{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:24:48Z","timestamp":1787761488733,"version":"build-2784847793"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,26]]},"DOI":"10.7759\/cureus.115235","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:54:19Z","timestamp":1787759659000},"source":"Crossref","is-referenced-by-count":0,"title":["Presentation and Management of Progestogen Hypersensitivity in a Male Patient in the Emergency Department and Intensive Care Unit"],"prefix":"10.7759","author":[{"given":"Arman","family":"Manjikian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kush","family":"Kapadia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"McWhorter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kord","family":"Strebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1947.tb05383.x","article-title":"Endocrine allergy: clinical reactions of allergy to endogenous hormones and their treatment","volume":"54","author":"Zondek B","year":"1947","unstructured":"Zondek B, Bromberg YM. Endocrine allergy: clinical reactions of allergy to endogenous hormones and their treatment. J Obstet Gynaecol Br Emp. 1947, 54:1-19. 10.1111\/j.1471-0528.1947.tb05383.x","journal-title":"J Obstet Gynaecol Br Emp"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070140041004","article-title":"Autoimmune progesterone dermatitis: cure by oophorectomy","volume":"190","author":"Shelley WB","year":"1964","unstructured":"Shelley WB, Preucel RW, Spoont SS. Autoimmune progesterone dermatitis: cure by oophorectomy. JAMA. 1964, 190:35-8. 10.1001\/jama.1964.03070140041004","journal-title":"JAMA"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.03.003","article-title":"Progestogen hypersensitivity in 24 cases: diagnosis, management, and proposed renaming and classification","volume":"4","author":"Foer D","year":"2016","unstructured":"Foer D, Buchheit KM, Gargiulo AR, Lynch DM, Castells M, Wickner PG. Progestogen hypersensitivity in 24 cases: diagnosis, management, and proposed renaming and classification. J Allergy Clin Immunol Pract. 2016, 4:723-9. 10.1016\/j.jaip.2016.03.003","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/s0190-9622(96)90055-9","article-title":"Drug-induced progesterone dermatitis","volume":"34","author":"Fisher DA","year":"1996","unstructured":"Fisher DA. Drug-induced progesterone dermatitis. J Am Acad Dermatol. 1996, 34:863-4. 10.1016\/s0190-9622(96)90055-9","journal-title":"J Am Acad Dermatol"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3389\/falgy.2024.1384140","article-title":"Diagnostic tests for progestogen hypersensitivity","volume":"5","author":"Alonso Bello CD","year":"2024","unstructured":"Alonso Bello CD, Gonz\u00e1lez Guzm\u00e1n OP, Moncayo Coello CV, Rojo Guti\u00e9rrez MI, Castrej\u00f3n V\u00e1zquez MI. Diagnostic tests for progestogen hypersensitivity. Front Allergy. 2024, 5:1384140. 10.3389\/falgy.2024.1384140","journal-title":"Front Allergy"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.01.019","article-title":"Progestogen hypersensitivity: heterogeneous manifestations with a common trigger","volume":"5","author":"Buchheit KM","year":"2017","unstructured":"Buchheit KM, Bernstein JA. Progestogen hypersensitivity: heterogeneous manifestations with a common trigger. J Allergy Clin Immunol Pract. 2017, 5:566-74. 10.1016\/j.jaip.2017.01.019","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/all.15032","article-title":"EAACI guidelines: anaphylaxis (2021 update)","volume":"77","author":"Muraro A","year":"2022","unstructured":"Muraro A, Worm M, Alviani C, et al.. EAACI guidelines: anaphylaxis (2021 update). Allergy. 2022, 77:357-77. 10.1111\/all.15032","journal-title":"Allergy"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157785","article-title":"Mechanisms governing anaphylaxis: inflammatory cells, mediators, endothelial gap junctions and beyond","volume":"22","author":"Nguyen SMT","year":"2021","unstructured":"Nguyen SMT, Rupprecht CP, Haque A, Pattanaik D, Yusin J, Krishnaswamy G. Mechanisms governing anaphylaxis: inflammatory cells, mediators, endothelial gap junctions and beyond. Int J Mol Sci. 2021, 22:7785. 10.3390\/ijms22157785","journal-title":"Int J Mol Sci"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1992.tb03743.x","article-title":"Autoimmune progesterone dermatitis","volume":"19","author":"Lee CW","year":"1992","unstructured":"Lee CW, Yoon KB, Yi JU, Cho SH. Autoimmune progesterone dermatitis. J Dermatol. 1992, 19:629-31. 10.1111\/j.1346-8138.1992.tb03743.x","journal-title":"J Dermatol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2016.07.037","article-title":"Autoimmune progesterone dermatitis with delayed intradermal skin reaction: A case report","volume":"117","author":"Frieder J","year":"2016","unstructured":"Frieder J, Younus M. Autoimmune progesterone dermatitis with delayed intradermal skin reaction: A case report. Ann Allergy Asthma Immunol. 2016, 117:438-9. 