{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:15:44Z","timestamp":1788192944584,"version":"build-2803163510"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"DOI":"10.7759\/cureus.115511","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:31:47Z","timestamp":1788190307000},"source":"Crossref","is-referenced-by-count":0,"title":["Melanocyte-Fibroblast Crosstalk Under Visible Light and Infrared-A Exposure: A Narrative Review of Implications for Photoaging and Dyschromia"],"prefix":"10.7759","author":[{"given":"Aylin Kerime","family":"Rojas L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alejandro","family":"Arragan Lezama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arismendy Yohen","family":"Maradiaga Irias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizel Valencia","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis de Jes\u00fas","family":"Arguello Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio C\u00e9sar","family":"Flores Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2026.01042","article-title":"The orchestrated network of skin photoaging: from intercellular crosstalk to molecular signaling","volume":"20","author":"Li B","year":"2026","unstructured":"Li B, Ren C, Zhang L, Gu W. The orchestrated network of skin photoaging: from intercellular crosstalk to molecular signaling. Biosci Trends. 2026, 20:178-91. 10.5582\/bst.2026.01042","journal-title":"Biosci Trends"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/JD9.0000000000000068","article-title":"Pathogenesis of photoaging in human dermal fibroblasts","volume":"3","author":"Li S","year":"2020","unstructured":"Li S, Zhao H, Wang Y. Pathogenesis of photoaging in human dermal fibroblasts. Int J Dermatol Venereol. 2020, 3:14-22. 10.1097\/JD9.0000000000000068","journal-title":"Int J Dermatol Venereol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.02.048","article-title":"Visible light. Part I: properties and cutaneous effects of visible light","volume":"84","author":"Austin E","year":"2021","unstructured":"Austin E, Geisler AN, Nguyen J, et al.. Visible light. Part I: properties and cutaneous effects of visible light. J Am Acad Dermatol. 2021, 84:1219-31. 10.1016\/j.jaad.2021.02.048","journal-title":"J Am Acad Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12684","article-title":"Melasma, a photoaging disorder","volume":"31","author":"Passeron T","year":"2018","unstructured":"Passeron T, Picardo M. Melasma, a photoaging disorder. Pigment Cell Melanoma Res. 2018, 31:461-5. 10.1111\/pcmr.12684","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12985","article-title":"Participation of keratinocyte- and fibroblast-derived factors in melanocyte homeostasis, the response to UV, and pigmentary disorders","volume":"34","author":"Upadhyay PR","year":"2021","unstructured":"Upadhyay PR, Ho T, Abdel-Malek ZA. Participation of keratinocyte- and fibroblast-derived factors in melanocyte homeostasis, the response to UV, and pigmentary disorders. Pigment Cell Melanoma Res. 2021, 34:762-76. 10.1111\/pcmr.12985","journal-title":"Pigment Cell Melanoma Res"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2017.06.018","article-title":"Precise role of dermal fibroblasts on melanocyte pigmentation","volume":"88","author":"Wang Y","year":"2017","unstructured":"Wang Y, Viennet C, Robin S, Berthon JY, He L, Humbert P. Precise role of dermal fibroblasts on melanocyte pigmentation. J Dermatol Sci. 2017, 88:159-66. 10.1016\/j.jdermsci.2017.06.018","journal-title":"J Dermatol Sci"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdsct.2025.100101","article-title":"Key targets and pathways in skin photoaging: a comprehensive review","volume":"2","author":"Zhu W","year":"2025","unstructured":"Zhu W, Ren H, Liu Y, et al.. Key targets and pathways in skin photoaging: a comprehensive review. J. Dermatol Sci Cosmet. 2025, 2:100101. 10.1016\/j.jdsct.2025.100101","journal-title":"J. Dermatol Sci Cosmet"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.25259\/JSSTD_34_2019","article-title":"Current concepts in melasma: a review article","volume":"2","author":"Passeron T","year":"2020","unstructured":"Passeron T, Picardo M, Rodrigues M. Current concepts in melasma: a review article. J Skin Sex Transm Dis. 2020, 2:13-7. 