{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T08:12:32Z","timestamp":1788509552146,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,4]]},"DOI":"10.7759\/cureus.115756","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:17:25Z","timestamp":1788506245000},"source":"Crossref","is-referenced-by-count":0,"title":["Microneedling Combined With Topical Poly-L-Lactic Acid and Hyaluronic Acid for Skin Elasticity and Hydration: A Pilot Comparative Study"],"prefix":"10.7759","author":[{"given":"Victoria","family":"Arutinova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nino","family":"Nishnianidze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Tsintsadze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kadzhaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Sulamanidze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2007.00415.x","article-title":"Intrinsic and extrinsic factors in skin ageing: a review","volume":"30","author":"Farage MA","year":"2008","unstructured":"Farage MA, Miller KW, Elsner P, Maibach HI. Intrinsic and extrinsic factors in skin ageing: a review. Int J Cosmet Sci. 2008, 30:87-95. 10.1111\/j.1468-2494.2007.00415.x","journal-title":"Int J Cosmet Sci"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/polym14081608","article-title":"Microneedles in action: microneedling and microneedles-assisted transdermal delivery","volume":"14","author":"Lim DJ","year":"2022","unstructured":"Lim DJ, Kim HJ. Microneedles in action: microneedling and microneedles-assisted transdermal delivery. Polymers (Basel). 2022, 14:1608. 10.3390\/polym14081608","journal-title":"Polymers (Basel)"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12761","article-title":"Multiple microneedling sessions for minimally invasive facial rejuvenation: an objective assessment","volume":"54","author":"El-Domyati M","year":"2015","unstructured":"El-Domyati M, Barakat M, Awad S, Medhat W, El-Fakahany H, Farag H. Multiple microneedling sessions for minimally invasive facial rejuvenation: an objective assessment. Int J Dermatol. 2015, 54:1361-9. 10.1111\/ijd.12761","journal-title":"Int J Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/dth.15903","article-title":"Benefits of topical hyaluronic acid for skin quality and signs of skin aging: from literature review to clinical evidence","volume":"35","author":"Bravo B","year":"2022","unstructured":"Bravo B, Correia P, Gon\u00e7alves Junior JE, Sant'Anna B, Kerob D. Benefits of topical hyaluronic acid for skin quality and signs of skin aging: from literature review to clinical evidence. Dermatol Ther. 2022, 35:e15903. 10.1111\/dth.15903","journal-title":"Dermatol Ther"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001772","article-title":"Randomized, controlled, multicentered, double-blind investigation of injectable poly-L-lactic acid for improving skin quality","volume":"45","author":"Bohnert K","year":"2019","unstructured":"Bohnert K, Dorizas A, Lorenc P, Sadick NS. Randomized, controlled, multicentered, double-blind investigation of injectable poly-L-lactic acid for improving skin quality. Dermatol Surg. 2019, 45:718-24. 10.1097\/DSS.0000000000001772","journal-title":"Dermatol Surg"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000037506","article-title":"Application of PLLA (poly-L-Lactic acid) for rejuvenation and reproduction of facial cutaneous tissue in aesthetics: a review","volume":"103","author":"Ao YJ","year":"2024","unstructured":"Ao YJ, Yi Y, Wu GH. Application of PLLA (poly-L-Lactic acid) for rejuvenation and reproduction of facial cutaneous tissue in aesthetics: a review. Medicine (Baltimore). 2024, 103:e37506. 10.1097\/MD.0000000000037506","journal-title":"Medicine (Baltimore)"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3390\/polym16182564","article-title":"Efficacy and safety of poly-L-lactic acid in facial aesthetics: a systematic review","volume":"16","author":"Signori R","year":"2024","unstructured":"Signori R, Barbosa AP, Cezar-Dos-Santos F, et al.. Efficacy and safety of poly-L-lactic acid in facial aesthetics: a systematic review. Polymers (Basel). 2024, 16:2564. 10.3390\/polym16182564","journal-title":"Polymers (Basel)"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.58529","article-title":"Microneedling with dermaroller","volume":"2","author":"Doddaballapur S","year":"2009","unstructured":"Doddaballapur S. Microneedling with dermaroller. J Cutan Aesthet Surg. 2009, 2:110-1. 10.4103\/0974-2077.58529","journal-title":"J Cutan Aesthet Surg"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001248","article-title":"Microneedling: a review and practical guide","volume":"44","author":"Alster TS","year":"2018","unstructured":"Alster TS, Graham PM. Microneedling: a review and practical guide. Dermatol Surg. 2018, 44:397-404. 