{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:18:48Z","timestamp":1787908728712,"version":"build-2784847793"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,28]]},"DOI":"10.7759\/cureus.115335","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:29:28Z","timestamp":1787905768000},"source":"Crossref","is-referenced-by-count":0,"title":["New Delhi Metallo-\u03b2-Lactamase-5 (NDM-5)-Producing Klebsiella pneumoniae Urinary Tract Infection in a Young Patient Without a History of Overseas Travel: A Case Suggesting Local Spread in Japan"],"prefix":"10.7759","author":[{"given":"Nao","family":"Nishimiura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotomo","family":"Nakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ichirou","family":"Yasunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00774-09","article-title":"Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India","volume":"53","author":"Yong D","year":"2009","unstructured":"Yong D, Toleman MA, Giske CG, Cho HS, Sundman K, Lee K, Walsh TR. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrob Agents Chemother. 2009, 53:5046-54. 10.1128\/AAC.00774-09","journal-title":"Antimicrob Agents Chemother"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae403","article-title":"Infectious Diseases Society of America 2024 Guidance on the treatment of antimicrobial-resistant Gram-negative infections","author":"Tamma PD","year":"2024","unstructured":"Tamma PD, Heil EL, Justo JA, Mathers AJ, Satlin MJ, Bonomo RA. Infectious Diseases Society of America 2024 Guidance on the treatment of antimicrobial-resistant Gram-negative infections. Clin Infect Dis. 2024, 10.1093\/cid\/ciae403","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa586","article-title":"Efficacy of ceftazidime-avibactam plus aztreonam in patients with bloodstream infections caused by metallo-\u03b2-lactamase-producing Enterobacterales","volume":"72","author":"Falcone M","year":"2021","unstructured":"Falcone M, Daikos GL, Tiseo G, et al.. Efficacy of ceftazidime-avibactam plus aztreonam in patients with bloodstream infections caused by metallo-\u03b2-lactamase-producing Enterobacterales. Clin Infect Dis. 2021, 72:1871-8. 10.1093\/cid\/ciaa586","journal-title":"Clin Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05108-11","article-title":"A novel variant, NDM-5, of the New Delhi metallo-\u03b2-lactamase in a multidrug-resistant Escherichia coli ST648 isolate recovered from a patient in the United Kingdom","volume":"55","author":"Hornsey M","year":"2011","unstructured":"Hornsey M, Phee L, Wareham DW. A novel variant, NDM-5, of the New Delhi metallo-\u03b2-lactamase in a multidrug-resistant Escherichia coli ST648 isolate recovered from a patient in the United Kingdom. Antimicrob Agents Chemother. 2011, 55:5952-4. 10.1128\/AAC.05108-11","journal-title":"Antimicrob Agents Chemother"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku403","article-title":"Biochemical characterization of New Delhi metallo-\u03b2-lactamase variants reveals differences in protein stability","volume":"70","author":"Makena A","year":"2015","unstructured":"Makena A, Brem J, Pfeffer I, et al.. Biochemical characterization of New Delhi metallo-\u03b2-lactamase variants reveals differences in protein stability. J Antimicrob Chemother. 2015, 70:463-9. 10.1093\/jac\/dku403","journal-title":"J Antimicrob Chemother"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiw282","article-title":"The epidemiology of carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace","volume":"215","author":"Logan LK","year":"2017","unstructured":"Logan LK, Weinstein RA. The epidemiology of carbapenem-resistant Enterobacteriaceae: the impact and evolution of a global menace. J Infect Dis. 2017, 215:S28-36. 10.1093\/infdis\/jiw282","journal-title":"J Infect Dis"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.18999\/nagjms.84.3.630","article-title":"Multicenter survey for carbapenemase-producing Enterobacterales in central Japan (Article in Japanese)","volume":"84","author":"Hara Y","year":"2022","unstructured":"Hara Y, Iguchi M, Tetsuka N, et al.. Multicenter survey for carbapenemase-producing Enterobacterales in central Japan (Article in Japanese). Nagoya J Med Sci. 2022, 84:630-9. 