10.25259\/JSSTD_34_2019","journal-title":"J Skin Sex Transm Dis"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12793","article-title":"Chronic infrared-A irradiation-induced photoaging of human dermal fibroblasts from different donors at physiological temperature","volume":"38","author":"Yang J","year":"2022","unstructured":"Yang J, Song J, Kim SJ, You G, Lee JB, Mok H. Chronic infrared-A irradiation-induced photoaging of human dermal fibroblasts from different donors at physiological temperature. Photodermatol Photoimmunol Photomed. 2022, 38:571-81. 10.1111\/phpp.12793","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12237488","article-title":"The emerging role of visible light in melanocyte biology and skin pigmentary disorders: friend or foe?","volume":"12","author":"He X","year":"2023","unstructured":"He X, Jin S, Dai X, Chen L, Xiang L, Zhang C. The emerging role of visible light in melanocyte biology and skin pigmentary disorders: friend or foe?. J Clin Med. 2023, 12:10.3390\/jcm12237488","journal-title":"J Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.07.833","article-title":"Melanocytes sense blue light and regulate pigmentation through opsin-3","volume":"138","author":"Regazzetti C","year":"2018","unstructured":"Regazzetti C, Sormani L, Debayle D, et al.. Melanocytes sense blue light and regulate pigmentation through opsin-3. J Invest Dermatol. 2018, 138:171-8. 10.1016\/j.jid.2017.07.833","journal-title":"J Invest Dermatol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.31031\/cojnh.2021.07.000659","article-title":"Epigenetic modifications in the pathogenesis of skin aging","volume":"6","author":"Hanyi Z","year":"2021","unstructured":"Hanyi Z, Yue Z, Xiaoliang T, Lihua G, Liyang K, Jinrong Z. Epigenetic modifications in the pathogenesis of skin aging. COJ Nursing Healthcare. 2021, 6:1-15. 10.31031\/cojnh.2021.07.000659","journal-title":"COJ Nursing Healthcare"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.07.034","article-title":"The pigmentation of blue light is mediated by both melanogenesis activation and autophagy inhibition through OPN3-TRPV1","volume":"145","author":"Yu E","year":"2025","unstructured":"Yu E, Oh SW, Park SH, et al.. The pigmentation of blue light is mediated by both melanogenesis activation and autophagy inhibition through OPN3-TRPV1. J Invest Dermatol. 2025, 145:908-18. 10.1016\/j.jid.2024.07.034","journal-title":"J Invest Dermatol"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2024.1513054","article-title":"Balancing act: optimizing blue light for melanogenesis while minimizing cellular damage in primary human skin cells","volume":"15","author":"Barolet AC","year":"2024","unstructured":"Barolet AC, Magne B, Ferland K, Uzunbajakava NE, Barolet D, Germain L. Balancing act: optimizing blue light for melanogenesis while minimizing cellular damage in primary human skin cells. Front Physiol. 2024, 15:1513054. 10.3389\/fphys.2024.1513054","journal-title":"Front Physiol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2022.0127","article-title":"Low-intensity visible and near-infrared light-induced cell signaling pathways in the skin: a comprehensive review","volume":"41","author":"Barolet AC","year":"2023","unstructured":"Barolet AC, Villarreal AM, Jfri A, Litvinov IV, Barolet D. Low-intensity visible and near-infrared light-induced cell signaling pathways in the skin: a comprehensive review. Photobiomodul Photomed Laser Surg. 2023, 41:147-66. 10.1089\/photob.2022.0127","journal-title":"Photobiomodul Photomed Laser Surg"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12736","article-title":"Effects of visible light on mechanisms of skin photoaging","volume":"38","author":"Pourang A","year":"2022","unstructured":"Pourang A, Tisack A, Ezekwe N, et al.. Effects of visible light on mechanisms of skin photoaging. Photodermatol Photoimmunol Photomed. 2022, 38:191-6. 10.1111\/phpp.12736","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1592596","article-title":"Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies","volume":"16","author":"Nan L","year":"2025","unstructured":"Nan L, Guo P, Hui W, Xia F, Yi C. Recent advances in dermal fibroblast senescence and skin aging: unraveling mechanisms and pioneering therapeutic strategies. Front Pharmacol. 2025, 16:1592596. 10.3389\/fphar.2025.1592596","journal-title":"Front Pharmacol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/php.13454","article-title":"Role of visible light on skin melanocytes: a systematic review","volume":"97","author":"Chauhan A","year":"2021","unstructured":"Chauhan A, Gretz N. Role of visible light on skin melanocytes: a systematic review. Photochem Photobiol. 