{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:25:17Z","timestamp":1787743517726,"version":"build-2784847793"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"DOI":"10.7759\/cureus.115217","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:14:12Z","timestamp":1787742852000},"source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Trajectories of Platelet Indices Across Dengue Severity in Children: A Linear Mixed-Model Analysis"],"prefix":"10.7759","author":[{"given":"Balam","family":"Rishitha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Kale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Saeed","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradnya M","family":"Joshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri  B","family":"Engade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Ingale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murali","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akankshya","family":"Mahapatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apeksha","family":"Rajeardad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt S","year":"2013","unstructured":"Bhatt S, Gething PW, Brady OJ, et al.. The global distribution and burden of dengue. Nature. 2013, 496:504-7. 10.1038\/nature12060","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1110265","article-title":"Dengue","volume":"366","author":"Simmons CP","year":"2012","unstructured":"Simmons CP, Farrar JJ, Nguyen vV, Wills B. Dengue. N Engl J Med. 2012, 366:1423-32. 10.1056\/NEJMra1110265","journal-title":"N Engl J Med"},{"key":"ref3","unstructured":"Dengue guidelines, for diagnosis, treatment, prevention and control. (2009). Accessed. October 7, 2024: https:\/\/www.who.int\/publications\/i\/item\/9789241547871."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2024.18","article-title":"Thrombocytopenia in dengue infection: mechanisms and a potential application","volume":"26","author":"Khazali AS","year":"2024","unstructured":"Khazali AS, Hadrawi WH, Ibrahim F, Othman S, Nor Rashid N. Thrombocytopenia in dengue infection: mechanisms and a potential application. Expert Rev Mol Med. 2024, 26:e26. 10.1017\/erm.2024.18","journal-title":"Expert Rev Mol Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4103\/GJTM.GJTM_39_18","article-title":"Role of red cell and platelet indices as a predictive tool for transfusions in dengue","volume":"3","author":"Kantharaj A","year":"2018","unstructured":"Kantharaj A. Role of red cell and platelet indices as a predictive tool for transfusions in dengue. Glob J Transfus Med. 2018, 3:103-8. 10.4103\/GJTM.GJTM_39_18","journal-title":"Glob J Transfus Med"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4103\/ajts.AJTS_24_20","article-title":"Comparison of platelet indices in dengue fever patients based on platelet transfusion: a prospective observational study in a tertiary care center","volume":"17","author":"Asha J","year":"2023","unstructured":"Asha J, Baiju NM, Innah SJ, Rafi A, John BM. Comparison of platelet indices in dengue fever patients based on platelet transfusion: a prospective observational study in a tertiary care center. Asian J Transfus Sci. 2023, 17:21-7. 10.4103\/ajts.AJTS_24_20","journal-title":"Asian J Transfus Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009808","article-title":"Predictive markers for the early prognosis of dengue severity: a systematic review and meta-analysis","volume":"15","author":"Thach TQ","year":"2021","unstructured":"Thach TQ, Eisa HG, Hmeda AB, et al.. Predictive markers for the early prognosis of dengue severity: a systematic review and meta-analysis. PLoS Negl Trop Dis. 2021, 15:e0009808. 10.1371\/journal.pntd.0009808","journal-title":"PLoS Negl Trop Dis"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.65553","article-title":"Exploring mean platelet volume and platelet count recovery in dengue patients: findings from an observational retrospective clinical study","volume":"16","author":"Pattnaik SS","year":"2024","unstructured":"Pattnaik SS, Patil U, Aggarwal L, Patro S, Mishra P, Mohanty A. Exploring mean platelet volume and platelet count recovery in dengue patients: findings from an observational retrospective clinical study. Cureus. 2024, 16:e65553. 