{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:15:30Z","timestamp":1788405330693,"version":"build-2803163510"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,2]]},"DOI":"10.7759\/cureus.115687","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:45:46Z","timestamp":1788403546000},"source":"Crossref","is-referenced-by-count":0,"title":["Progressive Liver Metastasis of Breast Cancer on Endocrine Therapy Showing Favorable Response to Additive Alternate-Day S-1 Therapy: A Case Report"],"prefix":"10.7759","author":[{"given":"Kasumi","family":"Arizumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Oura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/ctrv.1999.0161","article-title":"Systematic reviews of chemotherapy and endocrine therapy in metastatic breast cancer","volume":"26","author":"Stockler M","year":"2000","unstructured":"Stockler M, Wilcken NR, Ghersi D, Simes RJ. Systematic reviews of chemotherapy and endocrine therapy in metastatic breast cancer. Cancer Treat Rev. 2000, 26:151-68. 10.1053\/ctrv.1999.0161","journal-title":"Cancer Treat Rev"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.73","article-title":"Clinical management of breast cancer heterogeneity","volume":"12","author":"Zardavas D","year":"2015","unstructured":"Zardavas D, Irrthum A, Swanton C, Piccart M. Clinical management of breast cancer heterogeneity. Nat Rev Clin Oncol. 2015, 12:381-94. 10.1038\/nrclinonc.2015.73","journal-title":"Nat Rev Clin Oncol"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e3182745948","article-title":"Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer","volume":"7","author":"Weickhardt AJ","year":"2012","unstructured":"Weickhardt AJ, Scheier B, Burke JM, et al.. Local ablative therapy of oligoprogressive disease prolongs disease control by tyrosine kinase inhibitors in oncogene-addicted non-small-cell lung cancer. J Thorac Oncol. 2012, 7:1807-14. 10.1097\/JTO.0b013e3182745948","journal-title":"J Thorac Oncol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.37","article-title":"A late phase II study of RP56976 (docetaxel) in patients with advanced or recurrent breast cancer","volume":"73","author":"Adachi I","year":"1996","unstructured":"Adachi I, Watanabe T, Takashima S, Narabayashi M, Horikoshi N, Aoyama H, Taguchi T. A late phase II study of RP56976 (docetaxel) in patients with advanced or recurrent breast cancer. Br J Cancer. 1996, 73:210-6. 10.1038\/bjc.1996.37","journal-title":"Br J Cancer"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq054","article-title":"Randomized study of taxane versus TS-1 in women with metastatic or recurrent breast cancer (SELECT BC)","volume":"40","author":"Mukai H","year":"2010","unstructured":"Mukai H, Takashima T, Hozumi Y, et al.. Randomized study of taxane versus TS-1 in women with metastatic or recurrent breast cancer (SELECT BC). Jpn J Clin Oncol. 2010, 40:811-4. 10.1093\/jjco\/hyq054","journal-title":"Jpn J Clin Oncol"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-017-1157-3","article-title":"Randomized phase II study of daily and alternate-day administration of S-1 for advanced gastric cancer (JFMC43-1003)","volume":"22","author":"Tanaka H","year":"2017","unstructured":"Tanaka H, Kanda M, Morita S, et al.. Randomized phase II study of daily and alternate-day administration of S-1 for advanced gastric cancer (JFMC43-1003). Int J Clin Oncol. 2017, 22:1052-9. 10.1007\/s10147-017-1157-3","journal-title":"Int J Clin Oncol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-017-3250-8","article-title":"Multicenter, randomized, open-label Phase II study comparing S-1 alternate-day oral therapy with the standard daily regimen as a first-line treatment in patients with unresectable advanced pancreatic cancer","volume":"79","author":"Yamaue H","year":"2017","unstructured":"Yamaue H, Shimizu A, Hagiwara Y, et al.. Multicenter, randomized, open-label Phase II study comparing S-1 alternate-day oral therapy with the standard daily regimen as a first-line treatment in patients with unresectable advanced pancreatic cancer. Cancer Chemother Pharmacol. 2017, 79:813-23. 10.1007\/s00280-017-3250-8","journal-title":"Cancer Chemother Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn127","article-title":"Development history and concept of an oral anticancer agent S-1 (TS-1): its clinical usefulness and future vistas","volume":"39","author":"Shirasaka T","year":"2009","unstructured":"Shirasaka T. Development history and concept of an oral anticancer agent S-1 (TS-1): its clinical usefulness and future vistas. Jpn J Clin Oncol. 2009, 39:2-15. 10.1093\/jjco\/hyn127","journal-title":"Jpn J Clin Oncol"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.588136","article-title":"Prognosis and genomic landscape of liver metastasis in patients with breast cancer","volume":"11","author":"Tian C","year":"2021","unstructured":"Tian C, Liu S, Wang Y, Song X. Prognosis and genomic landscape of liver metastasis in patients with breast cancer. Front Oncol. 2021, 11:588136. 10.3389\/fonc.2021.588136","journal-title":"Front Oncol"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1996.14.1.58","article-title":"Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer","volume":"14","author":"Hudis CA","year":"1996","unstructured":"Hudis CA, Seidman AD, Crown JP, et al.. Phase II and pharmacologic study of docetaxel as initial chemotherapy for metastatic breast cancer. J Clin Oncol. 1996, 14:58-65. 10.1200\/JCO.1996.14.1.58","journal-title":"J Clin Oncol"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg500","article-title":"Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial","volume":"14","author":"Scheithauer W","year":"2003","unstructured":"Scheithauer W, McKendrick J, Begbie S, et al.. Oral capecitabine as an alternative to i.v. 5-fluorouracil-based adjuvant therapy for colon cancer: safety results of a randomized, phase III trial. Ann Oncol. 2003, 14:1735-43. 10.1093\/annonc\/mdg500","journal-title":"Ann Oncol"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.13.4.693","article-title":"Preclinical antitumor efficacy of S-1: a new oral formulation of 5-fluorouracil on human tumor xenografts","volume":"13","author":"Fukushima M","year":"1998","unstructured":"Fukushima M, Satake H, Uchida J, et al.. Preclinical antitumor efficacy of S-1: a new oral formulation of 5-fluorouracil on human tumor xenografts. Int J Oncol. 1998, 13:693-8. 10.3892\/ijo.13.4.693","journal-title":"Int J Oncol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/529162-progressive-liver-metastasis-of-breast-cancer-on-endocrine-therapy-showing-favorable-response-to-additive-alternate-day-s-1-therapy-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:45:50Z","timestamp":1788403550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/529162-progressive-liver-metastasis-of-breast-cancer-on-endocrine-therapy-showing-favorable-response-to-additive-alternate-day-s-1-therapy-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":12,"URL":"https:\/\/doi.org\/10.7759\/cureus.115687","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}