10.1097\/DSS.0000000000001248","journal-title":"Dermatol Surg"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-025-01626-5","article-title":"Transdermal delivery of poly-L-lactic acid via fractional microneedle radiofrequency for atrophic acne scars: a split-face randomized study in Fitzpatrick skin types III to V","volume":"16","author":"Kupwiwat R","year":"2026","unstructured":"Kupwiwat R, Techapichetvanich T, Bhorntarakcharoen W, Sittiwanaruk S, Li JB, Manuskiatti W. Transdermal delivery of poly-L-lactic acid via fractional microneedle radiofrequency for atrophic acne scars: a split-face randomized study in Fitzpatrick skin types III to V. Dermatol Ther (Heidelb). 2026, 16:1089-97. 10.1007\/s13555-025-01626-5","journal-title":"Dermatol Ther (Heidelb)"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000000895","article-title":"FACE-Q scales for health-related quality of life, early life impact, satisfaction with outcomes, and decision to have treatment: development and validation","volume":"135","author":"Klassen AF","year":"2015","unstructured":"Klassen AF, Cano SJ, Schwitzer JA, Scott AM, Pusic AL. FACE-Q scales for health-related quality of life, early life impact, satisfaction with outcomes, and decision to have treatment: development and validation. Plast Reconstr Surg. 2015, 135:375-86. 10.1097\/PRS.0000000000000895","journal-title":"Plast Reconstr Surg"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cps.2012.12.001","article-title":"Development and psychometric evaluation of the FACE-Q Satisfaction with Appearance scale: a new patient-reported outcome instrument for facial aesthetics patients","volume":"40","author":"Pusic AL","year":"2013","unstructured":"Pusic AL, Klassen AF, Scott AM, Cano SJ. Development and psychometric evaluation of the FACE-Q Satisfaction with Appearance scale: a new patient-reported outcome instrument for facial aesthetics patients. Clin Plast Surg. 2013, 40:249-60. 10.1016\/j.cps.2012.12.001","journal-title":"Clin Plast Surg"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29150.x","article-title":"A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds","volume":"29","author":"Narins RS","year":"2003","unstructured":"Narins RS, Brandt F, Leyden J, Lorenc ZP, Rubin M, Smith S. A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatol Surg. 2003, 29:588-95. 10.1046\/j.1524-4725.2003.29150.x","journal-title":"Dermatol Surg"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/srt.13385","article-title":"An innovative temperature-controlling handpiece for face and body skin laxity and tightening treatment with radiofrequency","volume":"29","author":"Alvaro P","year":"2023","unstructured":"Alvaro P, Alberto O, Matia F, Beatrice Marina P. An innovative temperature-controlling handpiece for face and body skin laxity and tightening treatment with radiofrequency. Skin Res Technol. 2023, 29:e13385. 10.1111\/srt.13385","journal-title":"Skin Res Technol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000006838","article-title":"The efficacy of combined microneedling and topical poly-D,L-lactic acid (Juvelook) application for facial pore reduction and skin texture improvement","volume":"13","author":"Wan J","year":"2025","unstructured":"Wan J, Seo SB, Yoon SE, Yi KH. The efficacy of combined microneedling and topical poly-D,L-lactic acid (Juvelook) application for facial pore reduction and skin texture improvement. Plast Reconstr Surg Glob Open. 2025, 13:e6838. 10.1097\/GOX.0000000000006838","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1201\/b17642","article-title":"Zein Obagi System of Skin Classification, Chapter 4","author":"Obagi ZE","year":"2014","unstructured":"Obagi ZE. Zein Obagi System of Skin Classification, Chapter 4. The Art of Skin Health Restoration and Rejuvenation. CRC Press, London; 2014. 94-5. 10.1201\/b17642"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16085","article-title":"Skin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: a preliminary study","volume":"23","author":"Seo SB","year":"2024","unstructured":"Seo SB, Park H, Jo JY, Ryu HJ. Skin rejuvenation effect of the combined PDLLA and non cross-linked hyaluronic acid: a preliminary study. J Cosmet Dermatol. 2024, 23:794-802. 10.1111\/jocd.16085","journal-title":"J Cosmet Dermatol"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjab052","article-title":"A single-center trial to evaluate the efficacy and tolerability of four microneedling treatments on fine lines and wrinkles of facial and neck skin in subjects with Fitzpatrick skin types I-IV: an objective assessment using noninvasive devices and 0.33-mm microbiopsies","volume":"41","author":"Wamsley CE","year":"2021","unstructured":"Wamsley CE, Kislevitz M, Barillas J, et al.. A single-center trial to evaluate the efficacy and tolerability of four microneedling treatments on fine lines and wrinkles of facial and neck skin in subjects with Fitzpatrick skin types I-IV: an objective assessment using noninvasive devices and 0.33-mm microbiopsies. Aesthet Surg J. 2021, 41:NP1603-18. 