10.7759\/cureus.65553","journal-title":"Cureus"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005498","article-title":"The value of daily platelet counts for predicting dengue shock syndrome: results from a prospective observational study of 2301 Vietnamese children with dengue","volume":"11","author":"Lam PK","year":"2017","unstructured":"Lam PK, Ngoc TV, Thu Thuy TT, et al.. The value of daily platelet counts for predicting dengue shock syndrome: results from a prospective observational study of 2301 Vietnamese children with dengue. PLoS Negl Trop Dis. 2017, 11:e0005498. 10.1371\/journal.pntd.0005498","journal-title":"PLoS Negl Trop Dis"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01156-13","article-title":"Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice","volume":"87","author":"Sridharan A","year":"2013","unstructured":"Sridharan A, Chen Q, Tang KF, Ooi EE, Hibberd ML, Chen J. Inhibition of megakaryocyte development in the bone marrow underlies dengue virus-induced thrombocytopenia in humanized mice. J Virol. 2013, 87:11648-58. 10.1128\/JVI.01156-13","journal-title":"J Virol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmni.2025.101624","article-title":"Platelet dynamics and thrombocytopenia in dengue fever: a prospective cohort study from Shenzhen, China","volume":"67","author":"Guo L","year":"2025","unstructured":"Guo L, Gu Y, Zhang Y, Zhang H, Weng W, Wu S, Yuan J. Platelet dynamics and thrombocytopenia in dengue fever: a prospective cohort study from Shenzhen, China. New Microbes New Infect. 2025, 67:101624. 10.1016\/j.nmni.2025.101624","journal-title":"New Microbes New Infect"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1123\/jmld.2019-0007","article-title":"Modeling longitudinal outcomes: a contrast of two methods","volume":"8","author":"Lohse KR","year":"2020","unstructured":"Lohse KR, Shen J, Kozlowski AJ. Modeling longitudinal outcomes: a contrast of two methods. J Mot Learn Dev. 2020, 8:145-55. 10.1123\/jmld.2019-0007","journal-title":"J Mot Learn Dev"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4097\/kja.25877","article-title":"Linear mixed-effects models for analysis of longitudinal repeated measures: a conceptual framework for clinical researchers","author":"Kim HJ","year":"2026","unstructured":"Kim HJ, Song K. Linear mixed-effects models for analysis of longitudinal repeated measures: a conceptual framework for clinical researchers. Korean J Anesthesiol. 2026, 10.4097\/kja.25877","journal-title":"Korean J Anesthesiol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008199","article-title":"Multivariate time-series analysis of biomarkers from a dengue cohort offers new approaches for diagnosis and prognosis","volume":"14","author":"Vasey B","year":"2020","unstructured":"Vasey B, Shankar AH, Herrera BB, et al.. Multivariate time-series analysis of biomarkers from a dengue cohort offers new approaches for diagnosis and prognosis. PLoS Negl Trop Dis. 2020, 14:e0008199. 10.1371\/journal.pntd.0008199","journal-title":"PLoS Negl Trop Dis"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.56829","article-title":"Correlation of platelet parameters with the severity of thrombocytopenia in dengue fever in children aged less than 18 years at a tertiary care centre: a cross-sectional study","volume":"16","author":"Sontakke RA","year":"2024","unstructured":"Sontakke RA, Aglave NR, Dua H. Correlation of platelet parameters with the severity of thrombocytopenia in dengue fever in children aged less than 18 years at a tertiary care centre: a cross-sectional study. Cureus. 2024, 16:e56829. 10.7759\/cureus.56829","journal-title":"Cureus"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-011-0075-1","article-title":"Evaluation of platelets as predictive parameters in dengue fever","volume":"27","author":"Jayashree K","year":"2011","unstructured":"Jayashree K, Manasa GC, Pallavi P, Manjunath GV. Evaluation of platelets as predictive parameters in dengue fever. Indian J Hematol Blood Transfus. 2011, 27:127-30. 10.1007\/s12288-011-0075-1","journal-title":"Indian J Hematol Blood Transfus"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4274\/jpr.galenos.2019.47568","article-title":"Platelet indices and the severity of dengue infection in children","volume":"6","author":"Chirnath SB","year":"2019","unstructured":"Chirnath SB, Avabratha KS. Platelet indices and the severity of dengue infection in children. J Pediatr Res. 2019, 6:242-6. 