{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:23:24Z","timestamp":1787660604660,"version":"build-2736575974"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,25]]},"DOI":"10.7759\/cureus.115147","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:38:52Z","timestamp":1787657932000},"source":"Crossref","is-referenced-by-count":0,"title":["Symptom Burden in Postural Orthostatic Tachycardia Syndrome (POTS) and Endometriosis: A Retrospective Cohort Study"],"prefix":"10.7759","author":[{"given":"Adeline Y","family":"Chin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan G","family":"Rilinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe","family":"Leboit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackaleigh A","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Nowacki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley R","family":"Brant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryl","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Gubbels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna  K","family":"Hayburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2018.06.007","article-title":"Moving from the present to the future of postural tachycardia syndrome - what we need","volume":"215","author":"Raj SR","year":"2018","unstructured":"Raj SR, Robertson D. Moving from the present to the future of postural tachycardia syndrome - what we need. Auton Neurosci. 2018, 215:126-8. 10.1016\/j.autneu.2018.06.007","journal-title":"Auton Neurosci"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2021.102828","article-title":"Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1","volume":"235","author":"Vernino S","year":"2021","unstructured":"Vernino S, Bourne KM, Stiles LE, et al.. Postural orthostatic tachycardia syndrome (POTS): state of the science and clinical care from a 2019 National Institutes of Health Expert Consensus Meeting - Part 1. Auton Neurosci. 2021, 235:102828. 10.1016\/j.autneu.2021.102828","journal-title":"Auton Neurosci"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2015.03.029","article-title":"2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope","volume":"12","author":"Sheldon RS","year":"2015","unstructured":"Sheldon RS, Grubb BP 2nd, Olshansky B, et al.. 2015 heart rhythm society expert consensus statement on the diagnosis and treatment of postural tachycardia syndrome, inappropriate sinus tachycardia, and vasovagal syncope. Heart Rhythm. 2015, 12:e41-63. 10.1016\/j.hrthm.2015.03.029","journal-title":"Heart Rhythm"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2020.102690","article-title":"Psychological correlates of patients with postural orthostatic tachycardia syndrome (POTS)","volume":"227","author":"Fisher CJ","year":"2020","unstructured":"Fisher CJ, Katzan I, Heinberg LJ, Schuster AT, Thompson NR, Wilson R. Psychological correlates of patients with postural orthostatic tachycardia syndrome (POTS). Auton Neurosci. 2020, 227:102690. 10.1016\/j.autneu.2020.102690","journal-title":"Auton Neurosci"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2022.2071482","article-title":"\"You're always fighting\": the lived experience of people with postural orthostatic tachycardia syndrome (POTS)","volume":"45","author":"Knoop I","year":"2023","unstructured":"Knoop I, Dunwoody L. \"You're always fighting\": the lived experience of people with postural orthostatic tachycardia syndrome (POTS). Disabil Rehabil. 2023, 45:1629-35. 10.1080\/09638288.2022.2071482","journal-title":"Disabil Rehabil"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan KT","year":"2020","unstructured":"Zondervan KT, Becker CM, Missmer SA. Endometriosis. N Engl J Med. 2020, 382:1244-56. 10.1056\/NEJMra1810764","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2024.104292","article-title":"Growing evidence that endometriosis is a systemic disease","volume":"49","author":"Tulandi T","year":"2024","unstructured":"Tulandi T, Vercellini P. Growing evidence that endometriosis is a systemic disease. Reprod Biomed Online. 2024, 49:104292. 10.1016\/j.rbmo.2024.104292","journal-title":"Reprod Biomed Online"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-070750","article-title":"Pathophysiology, diagnosis, and management of endometriosis","volume":"379","author":"Horne AW","year":"2022","unstructured":"Horne AW, Missmer SA. Pathophysiology, diagnosis, and management of endometriosis. BMJ. 2022, 379:e070750. 10.1136\/bmj-2022-070750","journal-title":"BMJ"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000516517","article-title":"Does endometriosis disturb mental health and quality of life? A systematic review and meta-analysis","volume":"86","author":"Wang Y","year":"2021","unstructured":"Wang Y, Li B, Zhou Y, et al.. Does endometriosis disturb mental health and quality of life? A systematic review and meta-analysis. Gynecol Obstet Invest. 