2021, 97:911-5. 10.1111\/php.13454","journal-title":"Photochem Photobiol"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902351RR","article-title":"Individual and combined effects of the infrared, visible, and ultraviolet light components of solar radiation on damage biomarkers in human skin cells","volume":"34","author":"Hudson L","year":"2020","unstructured":"Hudson L, Rashdan E, Bonn CA, Chavan B, Rawlings D, Birch-Machin MA. Individual and combined effects of the infrared, visible, and ultraviolet light components of solar radiation on damage biomarkers in human skin cells. FASEB J. 2020, 34:3874-83. 10.1096\/fj.201902351RR","journal-title":"FASEB J"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083849","article-title":"Cellular senescence and inflammaging in the skin microenvironment","volume":"22","author":"Lee YI","year":"2021","unstructured":"Lee YI, Choi S, Roh WS, Lee JH, Kim TG. Cellular senescence and inflammaging in the skin microenvironment. Int J Mol Sci. 2021, 22:10.3390\/ijms22083849","journal-title":"Int J Mol Sci"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.04.016","article-title":"Senescent fibroblast-derived GDF15 induces skin pigmentation","volume":"140","author":"Kim Y","year":"2020","unstructured":"Kim Y, Kang B, Kim JC, Park TJ, Kang HY. Senescent fibroblast-derived GDF15 induces skin pigmentation. J Invest Dermatol. 2020, 140:2478-86. 10.1016\/j.jid.2020.04.016","journal-title":"J Invest Dermatol"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S396272","article-title":"New mechanistic insights of melasma","volume":"16","author":"Liu W","year":"2023","unstructured":"Liu W, Chen Q, Xia Y. New mechanistic insights of melasma. Clin Cosmet Investig Dermatol. 2023, 16:429-42. 10.2147\/CCID.S396272","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15092640","article-title":"The cross talk between cellular senescence and melanoma: from molecular pathogenesis to target therapies","volume":"15","author":"Liu J","year":"2023","unstructured":"Liu J, Zheng R, Zhang Y, Jia S, He Y, Liu J. The cross talk between cellular senescence and melanoma: from molecular pathogenesis to target therapies. Cancers (Basel). 2023, 15:10.3390\/cancers15092640","journal-title":"Cancers (Basel)"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019101982","article-title":"Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction","volume":"38","author":"Victorelli S","year":"2019","unstructured":"Victorelli S, Lagnado A, Halim J, et al.. Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction. EMBO J. 2019, 38:e101982. 10.15252\/embj.2019101982","journal-title":"EMBO J"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/php.13039","article-title":"The xanthophyll carotenoid astaxanthin has distinct biological effects to prevent the photoaging of the skin even by its postirradiation treatment","volume":"95","author":"Imokawa G","year":"2019","unstructured":"Imokawa G. The xanthophyll carotenoid astaxanthin has distinct biological effects to prevent the photoaging of the skin even by its postirradiation treatment. Photochem Photobiol. 2019, 95:490-500. 10.1111\/php.13039","journal-title":"Photochem Photobiol"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.70185","article-title":"Global consensus on the management of melanin hyperpigmentation disorders","volume":"40","author":"Passeron T","year":"2026","unstructured":"Passeron T, Desai SR, Abdallah M, et al.. Global consensus on the management of melanin hyperpigmentation disorders. J Eur Acad Dermatol Venereol. 2026, 40:760-72. 10.1111\/jdv.70185","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1297637","article-title":"The role of cellular senescence in skin aging and age-related skin pathologies","volume":"14","author":"Chin T","year":"2023","unstructured":"Chin T, Lee XE, Ng PY, Lee Y, Dreesen O. The role of cellular senescence in skin aging and age-related skin pathologies. Front Physiol. 2023, 14:1297637. 10.3389\/fphys.2023.1297637","journal-title":"Front Physiol"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2024.02.007","article-title":"Emerging role of fibroblasts in vitiligo: a formerly underestimated rising star","volume":"144","author":"Wu Y","year":"2024","unstructured":"Wu Y, Yang Y, Lin Y, et al.. Emerging role of fibroblasts in vitiligo: a formerly underestimated rising star. J Invest Dermatol. 2024, 144:1696-706. 