{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:23:44Z","timestamp":1787736224312,"version":"build-2784847793"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"DOI":"10.7759\/cureus.115207","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:02:36Z","timestamp":1787734956000},"source":"Crossref","is-referenced-by-count":0,"title":["A Rare Dual Complication of First-Line Anti-tubercular Therapy: A Case Report of Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Ethambutol-Induced Optic Neuropathy"],"prefix":"10.7759","author":[{"given":"Koustav","family":"Kundu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aouf","family":"Alazzawi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","article-title":"World Health Organization: Global tuberculosis report 2025. World Health Organization","year":"2025","unstructured":"Global Tuberculosis Report 2025. World Health Organization, Geneva, Switzerland; 2025. https.\/\/www.who.int\/publications\/i\/item\/9789240116924."},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.01.033","article-title":"DRESS syndrome: part I. Clinical perspectives","volume":"68","author":"Husain Z","year":"2013","unstructured":"Husain Z, Reddy BY, Schwartz RA. DRESS syndrome: part I. Clinical perspectives. J Am Acad Dermatol. 2013, 68:693.e1-14; quiz 706-8. 10.1016\/j.jaad.2013.01.033","journal-title":"J Am Acad Dermatol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.50753","article-title":"Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by primary anti-tubercular medication: a case report","volume":"15","author":"Haward R","year":"2023","unstructured":"Haward R, Haward R, Sharma JP. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by primary anti-tubercular medication: a case report. Cureus. 2023, 15:e50753. 10.7759\/cureus.50753","journal-title":"Cureus"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.37399","article-title":"Drug reaction with eosinophilia and systemic symptoms-associated perimyocarditis after initiation of anti-tuberculosis therapy: a case report","volume":"15","author":"Kong D","year":"2023","unstructured":"Kong D, Dixit K, Konje S, Gandhi K, Salman S, Moras E, Agarwal V. Drug reaction with eosinophilia and systemic symptoms-associated perimyocarditis after initiation of anti-tuberculosis therapy: a case report. Cureus. 2023, 15:e37399. 10.7759\/cureus.37399","journal-title":"Cureus"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07704.x","article-title":"Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?","volume":"156","author":"Kardaun SH","year":"2007","unstructured":"Kardaun SH, Sidoroff A, Valeyrie-Allanore L, Halevy S, Davidovici BB, Mockenhaupt M, Roujeau JC. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist?. Br J Dermatol. 2007, 156:609-11. 10.1111\/j.1365-2133.2006.07704.x","journal-title":"Br J Dermatol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2023.114176","article-title":"Potential underlying mechanisms of ethambutol induced optic neuropathy: evidence from in vitro to clinical studies","volume":"182","author":"Kulniwatcharoen P","year":"2023","unstructured":"Kulniwatcharoen P, Hansapinyo L, Chattipakorn N, Chattipakorn SC. Potential underlying mechanisms of ethambutol induced optic neuropathy: evidence from in vitro to clinical studies. Food Chem Toxicol. 2023, 182:114176. 10.1016\/j.fct.2023.114176","journal-title":"Food Chem Toxicol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000416","article-title":"Ethambutol optic neuropathy","volume":"28","author":"Chamberlain PD","year":"2017","unstructured":"Chamberlain PD, Sadaka A, Berry S, Lee AG. Ethambutol optic neuropathy. Curr Opin Ophthalmol. 2017, 28:545-51. 10.1097\/ICU.0000000000000416","journal-title":"Curr Opin Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/toxics12080549","article-title":"Risk factors of optic neuropathy in ethambutol users: Interaction with isoniazid and other associated conditions of toxic optic neuropathy","volume":"12","author":"Kim J","year":"2024","unstructured":"Kim J, Ahn SJ. Risk factors of optic neuropathy in ethambutol users: Interaction with isoniazid and other associated conditions of toxic optic neuropathy. Toxics. 2024, 12:549. 10.3390\/toxics12080549","journal-title":"Toxics"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0277","article-title":"New drugs for the treatment of tuberculosis: hope and reality","volume":"16","author":"Grosset JH","year":"2012","unstructured":"Grosset JH, Singer TG, Bishai WR. New drugs for the treatment of tuberculosis: hope and reality. Int J Tuberc Lung Dis. 2012, 16:1005-14. 10.5588\/ijtld.12.0277","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000039365","article-title":"DRESS syndrome and tuberculosis: Implementation of a desensitization and re-desensitization protocol to recover antituberculosis drugs in a case series at a specialized TB Unit in Lima, Peru","volume":"103","author":"Mor\u00e1n-Mari\u00f1os C","year":"2024","unstructured":"Mor\u00e1n-Mari\u00f1os C, Llanos-Tejada F, Salas-Lopez J, et al.. DRESS syndrome and tuberculosis: Implementation of a desensitization and re-desensitization protocol to recover antituberculosis drugs in a case series at a specialized TB Unit in Lima, Peru. Medicine (Baltimore). 2024, 103:e39365. 10.1097\/MD.0000000000039365","journal-title":"Medicine (Baltimore)"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/511280-a-rare-dual-complication-of-first-line-anti-tubercular-therapy-a-case-report-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-and-ethambutol-induced-optic-neuropathy","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T09:02:36Z","timestamp":1787734956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/511280-a-rare-dual-complication-of-first-line-anti-tubercular-therapy-a-case-report-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-and-ethambutol-induced-optic-neuropathy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":10,"URL":"https:\/\/doi.org\/10.7759\/cureus.115207","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}