{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T05:12:34Z","timestamp":1788757954668,"version":"build-2803163510"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,6]]},"DOI":"10.7759\/cureus.115873","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:53:50Z","timestamp":1788756830000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparative Histopathological Spectrum of Periapical Lesions in Root Canal-Treated and Non-root Canal-Treated Teeth"],"prefix":"10.7759","author":[{"given":"Sachin","family":"Kandalkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadhvi","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chidipothu Sri","family":"Madhavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Vilekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Kuravatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradnya","family":"Relan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyabrat","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031480","article-title":"Inflammatory response mechanisms of the dentine-pulp complex and the periapical tissues","volume":"22","author":"Galler KM","year":"2021","unstructured":"Galler KM, Weber M, Korkmaz Y, Widbiller M, Feuerer M. Inflammatory response mechanisms of the dentine-pulp complex and the periapical tissues. Int J Mol Sci. 2021, 22:1480. 10.3390\/ijms22031480","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.14744\/eej.2020.42714","article-title":"Endodontic periapical lesion: an overview on the etiology, diagnosis and current treatment modalities","volume":"5","author":"Karamifar K","year":"2020","unstructured":"Karamifar K, Tondari A, Saghiri MA. Endodontic periapical lesion: an overview on the etiology, diagnosis and current treatment modalities. Eur Endod J. 2020, 5:54-67. 10.14744\/eej.2020.42714","journal-title":"Eur Endod J"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2020.01.007","article-title":"Evaluation of concordance between clinical and histopathological diagnoses in periapical lesions of endodontic origin","volume":"15","author":"Alotaibi O","year":"2020","unstructured":"Alotaibi O, Alswayyed S, Alshagroud R, AlSheddi M. Evaluation of concordance between clinical and histopathological diagnoses in periapical lesions of endodontic origin. J Dent Sci. 2020, 15:132-5. 10.1016\/j.jds.2020.01.007","journal-title":"J Dent Sci"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.08.026","article-title":"A study of periapical lesions correlating the presence of a radiopaque lamina with histological findings","volume":"101","author":"Ricucci D","year":"2006","unstructured":"Ricucci D, Mannocci F, Ford TR. A study of periapical lesions correlating the presence of a radiopaque lamina with histological findings. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006, 101:389-94. 10.1016\/j.tripleo.2005.08.026","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.9074","article-title":"Root canal therapy used in conjunction with follow-ups for the nonsurgical handling of an enormous periapical lesion of endodontic origin: clinical case record","volume":"12","author":"Rao NR","year":"2024","unstructured":"Rao NR, Mujeeb A, Kottur AA, Mathur A, Snigdha NT, Karobari MI. Root canal therapy used in conjunction with follow-ups for the nonsurgical handling of an enormous periapical lesion of endodontic origin: clinical case record. Clin Case Rep. 2024, 12:e9074. 10.1002\/ccr3.9074","journal-title":"Clin Case Rep"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2006.01099.x","article-title":"On the causes of persistent apical periodontitis: a review","volume":"39","author":"Nair PN","year":"2006","unstructured":"Nair PN. On the causes of persistent apical periodontitis: a review. Int Endod J. 2006, 39:249-81. 10.1111\/j.1365-2591.2006.01099.x","journal-title":"Int Endod J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.JPBS_68_20","article-title":"Assessment of constant periapical lesions and their connection with endodontic failures after apical microsurgery","volume":"12","author":"Kharat N","year":"2020","unstructured":"Kharat N, Waghmare P, Sarkar M, Nawal S, Sahu T, Dheeraj M. Assessment of constant periapical lesions and their connection with endodontic failures after apical microsurgery. J Pharm Bioallied Sci. 2020, 12:S233-7. 