{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:19:59Z","timestamp":1788013199089,"version":"build-2784847793"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,29]]},"DOI":"10.7759\/cureus.115398","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:10:22Z","timestamp":1788012622000},"source":"Crossref","is-referenced-by-count":0,"title":["Beyond the Eye of the Tiger: A Case Report of Adult-Onset Pantothenate Kinase-Associated Neurodegeneration Mimicking Progressive Supranuclear Palsy-Parkinsonism"],"prefix":"10.7759","author":[{"given":"Armon","family":"Moradian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian","family":"Memari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio A","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joren","family":"Manuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lissette P","family":"Lazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-63233-3.00019-1","article-title":"Neurodegeneration with brain iron accumulation","volume":"147","author":"Hayflick SJ","year":"2018","unstructured":"Hayflick SJ, Kurian MA, Hogarth P. Neurodegeneration with brain iron accumulation. Handb Clin Neurol. 2018, 147:293-305. 10.1016\/B978-0-444-63233-3.00019-1","journal-title":"Handb Clin Neurol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13294","article-title":"Natural history and genotype-phenotype correlation of pantothenate kinase-associated neurodegeneration","volume":"26","author":"Chang X","year":"2020","unstructured":"Chang X, Zhang J, Jiang Y, Wang J, Wu Y. Natural history and genotype-phenotype correlation of pantothenate kinase-associated neurodegeneration. CNS Neurosci Ther. 2020, 26:754-61. 10.1111\/cns.13294","journal-title":"CNS Neurosci Ther"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2023.105409","article-title":"Clinical, imaging and genetic profile of twenty-four patients with pantothenate kinase-associated neurodegeneration (PKAN)-a single centre study from India","volume":"111","author":"Sriram N","year":"2023","unstructured":"Sriram N, Holla VV, Kumari R, et al.. Clinical, imaging and genetic profile of twenty-four patients with pantothenate kinase-associated neurodegeneration (PKAN)-a single centre study from India. Parkinsonism Relat Disord. 2023, 111:105409. 10.1016\/j.parkreldis.2023.105409","journal-title":"Parkinsonism Relat Disord"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987","article-title":"Clinical diagnosis of progressive supranuclear palsy: the Movement Disorder Society criteria","volume":"32","author":"H\u00f6glinger GU","year":"2017","unstructured":"H\u00f6glinger GU, Respondek G, Stamelou M, et al.. Clinical diagnosis of progressive supranuclear palsy: the Movement Disorder Society criteria. Mov Disord. 2017, 32:853-64. 10.1002\/mds.26987","journal-title":"Mov Disord"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5514","article-title":"Looking deep into the eye-of-the-tiger in pantothenate kinase-associated neurodegeneration","volume":"39","author":"Lee JH","year":"2018","unstructured":"Lee JH, Gregory A, Hogarth P, Rogers C, Hayflick SJ. Looking deep into the eye-of-the-tiger in pantothenate kinase-associated neurodegeneration. AJNR Am J Neuroradiol. 2018, 39:583-8. 10.3174\/ajnr.A5514","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.8","article-title":"Eye-of-the-tiger sign is not pathognomonic of pantothenate kinase-associated neurodegeneration in adult cases","volume":"1","author":"Chang CL","year":"2011","unstructured":"Chang CL, Lin CM. Eye-of-the-tiger sign is not pathognomonic of pantothenate kinase-associated neurodegeneration in adult cases. Brain Behav. 2011, 1:55-6. 10.1002\/brb3.8","journal-title":"Brain Behav"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards S","year":"2015","unstructured":"Richards S, Aziz N, Bale S, et al.. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015, 17:405-24. 10.1038\/gim.2015.30","journal-title":"Genet Med"},{"key":"ref8","article-title":"Pantothenate kinase-associated neurodegeneration","author":"Gregory A","year":"2002","unstructured":"Gregory A, Hayflick SJ. Pantothenate kinase-associated neurodegeneration. GeneReviews\u00ae [Internet]. University of Washington, Seattle; 2002."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29737","article-title":"Novel PANK2 variant in Asian Indians with atypical pantothenate kinase associated neurodegeneration","volume":"39","author":"Saini A","year":"2024","unstructured":"Saini A, Holla VV, Kalikavil Puthanveedu D, et al.. Novel PANK2 variant in Asian Indians with atypical pantothenate kinase associated neurodegeneration. Mov Disord. 2024, 39:920-3. 10.1002\/mds.29737","journal-title":"Mov Disord"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30142-5","article-title":"Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: a randomised, double-blind, controlled trial and an open-label extension study","volume":"18","author":"Klopstock T","year":"2019","unstructured":"Klopstock T, Tricta F, Neumayr L, et al.. Safety and efficacy of deferiprone for pantothenate kinase-associated neurodegeneration: a randomised, double-blind, controlled trial and an open-label extension study. Lancet Neurol. 2019, 18:631-42. 10.1016\/S1474-4422(19)30142-5","journal-title":"Lancet Neurol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/mds.28392","article-title":"Fosmetpantotenate randomized controlled trial in pantothenate kinase-associated neurodegeneration","volume":"36","author":"Klopstock T","year":"2021","unstructured":"Klopstock T, Videnovic A, Bischoff AT, et al.. Fosmetpantotenate randomized controlled trial in pantothenate kinase-associated neurodegeneration. Mov Disord. 2021, 36:1342-52. 10.1002\/mds.28392","journal-title":"Mov Disord"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5114\/ppn.2024.141713","article-title":"Pathology and treatment methods in pantothenate kinase-associated neurodegeneration","volume":"33","author":"Kwinta R","year":"2024","unstructured":"Kwinta R, Kopcik K, Koberling A. Pathology and treatment methods in pantothenate kinase-associated neurodegeneration. Postep Psychiatr Neurol. 2024, 33:163-71. 10.5114\/ppn.2024.141713","journal-title":"Postep Psychiatr Neurol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/526894-beyond-the-eye-of-the-tiger-a-case-report-of-adult-onset-pantothenate-kinase-associated-neurodegeneration-mimicking-progressive-supranuclear-palsy-parkinsonism","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T14:10:23Z","timestamp":1788012623000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/526894-beyond-the-eye-of-the-tiger-a-case-report-of-adult-onset-pantothenate-kinase-associated-neurodegeneration-mimicking-progressive-supranuclear-palsy-parkinsonism"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.115398","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,29]]}}}