Rhodes A, Alhazzani W, et al.. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021, 47:1181-247. 10.1007\/s00134-021-06506-y","journal-title":"Intensive Care Med"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine","volume":"101","author":"Bone RC","year":"1992","unstructured":"Bone RC, Balk RA, Cerra FB, et al.. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine. Chest. 1992, 101:1644-55. 10.1378\/chest.101.6.1644","journal-title":"Chest"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Seymour CW","year":"2016","unstructured":"Seymour CW, Liu VX, Iwashyna TJ, et al.. Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016, 315:762-74. 10.1001\/jama.2016.0288","journal-title":"JAMA"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ienj.2008.05.008","article-title":"An audit of compliance with the sepsis resuscitation care bundle in patients admitted to A&E with severe sepsis or septic shock","volume":"16","author":"Baldwin LN","year":"2008","unstructured":"Baldwin LN, Smith SA, Fender V, Gisby S, Fraser J. An audit of compliance with the sepsis resuscitation care bundle in patients admitted to A&amp;E with severe sepsis or septic shock. Int Emerg Nurs. 2008, 16:250-6. 10.1016\/j.ienj.2008.05.008","journal-title":"Int Emerg Nurs"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/524262-improving-compliance-with-the-sepsis-six-care-bundle-in-the-surgical-emergency-department-a-closed-loop-clinical-audit","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:41:19Z","timestamp":1787654479000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/524262-improving-compliance-with-the-sepsis-six-care-bundle-in-the-surgical-emergency-department-a-closed-loop-clinical-audit"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":19,"URL":"https:\/\/doi.org\/10.7759\/cureus.115139","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,25]]}}}