10.4103\/jpbs.JPBS_68_20","journal-title":"J Pharm Bioallied Sci"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s1079-2104(96)80156-9","article-title":"Types and incidence of human periapical lesions obtained with extracted teeth","volume":"81","author":"Ramachandran Nair PN","year":"1996","unstructured":"Ramachandran Nair PN, Pajarola G, Schroeder HE. Types and incidence of human periapical lesions obtained with extracted teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1996, 81:93-102. 10.1016\/s1079-2104(96)80156-9","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.70409","article-title":"Rapidly progressing radicular cyst in an endodontically treated tooth: diagnostic challenges, advanced imaging, and surgical management","volume":"13","author":"Asgary S","year":"2025","unstructured":"Asgary S, Shamloo N. Rapidly progressing radicular cyst in an endodontically treated tooth: diagnostic challenges, advanced imaging, and surgical management. Clin Case Rep. 2025, 13:e70409. 10.1002\/ccr3.70409","journal-title":"Clin Case Rep"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2008.01500.x","article-title":"Histopathological profile of surgically removed persistent periapical radiolucent lesions of endodontic origin","volume":"42","author":"Love RM","year":"2009","unstructured":"Love RM, Firth N. Histopathological profile of surgically removed persistent periapical radiolucent lesions of endodontic origin. Int Endod J. 2009, 42:198-202. 10.1111\/j.1365-2591.2008.01500.x","journal-title":"Int Endod J"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280109.x","article-title":"Microbiology and treatment of dental abscesses and periodontal-endodontic lesions","volume":"28","author":"Dahl\u00e9n G","year":"2002","unstructured":"Dahl\u00e9n G. Microbiology and treatment of dental abscesses and periodontal-endodontic lesions. Periodontol 2000. 2002, 28:206-39. 10.1034\/j.1600-0757.2002.280109.x","journal-title":"Periodontol 2000"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.4103\/1119-3077.86770","article-title":"Periapical granuloma associated with extracted teeth","volume":"14","author":"Omoregie FO","year":"2011","unstructured":"Omoregie FO, Ojo MA, Saheeb B, Odukoya O. Periapical granuloma associated with extracted teeth. Niger J Clin Pract. 2011, 14:293-6. 10.4103\/1119-3077.86770","journal-title":"Niger J Clin Pract"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3390\/encyclopedia6060125","article-title":"Periapical lesions: diagnosis, pathophysiology, and management","volume":"6","author":"Reiser Y","year":"2026","unstructured":"Reiser Y, Markovi\u0107 L, Pelivan I, Ivani\u0161evi\u0107 A, Gabri\u0107 D. Periapical lesions: diagnosis, pathophysiology, and management. Encyclopedia. 2026, 6:125. 10.3390\/encyclopedia6060125","journal-title":"Encyclopedia"},{"key":"ref14","article-title":"Assessment of conformity between clinical (radiological) and histopathological diagnoses of chronic inflammatory periapical lesions treated with apicoectomy. Clinical and histopathological diagnoses of periapical lesions. Research article","volume":"60","author":"Myci\u0144ski P","year":"2020","unstructured":"Myci\u0144ski P, Dobro\u015b K, Kaczmarzyk T, Zarzecka J. Assessment of conformity between clinical (radiological) and histopathological diagnoses of chronic inflammatory periapical lesions treated with apicoectomy. Clinical and histopathological diagnoses of periapical lesions. Research article. Folia Med Cracov. 2020, 60:103-11.","journal-title":"Folia Med Cracov"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2021.vol35.0033","article-title":"Chronic inflammatory periapical diseases: a Brazilian multicenter study of 10,381 cases and literature review","volume":"35","author":"Couto AM","year":"2021","unstructured":"Couto AM, Meirelles DP, Valeriano AT, et al.. Chronic inflammatory periapical diseases: a Brazilian multicenter study of 10,381 cases and literature review. Braz Oral Res. 2021, 35:e033.","journal-title":"Braz Oral Res"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/528935-comparative-histopathological-spectrum-of-periapical-lesions-in-root-canal-treated-and-non-root-canal-treated-teeth","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T04:53:52Z","timestamp":1788756832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/528935-comparative-histopathological-spectrum-of-periapical-lesions-in-root-canal-treated-and-non-root-canal-treated-teeth"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,6]]},"references-count":15,"URL":"https:\/\/doi.org\/10.7759\/cureus.115873","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,6]]}}}