{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:16:56Z","timestamp":1788182216919,"version":"build-2803163510"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"DOI":"10.7759\/cureus.115499","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:23:39Z","timestamp":1788179019000},"source":"Crossref","is-referenced-by-count":0,"title":["Neoadjuvant Chemoradiotherapy for Oesophageal Carcinoma: Real-World Data From Practice Beyond the Chemoradiotherapy for Oesophageal Cancer Followed by Surgery Study (CROSS) Trial"],"prefix":"10.7759","author":[{"given":"Ningthoujam Dinita","family":"Devi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas K","family":"Jagtap","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Mahawar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onychia","family":"Synrem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumit","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthialisha","family":"Nongkynrih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batskhem","family":"Lyngkhoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donboklang","family":"Lynser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Raphael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.70090","article-title":"Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries","volume":"76","author":"Sung H","year":"2026","unstructured":"Sung H, Filho AM, Laversanne M, et al.. Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries. CA Cancer J Clin. 2026, 76:e70090. 10.3322\/caac.70090","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.023","article-title":"Epidemiology of esophageal squamous cell carcinoma","volume":"154","author":"Abnet CC","year":"2018","unstructured":"Abnet CC, Arnold M, Wei WQ. Epidemiology of esophageal squamous cell carcinoma. Gastroenterology. 2018, 154:360-73. 10.1053\/j.gastro.2017.08.023","journal-title":"Gastroenterology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030765","article-title":"Current status and future prospects for esophageal cancer","volume":"15","author":"Sheikh M","year":"2023","unstructured":"Sheikh M, Roshandel G, McCormack V, Malekzadeh R. Current status and future prospects for esophageal cancer. Cancers (Basel). 2023, 15:10.3390\/cancers15030765","journal-title":"Cancers (Basel)"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.89a.21053","article-title":"Esophageal adenocarcinoma: a dire need for early detection and treatment","volume":"89","author":"Joseph A","year":"2022","unstructured":"Joseph A, Raja S, Kamath S, et al.. Esophageal adenocarcinoma: a dire need for early detection and treatment. Cleve Clin J Med. 2022, 89:269-79. 10.3949\/ccjm.89a.21053","journal-title":"Cleve Clin J Med"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1254","article-title":"Esophageal cancer: An updated surveillance epidemiology and end results database analysis","volume":"11","author":"Then EO","year":"2020","unstructured":"Then EO, Lopez M, Saleem S, Gayam V, Sunkara T, Culliford A, Gaduputi V. Esophageal cancer: An updated surveillance epidemiology and end results database analysis. World J Oncol. 2020, 11:55-64. 10.14740\/wjon1254","journal-title":"World J Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60643-6","article-title":"Oesophageal carcinoma","volume":"381","author":"Pennathur A","year":"2013","unstructured":"Pennathur A, Gibson MK, Jobe BA, et al.. Oesophageal carcinoma. The Lancet. 2013, 381:400-12. 10.1016\/S0140-6736(12)60643-6","journal-title":"The Lancet"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70172-9","article-title":"Therapeutic strategies in oesophageal carcinoma: role of surgery and other modalities","volume":"1","author":"Mariette C","year":"2007","unstructured":"Mariette C, Piessen G, Triboulet JP. Therapeutic strategies in oesophageal carcinoma: role of surgery and other modalities. The lancet oncology. 2007, 1:545-53. 10.1016\/S1470-2045(07)70172-9","journal-title":"The lancet oncology"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0003-4975(03)00172-3","article-title":"Factors predictive of complete resection of operable esophageal cancer: a prospective study","volume":"1","author":"Mariette C","year":"2003","unstructured":"Mariette C, Finzi L, Fabre S, et al.. Factors predictive of complete resection of operable esophageal cancer: a prospective study. The Annals of thoracic surgery. 2003, 1:1720-6. 10.1016\/s0003-4975(03)00172-3","journal-title":"The Annals of thoracic surgery"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70039-6","article-title":"Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis","volume":"8","author":"Gebski V","year":"2007","unstructured":"Gebski V, Burmeister B, Smithers BM, et al.. Survival benefits from neoadjuvant chemoradiotherapy or chemotherapy in oesophageal carcinoma: a meta-analysis. The lancet oncology. 