{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:08:36Z","timestamp":1788844116195,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,7]]},"DOI":"10.7759\/cureus.115919","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:14:36Z","timestamp":1788840876000},"source":"Crossref","is-referenced-by-count":0,"title":["Limb Salvage Using Negative Pressure Wound Therapy and Split-Thickness Skin Grafting for Polymicrobial Ecthyma Gangrenosum in a Patient With Acute Lymphoblastic Leukemia: A Case Report"],"prefix":"10.7759","author":[{"given":"Andrea Nallely","family":"Garza-Cisneros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rito Jafeth","family":"Medellin-Cristerna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dayana Estefan\u00eda","family":"Gutierrez-Vega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Montenegro Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Miguel","family":"Su\u00e1rez Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart\u00edn","family":"Rodr\u00edguez-Garza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Hernandez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-014-2277-6","article-title":"Ecthyma gangrenosum and ecthyma-like lesions: review article","volume":"34","author":"Vaiman M","year":"2015","unstructured":"Vaiman M, Lazarovitch T, Heller L, Lotan G. Ecthyma gangrenosum and ecthyma-like lesions: review article. Eur J Clin Microbiol Infect Dis. 2015, 34:633-9. 10.1007\/s10096-014-2277-6","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idcr.2023.e01694","article-title":"Ecthyma gangrenosum","volume":"31","author":"Sutherland CA","year":"2023","unstructured":"Sutherland CA, Quest TL, Wanat KA. Ecthyma gangrenosum. IDCases. 2023, 31:e01694. 10.1016\/j.idcr.2023.e01694","journal-title":"IDCases"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00843.x","article-title":"Ecthyma gangrenosum without bacteraemia in a leukaemic patient","volume":"26","author":"Song WK","year":"2001","unstructured":"Song WK, Kim YC, Park HJ, Cinn YW. Ecthyma gangrenosum without bacteraemia in a leukaemic patient. Clin Exp Dermatol. 2001, 26:395-7. 10.1046\/j.1365-2230.2001.00843.x","journal-title":"Clin Exp Dermatol"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(79)91329-X","article-title":"The pathogenesis of ecthyma gangrenosum","volume":"1","author":"van den Broek PJ","year":"1979","unstructured":"van den Broek PJ, van der Meer JWM, Kunst MW. The pathogenesis of ecthyma gangrenosum. J Infect. 1979, 1:263-7. 10.1016\/S0163-4453(79)91329-X","journal-title":"J Infect"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2011_04_326","article-title":"Blood stream infections throughout the entire course of acute lymphoblastic leukemia treatment","volume":"58","author":"Katsibardi K","year":"2011","unstructured":"Katsibardi K, Papadakis V, Charisiadou A, Pangalis A, Polychronopoulou S. Blood stream infections throughout the entire course of acute lymphoblastic leukemia treatment. Neoplasma. 2011, 58:326-30. 10.4149\/neo_2011_04_326","journal-title":"Neoplasma"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13113","article-title":"Mucosal barrier injury, fever and infection in neutropenic patients with cancer: introducing the paradigm febrile mucositis","volume":"167","author":"van der Velden WJ","year":"2014","unstructured":"van der Velden WJ, Herbers AH, Netea MG, Blijlevens NM. Mucosal barrier injury, fever and infection in neutropenic patients with cancer: introducing the paradigm febrile mucositis. Br J Haematol. 2014, 167:441-52. 10.1111\/bjh.13113","journal-title":"Br J Haematol"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.84898","article-title":"Ecthyma gangrenosum of a single limb","volume":"15","author":"Varghese GM","year":"2011","unstructured":"Varghese GM, Eapen P, Abraham S. Ecthyma gangrenosum of a single limb. Indian J Crit Care Med. 2011, 15:188-9. 10.4103\/0972-5229.84898","journal-title":"Indian J Crit Care Med"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370020117047","article-title":"Ecthyma gangrenosum without bacteremia: report of six cases and review of the literature","volume":"147","author":"Huminer D","year":"1987","unstructured":"Huminer D, Siegman-Igra Y, Morduchowicz G, Pitlik SD. Ecthyma gangrenosum without bacteremia: report of six cases and review of the literature. Arch Intern Med. 1987, 147:299-301. 10.1001\/archinte.1987.00370020117047","journal-title":"Arch Intern Med"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.12658","article-title":"Deconstructing negative pressure wound therapy","volume":"14","author":"Lalezari S","year":"2017","unstructured":"Lalezari S, Lee CJ, Borovikova AA, Banyard DA, Paydar KZ, Wirth GA, Widgerow AD. Deconstructing negative pressure wound therapy. Int Wound J. 2017, 14:649-57. 10.1111\/iwj.12658","journal-title":"Int Wound J"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/iwj.70098","article-title":"Revisiting negative pressure wound therapy from a mechanobiological perspective supported by clinical and pathological data","volume":"21","author":"Gefen A","year":"2024","unstructured":"Gefen A, Russo S, Ciliberti M. Revisiting negative pressure wound therapy from a mechanobiological perspective supported by clinical and pathological data. Int Wound J. 2024, 21:e70098. 10.1111\/iwj.70098","journal-title":"Int Wound J"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2021.02.012","article-title":"Negative-pressure wound therapy in skin grafts: a systematic review and meta-analysis of randomized controlled trials","volume":"47","author":"Jiang ZY","year":"2021","unstructured":"Jiang ZY, Yu XT, Liao XC, Liu MZ, Fu ZH, Min DH, Guo GH. Negative-pressure wound therapy in skin grafts: a systematic review and meta-analysis of randomized controlled trials. Burns. 