10.18999\/nagjms.84.3.630","journal-title":"Nagoya J Med Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2022.04.004","article-title":"Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan","volume":"29","author":"Oka K","year":"2022","unstructured":"Oka K, Matsumoto A, Tetsuka N, et al.. Clinical characteristics and treatment outcomes of carbapenem-resistant Enterobacterales infections in Japan. J Glob Antimicrob Resist. 2022, 29:247-52. 10.1016\/j.jgar.2022.04.004","journal-title":"J Glob Antimicrob Resist"},{"key":"ref9","unstructured":"Japan Institute for Health Security. Surveillance of carbapenem resistant Enterobacteriaceae. (2026). Accessed. June 26, 2026: https:\/\/id-info.jihs.go.jp\/surveillance\/iasr\/pathogens\/vol47\/555\/555d05.html ."},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82166-8","article-title":"Increasing New Delhi metallo-\u03b2-lactamase-positive Escherichia coli among carbapenem non-susceptible Enterobacteriaceae in Taiwan during 2016 to 2018","volume":"11","author":"Huang YS","year":"2021","unstructured":"Huang YS, Tsai WC, Li JJ, et al.. Increasing New Delhi metallo-\u03b2-lactamase-positive Escherichia coli among carbapenem non-susceptible Enterobacteriaceae in Taiwan during 2016 to 2018. Sci Rep. 2021, 11:2609. 10.1038\/s41598-021-82166-8","journal-title":"Sci Rep"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2018.0237","article-title":"First detection of New Delhi metallo-\u03b2-lactamase-5-producing Escherichia coli from companion animals in Korea","volume":"25","author":"Hong JS","year":"2019","unstructured":"Hong JS, Song W, Park HM, Oh JY, Chae JC, Han JI, Jeong SH. First detection of New Delhi metallo-\u03b2-lactamase-5-producing Escherichia coli from companion animals in Korea. Microb Drug Resist. 2019, 25:344-9. 10.1089\/mdr.2018.0237","journal-title":"Microb Drug Resist"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-018-0349-6","article-title":"Dissemination of bla(NDM-5) gene via an IncX3-type plasmid among non-clonal Escherichia coli in China","volume":"7","author":"Li X","year":"2018","unstructured":"Li X, Fu Y, Shen M, et al.. Dissemination of bla(NDM-5) gene via an IncX3-type plasmid among non-clonal Escherichia coli in China. Antimicrob Resist Infect Control. 2018, 7:59. 10.1186\/s13756-018-0349-6","journal-title":"Antimicrob Resist Infect Control"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2024.06.020","article-title":"Transmission of global clones of NDM-producing Enterobacterales and interspecies spread of IncX3 plasmid harbouring bla(NDM-5) in Tokyo","volume":"38","author":"Harada S","year":"2024","unstructured":"Harada S, Aoki K, Nomura Y, et al.. Transmission of global clones of NDM-producing Enterobacterales and interspecies spread of IncX3 plasmid harbouring bla(NDM-5) in Tokyo. J Glob Antimicrob Resist. 2024, 38:309-16. 10.1016\/j.jgar.2024.06.020","journal-title":"J Glob Antimicrob Resist"},{"key":"ref14","article-title":"CLSI. Performance Standards for Antimicrobial Susceptibility TestingCLSI supplement M100","author":"Mather AJ","year":"2026","unstructured":"Mather AJ. Performance Standards for Antimicrobial Susceptibility Testing. CLSI Supplement M100 36th ed.. Clinical and Laboratory Standards Institute, Wayne, PA; 2026. https:\/\/webstore.ansi.org\/standards\/clsi\/clsim100ed36."},{"key":"ref15","unstructured":"DFAST. (2025). Accessed. December 24, 2025: https:\/\/dfast.ddbj.nig.ac.jp\/."},{"key":"ref16","unstructured":"ResFinder. (2025). Accessed. December 24, 2025: https:\/\/genepi.food.dtu.dk\/resfinder."},{"key":"ref17","unstructured":"Proksee. (2026). Accessed. June 24, 2026: https:\/\/proksee.ca\/."},{"key":"ref18","unstructured":"Comprehensive Antibiotic Resistance Database. (2026). Accessed. June 24, 2026: https:\/\/card.mcmaster.ca\/."},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad326","article-title":"Proksee: in-depth characterization and visualization of bacterial genomes","volume":"51","author":"Grant JR","year":"2023","unstructured":"Grant JR, Enns E, Marinier E, et al.. Proksee: in-depth characterization and visualization of bacterial genomes. Nucleic Acids Res. 2023, 51:W484-92. 10.1093\/nar\/gkad326","journal-title":"Nucleic Acids Res"},{"key":"ref20","unstructured":"iTOL. (2026). Accessed. June 24, 2026: https:\/\/itol.embl.de\/."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S232943","article-title":"Characterization of the IncFII-IncFIB(pB171) Plasmid Carrying bla (NDM-5) in Escherichia coli ST405 clinical isolate in Japan","volume":"13","author":"Takayama Y","year":"2020","unstructured":"Takayama Y, Sekizuka T, Matsui H, et al.. Characterization of the IncFII-IncFIB(pB171) Plasmid Carrying bla (NDM-5) in Escherichia coli ST405 clinical isolate in Japan. Infect Drug Resist. 