2007, 8:226-34. 10.1016\/S1470-2045(07)70039-6","journal-title":"The lancet oncology"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00040-6","article-title":"Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial","volume":"16","author":"Shapiro J","year":"2015","unstructured":"Shapiro J, Van Lanschot JJ, Hulshof MC, et al.. Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial. The lancet oncology. 2015, 16:1090-8. 10.1016\/S1470-2045(15)00040-6","journal-title":"The lancet oncology"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03614","article-title":"Ten-year outcome of neoadjuvant chemoradiotherapy plus surgery for esophageal cancer: the randomized controlled cross trial","volume":"39","author":"Eyck BM","year":"2021","unstructured":"Eyck BM, van Lanschot JJ, Hulshof MC, et al.. Ten-year outcome of neoadjuvant chemoradiotherapy plus surgery for esophageal cancer: the randomized controlled cross trial. J Clin Oncol. 2021, 39:1995-2004. 10.1200\/JCO.20.03614","journal-title":"J Clin Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2017.03.14","article-title":"8th edition AJCC\/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice","volume":"6","author":"Rice TW","year":"2017","unstructured":"Rice TW, Patil DT, Blackstone EH. 8th edition AJCC\/UICC staging of cancers of the esophagus and esophagogastric junction: application to clinical practice. Ann Cardiothorac Surg. 2017, 6:119-30. 10.21037\/acs.2017.03.14","journal-title":"Ann Cardiothorac Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.7150\/jca.61994","article-title":"Optimal size criterion for malignant lymph nodes and a novel lymph node clinical staging system for unresectable esophageal squamous cell carcinoma: evaluation by multislice spiral computed tomography","volume":"12","author":"Wang H","year":"2021","unstructured":"Wang H, Lin Z, Lin Y, et al.. Optimal size criterion for malignant lymph nodes and a novel lymph node clinical staging system for unresectable esophageal squamous cell carcinoma: evaluation by multislice spiral computed tomography. J Cancer. 2021, 12:6454-64. 10.7150\/jca.61994","journal-title":"J Cancer"},{"key":"ref14","unstructured":"NCCN clinical practice guidelines in oncology, esophageal and esophagogastric junction cancers, version 3.2026. Accessed. June 3, 2026: https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/esophageal.pdf."},{"key":"ref15","unstructured":"Common terminology criteria for adverse events (CTCAE) version 5.0. (2017). Accessed. 20 July 2026: https:\/\/dctd.cancer.gov\/research\/ctep-trials\/for-sites\/adverse-events\/ctcae-v5-5x7.pdf."},{"key":"ref16","article-title":"Esophagus","author":"American Joint Committee on Cancer","year":"2002","unstructured":"American Joint Committee on Cancer. Esophagus. AJCC Cancer Staging Manual. Greene FL et al. (ed): Springer, New York, NY; 2002."},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2482-8-21","article-title":"Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus (CROSS)","volume":"8","author":"van Heijl M","year":"2008","unstructured":"van Heijl M, van Lanschot JJ, Koppert LB, et al.. Neoadjuvant chemoradiation followed by surgery versus surgery alone for patients with adenocarcinoma or squamous cell carcinoma of the esophagus (CROSS). BMC Surg. 2008, 8:21. 10.1186\/1471-2482-8-21","journal-title":"BMC Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-017-5797-3","article-title":"Effect of extending the original eligibility criteria for the cross neoadjuvant chemoradiotherapy on toxicity and survival in esophageal cancer","volume":"24","author":"de Heer EC","year":"2017","unstructured":"de Heer EC, Hulshoff JB, Klerk D, Burgerhof JG, de Groot DJ, Plukker JT, Hospers GA. Effect of extending the original eligibility criteria for the cross neoadjuvant chemoradiotherapy on toxicity and survival in esophageal cancer. Ann Surg Oncol. 2017, 24:1811-20. 10.1245\/s10434-017-5797-3","journal-title":"Ann Surg Oncol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2021.1291","article-title":"Can the CROSS protocol be safely implemented in real world scenario with broader eligibility criteria? Experience from a tertiary care centre in India","volume":"15","author":"Bhattacharyya T","year":"2021","unstructured":"Bhattacharyya T, Arunsingh M, Chakraborty S, et al.. Can the CROSS protocol be safely implemented in real world scenario with broader eligibility criteria? Experience from a tertiary care centre in India. Ecancermedicalscience. 2021, 15:1291. 