10.1016\/j.jid.2024.02.007","journal-title":"J Invest Dermatol"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/biology14101402","article-title":"Unraveling melasma: from epidermal pigmentation to microenvironmental dysregulation","volume":"14","author":"Miao F","year":"2025","unstructured":"Miao F, Wan J, Zhou Y, Shi Y. Unraveling melasma: from epidermal pigmentation to microenvironmental dysregulation. Biology (Basel). 2025, 14:10.3390\/biology14101402","journal-title":"Biology (Basel)"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14400","article-title":"Visible light and human skin pigmentation: the importance of skin phototype","volume":"30","author":"Moreiras H","year":"2021","unstructured":"Moreiras H, O'Connor C, Bell M, Tobin DJ. Visible light and human skin pigmentation: the importance of skin phototype. Exp Dermatol. 2021, 30:1324-31. 10.1111\/exd.14400","journal-title":"Exp Dermatol"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.17242","article-title":"Photoprotection according to skin phototype and dermatoses: practical recommendations from an expert panel","volume":"35","author":"Passeron T","year":"2021","unstructured":"Passeron T, Lim HW, Goh CL, et al.. Photoprotection according to skin phototype and dermatoses: practical recommendations from an expert panel. J Eur Acad Dermatol Venereol. 2021, 35:1460-9. 10.1111\/jdv.17242","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.292501","article-title":"Erratum: Future therapies in melasma: what lies ahead?","volume":"86","author":"Sarkar R","year":"2020","unstructured":"Sarkar R, Bansal A, Ailawadi P. Erratum: Future therapies in melasma: what lies ahead?. Indian J Dermatol Venereol Leprol. 2020, 86:608. 10.4103\/0378-6323.292501","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.19677","article-title":"Photoprotection: current developments and controversies","volume":"38 Suppl 5","author":"Pellacani G","year":"2024","unstructured":"Pellacani G, Lim HW, Stockfleth E, Sibaud V, Brugu\u00e9s AO, Saint Aroman M. Photoprotection: current developments and controversies. J Eur Acad Dermatol Venereol. 2024, 38 Suppl 5:12-20. 10.1111\/jdv.19677","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.70033","article-title":"Visible light protection: an updated review of tinted sunscreens","volume":"41","author":"He M","year":"2025","unstructured":"He M, Chen X, Jin S, Zhang C. Visible light protection: an updated review of tinted sunscreens. Photodermatol Photoimmunol Photomed. 2025, 41:e70033. 10.1111\/phpp.70033","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1111\/phpp.12937","article-title":"Evaluation of the protection of sunscreen products against long wavelength ultraviolet A1 and visible light-induced biological effects","volume":"40","author":"Ezekwe N","year":"2024","unstructured":"Ezekwe N, Pourang A, Lyons AB, et al.. Evaluation of the protection of sunscreen products against long wavelength ultraviolet A1 and visible light-induced biological effects. Photodermatol Photoimmunol Photomed. 2024, 40:e12937. 10.1111\/phpp.12937","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2017.09.025","article-title":"Opsin3-A link to visible light-induced skin pigmentation","volume":"138","author":"Setty SR","year":"2018","unstructured":"Setty SR. Opsin3-A link to visible light-induced skin pigmentation. J Invest Dermatol. 2018, 138:13-5. 10.1016\/j.jid.2017.09.025","journal-title":"J Invest Dermatol"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.12.011","article-title":"Environmentally-induced (extrinsic) skin aging: exposomal factors and underlying mechanisms","volume":"141","author":"Krutmann J","year":"2021","unstructured":"Krutmann J, Schikowski T, Morita A, Berneburg M. Environmentally-induced (extrinsic) skin aging: exposomal factors and underlying mechanisms. J Invest Dermatol. 2021, 141:1096-103. 10.1016\/j.jid.2020.12.011","journal-title":"J Invest Dermatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/525323-melanocyte-fibroblast-crosstalk-under-visible-light-and-infrared-a-exposure-a-narrative-review-of-implications-for-photoaging-and-dyschromia","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T15:31:47Z","timestamp":1788190307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/525323-melanocyte-fibroblast-crosstalk-under-visible-light-and-infrared-a-exposure-a-narrative-review-of-implications-for-photoaging-and-dyschromia"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":37,"URL":"https:\/\/doi.org\/10.7759\/cureus.115511","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}