2021, 47:747-55. 10.1016\/j.burns.2021.02.012","journal-title":"Burns"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2009.21.4.389","article-title":"Ecthyma gangrenosum: a rare cutaneous manifestation caused by Stenotrophomonas maltophilia in a leukemic patient","volume":"21","author":"Son YM","year":"2009","unstructured":"Son YM, Na SY, Lee HY, Baek JO, Lee JR, Roh JY. Ecthyma gangrenosum: a rare cutaneous manifestation caused by Stenotrophomonas maltophilia in a leukemic patient. Ann Dermatol. 2009, 21:389-92. 10.5021\/ad.2009.21.4.389","journal-title":"Ann Dermatol"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.18683\/germs.2022.1314","article-title":"Double atypical co-infection in ecthyma gangrenosum: a peculiar case report","volume":"12","author":"Christopher PM","year":"2022","unstructured":"Christopher PM, Kristiani E, Cucunawangsih. Double atypical co-infection in ecthyma gangrenosum: a peculiar case report. Germs. 2022, 12:118-23. 10.18683\/germs.2022.1314","journal-title":"Germs"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.26326\/2281-9649.32.2.2350","article-title":"Acinetobacter baumannii-induced ecthyma gangrenosum: case report and review of non-pseudomonal cases reported in the literature","volume":"32","author":"Charaniya AL","year":"2022","unstructured":"Charaniya AL, Shilpashree P, Kavya HR. Acinetobacter baumannii-induced ecthyma gangrenosum: case report and review of non-pseudomonal cases reported in the literature. Eur J Pediatr Dermatol. 2022, 32:76-82. 10.26326\/2281-9649.32.2.2350","journal-title":"Eur J Pediatr Dermatol"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-019-0286-6","article-title":"Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis","volume":"15","author":"Nawijn F","year":"2020","unstructured":"Nawijn F, Smeeing DP, Houwert RM, Leenen LP, Hietbrink F. Time is of the essence when treating necrotizing soft tissue infections: a systematic review and meta-analysis. World J Emerg Surg. 2020, 15:4. 10.1186\/s13017-019-0286-6","journal-title":"World J Emerg Surg"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0000000000001857","article-title":"Optimal timing of initial debridement for necrotizing soft tissue infection: a practice management guideline from the Eastern Association for the Surgery of Trauma","volume":"85","author":"Gelbard RB","year":"2018","unstructured":"Gelbard RB, Ferrada P, Yeh DD, et al.. Optimal timing of initial debridement for necrotizing soft tissue infection: a practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2018, 85:208-14. 10.1097\/TA.0000000000001857","journal-title":"J Trauma Acute Care Surg"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1731792","article-title":"Negative pressure wound therapy: mechanism of action and clinical applications","volume":"35","author":"Normandin S","year":"2021","unstructured":"Normandin S, Safran T, Winocour S, Chu CK, Vorstenbosch J, Murphy AM, Davison PG. Negative pressure wound therapy: mechanism of action and clinical applications. Semin Plast Surg. 2021, 35:164-70. 10.1055\/s-0041-1731792","journal-title":"Semin Plast Surg"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2009.02.002","article-title":"The mechanisms of action of vacuum assisted closure: more to learn","volume":"146","author":"Orgill DP","year":"2009","unstructured":"Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC, Ehrlich HP. The mechanisms of action of vacuum assisted closure: more to learn. Surgery. 2009, 146:40-51. 10.1016\/j.surg.2009.02.002","journal-title":"Surgery"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2025.01.036","article-title":"Benefits of negative pressure wound therapy in skin grafts: a systematic review and meta-analysis of randomised controlled trials","volume":"102","author":"Lee SC","year":"2025","unstructured":"Lee SC, Bayan L, Sato A, et al.. Benefits of negative pressure wound therapy in skin grafts: a systematic review and meta-analysis of randomised controlled trials. J Plast Reconstr Aesthet Surg. 2025, 102:204-17. 10.1016\/j.bjps.2025.01.036","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.5999\/aps.2021.00297","article-title":"New proposal for skin grafts on tendon-exposed wounds","volume":"49","author":"Um JH","year":"2022","unstructured":"Um JH, Jo DI, Kim SH. New proposal for skin grafts on tendon-exposed wounds. Arch Plast Surg. 2022, 49:86-90. 10.5999\/aps.2021.00297","journal-title":"Arch Plast Surg"}],"container-title":["Cureus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cureus.com\/articles\/527709-limb-salvage-using-negative-pressure-wound-therapy-and-split-thickness-skin-grafting-for-polymicrobial-ecthyma-gangrenosum-in-a-patient-with-acute-lymphoblastic-leukemia-a-case-report","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:14:37Z","timestamp":1788840877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cureus.com\/articles\/527709-limb-salvage-using-negative-pressure-wound-therapy-and-split-thickness-skin-grafting-for-polymicrobial-ecthyma-gangrenosum-in-a-patient-with-acute-lymphoblastic-leukemia-a-case-report"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":20,"URL":"https:\/\/doi.org\/10.7759\/cureus.115919","relation":{},"ISSN":["2168-8184"],"issn-type":[{"value":"2168-8184","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,7]]}}}