10.4274\/jpr.galenos.2019.47568","journal-title":"J Pediatr Res"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.7199\/ped.oncall.2020.10","article-title":"Role of platelet parameters in dengue fever in children","volume":"17","author":"Chatterjee AB","year":"2020","unstructured":"Chatterjee AB, Matti M, Kulkarni V. Role of platelet parameters in dengue fever in children. Pediatr Oncall J. 2020, 17:12-15. 10.7199\/ped.oncall.2020.10","journal-title":"Pediatr Oncall J"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1088\/1757-899X\/434\/1\/012312","article-title":"Correlation of enhancement platelet distribution width (PDW) with severity of dengue infection","volume":"434","author":"Dewi SR","year":"2018","unstructured":"Dewi SR, Sukorini U, Intansari US. Correlation of enhancement platelet distribution width (PDW) with severity of dengue infection. IOP Conf Ser Mater Sci Eng. 2018, 434:012312. 10.1088\/1757-899X\/434\/1\/012312","journal-title":"IOP Conf Ser Mater Sci Eng"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2015\/14285.6710","article-title":"Association of mean platelet volume with severity, serology & treatment outcome in dengue fever: prognostic utility","volume":"9","author":"Sharma K","year":"2015","unstructured":"Sharma K, Yadav A. Association of mean platelet volume with severity, serology &amp; treatment outcome in dengue fever: prognostic utility. J Clin Diagn Res. 2015, 9:EC01-3. 10.7860\/JCDR\/2015\/14285.6710","journal-title":"J Clin Diagn Res"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.26452\/ijrps.v11iSPL2.2696","article-title":"Analysis of platelet indices and its correlation with platelet count in dengue","volume":"11","author":"Menon D","year":"2020","unstructured":"Menon D, Sekhar G, Siddharth AR, Sridevi M. Analysis of platelet indices and its correlation with platelet count in dengue. Int J Res Pharm Sci. 2020, 11:284-9. 10.26452\/ijrps.v11iSPL2.2696","journal-title":"Int J Res Pharm Sci"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.5281\/zenodo.7085729","article-title":"Significance of platelet indices in dengue fever patients","volume":"5","author":"Jacob AA","year":"2022","unstructured":"Jacob AA, Joseph E, Poothiode U. Significance of platelet indices in dengue fever patients. Int J Med Sci Clin Res Rev. 2022, 5:531-9. 10.5281\/zenodo.7085729","journal-title":"Int J Med Sci Clin Res Rev"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0320(19991015)38:5<250::aid-cyto8>3.3.co;2-b","article-title":"Use of mean platelet component to measure platelet activation on the ADVIA 120 haematology system","volume":"38","author":"Macey MG","year":"1999","unstructured":"Macey MG, Carty E, Webb L, et al.. Use of mean platelet component to measure platelet activation on the ADVIA 120 haematology system. Cytometry. 1999, 38:250-5. 10.1002\/(sici)1097-0320(19991015)38:5&lt;250::aid-cyto8&gt;3.3.co;2-b","journal-title":"Cytometry"},{"key":"ref24","article-title":"Thrombocytopenia in dengue illness: destruction, suppression and composite platelet index: a retrospective study","volume":"3","author":"Krishnamurthy V","year":"2016","unstructured":"Krishnamurthy V, Rajeshakar R, Doreswamy SM. Thrombocytopenia in dengue illness: destruction, suppression and composite platelet index: a retrospective study. Ann Pathol Lab Med. 2016, 3:465-70.","journal-title":"Ann Pathol Lab Med"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.31031\/RPN.2018.03.000556","article-title":"Clinico-haematological profile and composite platelet index in paediatric dengue illness: a retrospective study","volume":"3","author":"Doreswamy SM","year":"2018","unstructured":"Doreswamy SM, Krishnamurthy V, Skater R. Clinico-haematological profile and composite platelet index in paediatric dengue illness: a retrospective study. Res Pediatr Neonatol. 2018, 3:000556. 10.31031\/RPN.2018.03.000556","journal-title":"Res Pediatr Neonatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/523616-longitudinal-trajectories-of-platelet-indices-across-dengue-severity-in-children-a-linear-mixed-model-analysis","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:14:14Z","timestamp":1787742854000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/523616-longitudinal-trajectories-of-platelet-indices-across-dengue-severity-in-children-a-linear-mixed-model-analysis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.115217","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}