2020, 13:561-6. 10.2147\/IDR.S232943","journal-title":"Infect Drug Resist"},{"key":"ref22","unstructured":"IASR, 2020. 41. p. 86. (2020). Accessed: 26 June 2026: https:\/\/id-info.jihs.go.jp\/niid\/ja\/cre-m\/cre-iasrd\/9636-483d01.html."},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2019.0046","article-title":"Outbreak of bla(NDM-5)-harboring Klebsiella pneumoniae ST290 in a tertiary hospital in China","volume":"25","author":"Wang Z","year":"2019","unstructured":"Wang Z, Li M, Shen X, et al.. Outbreak of bla(NDM-5)-harboring Klebsiella pneumoniae ST290 in a tertiary hospital in China. Microb Drug Resist. 2019, 25:1443-8. 10.1089\/mdr.2019.0046","journal-title":"Microb Drug Resist"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01365-16","article-title":"Emergence of NDM-5- and MCR-1-Producing Escherichia coli Clones ST648 and ST156 from a single Muscovy Duck (Cairina moschata)","volume":"60","author":"Yang RS","year":"2016","unstructured":"Yang RS, Feng Y, Lv XY, et al.. Emergence of NDM-5- and MCR-1-Producing Escherichia coli Clones ST648 and ST156 from a single Muscovy Duck (Cairina moschata). Antimicrob Agents Chemother. 2016, 60:6899-902. 10.1128\/AAC.01365-16","journal-title":"Antimicrob Agents Chemother"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01339-23","article-title":"Escherichia coli sequence type 410 with carbapenemases: a paradigm shift within E. coli toward multidrug resistance","volume":"68","author":"Pitout JD","year":"2024","unstructured":"Pitout JD, Peirano G, Matsumura Y, DeVinney R, Chen L. Escherichia coli sequence type 410 with carbapenemases: a paradigm shift within E. coli toward multidrug resistance. Antimicrob Agents Chemother. 2024, 68:e0133923. 10.1128\/aac.01339-23","journal-title":"Antimicrob Agents Chemother"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2025.124136","article-title":"Occurrence of antibiotics and antibiotic-resistant bacteria in a Japanese city revealed by wastewater surveillance in the sewer system","volume":"285","author":"Tang Y","year":"2025","unstructured":"Tang Y, Gomi R, Takeuchi H, Nishimura F, Ihara M. Occurrence of antibiotics and antibiotic-resistant bacteria in a Japanese city revealed by wastewater surveillance in the sewer system. Water Res. 2025, 285:124136. 10.1016\/j.watres.2025.124136","journal-title":"Water Res"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S215273","article-title":"Characterization of NDM-5- and CTX-M-55-coproducing Escherichia coli GSH8M-2 isolated from the effluent of a wastewater treatment plant in Tokyo Bay","volume":"12","author":"Sekizuka T","year":"2019","unstructured":"Sekizuka T, Inamine Y, Segawa T, Kuroda M. Characterization of NDM-5- and CTX-M-55-coproducing Escherichia coli GSH8M-2 isolated from the effluent of a wastewater treatment plant in Tokyo Bay. Infect Drug Resist. 2019, 12:2243-9. 10.2147\/IDR.S215273","journal-title":"Infect Drug Resist"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02670-21","article-title":"Occurrence of high levels of cefiderocol resistance in carbapenem-resistant Escherichia coli before its approval in China: a report from China CRE-Network","volume":"10","author":"Wang Q","year":"2022","unstructured":"Wang Q, Jin L, Sun S, et al.. Occurrence of high levels of cefiderocol resistance in carbapenem-resistant Escherichia coli before its approval in China: a report from China CRE-Network. Microbiol Spectr. 2022, 10:e0267021. 10.1128\/spectrum.02670-21","journal-title":"Microbiol Spectr"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/522216-new-delhi-metallo--lactamase-5-ndm-5-producing-klebsiella-pneumoniae-urinary-tract-infection-in-a-young-patient-without-a-history-of-overseas-travel-a-case-suggesting-local-spread-in-japan","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:29:30Z","timestamp":1787905770000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/522216-new-delhi-metallo--lactamase-5-ndm-5-producing-klebsiella-pneumoniae-urinary-tract-infection-in-a-young-patient-without-a-history-of-overseas-travel-a-case-suggesting-local-spread-in-japan"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,28]]},"references-count":28,"URL":"https:\/\/doi.org\/10.7759\/cureus.115335","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,28]]}}}