10.1016\/j.anai.2016.07.037","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb00286.x","article-title":"Corticosteroid or steroid allergy?","volume":"26","author":"Schoenmakers A","year":"1992","unstructured":"Schoenmakers A, Vermorken A, Degreef H, Dooms-Goossens A. Corticosteroid or steroid allergy?. Contact Dermatitis. 1992, 26:159-62. 10.1111\/j.1600-0536.1992.tb00286.x","journal-title":"Contact Dermatitis"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2017.01.003","article-title":"Anaphylaxis due to progesterone hypersensitivity successfully treated with omalizumab","volume":"5","author":"Heffler E","year":"2017","unstructured":"Heffler E, Fichera S, Nicolosi G, Crimi N. Anaphylaxis due to progesterone hypersensitivity successfully treated with omalizumab. J Allergy Clin Immunol Pract. 2017, 5:852-4. 10.1016\/j.jaip.2017.01.003","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031069","article-title":"The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men","volume":"89","author":"Malkin CJ","year":"2004","unstructured":"Malkin CJ, Pugh PJ, Jones RD, Kapoor D, Channer KS, Jones TH. The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men. J Clin Endocrinol Metab. 2004, 89:3313-8. 10.1210\/jc.2003-031069","journal-title":"J Clin Endocrinol Metab"},{"key":"ref14","article-title":"Depo-Testosterone (testosterone cypionate injection, solution): package insert","year":"2020","unstructured":"Depo-Testosterone (testosterone cypionate injection, solution). package insert. Pharmacia and Upjohn Company LLC, New York; 2020."},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000544","article-title":"Recommendations for follow-up after colonoscopy and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer","volume":"115","author":"Gupta S","year":"2020","unstructured":"Gupta S, Lieberman D, Anderson JC, et al.. Recommendations for follow-up after colonoscopy and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer. Am J Gastroenterol. 2020, 115:415-34. 10.14309\/ajg.0000000000000544","journal-title":"Am J Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3167","article-title":"Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression","volume":"10","author":"Lin C","year":"2015","unstructured":"Lin C, Wu J, Gao Z, Qu G, Wang W, Yu G. Primary carcinoid tumor of the kidney with estrogen and progesterone receptor expression. Oncol Lett. 2015, 10:449-52. 10.3892\/ol.2015.3167","journal-title":"Oncol Lett"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-44-1-116","article-title":"Twenty-four hour integrated concentrations of progesterone, 17-hydroxyprogesterone and cortisol in normal male subjects","volume":"44","author":"Gutai JP","year":"1977","unstructured":"Gutai JP, Meyer WJ 3rd, Kowarski AA, Migeon CJ. Twenty-four hour integrated concentrations of progesterone, 17-hydroxyprogesterone and cortisol in normal male subjects. J Clin Endocrinol Metab. 1977, 44:116-20. 10.1210\/jcem-44-1-116","journal-title":"J Clin Endocrinol Metab"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-45-4-617","article-title":"Progesterone and 5alpha-pregnane-3,20-dione in peripheral blood of normal young women: Daily measurements throughout the menstrual cycle","volume":"45","author":"Milewich L","year":"1977","unstructured":"Milewich L, Gomez-Sanchez C, Crowley G, Porter JC, Madden JD, MacDonald PC. Progesterone and 5alpha-pregnane-3,20-dione in peripheral blood of normal young women: Daily measurements throughout the menstrual cycle. J Clin Endocrinol Metab. 1977, 45:617-22. 10.1210\/jcem-45-4-617","journal-title":"J Clin Endocrinol Metab"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2024.119852","article-title":"Sex- and age-specific reference intervals of 16 steroid metabolites quantified simultaneously by LC-MS\/MS in sera from 2458 healthy subjects aged 0 to 77 years","volume":"562","author":"Frederiksen H","year":"2024","unstructured":"Frederiksen H, Johannsen TH, Andersen SE, et al.. Sex- and age-specific reference intervals of 16 steroid metabolites quantified simultaneously by LC-MS\/MS in sera from 2458 healthy subjects aged 0 to 77 years. Clin Chim Acta. 2024, 562:119852. 10.1016\/j.cca.2024.119852","journal-title":"Clin Chim Acta"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020.101386","article-title":"Adrenocortical hyperplasia: a multifaceted disease","volume":"34","author":"Bourdeau I","year":"2020","unstructured":"Bourdeau I, Parisien-La Salle S, Lacroix A. Adrenocortical hyperplasia: a multifaceted disease. Best Pract Res Clin Endocrinol Metab. 2020, 34:101386. 10.1016\/j.beem.2020.101386","journal-title":"Best Pract Res Clin Endocrinol Metab"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/525161-presentation-and-management-of-progestogen-hypersensitivity-in-a-male-patient-in-the-emergency-department-and-intensive-care-unit","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:54:19Z","timestamp":1787759659000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/525161-presentation-and-management-of-progestogen-hypersensitivity-in-a-male-patient-in-the-emergency-department-and-intensive-care-unit"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.115235","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,26]]}}}