10.1093\/asj\/sjab052","journal-title":"Aesthet Surg J"},{"key":"ref19","article-title":"Safety and effectiveness of an automated microneedling device in improving the signs of aging skin","volume":"11","author":"Ablon G","year":"2018","unstructured":"Ablon G. Safety and effectiveness of an automated microneedling device in improving the signs of aging skin. J Clin Aesthet Dermatol. 2018, 11:29-34.","journal-title":"J Clin Aesthet Dermatol"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12244","article-title":"A potential relationship between skin hydration and stamp-type microneedle intradermal hyaluronic acid injection in middle-aged male face","volume":"15","author":"Seok J","year":"2016","unstructured":"Seok J, Hong JY, Choi SY, Park KY, Kim BJ. A potential relationship between skin hydration and stamp-type microneedle intradermal hyaluronic acid injection in middle-aged male face. J Cosmet Dermatol. 2016, 15:578-82. 10.1111\/jocd.12244","journal-title":"J Cosmet Dermatol"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjaa231","article-title":"Fine wrinkle treatment and hydration on the facial dermis using hydrotoxin mixture of MicroBotox and MicroHyaluronic Acid","volume":"41","author":"Kim JS","year":"2021","unstructured":"Kim JS. Fine wrinkle treatment and hydration on the facial dermis using hydrotoxin mixture of MicroBotox and MicroHyaluronic Acid. Aesthet Surg J. 2021, 41:NP538-49. 10.1093\/asj\/sjaa231","journal-title":"Aesthet Surg J"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.70137","article-title":"Facial rejuvenation with an innovative poly-L-lactic acid (Jul\u00e4ine) for nasolabial folds: interim data analysis of a prospective, non-randomized, multicenter, open-label Spanish study","volume":"24","author":"Urdiales-G\u00e1lvez F","year":"2025","unstructured":"Urdiales-G\u00e1lvez F, Ben\u00edtez PA, D\u00edaz I. Facial rejuvenation with an innovative poly-L-lactic acid (Jul\u00e4ine) for nasolabial folds: interim data analysis of a prospective, non-randomized, multicenter, open-label Spanish study. J Cosmet Dermatol. 2025, 24:e70137. 10.1111\/jocd.70137","journal-title":"J Cosmet Dermatol"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.21518\/ms2025-087","article-title":"Hybrid one session treatment with poly-l-lactic acid and high-molecular weight hyaluronic acid for skin rejuvenation: clinical, ultrasound and histological assessment. (Article in Russian)","volume":"19","author":"Razumovskaya EA","year":"2025","unstructured":"Razumovskaya EA, Kapuler OM, Murakov SV, Glavnova AM. Hybrid one session treatment with poly-l-lactic acid and high-molecular weight hyaluronic acid for skin rejuvenation: clinical, ultrasound and histological assessment. (Article in Russian). Meditsinskiy Sovet. 2025, 19:125-34. 10.21518\/ms2025-087","journal-title":"Meditsinskiy Sovet"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111\/dth.13963","article-title":"Effects of hyaluronic acid injected using the mesogun injector with stamp-type microneedle on skin hydration","volume":"33","author":"Choi SY","year":"2020","unstructured":"Choi SY, Ko EJ, Yoo KH, Han HS, Kim BJ. Effects of hyaluronic acid injected using the mesogun injector with stamp-type microneedle on skin hydration. Dermatol Ther. 2020, 33:e13963. 10.1111\/dth.13963","journal-title":"Dermatol Ther"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14518","article-title":"Facial rejuvenation using a microneedle-based device with a revitalizing solution and free hyaluronic acid","volume":"20","author":"Dell'Avanzato R","year":"2021","unstructured":"Dell'Avanzato R, Gualdi A, Vescovi E, et al.. Facial rejuvenation using a microneedle-based device with a revitalizing solution and free hyaluronic acid. J Cosmet Dermatol. 2021, 20:3708-9. 10.1111\/jocd.14518","journal-title":"J Cosmet Dermatol"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/517394-microneedling-combined-with-topical-poly-l-lactic-acid-and-hyaluronic-acid-for-skin-elasticity-and-hydration-a-pilot-comparative-study","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T07:17:26Z","timestamp":1788506246000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/517394-microneedling-combined-with-topical-poly-l-lactic-acid-and-hyaluronic-acid-for-skin-elasticity-and-hydration-a-pilot-comparative-study"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,4]]},"references-count":25,"URL":"https:\/\/doi.org\/10.7759\/cureus.115756","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,4]]}}}