2021, 86:315-35. 10.1159\/000516517","journal-title":"Gynecol Obstet Invest"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2023.07.033","article-title":"Associations between endometriosis and common symptoms: findings from the Australian Longitudinal Study on Women's Health","volume":"229","author":"Gete DG","year":"2023","unstructured":"Gete DG, Doust J, Mortlock S, Montgomery G, Mishra GD. Associations between endometriosis and common symptoms: findings from the Australian Longitudinal Study on Women's Health. Am J Obstet Gynecol. 2023, 229:536.e1-536.e20. 10.1016\/j.ajog.2023.07.033","journal-title":"Am J Obstet Gynecol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126473","article-title":"Endometriosis, pain, and related psychological disorders: unveiling the interplay among the microbiome, inflammation, and oxidative stress as a common thread","volume":"25","author":"Cuffaro F","year":"2024","unstructured":"Cuffaro F, Russo E, Amedei A. Endometriosis, pain, and related psychological disorders: unveiling the interplay among the microbiome, inflammation, and oxidative stress as a common thread. Int J Mol Sci. 2024, 25:6473. 10.3390\/ijms25126473","journal-title":"Int J Mol Sci"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.10.013","article-title":"COMPASS 31: a refined and abbreviated Composite Autonomic Symptom Score","volume":"87","author":"Sletten DM","year":"2012","unstructured":"Sletten DM, Suarez GA, Low PA, Mandrekar J, Singer W. COMPASS 31: a refined and abbreviated Composite Autonomic Symptom Score. Mayo Clin Proc. 2012, 87:1196-201. 10.1016\/j.mayocp.2012.10.013","journal-title":"Mayo Clin Proc"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-009-9496-9","article-title":"Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items","volume":"18","author":"Hays RD","year":"2009","unstructured":"Hays RD, Bjorner JB, Revicki DA, Spritzer KL, Cella D. Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items. Qual Life Res. 2009, 18:873-80. 10.1007\/s11136-009-9496-9","journal-title":"Qual Life Res"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer RL","year":"2006","unstructured":"Spitzer RL, Kroenke K, Williams JB, L\u00f6we B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. 2006, 166:1092-7. 10.1001\/archinte.166.10.1092","journal-title":"Arch Intern Med"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke K","year":"2001","unstructured":"Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001, 16:606-13. 10.1046\/j.1525-1497.2001.016009606.x","journal-title":"J Gen Intern Med"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris PA","year":"2009","unstructured":"Harris PA, Taylor R, Thielke R, Payne J, Gonzalez N, Conde JG. Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2009, 42:377-81. 10.1016\/j.jbi.2008.08.010","journal-title":"J Biomed Inform"},{"key":"ref17","unstructured":"The R Project for Statistical Computing. (2025). Accessed. February 9, 2026: https:\/\/www.R-project.org."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.0268","article-title":"Prevalence of depression and anxiety among adults with chronic pain: a systematic review and meta-analysis","volume":"8","author":"Aaron RV","year":"2025","unstructured":"Aaron RV, Ravyts SG, Carnahan ND, et al.. Prevalence of depression and anxiety among adults with chronic pain: a systematic review and meta-analysis. JAMA Netw Open. 2025, 8:e250268. 10.1001\/jamanetworkopen.2025.0268","journal-title":"JAMA Netw Open"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2018.03.004","article-title":"Cognitive and psychological issues in postural tachycardia syndrome","volume":"215","author":"Raj V","year":"2018","unstructured":"Raj V, Opie M, Arnold AC. Cognitive and psychological issues in postural tachycardia syndrome. Auton Neurosci. 2018, 215:46-55. 10.1016\/j.autneu.2018.03.004","journal-title":"Auton Neurosci"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2025.53694","article-title":"Prevalence of central sensitization in postural tachycardia syndrome","volume":"9","author":"Mathew GT","year":"2026","unstructured":"Mathew GT, Novak P. Prevalence of central sensitization in postural tachycardia syndrome. JAMA Netw Open. 2026, 9:e2553694. 10.1001\/jamanetworkopen.2025.53694","journal-title":"JAMA Netw Open"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2024.102977","article-title":"Pathophysiology and management of postural orthostatic tachycardia syndrome (POTS): a literature review","volume":"50","author":"Ghazal M","year":"2025","unstructured":"Ghazal M, Akkawi AR, Fancher A, Oundo E, Tanzeem H, Sajjad L, Briasoulis A. Pathophysiology and management of postural orthostatic tachycardia syndrome (POTS): a literature review. Curr Probl Cardiol. 