10.3332\/ecancer.2021.1291","journal-title":"Ecancermedicalscience"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-09372-y","article-title":"Effect of extending the original cross criteria on tumor response to neoadjuvant chemoradiotherapy in esophageal cancer patients: a national multicenter cohort analysis","volume":"28","author":"Wang HH","year":"2021","unstructured":"Wang HH, de Heer EC, Hulshoff JB, et al.. Effect of extending the original cross criteria on tumor response to neoadjuvant chemoradiotherapy in esophageal cancer patients: a national multicenter cohort analysis. Ann Surg Oncol. 2021, 28:3951-60. 10.1245\/s10434-020-09372-y","journal-title":"Ann Surg Oncol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112088","article-title":"Preoperative chemoradiotherapy for esophageal or junctional cancer","volume":"366","author":"van Hagen P","year":"2012","unstructured":"van Hagen P, Hulshof MC, van Lanschot JJ, et al.. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012, 366:2074-84. 10.1056\/NEJMoa1112088","journal-title":"N Engl J Med"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doae057.386","article-title":"790. Risk factors for esophageal cancer in Northeast India: a multi-centric case-control study","volume":"57","author":"Harris C","year":"2024","unstructured":"Harris C, Mawlong A, Tapkire R, et al.. 790. Risk factors for esophageal cancer in Northeast India: a multi-centric case-control study. Diseases of the Esophagus. 2024, 57:386. 10.1093\/dote\/doae057.386","journal-title":"Diseases of the Esophagus"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-3331","article-title":"Pathological complete response after neoadjuvant treatment determines survival in esophageal squamous cell carcinoma patients (NEOCRTEC5010)","volume":"9","author":"Shen J","year":"2021","unstructured":"Shen J, Kong M, Yang H, et al.. Pathological complete response after neoadjuvant treatment determines survival in esophageal squamous cell carcinoma patients (NEOCRTEC5010). Ann Transl Med. 2021, 9:1516. 10.21037\/atm-21-3331","journal-title":"Ann Transl Med"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00745-1","article-title":"Doublet chemotherapy, triplet chemotherapy, or doublet chemotherapy combined with radiotherapy as neoadjuvant treatment for locally advanced oesophageal cancer (JCOG1109 NExT): a randomised, controlled, open-label, phase 3 trial","volume":"6","author":"Kato K","year":"2024","unstructured":"Kato K, Machida R, Ito Y, et al.. Doublet chemotherapy, triplet chemotherapy, or doublet chemotherapy combined with radiotherapy as neoadjuvant treatment for locally advanced oesophageal cancer (JCOG1109 NExT): a randomised, controlled, open-label, phase 3 trial. The Lancet. 2024, 6:55-66. 10.1016\/S0140-6736(24)00745-1","journal-title":"The Lancet"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-14548-4","article-title":"Recurrence patterns and long-term survival of locally advanced esophageal cancer patients with pathological complete response after different neoadjuvant therapies followed by surgery","volume":"25","author":"Wu J","year":"2025","unstructured":"Wu J, Qin Y, Li K, Hao W, Liu X, Xing W, Zheng Y. Recurrence patterns and long-term survival of locally advanced esophageal cancer patients with pathological complete response after different neoadjuvant therapies followed by surgery. BMC Cancer. 2025, 25:1135. 10.1186\/s12885-025-14548-4","journal-title":"BMC Cancer"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-025-02462-x","article-title":"Setting up an oncology multidisciplinary team in Northeast India: challenges and initial experience","volume":"17","author":"Harris C","year":"2025","unstructured":"Harris C, Laishram PD, Wankhar B, et al.. Setting up an oncology multidisciplinary team in Northeast India: challenges and initial experience. Indian J Surg Oncol. 2025, 17:1537-41. 10.1007\/s13193-025-02462-x","journal-title":"Indian J Surg Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/527407-neoadjuvant-chemoradiotherapy-for-oesophageal-carcinoma-real-world-data-from-practice-beyond-the-chemoradiotherapy-for-oesophageal-cancer-followed-by-surgery-study-cross-trial","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T12:23:40Z","timestamp":1788179020000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/527407-neoadjuvant-chemoradiotherapy-for-oesophageal-carcinoma-real-world-data-from-practice-beyond-the-chemoradiotherapy-for-oesophageal-cancer-followed-by-surgery-study-cross-trial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":26,"URL":"https:\/\/doi.org\/10.7759\/cureus.115499","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}