2025, 50:102977. 10.1016\/j.cpcardiol.2024.102977","journal-title":"Curr Probl Cardiol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1177\/17423953211054032","article-title":"Experiences of living with postural tachycardia syndrome","volume":"19","author":"Waterman S","year":"2023","unstructured":"Waterman S, Opie M, Waterman D, Langdon D. Experiences of living with postural tachycardia syndrome. Chronic Illn. 2023, 19:184-96. 10.1177\/17423953211054032","journal-title":"Chronic Illn"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v15.i10.107147","article-title":"Depression and anxiety in patients with endometriosis-associated chronic pain: neuroimmune mechanisms mediated by inflammatory factors","volume":"15","author":"Yang FC","year":"2025","unstructured":"Yang FC, Zhou Y, Zhang SY, Ma R. Depression and anxiety in patients with endometriosis-associated chronic pain: neuroimmune mechanisms mediated by inflammatory factors. World J Psychiatry. 2025, 15:107147. 10.5498\/wjp.v15.i10.107147","journal-title":"World J Psychiatry"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.04.014","article-title":"Gynecologic disorders and menstrual cycle lightheadedness in postural tachycardia syndrome","volume":"118","author":"Peggs KJ","year":"2012","unstructured":"Peggs KJ, Nguyen H, Enayat D, Keller NR, Al-Hendy A, Raj SR. Gynecologic disorders and menstrual cycle lightheadedness in postural tachycardia syndrome. Int J Gynaecol Obstet. 2012, 118:242-6. 10.1016\/j.ijgo.2012.04.014","journal-title":"Int J Gynaecol Obstet"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00031.2005","article-title":"Progesterone increases plasma volume independent of estradiol","volume":"98","author":"Stachenfeld NS","year":"2005","unstructured":"Stachenfeld NS, Taylor HS. Progesterone increases plasma volume independent of estradiol. J Appl Physiol (1985). 2005, 98:1991-7. 10.1152\/japplphysiol.00031.2005","journal-title":"J Appl Physiol (1985)"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20220212","article-title":"Medical invalidation in the clinical encounter: a qualitative study of the health care experiences of young women and nonbinary people living with chronic illnesses","volume":"11","author":"Sebring JC","year":"2023","unstructured":"Sebring JC, Kelly C, McPhail D, Woodgate RL. Medical invalidation in the clinical encounter: a qualitative study of the health care experiences of young women and nonbinary people living with chronic illnesses. CMAJ Open. 2023, 11:E915-21. 10.9778\/cmajo.20220212","journal-title":"CMAJ Open"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20021080","article-title":"Women's health and working life: a scoping review","volume":"20","author":"Gjellestad M","year":"2023","unstructured":"Gjellestad M, Haraldstad K, Enehaug H, Helmersen M. Women's health and working life: a scoping review. Int J Environ Res Public Health. 2023, 20:1080. 10.3390\/ijerph20021080","journal-title":"Int J Environ Res Public Health"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14134761","article-title":"Understanding the role of social negativity in perceived life course impact and mental health among women with endometriosis","volume":"14","author":"Zarecki C","year":"2025","unstructured":"Zarecki C, Satran C, Kaldawy A, Tesler R, Bord S. Understanding the role of social negativity in perceived life course impact and mental health among women with endometriosis. J Clin Med. 2025, 14:4761. 10.3390\/jcm14134761","journal-title":"J Clin Med"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1155\/ogi\/8872884","article-title":"The long-term postural orthostatic tachycardia syndrome outcomes survey-gynecologic findings: a cross-sectional survey in young women","volume":"2025","author":"Boris JR","year":"2025","unstructured":"Boris JR, Shadiack EC 3rd, McCormick EM, MacMullen LE, George-Sankoh I, Fitzgerald F, Falk M. The long-term postural orthostatic tachycardia syndrome outcomes survey-gynecologic findings: a cross-sectional survey in young women. Obstet Gynecol Int. 2025, 2025:8872884. 10.1155\/ogi\/8872884","journal-title":"Obstet Gynecol Int"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/510799-symptom-burden-in-postural-orthostatic-tachycardia-syndrome-pots-and-endometriosis-a-retrospective-cohort-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:38:53Z","timestamp":1787657933000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/510799-symptom-burden-in-postural-orthostatic-tachycardia-syndrome-pots-and-endometriosis-a-retrospective-cohort-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":29,"URL":"https:\/\/doi.org\/10.7759\/cureus.115147","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,25]]}}}